Reading view

Circadian-based individualised protection against inflammation-cancer transition in atrophic gastritis patients

By: Ceng Shan · Min Guo · Feifan Feng · Xihong Wang · Mohang Li · Weichao Xu · Keyu Jia · Yifei Liu · Yifan Jia

2 September 2026 at 18:00

EPMA J. 2026 Aug 21;17(3):665-700. doi: 10.1007/s13167-026-00465-4. eCollection 2026 Sep.

ABSTRACT

Chronic atrophic gastritis (CAG) is a critical precancerous stage in the development of gastric cancer (GC). Circadian rhythm disruption perturbs the core clock gene network, including circadian locomotor output cycles kaput (CLOCK), brain and muscle ARNT-like 1 (BMAL1), period circadian protein homolog (PER), and cryptochrome (CRY). These alterations contribute to a multi-layered pathological cascade involving DNA damage accumulation, epigenetic remodeling, altered epithelial cell plasticity, cellular senescence, microbiota dysbiosis, tumor microenvironment remodeling, metabolic reprogramming, aberrant angiogenesis, and dysregulated cell death, thereby accelerating CAG to GC progression. However, existing studies have predominantly treated the circadian rhythm as a passive risk factor for disease onset and have yet to elevate it to an actionable interventional target within the full-course management of gastric precancerous lesions. Building on a systematic synthesis of the mechanistic evidence outlined above, this review proposes a predictive, preventive and personalised medicine (PPPM/3PM) three-tier management framework grounded in circadian-based individualised protection. At the predictive level, digital biomarkers (sleep-wake rhythms, light exposure, physical activity, and dietary behavior), multi-omics profiles, and circadian-related molecular signatures are integrated to achieve dynamic risk stratification of CAG populations. At the targeted prevention level, pharmacological agents and natural compounds with circadian-regulating potential are deployed to develop proactive protective strategies tailored to distinct pathological stages and circadian phenotypes. At the personalised treatment level, lifestyle interventions, chronotherapy, nano-carrier-based circadian-synchronised delivery, and dynamic biomarker monitoring are combined to formulate precision intervention regimens informed by individual circadian phenotypes. This framework repositions the circadian rhythm from a latent risk factor to a protectable and therapeutically targetable axis, offering new insights into time-optimised intervention strategies for the inflammation to cancer transition in CAG.

PMID:42682657 | PMC:PMC13530114 | DOI:10.1007/s13167-026-00465-4

Enhancing Structural Mapping with LLM-derived Abstractions for Analogical Reasoning in Narratives

cs.AI, q-bio.NC updates on arXiv.org

By: Mohammadhossein Khojasteh · Yifan Jiang · Stefano De Giorgis · Frank van Harmelen · Filip Ilievski

1 April 2026 at 12:00

arXiv:2603.29997v1 Announce Type: cross Abstract: Analogical reasoning is a key driver of human generalization in problem-solving and argumentation. Yet, analogies between narrative structures remain challenging for machines. Cognitive engines for structural mapping are not directly applicable, as they assume pre-extracted entities, whereas LLMs' performance is sensitive to prompt format and the degree of surface similarity between narratives. This gap motivates a key question: What is the impact of enhancing structural mapping with LLM-derived abstractions on their analogical reasoning ability in narratives? To that end, we propose a modular framework named YARN (Yielding Abstractions for Reasoning in Narratives), which uses LLMs to decompose narratives into units, abstract these units, and then passes them to a mapping component that aligns elements across stories to perform analogical reasoning. We define and operationalize four levels of abstraction that capture both the general meaning of units and their roles in the story, grounded in prior work on framing. Our experiments reveal that abstractions consistently improve model performance, resulting in competitive or better performance than end-to-end LLM baselines. Closer error analysis reveals the remaining challenges in abstraction at the right level, in incorporating implicit causality, and an emerging categorization of analogical patterns in narratives. YARN enables systematic variation of experimental settings to analyze component contributions, and to support future work, we make the code for YARN openly available.