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Warren presses Pentagon over decision to grant xAI access to classified networks
Memories AI is building the visual memory layer for wearables and robotics
Nvidia’s DLSS 5 uses generative AI to boost photorealism in video games, with ambitions beyond gaming
The Download: glass chips and “AI-free” logos
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.
Future AI chips could be built on glass
Human-made glass is thousands of years old. But it’s now poised to find its way into the AI chips used in the world’s newest and largest data centers.
This year, a South Korean company called Absolics will start producing special glass panels that make next-generation computing hardware more powerful and efficient. Other companies, including Intel, are also pushing forward in this area.
If all goes well, the technology could reduce the energy demands of chips in AI data centers—and even consumer laptops and mobile devices. Read the full story.
—Jeremy Hsu
The must-reads
I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.
1 The race is on to establish a globally recognized “AI-free” logo
Organizations are rushing to develop a universal label for human-made products. (BBC)
+ A “QuitGPT” campaign is urging people to ditch ChatGPT. (MIT Technology Review)
2 Elizabeth Warren wants answers on xAI’s access to military data
The Pentagon reportedly gave it access to classified networks. (NBC News)
+ Here’s how chatbots could be used for targeting decisions. (MIT Technology Review)
+ The DoD is struggling to upgrade software for fighter jets. (Bloomberg $)
3 Models are applying to be the faces of AI romance scams
The “AI face models” are duping victims out of their money. (Wired $)
+ Survivors have revealed how the “pig butchering” scams work. (MIT Technology Review)
4 Meta is planning layoffs that could affect over 20% of staff
The job cuts could offset its costly bet on AI. (Reuters $)
+ There’s a long history of fears about AI’s impact on jobs. (MIT Technology Review)
5 ByteDance delayed launching a video AI model after copyright disputes
It famously generated footage of Tom Cruise and Brad Pitt fighting. (The Information $)
6 Cybersecurity investigators have exposed a huge North Korean con
The scammers secured remote jobs in the US, then stole money and sensitive information. (NBC News)
7 A Chinese AI startup is set for a whopping $18 billion valuation
That’s more than quadruple its valuation just three months ago. (Bloomberg $)
+ Chinese open models are spreading fast—here’s why that matters. (MIT Technology Review)
8 Peter Thiel has started a lecture series about the antichrist in Rome
His plans have drawn attention from the Catholic Church. (Reuters $)
9 Norway is fighting back against internet enshittification
It’s joined a global campaign against the online world’s decay. (The Guardian)
+ We may need to move beyond the big platforms. (MIT Technology Review)
10 How a startup plans to resurrect the dodo
Humans wiped them out nearly 400 years ago—can gene editing bring them back now? (Guardian)
Quote of the day
“I would build fission weapons. I would build fusion weapons. Nuclear weapons have been one of the most stabilizing forces in history—ever.”
—Anduril founder Palmer Luckey shares his love of nukes with Axios.
One More Thing
We need a moonshot for computing
The US government is organizing itself for the next era of computing. Ultimately, it has one big choice to make: adopt a conservative strategy that aims to preserve its lead for the next five years—or orient itself toward genuine computing moonshots.
There is no shortage of candidates, including quantum computing, neuromorphic computing and reversible computing. And there are plenty of novel materials and devices. These possibilities could even be combined to form hybrid computing systems.
The National Semiconductor Technology Center can drive these ideas forward. To be successful, it would do well to follow DARPA’s lead by focusing on moonshot programs. Read the full story.
—Brady Helwig & PJ Maykish
We can still have nice things
A place for comfort, fun and distraction to brighten up your day. (Got any ideas? Drop me a line.)
+ A UPS delivery driver heroically escaped from two murderous turkeys.
+ Art’s love affair with cats is charmingly depicted in a new book.
+ The humble pea and six other forgotten superfoods promise accessible nutritional power.
+ MF DOOM: Long Island to Leeds is the Transatlantic tale of your favorite rapper’s favorite rapper.
Tumor-informed liquid biopsy detection of structural variants in high grade serous ovarian cancer
Oncoscience. 2026 Mar 5;13:44-54. doi: 10.18632/oncoscience.645. eCollection 2026.
ABSTRACT
BACKGROUND: High grade serous ovarian cancer (HGSOC) recurs frequently and commercial tests have emerged for tumor-informed, cell-free DNA (cfDNA)-based detection of minimal residual disease. These tests are based on somatic single nucleotide variants prevalent in many cancers and thus are not well matched to HGSOC, which is dominated by structural genomic rearrangements. The purpose of this study was to evaluate the feasibility of a structural-variant (SV)-informed, cfDNA-based method for detecting clonal and subclonal HGSOC disease burden.
METHODS: A method was developed for detecting patient-specific SV breakpoints using digital droplet PCR (ddPCR) with custom tumor-informed primer/probe pairs. Test parameters were first estimated using synthetic cfDNA generated by ultrasonication of genomic DNA from ovarian cancer cell lines. The optimized workflow was implemented in which whole genome sequencing of multisite pre-treatment HGSOC biopsies performed and high confidence SVs were called by multiple published SV callers. Real-time PCR and ddPCR were used for assay development.
RESULTS: Following the optimized workflow, tumor-specific SV breakpoint-spanning primers/probe sets of four HGSOC patients' multisite biopsies were designed and validated by real-time PCR and ddPCR. Together with four HGSOCs, a total of 29 SVs breakpoints-spanning tumor-informed primers/probe sets were designed and validated in multisite biopsies. 15 validated tumor-specific SVs were selected for quantification in their corresponding liquid biopsies using the validated ddPCR, and 9 had measurements in liquid biopsies.
CONCLUSIONS: Our result shows the detection of SVs from pre-treatment cfDNA using tumor-informed breakpoints-spanning ddPCR is feasible and may enable a novel and sensitive method for monitoring on-treatment disease burden.
PMID:41835357 | PMC:PMC12981705 | DOI:10.18632/oncoscience.645
