In the infection courses of different SARS-CoV-2 variants, disease outcomes and signatures were delineated by physiological changes, viral load, pathology, and pulmonary transcriptome analysis. This multi-dimensional landscape of disease outcomes and underlying mechanisms might provide important clues for immunotherapy of SARS-CoV-2 infection and pneumonia caused by other respiratory viruses.

arXiv:2602.10604v2 Announce Type: replace-cross Abstract: We introduce Step 3.5 Flash, a sparse Mixture-of-Experts (MoE) model that bridges frontier-level agentic intelligence and computational efficiency. We focus on what matters most when building agents: sharp reasoning and fast, reliable execution. Step 3.5 Flash pairs a 196B-parameter foundation with 11B active parameters for efficient inference. It is optimized with interleaved 3:1 sliding-window/full attention and Multi-Token Prediction (MTP-3) to reduce the latency and cost of multi-round agentic interactions. To reach frontier-level intelligence, we design a scalable reinforcement learning framework that combines verifiable signals with preference feedback, while remaining stable under large-scale off-policy training, enabling consistent self-improvement across mathematics, code, and tool use. Step 3.5 Flash demonstrates strong performance across agent, coding, and math tasks, achieving 85.4% on IMO-AnswerBench, 86.4% on LiveCodeBench-v6 (2024.08-2025.05), 88.2% on tau2-Bench, 69.0% on BrowseComp (with context management), and 51.0% on Terminal-Bench 2.0, comparable to frontier models such as GPT-5.2 xHigh and Gemini 3.0 Pro. By redefining the efficiency frontier, Step 3.5 Flash provides a high-density foundation for deploying sophisticated agents in real-world industrial environments.

arXiv:2602.14043v1 Announce Type: cross Abstract: Social simulation is critical for mining complex social dynamics and supporting data-driven decision making. LLM-based methods have emerged as powerful tools for this task by leveraging human-like social questionnaire responses to model group behaviors. Existing LLM-based approaches predominantly focus on group-level values at discrete time points, treating them as static snapshots rather than dynamic processes. However, group-level values are not fixed but shaped by long-term social changes. Modeling their dynamics is thus crucial for accurate social evolution prediction--a key challenge in both data mining and social science. This problem remains underexplored due to limited longitudinal data, group heterogeneity, and intricate historical event impacts. To bridge this gap, we propose a novel framework for group-level dynamic social simulation by integrating historical value trajectories into LLM-based human response modeling. We select China and the U.S. as representative contexts, conducting stratified simulations across four core sociodemographic dimensions (gender, age, education, income). Using the World Values Survey, we construct a multi-wave, group-level longitudinal dataset to capture historical value evolution, and then propose the first event-based prediction method for this task, unifying social events, current value states, and group attributes into a single framework. Evaluations across five LLM families show substantial gains: a maximum 30.88\% improvement on seen questions and 33.97\% on unseen questions over the Vanilla baseline. We further find notable cross-group heterogeneity: U.S. groups are more volatile than Chinese groups, and younger groups in both countries are more sensitive to external changes. These findings advance LLM-based social simulation and provide new insights for social scientists to understand and predict social value changes.