Zhang and colleagues reveal that GPX4 serves as a critical regulator of NRF2-mediated otoprotection against aminoglycoside-induced hair cell injury. Their findings identify a GPX4-dependent antioxidant mechanism that enables therapeutic activation of NRF2 and provides new insights into strategies for preventing drug-induced hearing loss.

arXiv:2601.08654v3 Announce Type: replace-cross Abstract: Rubric-based text evaluation increasingly relies on large language models (LLMs) as scalable judges, yet frozen black-box models can interpret the same criteria inconsistently, produce score attributions that are difficult to audit, and map judgments poorly onto human scoring scales. We define this challenge as criteria transfer: translating human rubric intent into a stable, auditable inference-time scoring protocol. We introduce Rulers, which locks a task-level rubric specification, executes it through structured, evidence-grounded judgments, and calibrates the resulting signals to human score boundaries. Across four rubric-governed benchmarks and multiple frozen backbone models, Rulers achieves stronger agreement with human scores in most evaluated settings, while better matching empirical score distributions and remaining more stable under semantically equivalent rubric perturbations. Calibration controls and component ablations show that these gains cannot be attributed to post-hoc alignment alone, but depend on the combination of fixed criteria, traceable evidence, and calibrated score interpretation. These findings suggest that reliable LLM judging requires faithfully operationalizing human evaluation standards rather than relying on prompt-level scoring alone. Our code is available at https://github.com/LabRAI/Rulers.git.

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10527-2

A reconstruction method based on Gaussian-apodized single-sideband electron ptychography removes artefacts to enable the high-fidelity identification of guest species in porous materials.

arXiv:2602.03584v2 Announce Type: replace-cross Abstract: Policy gradient methods rely on a baseline to measure the relative advantage of an action, ensuring the model reinforces behaviors that outperform its current average capability. In the training of Large Language Models (LLMs) using Actor-Critic methods (e.g., PPO), this baseline is typically estimated by a Value Model (Critic) often as large as the policy model itself. However, as the policy continuously evolves, the value model requires expensive, synchronous incremental training to accurately track the shifting capabilities of the policy. To avoid this overhead, Group Relative Policy Optimization (GRPO) eliminates the coupled value model by using the average reward of a group of rollouts as the baseline; yet, this approach necessitates extensive sampling to maintain estimation stability. In this paper, we propose $V_0$, a Generalist Value Model capable of estimating the expected performance of any model on unseen prompts without requiring parameter updates. We reframe value estimation by treating the policy's dynamic capability as an explicit context input; specifically, we leverage a history of instruction-performance pairs to dynamically profile the model, departing from the traditional paradigm that relies on parameter fitting to perceive capability shifts. Focusing on value estimation at State Zero (i.e., the initial prompt, hence $V_0$), our model serves as a critical resource scheduler. During GRPO training, $V_0$ predicts success rates prior to rollout, allowing for efficient sampling budget allocation; during deployment, it functions as a router, dispatching instructions to the most cost-effective and suitable model. Empirical results demonstrate that $V_0$ significantly outperforms heuristic budget allocation and achieves a Pareto-optimal trade-off between performance and cost in LLM routing tasks.

arXiv:2602.10604v2 Announce Type: replace-cross Abstract: We introduce Step 3.5 Flash, a sparse Mixture-of-Experts (MoE) model that bridges frontier-level agentic intelligence and computational efficiency. We focus on what matters most when building agents: sharp reasoning and fast, reliable execution. Step 3.5 Flash pairs a 196B-parameter foundation with 11B active parameters for efficient inference. It is optimized with interleaved 3:1 sliding-window/full attention and Multi-Token Prediction (MTP-3) to reduce the latency and cost of multi-round agentic interactions. To reach frontier-level intelligence, we design a scalable reinforcement learning framework that combines verifiable signals with preference feedback, while remaining stable under large-scale off-policy training, enabling consistent self-improvement across mathematics, code, and tool use. Step 3.5 Flash demonstrates strong performance across agent, coding, and math tasks, achieving 85.4% on IMO-AnswerBench, 86.4% on LiveCodeBench-v6 (2024.08-2025.05), 88.2% on tau2-Bench, 69.0% on BrowseComp (with context management), and 51.0% on Terminal-Bench 2.0, comparable to frontier models such as GPT-5.2 xHigh and Gemini 3.0 Pro. By redefining the efficiency frontier, Step 3.5 Flash provides a high-density foundation for deploying sophisticated agents in real-world industrial environments.