Oncogene, Published online: 07 April 2026; doi:10.1038/s41388-026-03762-4

NSUN2/ALYREF-mediated RNA m5c modification promotes anoikis resistance of prostate cancer through activating autophagy

arXiv:2601.08462v2 Announce Type: replace Abstract: Existing benchmarks for LLM agents' social behavior typically focus on a single capability dimension and evaluate only behavioral outcomes, overlooking process signals from reasoning and communication. We present M3-BENCH, a benchmark of 24 mixed-motive games with a process-aware evaluation framework spanning three complementary views: Behavioral Trajectory Analysis (BTA), Reasoning Process Analysis (RPA), and Communication Content Analysis (CCA). Evaluating 11 frontier LLMs and a human baseline, M3-BENCH reveals substantial differences in social competence that outcome-only evaluation misses. In particular, we identify an "overthink-undercommunicate" pattern: reasoning models achieve strong internal deliberation scores but often fail to translate them into effective social communication. Although top models can surpass humans on task outcomes, humans exhibit markedly higher cross-view consistency, suggesting that current LLM agents still lack the behavioral coherence characteristic of human social competence. Our analysis further shows that the three-view decomposition surfaces safety-relevant risks, such as cooperative behavior paired with latent opportunistic reasoning, that remain hidden under outcome-only metrics.

Background: Evidence-based physician-pharmacist collaborative clinics have demonstrated significant short-term benefits for patients with type 2 diabetes (T2D), but their long-term effectiveness remains unclear, especially in primary health care settings. Objective: This study aimed to explore the long-term effectiveness and cost-effectiveness of a novel, digital-driven, multifaceted physician-pharmacist collaborative model for managing patients with T2D in underresourced settings. Methods: We conducted a 12-month cluster randomized controlled trial from May 2021 to December 2022 across 6 primary health care settings in China. Guided by the theory of planned behavior, the intervention involved routine therapy from physicians along with pharmaceutical interventions from pharmacists. These were delivered through a combination of face-to-face visits and mobile health care. The intervention group received 4 face-to-face visits and biweekly remote education sessions over the 12 months. We conducted intention-to-treat analyses to estimate differences in clinical and behavior indicators between the intervention and control groups. Primary outcomes included glycosylated hemoglobin and 10-year atherosclerotic cardiovascular risk. Data were analyzed using adjusted generalized estimation equations. Results: This study included 574 patients (291 in the intervention group and 283 in the control group). Over 12 months, patients in the intervention group had significant reductions in hemoglobin A_1c (–2.57 vs –1.96, respectively; P<.001; 95% CI –1.027 to –0.238) and 10-year atherosclerotic cardiovascular risk (–1.35 vs 0.01, respectively; P<.001; 95% CI –1.690 to –0.630) compared with the control group. Substantial improvements were also observed in several secondary outcomes, including fasting blood glucose, 2-hour postprandial blood glucose, waist circumference, waist-to-hip ratio, blood pressure, triglyceride, and total cholesterol. Total diabetes-related costs decreased, and patient satisfaction improved significantly in the intervention group. There were no significant differences in BMI, high-density lipoprotein, or low-density lipoprotein. Conclusions: These findings suggest that the physician-pharmacist collaborative model could improve the long-term quality and efficiency of T2D management and reduce medical costs in underresourced areas globally. Patients with T2D, especially those with central obesity or high cardiovascular risk, may benefit more from collaborative clinics. Trial Registration: Chinese Clinical Trial Registry ChiCTR2000031839; https://www.chictr.org.cn/showproj.html?proj=51910

arXiv:2601.02950v2 Announce Type: replace Abstract: Current Large Language Model reasoning systems process queries independently, discarding valuable cross-instance signals such as shared reasoning patterns and consistency constraints. We introduce Batch-of-Thought (BoT), a training-free method that processes related queries jointly to enable cross-instance learning. By performing comparative analysis across batches, BoT identifies high-quality reasoning templates, detects errors through consistency checks, and amortizes computational costs. We instantiate BoT within a multi-agent reflection architecture (BoT-R), where a Reflector performs joint evaluation to unlock mutual information gain unavailable in isolated processing. Experiments across three model families and six benchmarks demonstrate that BoT-R consistently improves accuracy and confidence calibration while reducing inference costs by up to 61%. Our theoretical and experimental analysis reveals when and why batch-aware reasoning benefits LLM systems. Our code is available at https://github.com/xuanyang19/BoT