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ST-BiBench: Benchmarking Multi-Stream Multimodal Coordination in Bimanual Embodied Tasks for MLLMs

arXiv:2602.08392v2 Announce Type: replace-cross Abstract: Multimodal Large Language Models (MLLMs) have significantly advanced the landscape of embodied AI, yet transitioning to synchronized bimanual coordination introduces formidable challenges in multi-stream multimodal integration. We introduce ST-BiBench, a comprehensive multi-tier framework for evaluating spatio-temporal multimodal coordination. Our approach centers on Strategic Coordination Planning, assessing high-level cross-modal reasoning over multiple action and perception streams. To investigate the "proximity paradox"-where semantically coherent plans fail to align with spatially grounded visual inputs-we incorporate Foundational Spatial Grounding to verify workspace awareness and arm-selection logic. Furthermore, we probe model frontiers through Fine-Grained Action Control, investigating whether MLLMs can directly synthesize high-dimensional continuous action modalities (16-Dim) from complex multimodal metadata. Evaluating 30+ state-of-the-art MLLMs, we uncover a persistent and pervasive "coordination paradox"-a significant gap between high-level strategic reasoning and fine-grained physical execution. Results reveal that while frontier MLLMs excel at logic-driven strategy, they frequently suffer from perception-logic disconnection and multi-stream interference during multimodal fusion. ST-BiBench provides a platform for identifying critical bottlenecks in multi-stream multimodal fusion and cross-modal alignment for complex embodied tasks.
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The Latent Space: Foundation, Evolution, Mechanism, Ability, and Outlook

arXiv:2604.02029v1 Announce Type: new Abstract: Latent space is rapidly emerging as a native substrate for language-based models. While modern systems are still commonly understood through explicit token-level generation, an increasing body of work shows that many critical internal processes are more naturally carried out in continuous latent space than in human-readable verbal traces. This shift is driven by the structural limitations of explicit-space computation, including linguistic redundancy, discretization bottlenecks, sequential inefficiency, and semantic loss. This survey aims to provide a unified and up-to-date landscape of latent space in language-based models. We organize the survey into five sequential perspectives: Foundation, Evolution, Mechanism, Ability, and Outlook. We begin by delineating the scope of latent space, distinguishing it from explicit or verbal space and from the latent spaces commonly studied in generative visual models. We then trace the field's evolution from early exploratory efforts to the current large-scale expansion. To organize the technical landscape, we examine existing work through the complementary lenses of mechanism and ability. From the perspective of Mechanism, we identify four major lines of development: Architecture, Representation, Computation, and Optimization. From the perspective of Ability, we show how latent space supports a broad capability spectrum spanning Reasoning, Planning, Modeling, Perception, Memory, Collaboration, and Embodiment. Beyond consolidation, we discuss the key open challenges, and outline promising directions for future research. We hope this survey serves not only as a reference for existing work, but also as a foundation for understanding latent space as a general computational and systems paradigm for next-generation intelligence.
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Dynamic Targetable Extracellular Vesicle Surface Proteins Monitor Depth of Response to CAR T Therapy

Res Sq [Preprint]. 2026 Mar 18:rs.3.rs-8913641. doi: 10.21203/rs.3.rs-8913641/v1.

ABSTRACT

Extracellular vesicles (EVs) represent a promising liquid biopsy platform in multiple myeloma (MM). We developed an MM EV Surface Protein Assay to quantify and dynamically monitor four MM EV subpopulations defined by targetable MM surface proteins (BCMA, CD38, GPRC5D, and CD319) across 336 serial blood samples from 45 relapsed/refractory MM (RRMM) patients treated with anti-BCMA chimeric antigen receptor (CAR) T-cell therapy. All four MM EV subpopulations significantly decreased in 43 patients with initial response, while BCMA+, GPRC5D+, and CD319+ MM EVs increased in 19 patients with progression, and antigen escape was detected by BCMA+ MM EVs. MM EV subpopulations differentiated minimal residual disease (MRD) status and complemented MRD for detecting early relapse before clinical progression. Notably, CD319+ MM EVs were early predictors of progression-free and overall survival in MRD-negative patients. This assay enables noninvasive monitoring of deep response, progression, and antigen escape, and stratifies survival in MRD-negative patients with RRMM.

PMID:41890853 | PMC:PMC13015583 | DOI:10.21203/rs.3.rs-8913641/v1

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