Targeting KRAS reprograms a Treg-dominant immunosuppressive microenvironment and sensitizes KRAS-mutant gastric adenocarcinoma to CTLA-4 immunotherapy

(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)

By: Xiaohuan Tang · Peiyao Yang · Xiaoyong Guo · Shuhua Wei · Xiaojing Cheng · Mengyuan Li · Yigang Bao · Sachiyo Nomura · Yu Sun · Longtao Huangfu · Xiaofang Xing · Yongning Jia · Fei Shan · Xiangyu Gao · Chuanhui Han · Ziyu Li

9 September 2026 at 18:00

Sci China Life Sci. 2026 Sep 3. doi: 10.1007/s11427-026-3438-4. Online ahead of print.

ABSTRACT

Oncogenic KRAS mutations define a distinct molecular subset of gastric adenocarcinoma (GA), yet their impact on the tumor immune microenvironment remains incompletely understood. In this study, we established a genetically faithful and immunocompetent KRAS^G12D-driven mouse model of GA, together with matched organoids and cell lines, to investigate how oncogenic KRAS shapes tumor-immune interactions. KRAS-mutant tumors consistently developed an immunosuppressive microenvironment characterized by enrichment of regulatory T cells (Tregs), accompanied by reduced cytotoxic lymphocyte infiltration and intrinsic resistance to PD-1 blockade. Although pharmacologic targeting of KRAS effectively suppressed tumor growth and increased immune cell infiltration, functional immune analyses revealed persistent Treg-mediated immunosuppression that limited effective antitumor immunity. Mechanistically, TGF-β signaling was required to maintain Treg dominance and suppress effector T cell function in KRAS-driven tumors. Importantly, disruption of this suppressive axis through combined KRAS inhibition and CTLA-4 blockade attenuated TGF-β activity, impaired Treg function, and enhanced antitumor immune responses in vivo. Collectively, these findings identify oncogenic KRAS as a key regulator of TGF-β-dependent immune suppression in GA and provide mechanistic insight into immune evasion within this molecular subtype.

PMID:42714795 | DOI:10.1007/s11427-026-3438-4

SaaS-Bench: Can Computer-Use Agents Leverage Real-World SaaS to Solve Professional Workflows?

cs.AI, q-bio.NC updates on arXiv.org

By: Kean Shi · Zihang Li · Tianyi Ma · Zengji Tu · Jialong Wu · Xinbo Xu · Qingyao Yang · Ruoyu Wu · Weichu Xie · Ming Wu · Jason Zeng · Michael Heinrich · Elvis Zhang · Liang Chen · Kuan Li · Baobao Chang

26 May 2026 at 12:00

arXiv:2605.15777v2 Announce Type: replace Abstract: Computer-Using Agents (CUAs) are rapidly extending large language models (LLMs) beyond text-based reasoning toward action execution in more complex environments, such as web browsers and graphical user interfaces (GUIs). However, existing web and GUI agent benchmarks often rely on simplified settings, isolated tasks, or short-horizon interactions, making it difficult to assess capabilities of agents in realistic professional workflows. Software-as-a-Service (SaaS) environments are a natural choice for CUA evaluation, as they host a large share of modern digital work and naturally involve dynamic system states, cross-application coordination, domain-specific knowledge, and long-horizon dependencies. To this end, we introduce SaaS-Bench, a benchmark built on 23 deployable SaaS systems across six professional domains, containing 106 tasks grounded in realistic work scenarios. These tasks require long-horizon execution, cover both text-only and multimodal settings, and are evaluated with weighted verification checkpoints that measure strict task completion and partial progress. Experiments show that representative LLM-based agents struggle on SaaS-Bench, with even the strongest model completing fewer than 4% of tasks end-to-end, exposing limitations in planning, state tracking, cross-application context maintenance, and error recovery. Code are available at https://github.com/UniPat-AI/SaaS-Bench for reproduction.

Compressed-Domain-Aware Online Video Super-Resolution

cs.AI, q-bio.NC updates on arXiv.org

By: Yuhang Wang · Hai Li · Shujuan Hou · Zhetao Dong · Xiaoyao Yang

10 March 2026 at 12:00

arXiv:2603.07694v1 Announce Type: cross Abstract: In bandwidth-limited online video streaming, videos are usually downsampled and compressed. Although recent online video super-resolution (online VSR) approaches achieve promising results, they are still compute-intensive and fall short of real-time processing at higher resolutions, due to complex motion estimation for alignment and redundant processing of consecutive frames. To address these issues, we propose a compressed-domain-aware network (CDA-VSR) for online VSR, which utilizes compressed-domain information, including motion vectors, residual maps, and frame types to balance quality and efficiency. Specifically, we propose a motion-vector-guided deformable alignment module that uses motion vectors for coarse warping and learns only local residual offsets for fine-tuned adjustments, thereby maintaining accuracy while reducing computation. Then, we utilize a residual map gated fusion module to derive spatial weights from residual maps, suppressing mismatched regions and emphasizing reliable details. Further, we design a frame-type-aware reconstruction module for adaptive compute allocation across frame types, balancing accuracy and efficiency. On the REDS4 dataset, our CDA-VSR surpasses the state-of-the-art method TMP, with a maximum PSNR improvement of 0.13 dB while delivering more than double the inference speed. The code will be released at https://github.com/sspBIT/CDA-VSR.

Post-Routing Arithmetic in Llama-3: Last-Token Result Writing and Rotation-Structured Digit Directions

cs.AI, q-bio.NC updates on arXiv.org

By: Yao Yan

24 February 2026 at 13:00

arXiv:2602.19109v1 Announce Type: new Abstract: We study three-digit addition in Meta-Llama-3-8B (base) under a one-token readout to characterize how arithmetic answers are finalized after cross-token routing becomes causally irrelevant. Causal residual patching and cumulative attention ablations localize a sharp boundary near layer~17: beyond it, the decoded sum is controlled almost entirely by the last input token and late-layer self-attention is largely dispensable. In this post-routing regime, digit(-sum) direction dictionaries vary with a next-higher-digit context but are well-related by an approximately orthogonal map inside a shared low-rank subspace (low-rank Procrustes alignment). Causal digit editing matches this geometry: naive cross-context transfer fails, while rotating directions through the learned map restores strict counterfactual edits; negative controls do not recover.

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