Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10244-w

A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.

arXiv:2603.00040v2 Announce Type: replace-cross Abstract: Achieving reliable 4-bit attention is a prerequisite for end-to-end FP4 computation on emerging FP4-capable GPUs, yet attention remains the main obstacle due to FP4's tiny dynamic range and attention's heavy-tailed activations. This paper presents the first systematic study of 4-bit quantization-aware training (QAT) for attention. We find that "drop-in" QAT, which naively combines an FP4 forward pass with a high-precision Flash Attention (FA)-style backward pass, leads to training instability. We identify two key principles for stable FP4 attention: (1) matching low-precision recomputation of attention scores in the backward pass, and (2) resolving implicit precision assumptions in FA's gradient calculation. Based on these insights, we propose Attn-QAT and implement fused Triton kernels for training as well as FP4 inference kernels. Across diffusion and language models, Attn-QAT recovers the quality drop from FP4 attention without explicit outlier-mitigation heuristics used in prior FP4 attention, and delivers up to a 1.5x speedup on an RTX 5090. Video demos can be found at https://drive.google.com/drive/folders/190F6xbBDUF2kGQYIcXBt3ehSYij5jlim?usp=sharing.

arXiv:2603.04385v2 Announce Type: replace-cross Abstract: Feed-forward transformer models have driven rapid progress in 3D vision, but state-of-the-art methods such as VGGT and $\pi^3$ have a computational cost that scales quadratically with the number of input images, making them inefficient when applied to large image collections. Sequential-reconstruction approaches reduce this cost but sacrifice reconstruction quality. We introduce ZipMap, a stateful feed-forward model that achieves linear-time, bidirectional 3D reconstruction while matching or surpassing the accuracy of quadratic-time methods. ZipMap employs test-time training layers to zip an entire image collection into a compact hidden scene state in a single forward pass, enabling reconstruction of over 700 frames in under 10 seconds on a single H100 GPU, more than $20\times$ faster than state-of-the-art methods such as VGGT. Moreover, we demonstrate the benefits of having a stateful representation in real-time scene-state querying and its extension to sequential streaming reconstruction.

Oncogene, Published online: 05 March 2026; doi:10.1038/s41388-026-03713-z

KRAS-extrachromosomal DNA drives intratumoral heterogeneity in gastric cancer

arXiv:2603.04128v1 Announce Type: cross Abstract: Developing Audio-Visual Large Language Models (AV-LLMs) for unified scene understanding is pivotal in multimodal intelligence. While instruction tuning enables pre-trained models with multi-task abilities, we observe that conventional multi-task unification methods often suffer from severe negative transfer, where nearly 55% of tasks degrade compared to single-task training. We attribute this phenomenon to audio-visual task heterogeneity, characterized by disparate task granularity and divergent capability demands, which lead to negative interference under joint training. To tackle this, we present Crab$^{+}$, a scalable and unified audio-visual scene understanding model that addresses task heterogeneity through explicit cooperation from both data and model perspectives. On the data side, we introduce AV-UIE v2, a comprehensive Audio-Visual Unified Instruction-tuning dataset with Explicit reasoning processes. It contains approximately 222K samples spanning 17 datasets and 7 tasks, enabling the model to capture cross-task relationships at different levels of granularity. On the model side, we design a unified interface to align heterogeneous task formulations, and propose Interaction-aware LoRA (I-LoRA), which explicitly models inter-task relationships via dynamic routing to coordinate distinct audio-visual interaction patterns, mitigating parameter interference. Extensive experiments show Crab$^{+}$ covers broader tasks than existing unified models while outperforming specialized models on various benchmarks. We successfully reverse the negative transfer trend, achieving positive transfer where multi-task learning surpasses single-task baselines in nearly 88% of tasks. These results hold across diverse AV-LLM paradigms and are validated through in-depth visualization, positioning Crab$^{+}$ as a robust step towards holistic audio-visual scene understanding.

arXiv:2603.04385v1 Announce Type: cross Abstract: Feed-forward transformer models have driven rapid progress in 3D vision, but state-of-the-art methods such as VGGT and $\pi^3$ have a computational cost that scales quadratically with the number of input images, making them inefficient when applied to large image collections. Sequential-reconstruction approaches reduce this cost but sacrifice reconstruction quality. We introduce ZipMap, a stateful feed-forward model that achieves linear-time, bidirectional 3D reconstruction while matching or surpassing the accuracy of quadratic-time methods. ZipMap employs test-time training layers to zip an entire image collection into a compact hidden scene state in a single forward pass, enabling reconstruction of over 700 frames in under 10 seconds on a single H100 GPU, more than $20\times$ faster than state-of-the-art methods such as VGGT. Moreover, we demonstrate the benefits of having a stateful representation in real-time scene-state querying and its extension to sequential streaming reconstruction.

arXiv:2603.01562v2 Announce Type: replace Abstract: As Large Language Model (LLM) alignment evolves from simple completions to complex, highly sophisticated generation, Reward Models are increasingly shifting toward rubric-guided evaluation to mitigate surface-level biases. However, the community lacks a unified benchmark to assess this evaluation paradigm, as existing benchmarks lack both the discriminative complexity and the ground-truth rubric annotations required for rigorous analysis. To bridge this gap, we introduce RubricBench, a curated benchmark with 1,147 pairwise comparisons specifically designed to assess the reliability of rubric-based evaluation. Our construction employs a multi-dimensional filtration pipeline to target hard samples featuring nuanced input complexity and misleading surface bias, augmenting each with expert-annotated, atomic rubrics derived strictly from instructions. Comprehensive experiments reveal a substantial capability gap between human-annotated and model-generated rubrics, indicating that even state-of-the-art models struggle to autonomously specify valid evaluation criteria, lagging considerably behind human-guided performance.

arXiv:2602.18962v2 Announce Type: replace-cross Abstract: The double empathy problem frames communication difficulties between neurodivergent and neurotypical individuals as arising from mutual misunderstanding, yet most interventions focus on autistic individuals. We present NeuroWise, a multi-agent LLM-based coaching system that supports neurotypical users through stress visualization, interpretation of internal experiences, and contextual guidance. In a between-subjects study (N=30), NeuroWise was rated as helpful by all participants and showed a significant condition-time effect on deficit-based attributions (p=0.02): NeuroWise users reduced deficit framing, while baseline users shifted toward blaming autistic "deficits" after difficult interactions. NeuroWise users also completed conversations more efficiently (37% fewer turns, p=0.03). These findings suggest that AI-based interpretation can support attributional change by helping users recognize communication challenges as mutual.

arXiv:2602.18929v1 Announce Type: cross Abstract: Conventional sequential recommendation models have achieved remarkable success in mining implicit behavioral patterns. However, these architectures remain structurally blind to explicit user intent: they struggle to adapt when a user's immediate goal (e.g., expressed via a natural language prompt) deviates from their historical habits. While Large Language Models (LLMs) offer the semantic reasoning to interpret such intent, existing integration paradigms force a dilemma: LLM-as-a-recommender paradigm sacrifices the efficiency and collaborative precision of ID-based retrieval, while Reranking methods are inherently bottlenecked by the recall capabilities of the underlying model. In this paper, we propose Decoupled Promptable Sequential Recommendation (DPR), a model-agnostic framework that empowers conventional sequential backbones to natively support Promptable Recommendation, the ability to dynamically steer the retrieval process using natural language without abandoning collaborative signals. DPR modulates the latent user representation directly within the retrieval space. To achieve this, we introduce a Fusion module to align the collaborative and semantic signals, a Mixture-of-Experts (MoE) architecture that disentangles the conflicting gradients from positive and negative steering, and a three-stage training strategy that progressively aligns the semantic space of prompts with the collaborative space. Extensive experiments on real-world datasets demonstrate that DPR significantly outperforms state-of-the-art baselines in prompt-guided tasks while maintaining competitive performance in standard sequential recommendation scenarios.

arXiv:2602.18962v1 Announce Type: cross Abstract: The double empathy problem frames communication difficulties between neurodivergent and neurotypical individuals as arising from mutual misunderstanding, yet most interventions focus on autistic individuals. We present NeuroWise, a multi-agent LLM-based coaching system that supports neurotypical users through stress visualization, interpretation of internal experiences, and contextual guidance. In a between-subjects study (N=30), NeuroWise was rated as helpful by all participants and showed a significant condition-time effect on deficit-based attributions (p=0.02): NeuroWise users reduced deficit framing, while baseline users shifted toward blaming autistic "deficits" after difficult interactions. NeuroWise users also completed conversations more efficiently (37% fewer turns, p=0.03). These findings suggest that AI-based interpretation can support attributional change by helping users recognize communication challenges as mutual.

arXiv:2602.19455v1 Announce Type: cross Abstract: Time-series diagnostic reasoning is essential for many applications, yet existing solutions face a persistent gap: general reasoning large language models (GRLMs) possess strong reasoning skills but lack the domain-specific knowledge to understand complex time-series patterns. Conversely, fine-tuned time-series LLMs (TSLMs) understand these patterns but lack the capacity to generalize reasoning for more complicated questions. To bridge this gap, we propose a hybrid knowledge-injection framework that injects TSLM-generated insights directly into GRLM's reasoning trace, thereby achieving strong time-series reasoning with in-domain knowledge. As collecting data for knowledge injection fine-tuning is costly, we further leverage a reinforcement learning-based approach with verifiable rewards (RLVR) to elicit knowledge-rich traces without human supervision, then transfer such an in-domain thinking trace into GRLM for efficient knowledge injection. We further release SenTSR-Bench, a multivariate time-series-based diagnostic reasoning benchmark collected from real-world industrial operations. Across SenTSR-Bench and other public datasets, our method consistently surpasses TSLMs by 9.1%-26.1% and GRLMs by 7.9%-22.4%, delivering robust, context-aware time-series diagnostic insights.

arXiv:2602.14602v1 Announce Type: cross Abstract: The opioid epidemic continues to ravage communities worldwide, straining healthcare systems, disrupting families, and demanding urgent computational solutions. To combat this lethal opioid crisis, graph learning methods have emerged as a promising paradigm for modeling complex drug-related phenomena. However, a significant gap remains: there is no comprehensive benchmark for systematically evaluating these methods across real-world opioid crisis scenarios. To bridge this gap, we introduce OPBench, the first comprehensive opioid benchmark comprising five datasets across three critical application domains: opioid overdose detection from healthcare claims, illicit drug trafficking detection from digital platforms, and drug misuse prediction from dietary patterns. Specifically, OPBench incorporates diverse graph structures, including heterogeneous graphs and hypergraphs, to preserve the rich and complex relational information among drug-related data. To address data scarcity, we collaborate with domain experts and authoritative institutions to curate and annotate datasets while adhering to privacy and ethical guidelines. Furthermore, we establish a unified evaluation framework with standardized protocols, predefined data splits, and reproducible baselines to facilitate fair and systematic comparison among graph learning methods. Through extensive experiments, we analyze the strengths and limitations of existing graph learning methods, thereby providing actionable insights for future research in combating the opioid crisis. Our source code and datasets are available at https://github.com/Tianyi-Billy-Ma/OPBench.

arXiv:2602.14919v1 Announce Type: cross Abstract: Hypergraph Neural Networks (HyGNNs) have demonstrated remarkable success in modeling higher-order relationships among entities. However, their performance often degrades on heterophilic hypergraphs, where nodes connected by the same hyperedge tend to have dissimilar semantic representations or belong to different classes. While several HyGNNs, including our prior work BHyGNN, have been proposed to address heterophily, their reliance on labeled data significantly limits their applicability in real-world scenarios where annotations are scarce or costly. To overcome this limitation, we introduce BHyGNN+, a self-supervised learning framework that extends BHyGNN for representation learning on heterophilic hypergraphs without requiring ground-truth labels. The core idea of BHyGNN+ is hypergraph duality, a structural transformation where the roles of nodes and hyperedges are interchanged. By contrasting augmented views of a hypergraph against its dual using cosine similarity, our framework captures essential structural patterns in a fully unsupervised manner. Notably, this duality-based formulation eliminates the need for negative samples, a common requirement in existing hypergraph contrastive learning methods that is often difficult to satisfy in practice. Extensive experiments on eleven benchmark datasets demonstrate that BHyGNN+ consistently outperforms state-of-the-art supervised and self-supervised baselines on both heterophilic and homophilic hypergraphs. Our results validate the effectiveness of leveraging hypergraph duality for self-supervised learning and establish a new paradigm for representation learning on challenging, unlabeled hypergraphs.

arXiv:2602.05847v2 Announce Type: replace Abstract: While humans perceive the world through diverse modalities that operate synergistically to support a holistic understanding of their surroundings, existing omnivideo models still face substantial challenges on audio-visual understanding tasks. In this paper, we propose OmniVideo-R1, a novel reinforced framework that improves mixed-modality reasoning. OmniVideo-R1 empowers models to "think with omnimodal cues" by two key strategies: (1) query-intensive grounding based on self-supervised learning paradigms; and (2) modality-attentive fusion built upon contrastive learning paradigms. Extensive experiments on multiple benchmarks demonstrate that OmniVideo-R1 consistently outperforms strong baselines, highlighting its effectiveness and robust generalization capabilities.