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Engineered immunosuppressive dendritic cells protect against cardiac remodelling

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10346-5

Lesion-targeted immune modulation is a feasible strategy to control cardiac fibrosis, and engineered dendritic cells are a promising therapeutic platform for treating cardiac remodelling and heart failure.
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PIAS4 inhibition induces cell cycle arrest and exhibits a synergistic effect in combination with CDK4/6 inhibitor in breast cancer treatment

Oncogene, Published online: 07 April 2026; doi:10.1038/s41388-026-03753-5

PIAS4 inhibition induces cell cycle arrest and exhibits a synergistic effect in combination with CDK4/6 inhibitor in breast cancer treatment
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CAPT: Confusion-Aware Prompt Tuning for Reducing Vision-Language Misalignment

arXiv:2603.02557v1 Announce Type: cross Abstract: Vision-language models like CLIP have achieved remarkable progress in cross-modal representation learning, yet suffer from systematic misclassifications among visually and semantically similar categories. We observe that such confusion patterns are not random but persistently occur between specific category pairs, revealing the model's intrinsic bias and limited fine-grained discriminative ability. To address this, we propose CAPT, a Confusion-Aware Prompt Tuning framework that enables models to learn from their own misalignment. Specifically, we construct a Confusion Bank to explicitly model stable confusion relationships across categories and misclassified samples. On this basis, we introduce a Semantic Confusion Miner (SEM) to capture global inter-class confusion through semantic difference and commonality prompts, and a Sample Confusion Miner (SAM) to retrieve representative misclassified instances from the bank and capture sample-level cues through a Diff-Manner Adapter that integrates global and local contexts. To further unify confusion information across different granularities, a Multi-Granularity Difference Expert (MGDE) module is designed to jointly leverage semantic- and sample-level experts for more robust confusion-aware reasoning. Extensive experiments on 11 benchmark datasets demonstrate that our method significantly reduces confusion-induced errors while enhancing the discriminability and generalization of both base and novel classes, successfully resolving 50.72 percent of confusable sample pairs. Code will be released at https://github.com/greatest-gourmet/CAPT.
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