Exhausted T cells experience a breakdown of proteostasis, characterized by unfolded protein accumulation and rescuable by E3 ubiquitin ligase activity. Targeting T cell proteostasis highlights a promising strategy for cancer immunotherapy.

Oncogene, Published online: 14 March 2026; doi:10.1038/s41388-026-03714-y

LINC-AC092535.5 regulates MICAL2 mRNA level to inhibit p53-mediated ferroptosis in nasopharyngeal carcinoma