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Co-Designing Quantum Codes with Transversal Diagonal Gates via Multi-Agent Systems

arXiv:2510.20728v3 Announce Type: replace-cross Abstract: Exact scientific discovery requires more than heuristic search: candidate constructions must be turned into exact objects and checked independently. We address this gap by extending TeXRA with an independent Lean 4 verification layer, turning it into a human-guided multi-agent platform for exact scientific discovery. The platform couples symbolic synthesis, combinatorial and linear-programming search, exact reconstruction of numerical candidates, and formal verification in Lean. We apply this platform to nonadditive quantum error-correcting codes with prescribed transversal diagonal gates within the subset-sum linear-programming (SSLP) framework. In the distance-2 regime where logical states occupy distinct residue classes, the platform yields a Lean-certified catalogue of 14,116 codes for $K\in\{2,3,4\}$ and up to six physical qubits, realizing cyclic logical orders 2 through 18, from which we extract closed-form infinite families. We also construct a residue-degenerate $((6,4,2))$ code implementing the logical controlled-phase gate $\mathrm{diag}(1,1,1,i)$. At distance 3, we resolve the transversal-$T$ problem for $((7,2,3))$ codes within the complementary binary-dihedral $\mathrm{BD}_{16}$ setting: among the 12 candidates surviving the SSLP filters, 10 admit exact realizations and 2 are excluded by no-go proofs. All accepted constructions, families, and no-go results are formalized and checked in Lean, illustrating how AI-assisted workflows can bridge search, exact reconstruction, and formal proof in the physical sciences.
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RFC4 drives temozolomide resistance in glioblastoma by activating STK38-BECN1-dependent autophagy

Nat Commun. 2026 Mar 23. doi: 10.1038/s41467-026-70798-1. Online ahead of print.

ABSTRACT

Glioblastoma (GBM) remains a lethal brain tumor due to therapy resistance. While autophagy contributes to temozolomide (TMZ) resistance, its regulation is incompletely understood. This study investigates the role of replication factor RFC4, which is associated with poor prognosis and TMZ resistance in GBM. Multi-omics analyses and molecular experiments reveal that TMZ-induced chromatin accessibility enables transcription factor YY1 to bind the RFC4 promoter and upregulate its expression. RFC4, in turn, stabilizes the kinase STK38, which is essential for autophagosome formation. The RFC4-STK38 interaction facilitates BECN1 recruitment, thereby activating autophagy. Phosphorylation of STK38 at T444 stabilizes this complex, whereas a phospho-deficient mutant impairs autophagy. In vivo, RFC4 overexpression confers TMZ resistance, reversible by autophagy inhibition. Thus, our findings identify the RFC4-STK38-BECN1 axis as a mechanism underlying TMZ resistance and a potential target for precision therapy in GBM.

PMID:41872171 | DOI:10.1038/s41467-026-70798-1

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Adaptation of Agentic AI: A Survey of Post-Training, Memory, and Skills

arXiv:2512.16301v3 Announce Type: replace Abstract: Large language model (LLM) agents are moving beyond prompting alone. ChatGPT marked the rise of general-purpose LLM assistants, DeepSeek showed that on-policy reinforcement learning with verifiable rewards can improve reasoning and tool use, and OpenClaw highlights a newer direction in which agents accumulate persistent memory and reusable skills. Yet the research landscape remains fragmented across post-training, retrieval, memory, and skill systems. This survey studies these developments under a single notion of \emph{adaptation}: improving an agent, its tools, or their interaction after pretraining. We organize the field with a four-paradigm framework spanning agent adaptation and tool adaptation. On the agent side, A1 (tool-execution-signaled) and A2 (agent-output-signaled) improve the agent itself through supervised fine-tuning, preference optimization, and reinforcement learning with verifiable rewards. On the tool side, T1 (agent-agnostic) provides reusable pre-trained modules any agent can call, while T2 (agent-supervised) uses the agent's outputs to train memory systems, skill libraries, or lightweight subagents. Using this framework, we review post-training methods, adaptive memory architectures, and agent skills; compare their trade-offs in cost, flexibility, and generalization; and summarize evaluation practices across deep research, software development, computer use, and drug discovery. We conclude by outlining open problems in agent-tool co-adaptation, continual learning, safety, and efficient deployment.
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