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A structure-based mRNA vaccine for Nipah virus in healthy adults: a phase 1 trial

Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04265-1

In this phase 1, open-label dose-escalation study in healthy adults found that the mRNA vaccine (mRNA-1215), encoding the Nipah virus Malaysian strain chimeric pre-fusion F protein linked to glycoprotein G, was safe and induced elevated immune responses at 1 year of follow-up, indicating that this is a promising vaccine candidate for further development.
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A clinical environment simulator for dynamic AI evaluation

Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04252-6

The authors propose a framework for clinical AI evaluation within simulated digital hospital environments that capture the evolving constraints, and cascading effects, of clinical decisions.
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The dynamic basis of G-protein recognition and activation by a GPCR

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10228-w

Conventional and time-resolved cryo-electron microscopy reveal how NTSR1 dynamically engages and releases different G proteins, capturing over 20 intermediates and uncovering key mechanistic steps in GDP- and GTP-driven activation, subtype selectivity and distinct dissociation pathways.
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Lense–Thirring precessing magnetar engine drives a superluminous supernova

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10151-0

Observations of a nearby type I superluminous supernova showing oscillating light-curve bumps provide evidence of a centrally located magnetar in the wake of the explosion, surrounded by an infalling accretion disk undergoing Lense–Thirring precession.
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Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10120-7

Time-resolved cryo-electron microscopy during activation of Gαi1βγ and Gα11βγ heterotrimers bound to NTSR1 enables isolation of multiple transient complexes along the activation pathway and reveals structural motifs that stabilize these intermediates.
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A sorghum pangenome reference improves global crop trait discovery

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10229-9

A pangenome reference for the phenotypically diverse crop sorghum aims to help accelerate future efforts to breed crops that are better adapted to changing environments.
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Nanophotonic waveguide chip-to-world beam scanning

Nature, Published online: 11 March 2026; doi:10.1038/s41586-025-10038-6

A monolithically integrated photonic ski-jump enables scalable, diffraction-limited 2D beam scanning from photonic chips, achieving ultrahigh spot rates, compact footprints and applications spanning displays, sensing and quantum photonics.
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Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04288-8

Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study
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Immune evasive DNA donors and recombinases license kilobase-scale writing

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10241-z

INSTALL overcomes fundamental challenges for DNA delivery and integration methods by synergizing immune-stealth nucleic acids with recombinases to enable kilobase-scale integration strategies without viral vectors.
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Clinical development of cancer vaccines

Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04241-9

This Review highlights insights from recent clinical trials and discusses critical factors for optimizing cancer vaccines, with a focus on proxies for vaccine efficacy, neoantigen selection, modular platforms and early intervention.
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Natural maternal immunity protects neonates from <i>Escherichia coli</i> sepsis

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10225-z

Neonatal sepsis caused by Escherichia coli is associated with reduced transfer of pathogen-specific maternal antibodies and, in a mouse model, can be prevented by maternal preconceptual colonization with probiotic E. coli.
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Ageing promotes metastasis via activation of the integrated stress response

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10216-0

Ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrated stress response, and a therapeutic opportunity in older patients is revealed.
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A mechanism to initiate emergency type 2 myelopoiesis

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10256-6

Myelopoiesis in response to a parasitic worm infection and the mechanism selective to this form of parasite are revealed.
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Impact of using artificial intelligence as a second reader in breast screening including arbitration

Nature Cancer, Published online: 10 March 2026; doi:10.1038/s43018-026-01128-z

Warren et al. used data from a retrospective cohort of 50,000 women attending breast screening. Arbitration between human and AI decisions was performed in a reader study following normal arbitration workflow. After arbitration, replacing the second human reader with AI in a double-read breast screening workflow was noninferior to two human readers.
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Foundational World Models Accurately Detect Bimanual Manipulator Failures

arXiv:2603.06987v1 Announce Type: cross Abstract: Deploying visuomotor robots at scale is challenging due to the potential for anomalous failures to degrade performance, cause damage, or endanger human life. Bimanual manipulators are no exception; these robots have vast state spaces comprised of high-dimensional images and proprioceptive signals. Explicitly defining failure modes within such state spaces is infeasible. In this work, we overcome these challenges by training a probabilistic, history informed, world model within the compressed latent space of a pretrained vision foundation model (NVIDIA's Cosmos Tokenizer). The model outputs uncertainty estimates alongside its predictions that serve as non-conformity scores within a conformal prediction framework. We use these scores to develop a runtime monitor, correlating periods of high uncertainty with anomalous failures. To test these methods, we use the simulated Push-T environment and the Bimanual Cable Manipulation dataset, the latter of which we introduce in this work. This new dataset features trajectories with multiple synchronized camera views, proprioceptive signals, and annotated failures from a challenging data center maintenance task. We benchmark our methods against baselines from the anomaly detection and out-of-distribution detection literature, and show that our approach considerably outperforms statistical techniques. Furthermore, we show that our approach requires approximately one twentieth of the trainable parameters as the next-best learning-based approach, yet outperforms it by 3.8% in terms of failure detection rate, paving the way toward safely deploying manipulator robots in real-world environments where reliability is non-negotiable.
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The Dual-Stream Transformer: Channelized Architecture for Interpretable Language Modeling

arXiv:2603.07461v1 Announce Type: cross Abstract: Standard transformers entangle all computation in a single residual stream, obscuring which components perform which functions. We introduce the Dual-Stream Transformer, which decomposes the residual stream into two functionally distinct components: a token stream updated by attention and a context stream updated by feed-forward networks. Information flow between attention heads is controlled through a hierarchy of mixing strategies, from fully independent (maximum interpretability) to dense (standard transformer behavior). This design exposes a tunable tradeoff between interpretability and performance. We measure this tradeoff on language modeling tasks at 29M parameters. Fully independent head mixing increases validation loss by 8\% relative to dense baselines. The recommended Kronecker mixing strategy, which permits scalar communication between heads while preserving within-head structure, costs only 2.5\%. All configurations maintain functional generation under attention amplification (scaling logits by factors up to 16 at inference time), with degradation ranging from 16\% to 27\%. This robustness suggests the architectures learn discrete algorithms that operate independently of soft probabilistic mixing. The architecture provides a foundation for interpretable language models where internal structure is exposed by design. \footnote{This work was partially supported by DARPA Contract HR001125C0302.}
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