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Retrieval-Augmented Generation with Covariate Time Series

arXiv:2603.04951v2 Announce Type: replace Abstract: While RAG has greatly enhanced LLMs, extending this paradigm to Time-Series Foundation Models (TSFMs) remains a challenge. This is exemplified in the Predictive Maintenance of the Pressure Regulating and Shut-Off Valve (PRSOV), a high-stakes industrial scenario characterized by (1) data scarcity, (2) short transient sequences, and (3) covariate coupled dynamics. Unfortunately, existing time-series RAG approaches predominantly rely on generated static vector embeddings and learnable context augmenters, which may fail to distinguish similar regimes in such scarce, transient, and covariate coupled scenarios. To address these limitations, we propose RAG4CTS, a regime-aware, training-free RAG framework for Covariate Time-Series. Specifically, we construct a hierarchal time-series native knowledge base to enable lossless storage and physics-informed retrieval of raw historical regimes. We design a two-stage bi-weighted retrieval mechanism that aligns historical trends through point-wise and multivariate similarities. For context augmentation, we introduce an agent-driven strategy to dynamically optimize context in a self-supervised manner. Extensive experiments on PRSOV demonstrate that our framework significantly outperforms state-of-the-art baselines in prediction accuracy. The proposed system is deployed in Apache IoTDB within China Southern Airlines. Since deployment, our method has successfully identified one PRSOV fault in two months with zero false alarm.
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19-Hydroxybufalin Inhibits Gastric Cancer Cell Proliferation by Modulating Metabolic Reprogramming

J Proteome Res. 2026 Apr 3;25(4):2014-2023. doi: 10.1021/acs.jproteome.5c00983. Epub 2026 Mar 17.

ABSTRACT

OBJECTIVE: 19-Hydroxybufalin (19-H) is a natural bioactive compound with anticancer potential, but its molecular target and mechanism of action remain unclear. This study aimed to systematically evaluate its antigastric cancer activity and identify potential molecular targets.

METHODS: The antitumor effect of 19-H was evaluated in both in vitro and in vivo models. Multiomics analysis, thermal proteome profiling, molecular docking, and molecular dynamics simulations were employed to elucidate the mechanism of action. Functional assays were further conducted to validate the key target.

RESULTS: 19-H exhibited nanomolar-level inhibitory activity against various gastric cancer cell lines, significantly suppressing tumor growth in subcutaneous xenograft and patient-derived xenograft models. Multiomics analysis revealed that 19-H reshaped metabolic pathways in gastric cancer. TPP screening identified PLPP2 as a potential target with significantly increased thermal stability upon 19-H treatment. Molecular simulations further revealed that 19-H binds stably to the Ξ±-helical region of PLPP2.

CONCLUSIONS: 19-H exerts its antigastric cancer effect by targeting PLPP2 and remodeling the metabolic network. PLPP2 may represent a novel therapeutic target for gastric cancer.

PMID:41842934 | DOI:10.1021/acs.jproteome.5c00983

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FinToolBench: Evaluating LLM Agents for Real-World Financial Tool Use

arXiv:2603.08262v1 Announce Type: new Abstract: The integration of Large Language Models (LLMs) into the financial domain is driving a paradigm shift from passive information retrieval to dynamic, agentic interaction. While general-purpose tool learning has witnessed a surge in benchmarks, the financial sector, characterized by high stakes, strict compliance, and rapid data volatility, remains critically underserved. Existing financial evaluations predominantly focus on static textual analysis or document-based QA, ignoring the complex reality of tool execution. Conversely, general tool benchmarks lack the domain-specific rigor required for finance, often relying on toy environments or a negligible number of financial APIs. To bridge this gap, we introduce FinToolBench, the first real-world, runnable benchmark dedicated to evaluating financial tool learning agents. Unlike prior works limited to a handful of mock tools, FinToolBench establishes a realistic ecosystem coupling 760 executable financial tools with 295 rigorous, tool-required queries. We propose a novel evaluation framework that goes beyond binary execution success, assessing agents on finance-critical dimensions: timeliness, intent type, and regulatory domain alignment. Furthermore, we present FATR, a finance-aware tool retrieval and reasoning baseline that enhances stability and compliance. By providing the first testbed for auditable, agentic financial execution, FinToolBench sets a new standard for trustworthy AI in finance. The tool manifest, execution environment, and evaluation code will be open-sourced to facilitate future research.
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Regression Models Meet Foundation Models: A Hybrid-AI Approach to Practical Electricity Price Forecasting

arXiv:2603.06726v1 Announce Type: cross Abstract: Electricity market prices exhibit extreme volatility, nonlinearity, and non-stationarity, making accurate forecasting a significant challenge. While cutting-edge time series foundation models (TSFMs) effectively capture temporal dependencies, they typically underutilize cross-variate correlations and non-periodic patterns that are essential for price forecasting. Conversely, regression models excel at capturing feature interactions but are limited to future-available inputs, ignoring crucial historical drivers that are unavailable at forecast time. To bridge this gap, we propose FutureBoosting, a novel paradigm that enhances regression-based forecasts by integrating forecasted features generated from a frozen TSFM. This approach leverages the TSFM's ability to model historical patterns and injects these insights as enriched inputs into a downstream regression model. We instantiate this paradigm into a lightweight, plug-and-play framework for electricity price forecasting. Extensive evaluations on real-world electricity market data demonstrate that our framework consistently outperforms state-of-the-art TSFMs and regression baselines, achieving reductions in Mean Absolute Error (MAE) of more than 30% at most. Through ablation studies and explainable AI (XAI) techniques, we validate the contribution of forecasted features and elucidate the model's decision-making process. FutureBoosting establishes a robust, interpretable, and effective solution for practical market participation, offering a general framework for enhancing regression models with temporal context.
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Lysophosphatidylcholine acyltransferase 1 promotes head and neck squamous cell carcinoma progression by enhancing COX17-dependent oxidative phosphorylation

Cell Death Discovery, Published online: 06 March 2026; doi:10.1038/s41420-026-02994-3

Lysophosphatidylcholine acyltransferase 1 promotes head and neck squamous cell carcinoma progression by enhancing COX17-dependent oxidative phosphorylation
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Nightjar: Dynamic Adaptive Speculative Decoding for Large Language Models Serving

arXiv:2512.22420v4 Announce Type: replace-cross Abstract: Speculative decoding (SD) accelerates LLM inference by verifying draft tokens in parallel. However, this method presents a critical trade-off: it improves throughput in low-load, memory-bound systems but degrades performance in high-load, compute-bound environments due to verification overhead. Existing speculative decoding methods use fixed lengths and cannot adapt to workload changes or decide when to stop speculation. The cost of restarting speculative inference also remains unquantified. Under high load, the benefit of speculation diminishes, while retaining the draft model reduces KV-cache capacity, limiting batch size and degrading throughput. To overcome this, we propose Nightjar, a resource-aware adaptive speculative framework. It first adjusts to the request load by dynamically selecting the optimal speculative length for different batch sizes. Crucially, Nightjar proactively disables speculative decoding when the MAB planner determines that speculation is no longer beneficial, and during the disabled phase, offloads the draft model to the CPU only under GPU memory pressure. This reclaims memory for the KV cache, thereby facilitating larger batch sizes and maximizing overall system throughput. Experiments show that Nightjar achieves average 27.29% higher throughput and up to 20.18% lower latency compared to standard speculative decoding under dynamic request arrival rates in real-time LLM serving scenarios.
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Nightjar: Dynamic Adaptive Speculative Decoding for Large Language Models Serving

arXiv:2512.22420v3 Announce Type: replace-cross Abstract: Speculative decoding (SD) accelerates LLM inference by verifying draft tokens in parallel. However, this method presents a critical trade-off: it improves throughput in low-load, memory-bound systems but degrades performance in high-load, compute-bound environments due to verification overhead. Existing Speculative Decoding strategies typically rely on static speculative lengths, failing to adapt to fluctuating request loads or identify the optimal moment to halt speculation. The cost of restarting speculative inference also remains unquantified. During traffic surges, the marginal utility of speculation diminishes; yet, the draft model's persistent memory footprint competes for available KV cache. This resource contention limits the maximum batch size, thereby degrading overall system throughput. To overcome this, we propose Nightjar, a resource-aware adaptive speculative framework. It first adjusts to the request load by dynamically selecting the optimal speculative length for different batch sizes. Crucially, upon detecting significant request queuing or KV cache shortages, it disables speculative decoding and offloads the draft model to the CPU. This reclaims memory for the KV cache, thereby facilitating larger batch sizes and maximizing overall system throughput. Experiments show that Nightjar achieves up to 27.29% higher throughput and 12.90% lower latency compared to standard speculative decoding under dynamic request arrival rates in real-time LLM serving scenarios.
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Train Less, Learn More: Adaptive Efficient Rollout Optimization for Group-Based Reinforcement Learning

arXiv:2602.14338v1 Announce Type: cross Abstract: Reinforcement learning (RL) plays a central role in large language model (LLM) post-training. Among existing approaches, Group Relative Policy Optimization (GRPO) is widely used, especially for RL with verifiable rewards (RLVR) fine-tuning. In GRPO, each query prompts the LLM to generate a group of rollouts with a fixed group size $N$. When all rollouts in a group share the same outcome, either all correct or all incorrect, the group-normalized advantages become zero, yielding no gradient signal and wasting fine-tuning compute. We introduce Adaptive Efficient Rollout Optimization (AERO), an enhancement of GRPO. AERO uses an adaptive rollout strategy, applies selective rejection to strategically prune rollouts, and maintains a Bayesian posterior to prevent zero-advantage dead zones. Across three model configurations (Qwen2.5-Math-1.5B, Qwen2.5-7B, and Qwen2.5-7B-Instruct), AERO improves compute efficiency without sacrificing performance. Under the same total rollout budget, AERO reduces total training compute by about 48% while shortening wall-clock time per step by about 45% on average. Despite the substantial reduction in compute, AERO matches or improves Pass@8 and Avg@8 over GRPO, demonstrating a practical, scalable, and compute-efficient strategy for RL-based LLM alignment.
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Nightjar: Dynamic Adaptive Speculative Decoding for Large Language Models Serving

arXiv:2512.22420v2 Announce Type: replace-cross Abstract: Speculative decoding (SD) accelerates LLM inference by verifying draft tokens in parallel. However, this method presents a critical trade-off: it improves throughput in low-load, memory-bound systems but degrades performance in high-load, compute-bound environments due to verification overhead. Current SD implementations use a fixed speculative length, failing to adapt to dynamic request rates and creating a significant performance bottleneck in real-world serving scenarios. To overcome this, we propose Nightjar, a novel learning-based algorithm for adaptive speculative inference that adjusts to request load by dynamically selecting the optimal speculative length for different batch sizes and even disabling speculative decoding when it provides no benefit. Experiments show that Nightjar achieves up to 14.8% higher throughput and 20.2% lower latency compared to standard speculative decoding, demonstrating robust efficiency for real-time serving.
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