Reading view
Geometric Mixture-of-Experts with Curvature-Guided Adaptive Routing for Graph Representation Learning
An Accurate and Interpretable Framework for Trustworthy Process Monitoring
Comment on "Integrated multi-Omics and network toxicology elucidate the multi-target mechanisms of environmental hormones in driving hepatocellular carcinoma"
Ecotoxicol Environ Saf. 2026 Apr 1;314:120063. doi: 10.1016/j.ecoenv.2026.120063. Epub 2026 Mar 23.
NO ABSTRACT
PMID:41875554 | DOI:10.1016/j.ecoenv.2026.120063
Comment on "Integrated multi-Omics and network toxicology elucidate the multi-target mechanisms of environmental hormones in driving hepatocellular carcinoma"
Ecotoxicol Environ Saf. 2026 Mar 23;314:120063. doi: 10.1016/j.ecoenv.2026.120063. Online ahead of print.
NO ABSTRACT
PMID:41875554 | DOI:10.1016/j.ecoenv.2026.120063
NUP85 as a Pan-Cancer Immune Biomarker: Integrated Multi Omics and Functional Analyses Reveal Its Role in Tumor Prognosis
Immunotargets Ther. 2026 Mar 17;15:541852. doi: 10.2147/ITT.S541852. eCollection 2026.
ABSTRACT
PURPOSE: NUP85 encodes protein components of the Nup107-160 subunit of the nuclear pore complex, belonging to the Nucleoporins (NUPs) family, potentially implicating its role in human cancer. This study aims to elucidate the potential involvement of NUP85 in cancer pathogenesis.
METHODS: Leveraging data from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), Clinical Proteomic Tumor Analysis Consortium (CPTAC), Cancer Cell Line Encyclopedia (CCLE), Human Protein Atlas (HPA), Gene Expression Profiling Interactive Analysis (GEPIA), CellMiner, and GeneMANIA databases, we investigated the role of NUP85 across various tumors. Correlations between NUP85 expression and pathological stage, histological grade, survival, immune infiltration, tumor mutational burden (TMB), microsatellite instability (MSI), drug resistance, DNA methylation, copy number variation (CNV), and single-cell expression were analyzed. Gene functional enrichment analysis was conducted to explore NUP85-associated pathways. Molecular biology experiments including Western blotting, flow cytometry, trans-well migration, and invasion assays were performed to validate NUP85's oncogenic role in lung adenocarcinoma (LUAD) and oral squamous cell carcinoma (OSCC) cell lines.
RESULTS: Our findings reveal up-regulated expression of NUP85 in most tumor tissues, with significant correlations observed with pathological stage, survival, immune infiltration, TMB, MSI, drug resistance, DNA methylation, and CNV. Molecular biology experiments confirm NUP85's tumor-promoting role in LUAD and OSCC cell lines. Single-cell sequencing data suggest elevated NUP85 expression primarily in proliferative T cells (Tprolif).
CONCLUSION: NUP85 emerges as a potential tumor marker associated with tumor immunity and poor prognosis. These insights offer avenues for the development of novel therapeutic targets and anti-neoplastic drugs.
PMID:41869435 | PMC:PMC13005628 | DOI:10.2147/ITT.S541852
SkillsBench: Benchmarking How Well Agent Skills Work Across Diverse Tasks
OpenVision 3: A Family of Unified Visual Encoder for Both Understanding and Generation
A logic-gated trispecific engager enhances macrophage killing of cancer cells in solid tumors
Nature Biotechnology, Published online: 13 March 2026; doi:10.1038/s41587-026-03057-9
A trispecific macrophage engager amplifies the antitumor response of macrophages in solid tumors.