Li and colleagues identified RhoA as a “redox rheostat” governing mitochondrial dynamics during oncolytic virotherapy and thereby engineered rNDV-RHOA, an NDV-based oncolytic virus overexpressing RhoA. This tumor-targeted RhoA overexpression synergizes oxidative stress and viral oncolysis, transcending conventional oncolysis by surmounting tumor heterogeneity through exploiting inherent tumor redox dependency.

arXiv:2602.03955v3 Announce Type: replace Abstract: While large language model (LLM) multi-agent systems achieve superior reasoning performance through iterative debate, practical deployment is limited by their high computational cost and error propagation. This paper proposes AgentArk, a novel framework to distill multi-agent dynamics into the weights of a single model, effectively transforming explicit test-time interactions into implicit model capabilities. This equips a single agent with the intelligence of multi-agent systems while remaining computationally efficient. Specifically, we investigate three hierarchical distillation strategies across various models, tasks, scaling, and scenarios: reasoning-enhanced fine-tuning; trajectory-based augmentation; and process-aware distillation. By shifting the burden of computation from inference to training, the distilled models preserve the efficiency of one agent while exhibiting strong reasoning and self-correction performance of multiple agents. They further demonstrate enhanced robustness and generalization across diverse reasoning tasks. We hope this work can shed light on future research on efficient and robust multi-agent development. Our code is at https://github.com/AIFrontierLab/AgentArk.

arXiv:2604.01687v1 Announce Type: new Abstract: Anthropic proposes the concept of skills for LLM agents to tackle multi-step professional tasks that simple tool invocations cannot address. A tool is a single, self-contained function, whereas a skill is a structured bundle of interdependent multi-file artifacts. Currently, skill generation is not only label-intensive due to manual authoring, but also may suffer from human--machine cognitive misalignment, which can lead to degraded agent performance, as evidenced by evaluations on SkillsBench. Therefore, we aim to enable agents to autonomously generate skills. However, existing self-evolving methods designed for tools cannot be directly applied to skills due to their increased complexity. To address these issues, we propose EvoSkills, a self-evolving skills framework that enables agents to autonomously construct complex, multi-file skill packages. Specifically, EvoSkills couples a Skill Generator that iteratively refines skills with a Surrogate Verifier that co-evolves to provide informative and actionable feedback without access to ground-truth test content. On SkillsBench, EvoSkills achieves the highest pass rate among five baselines on both Claude Code and Codex, and also exhibits strong generalization capabilities to six additional LLMs.

arXiv:2603.12634v1 Announce Type: cross Abstract: Test-time scaling has become a dominant paradigm for improving LLM agent reliability, yet current approaches treat compute as an abundant resource, allowing agents to exhaust token and tool budgets on redundant steps or dead-end trajectories. Existing budget-aware methods either require expensive fine-tuning or rely on coarse, trajectory-level heuristics that cannot intervene mid-execution. We propose the Budget-Aware Value Tree (BAVT), a training-free inference-time framework that models multi-hop reasoning as a dynamic search tree guided by step-level value estimation within a single LLM backbone. Another key innovation is a budget-conditioned node selection mechanism that uses the remaining resource ratio as a natural scaling exponent over node values, providing a principled, parameter-free transition from broad exploration to greedy exploitation as the budget depletes. To combat the well-known overconfidence of LLM self-evaluation, BAVT employs a residual value predictor that scores relative progress rather than absolute state quality, enabling reliable pruning of uninformative or redundant tool calls. We further provide a theoretical convergence guarantee, proving that BAVT reaches a terminal answer with probability at least $1-\epsilon$ under an explicit finite budget bound. Extensive evaluations on four multi-hop QA benchmarks across two model families demonstrate that BAVT consistently outperforms parallel sampling baselines. Most notably, BAVT under strict low-budget constraints surpasses baseline performance at $4\times$ the resource allocation, establishing that intelligent budget management fundamentally outperforms brute-force compute scaling.

arXiv:2506.17337v3 Announce Type: replace-cross Abstract: Vision Language Models (VLMs) have shown promise in automating image diagnosis and interpretation in clinical settings. However, developing specialist medical VLMs requires substantial computational resources and carefully curated datasets, and it remains unclear under which conditions generalist and specialist medical VLMs each perform best. This study highlights the complementary strengths of specialist medical and generalist VLMs. Specialists remain valuable in modality-aligned use cases, but we find that efficiently fine-tuned generalist VLMs can achieve comparable or even superior performance in most tasks, particularly when transferring to unseen or rare OOD medical modalities. These results suggest that generalist VLMs, rather than being constrained by their lack of specialist medical pretraining, may offer a scalable and cost-effective pathway for advancing clinical AI development.