Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution

Nature - Issue - nature.com science feeds

By: Zhao Feng · Xiangning Li · Yue Luo · Xin Liu · Ben Long · Tao Jiang · Xueyan Jia · Xiaowei Chen · Jie Luo · Xiaokang Chai · Zhen Wang · Miao Ren · Xin Lu · Gang Yao · Mengting Zhao · Yuxin Li · Zhixiang Liu · Hong Ni · Chuhao Dou · Shengda Bao · Shicheng Yang · Zoutao Zhang · Jiandong Zhou · Lingyi Cai · Qi Zhang · Ayizuohere Tudi · Chaozhen Tan · Zhengchao Xu · Siqi Chen · Wenxiang Ding · Wenjuan Shi · Anan Li · Hong-wei Dong · Hui Gong · Qingming Luo

7 September 2026 at 08:00

Nature, Published online: 07 September 2026; doi:10.1038/s41586-026-11094-2

Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution

Detecting Unfaithful Chain-of-Thought via Circuit-Guided Internal-External Discrepancy

cs.AI, q-bio.NC updates on arXiv.org

By: Xu Shen · Zhen Tan · Song Wang · Pingjun Hong · Rui Miao · Xin Wang · Tianlong Chen

26 May 2026 at 12:00

arXiv:2605.25603v1 Announce Type: new Abstract: Chain-of-thought (CoT) reasoning improves the problem-solving ability of large language models (LLMs), but generated reasoning traces may not faithfully reflect the model's actual decision process. Existing CoT unfaithfulness detectors mainly rely on external signals from generated rationales, such as textual plausibility or answer consistency, while overlooking evidence from the model's internal computation. Although recent circuit tracing methods provide a way to obtain model-internal evidence by tracing how information flows through model components during reasoning, constructing full reasoning circuits for long CoTs is costly and difficult to scale. To address these challenges, we propose Circuit-guided Internal-External Discrepancy Scorer (CIE-Scorer), a framework for instance-level CoT unfaithfulness detection. The key idea is that faithful reasoning traces should align with the model's computational process, whereas unfaithful traces may diverge from it. CIE-Scorer efficiently traces compact sentence-level circuits from informative reasoning tokens, constructs internal and external reasoning graphs, and measures their discrepancy using Fused Gromov--Wasserstein distance. Experiments on four datasets from FaithCoT-Bench show that CIE-Scorer achieves state-of-the-art performance while reducing the cost of circuit construction, demonstrating the effectiveness of combining mechanistic interpretability signals with external reasoning traces for CoT unfaithfulness detection.

Integrative bioinformatics and experimental validation reveal quercetin as a potential multi-target therapeutic agent in hepatocellular carcinoma

Omics in Hepatocellular

By: Longfei Zeng · Gang Zhu · Shaozhen Tang · Tao Wu · Liu Yang · Xin Zhang · Li Dai

18 May 2026 at 18:00

Cytotechnology. 2026 Jun;78(3):119. doi: 10.1007/s10616-026-00993-x. Epub 2026 May 14.

ABSTRACT

Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer worldwide, with increasing incidence and mortality rates. Although several targeted therapies are currently available, the therapeutic outcomes remain unsatisfactory due to the high heterogeneity and drug resistance of HCC. Therefore, novel molecular mechanisms and therapeutic strategies urgently need to be explored. In this study, we obtained the GSE39791 dataset from the GEO database and identified 1,186 differentially expressed genes (DEGs). Weighted gene co-expression network analysis (WGCNA) was conducted to obtain 776 key module genes, which were intersected with 11,671 HCC-related genes from the GeneCards database, resulting in 226 candidate genes. A protein-protein interaction (PPI) network was constructed using the STRING database, and the top 20 hub genes were identified using the MNC algorithm in Cytoscape. Among these, the five most significant hub genes-RFC4, TOP2A, AURKA, HSP90AA1, and MCM4-were selected for further analysis. KEGG enrichment analysis was performed to explore their functional pathways. Potential therapeutic agents were predicted using the CMap database, and molecular docking was conducted via AutoDock Vina. To validate the computational predictions, a quercetin intervention model was established. The optimal dose was determined through CCK-8 assays in HepG2 cells, and the expression of the five hub genes was examined in normal liver cells (LO2), HepG2 cells, and HepG2 cells treated with quercetin using RT-qPCR. The five hub genes-RFC4, TOP2A, AURKA, HSP90AA1, and MCM4-were significantly overexpressed in both HCC tissues and cell lines. Enrichment analysis revealed that these genes were mainly involved in cancer-related pathways, including the cell cycle, p53 signaling pathway, and FoxO signaling pathway. Drug prediction analysis showed that quercetin exhibited a negative regulatory pattern with respect to HCC and displayed binding energies below - 5 kcal/mol with all five hub proteins. CCK-8 assays confirmed the dose-dependent inhibitory effect of quercetin on HepG2 cell viability. RT-qPCR results demonstrated that quercetin significantly downregulated the expression of the five hub genes, consistent with the bioinformatics predictions. This study integrated multi-omics analysis and experimental validation to identify five core genes closely associated with HCC and suggested that quercetin may exert anti-HCC effects partly associated with the regulation of these genes. Our findings offer new insights into the molecular mechanisms of HCC and provide a promising strategy for the development of targeted therapeutics.

SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10616-026-00993-x.

PMID:42145839 | PMC:PMC13176377 | DOI:10.1007/s10616-026-00993-x

Decoding Tourist Perception in Historic Urban Quarters with Multimodal Social Media Data: An AI-Based Framework and Evidence from Shanghai

cs.AI, q-bio.NC updates on arXiv.org

By: Kaizhen Tan · Yufan Wu · Yuxuan Liu · Haoran Zeng

24 February 2026 at 13:00

arXiv:2509.03830v3 Announce Type: replace Abstract: Historic urban quarters are increasingly shaped by tourism and lifestyle consumption, yet planners often lack scalable evidence on what visitors notice, prefer, and criticize in these environments. This study proposes an AI-based, multimodal framework to decode tourist perception by combining visual attention, color-based aesthetic representation, and multidimensional satisfaction. We collect geotagged photos and review texts from a major Chinese platform and assemble a street view image set as a baseline for comparison across 12 historic urban quarters in Shanghai. We train a semantic segmentation model to quantify foregrounded visual elements in tourist-shared imagery, extract and compare color palettes between social media photos and street views, and apply a multi-task sentiment classifier to assess satisfaction across four experience dimensions that correspond to activity, physical setting, supporting services, and commercial offerings. Results show that tourist photos systematically foreground key streetscape elements and that the color composition represented on social media can differ from on-site street views, indicating a perception-reality gap that varies by quarter. The framework offers an interpretable and transferable approach to diagnose such gaps and to inform heritage management and visitor-oriented urban design.

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