Oncogene, Published online: 13 March 2026; doi:10.1038/s41388-026-03706-y

METTL16 enhances proteasome inhibitor resistance in multiple myeloma by inhibiting eIF2α-PERK interaction and promoting PSMB5 translation

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10215-1

SUMM2, a coiled-coil NLR, promotes the assembly of higher-order resistosome clusters to initiate cell death in plants.

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10244-w

A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.

Cell Death Discovery, Published online: 11 March 2026; doi:10.1038/s41420-026-02990-7

MAPK14/SLC7A11/GPX4 axis dysregulation drives podocyte ferroptosis via mediating glycerophospholipid metabolism

arXiv:2603.07438v1 Announce Type: new Abstract: Regulatory stress testing requires projecting credit losses under hypothetical macroeconomic scenarios -- a fundamentally causal question typically treated as a prediction problem. We propose a framework for policy-path counterfactual inference in panels that transparently separates what can be learned from data from what requires assumptions about confounding. Our approach has four components: (i) observational identification of path-conditional means via iterated regression, enabling continuous macro-path contrasts without requiring a control group; (ii) causal set identification under bounded confounding, yielding sharp identified sets with interpretable breakdown values that communicate robustness in a single number; (iii) an oracle inequality showing that recursive rollout error is governed by a horizon-dependent amplification factor, providing a concrete answer to how far ahead one can reliably predict under stress; and (iv) importance-weighted conformal calibration bands with diagnostics that quantify extrapolation cost and trigger abstention when coverage guarantees degrade. The final output is a three-layer uncertainty decomposition that cleanly separates estimation uncertainty from confounding uncertainty. We validate all results through simulation and semi-synthetic experiments with real unemployment data, including a Covid retrospective demonstrating the framework's diagnostic value under extreme scenarios.

arXiv:2603.07997v1 Announce Type: new Abstract: Although large language models (LLMs) are introduced into vision-and-language navigation (VLN) to improve instruction comprehension and generalization, existing LLM- based VLN lacks the ability to selectively recall and use relevant priori experiences to help navigation tasks, limiting their performance in long-horizon and unfamiliar scenarios. In this work, we propose CMMR-VLN (Continual Multimodal Memory Retrieval based VLN), a VLN framework that endows LLM agents with structured memory and reflection capabilities. Specifically, the CMMR-VLN constructs a multimodal experi- ence memory indexed by panoramic visual images and salient landmarks to retrieve relevant experiences during navigation, introduces a retrieved-augmented generation pipeline to mimick how experienced human navigators leverage priori knowledge, and incorporates a reflection-based memory update strategy that selectively stores complete successful paths and the key initial mistake in failure cases. Comprehensive tests illustrate average success rate improvements of 52.9%, 20.9% and 20.9%, and 200%, 50% and 50% over the NavGPT, the MapGPT, and the DiscussNav in simulation and real tests, respectively eluci- dating the great potential of the CMMR-VLN as a backbone VLN framework.

arXiv:2603.08117v1 Announce Type: new Abstract: Recent advancements in LLM-based information-seeking agents have achieved record-breaking performance on established benchmarks. However, these agents remain heavily reliant on search-engine-indexed knowledge, leaving a critical blind spot: Unindexed Information Seeking (UIS). This paper identifies and explores the UIS problem, where vital information is not captured by search engine crawlers, such as overlooked content, dynamic webpages, and embedded files. Despite its significance, UIS remains an underexplored challenge. To address this gap, we introduce UIS-QA, the first dedicated UIS benchmark, comprising 110 expert-annotated QA pairs. Notably, even state-of-the-art agents experience a drastic performance drop on UIS-QA (e.g., from 70.90 on GAIA and 46.70 on BrowseComp-zh to 24.55 on UIS-QA), underscoring the severity of the problem. To mitigate this, we propose UIS-Digger, a novel multi-agent framework that incorporates dual-mode browsing and enables simultaneous webpage searching and file parsing. With a relatively small $\sim$30B-parameter backbone LLM optimized using SFT and RFT training strategies, UIS-Digger sets a strong baseline at 27.27\%, outperforming systems integrating sophisticated LLMs such as O3 and GPT-4.1. This demonstrates the importance of proactive interaction with unindexed sources for effective and comprehensive information-seeking. Our work not only uncovers a fundamental limitation in current agent evaluation paradigms but also provides the first toolkit for advancing UIS research, defining a new and promising direction for robust information-seeking systems.

arXiv:2507.11202v1 Announce Type: cross Abstract: Multimodal Emotion Recognition (MER) often encounters incomplete multimodality in practical applications due to sensor failures or privacy protection requirements. While existing methods attempt to address various incomplete multimodal scenarios by balancing the training of each modality combination through additional gradients, these approaches face a critical limitation: training gradients from different modality combinations conflict with each other, ultimately degrading the performance of the final prediction model. In this paper, we propose a unimodal decoupled dynamic low-rank adaptation method based on modality combinations, named MCULoRA, which is a novel framework for the parameter-efficient training of incomplete multimodal learning models. MCULoRA consists of two key modules, modality combination aware low-rank adaptation (MCLA) and dynamic parameter fine-tuning (DPFT). The MCLA module effectively decouples the shared information from the distinct characteristics of individual modality combinations. The DPFT module adjusts the training ratio of modality combinations based on the separability of each modality's representation space, optimizing the learning efficiency across different modality combinations. Our extensive experimental evaluation in multiple benchmark datasets demonstrates that MCULoRA substantially outperforms previous incomplete multimodal learning approaches in downstream task accuracy.

arXiv:2603.06612v1 Announce Type: cross Abstract: Pass@k and other methods of scaling inference compute can improve language model performance in domains with external verifiers, including mathematics and code, where incorrect candidates can be filtered reliably. This raises a natural question: can we similarly scale compute to elicit gains in truthfulness for domains without convenient verification? We show that across five benchmarks and models, surprisingly, it cannot. Even at 25x the inference cost of naive sampling, polling-style aggregation yields no consistent accuracy gains over single-sample baselines and often amplifies shared misconceptions. We find that under uncertainty, models are better at predicting what other models will say within model ensembles than at identifying what is true, revealing a separation between social prediction and truth verification. Across models and benchmarks, aggregation fails to provide a robust truth signal because language model errors are strongly correlated. The source of correlation goes beyond any individual benchmark: we show that even when conditioned on out of distribution random strings and asked to produce pseudo-random outputs, different models produce correlated outputs. Confidence-based weighting provides no benefit because self-reported confidence fails to reliably distinguish correct from incorrect answers. These results delineate a boundary for inference-time scaling: in verified domains, additional samples provide more candidates for a verifier to filter; in unverified domains, additional samples merely reinforce shared misconceptions.

arXiv:2603.06651v1 Announce Type: cross Abstract: Euclidean gradient descent algorithms barely capture the geometry of objective function-induced hypersurfaces and risk driving update trajectories off the hypersurfaces. Riemannian gradient descent algorithms address these issues but fail to represent complex hypersurfaces via a single classic manifold. We propose geodesic gradient descent (GGD), a generic and learning-rate-free Riemannian gradient descent algorithm. At each iteration, GGD uses an n-dimensional sphere to approximate a local neighborhood on the objective function-induced hypersurface, adapting to arbitrarily complex geometries. A tangent vector derived from the Euclidean gradient is projected onto the sphere to form a geodesic, ensuring the update trajectory stays on the hypersurface. Parameter updates are performed using the endpoint of the geodesic. The maximum step size of the gradient in GGD is equal to a quarter of the arc length on the n-dimensional sphere, thus eliminating the need for a learning rate. Experimental results show that compared with the classic Adam algorithm, GGD achieves test MSE reductions ranging from 35.79% to 48.76% for fully connected networks on the Burgers' dataset, and cross-entropy loss reductions ranging from 3.14% to 11.59% for convolutional neural networks on the MNIST dataset.

arXiv:2603.06665v1 Announce Type: cross Abstract: Large vision-language models (VLMs) often benefit from chain-of-thought (CoT) prompting in general domains, yet its efficacy in medical vision-language tasks remains underexplored. We report a counter-intuitive trend: on medical visual question answering, CoT frequently underperforms direct answering (DirA) across general-purpose and medical-specific models. We attribute this to a \emph{medical perception bottleneck}: subtle, domain-specific cues can weaken visual grounding, and CoT may compound early perceptual uncertainty rather than correct it. To probe this hypothesis, we introduce two training-free, inference-time grounding interventions: (i) \emph{perception anchoring} via region-of-interest cues and (ii) \emph{description grounding} via high-quality textual guidance. Across multiple benchmarks and model families, these interventions improve accuracy, mitigate CoT degradation, and in several settings reverse the CoT--DirA inversion. Our findings suggest that reliable clinical VLMs require robust visual grounding and cross-modal alignment, beyond extending text-driven reasoning chains. Code is available \href{https://github.com/TianYin123/Better_Eyes_Better_Thoughts}{here}.

arXiv:2603.07020v1 Announce Type: cross Abstract: Neural approaches to the Flexible Job Shop Scheduling Problem (FJSP), particularly those based on deep reinforcement learning (DRL), have gained growing attention in recent years. However, existing methods rely on complex feature-engineered state representations (i.e., often requiring more than 20 handcrafted features) and graph-biased neural architectures. To reduce modeling complexity and advance a more generalizable framework for FJSP, we introduce \textsc{ReSched}, a minimalist DRL framework that rethinks both the scheduling formulation and model design. First, by revisiting the Markov Decision Process (MDP) formulation of FJSP, we condense the state space to just four essential features, eliminating historical dependencies through a subproblem-based perspective. Second, we employ Transformer blocks with dot-product attention, augmented by three lightweight but effective architectural modifications tailored to scheduling tasks. Extensive experiments show that \textsc{ReSched} outperforms classical dispatching rules and state-of-the-art DRL methods on FJSP. Moreover, \textsc{ReSched} also generalizes well to the Job Shop Scheduling Problem (JSSP) and the Flexible Flow Shop Scheduling Problem (FFSP), achieving competitive performance against neural baselines specifically designed for these variants.

arXiv:2603.07909v1 Announce Type: cross Abstract: Accurate intraoperative navigation is essential for robot-assisted endoluminal intervention, but remains difficult because of limited endoscopic field of view and dynamic artifacts. Existing navigation platforms often rely on external localization technologies, such as electromagnetic tracking or shape sensing, which increase hardware complexity and remain vulnerable to intraoperative anatomical mismatch. We present a vision-only autonomy framework that performs long-horizon bronchoscopic navigation using preoperative CT-derived virtual targets and live endoscopic video, without external tracking during navigation. The framework uses hierarchical long-short agents: a short-term reactive agent for continuous low-latency motion control, and a long-term strategic agent for decision support at anatomically ambiguous points. When their recommendations conflict, a world-model critic predicts future visual states for candidate actions and selects the action whose predicted state best matches the target view. We evaluated the system in a high-fidelity airway phantom, three ex vivo porcine lungs, and a live porcine model. The system reached all planned segmental targets in the phantom, maintained 80\% success to the eighth generation ex vivo, and achieved in vivo navigation performance comparable to the expert bronchoscopist. These results support the preclinical feasibility of sensor-free autonomous bronchoscopic navigation.

arXiv:2603.08007v1 Announce Type: cross Abstract: Existing aerial Vision-Language Navigation (VLN) methods predominantly adopt a detection-and-planning pipeline, which converts open-vocabulary detections into discrete textual scene graphs. These approaches are plagued by inadequate spatial reasoning capabilities and inherent linguistic ambiguities. To address these bottlenecks, we propose a Visual-Spatial Reasoning (ViSA) enhanced framework for aerial VLN. Specifically, a triple-phase collaborative architecture is designed to leverage structured visual prompting, enabling Vision-Language Models (VLMs) to perform direct reasoning on image planes without the need for additional training or complex intermediate representations. Comprehensive evaluations on the CityNav benchmark demonstrate that the ViSA-enhanced VLN achieves a 70.3\% improvement in success rate compared to the fully trained state-of-the-art (SOTA) method, elucidating its great potential as a backbone for aerial VLN systems.

arXiv:2603.08014v1 Announce Type: cross Abstract: Federated fine-tuning of large language models (LLMs) with low-rank adaptation (LoRA) offers a communication-efficient and privacy-preserving solution for task-specific adaptation. Naive aggregation of LoRA modules introduces noise due to mathematical incorrectness when averaging the downsampling and upsampling matrices independently. However, existing noise-free aggregation strategies inevitably compromise the structural expressiveness of LoRA, limiting its ability to retain client-specific adaptations by either improperly reconstructing the low-rank structure or excluding partially trainable components. We identify this problem as loss of training momentum, where LoRA updates fail to accumulate effectively across rounds, resulting in slower convergence and suboptimal performance. To address this, we propose FedMomentum, a novel framework that enables structured and momentum-preserving LoRA aggregation via singular value decomposition (SVD). Specifically, after aggregating low-rank updates in a mathematically correct manner, FedMomentum applies SVD to extract the dominant components that capture the main update directions. These components are used to reconstruct the LoRA modules with the same rank, while residual components can be retained and later merged into the backbone to preserve semantic information and ensure robustness. Extensive experiments across multiple tasks demonstrate that FedMomentum consistently outperforms prior state-of-the-art methods in convergence speed and final accuracy.

arXiv:2603.08148v1 Announce Type: cross Abstract: Recently, large language models (LLMs) have gained much attention for the emergence of human-comparable capabilities and huge potential. However, for open-domain implicit question-answering problems, LLMs may not be the ultimate solution due to the reasons of: 1) uncovered or out-of-date domain knowledge, 2) one-shot generation and hence restricted comprehensiveness. To this end, this work proposes a gradual knowledge excavation framework for open-domain complex question answering, where LLMs iteratively and actively acquire external information, and then reason based on acquired historical knowledge. Specifically, during each step of the solving process, the model selects an action to execute, such as querying external knowledge or performing a single logical reasoning step, to gradually progress toward a final answer. Our method can effectively leverage plug-and-play external knowledge and dynamically adjust the strategy for solving complex questions. Evaluated on the StrategyQA dataset, our method achieves 78.17% accuracy with less than 6% parameters of its competitors, setting new SOTA for ~10B-scale LLMs.

arXiv:2603.08324v1 Announce Type: cross Abstract: Robot-assisted endoluminal procedures are increasingly used for early cancer intervention. However, the intricate, narrow and tortuous pathways within the luminal anatomy pose substantial difficulties for robot navigation. Vision-based navigation offers a promising solution, but existing localization approaches are error-prone due to tissue deformation, in vivo artifacts and a lack of distinctive landmarks for consistent localization. This paper presents a novel EndoSERV localization method to address these challenges. It includes two main parts, \textit{i.e.}, \textbf{SE}gment-to-structure and \textbf{R}eal-to-\textbf{V}irtual mapping, and hence the name. For long-range and complex luminal structures, we divide them into smaller sub-segments and estimate the odometry independently. To cater for label insufficiency, an efficient transfer technique maps real image features to the virtual domain to use virtual pose ground truth. The training phases of EndoSERV include an offline pretraining to extract texture-agnostic features, and an online phase that adapts to real-world conditions. Extensive experiments based on both public and clinical datasets have been performed to demonstrate the effectiveness of the method even without any real pose labels.

arXiv:2602.12566v2 Announce Type: replace Abstract: Reinforcement Learning with Verifiable Rewards (RLVR) plays a key role in stimulating the explicit reasoning capability of Large Language Models (LLMs). We can achieve expert-level performance in some specific domains via RLVR, such as coding or math. When a general multi-domain expert-level model is required, we need to carefully consider the collaboration of RLVR across different domains. The current state-of-the-art models mainly employ two different training paradigms for multi-domain RLVR: mixed multi-task RLVR and separate RLVR followed by model merging. However, most of the works did not provide a detailed comparison and analysis about these paradigms. To this end, we choose multiple commonly used high-level tasks (e.g., math, coding, science, instruction following, and agent) as our target domains and design extensive qualitative and quantitative experiments using open-source datasets. We find the RLVR across domains exhibits few mutual interferences, and reasoning-intensive domains demonstrate mutually synergistic effects. Furthermore, we analyze the internal mechanisms of mutual gains from the perspectives of weight space geometry, model prediction behavior, information constraints and self-verification. This project is named as M2RL that means Mixed multi-task training or separate training followed by model Merging for Reinforcement Learning, and the homepage is at https://github.com/mosAI25/M2RL.

arXiv:2602.13695v2 Announce Type: replace Abstract: Large language models (LLMs) have recently achieved remarkable success in generating rigorous mathematical proofs, with "AI for Math" emerging as a vibrant field of research (Ju et al., 2026). While these models have mastered competition-level benchmarks like the International Mathematical Olympiad (Huang et al., 2025; Duan et al., 2025) and show promise in research applications through auto-formalization (Wang et al., 2025), their deployment via lightweight, natural-language pipelines for research problems remains underexplored. In this work, we demonstrate that next-generation models (e.g., Gemini 3 Pro, GPT-5.2 Pro), when integrated into a streamlined automated pipeline optimized for citation-based verification, can solve sophisticated research-grade problems. We evaluate our pipeline on two novel datasets: (1) the ICCM (2025) problem sets (comparable to the S.-T. Yau College Student Mathematics Contest) proposed by leading mathematicians (Shanghai Math Challenge, 2026), and (2) the "First Proof" problem set (Abouzaid et al., 2026), consisting of previously unpublished research questions. Our pipeline generated candidate proofs for all problems in the first two ICCM sets and the "First Proof" set. The solutions for the first two ICCM sets and Problem 4 of the "First Proof" set have been fully verified by our team. All generated proofs have been submitted to the official organization, and our generated results are publicly available at https://github.com/ml1301215/question_sets-test_results. We have open-sourced the code and developed a user-friendly UI for this workflow, accessible at https://github.com/ml1301215/research-math-assistant.