arXiv:2603.29200v1 Announce Type: cross Abstract: Deep learning-based tropical cyclone (TC) forecasting methods have demonstrated significant potential and application advantages, as they feature much lower computational cost and faster operation speed than numerical weather prediction models. However, existing deep learning methods still have key limitations: they can only process a single type of sequential trajectory data or homogeneous meteorological variables, and fail to achieve accurate forecasting of abnormal deflected TCs. To address these challenges, we present two groundbreaking contributions. First, we have constructed a multimodal and multi-source dataset named AOT-TCs for TC forecasting in the Northwest Pacific basin. As the first dataset of its kind, it innovatively integrates heterogeneous variables from the atmosphere, ocean, and land, thus obtaining a comprehensive and information-rich meteorological dataset. Second, based on the AOT-TCs dataset, we propose a forecasting model that can handle both normal and abnormally deflected TCs. This is the first TC forecasting model to adopt an explicit atmosphere-ocean-terrain coupling architecture, enabling it to effectively capture complex interactions across physical domains. Extensive experiments on all TC cases in the Northwest Pacific from 2017 to 2024 show that our model achieves state-of-the-art performance in TC forecasting: it not only significantly improves the forecasting accuracy of normal TCs but also breaks through the technical bottleneck in forecasting abnormally deflected TCs.

Oncogene, Published online: 01 April 2026; doi:10.1038/s41388-026-03737-5

LDHA-driven lactate metabolism promotes MDSC activation and immunosuppressive microenvironment in prostate cancer

arXiv:2603.22364v1 Announce Type: cross Abstract: Diffusion models have achieved state-of-the-art performance in generative modeling, but their success often relies heavily on classifier-free guidance (CFG), an inference-time heuristic that modifies the sampling trajectory. From a theoretical perspective, diffusion models trained with standard denoising score matching (DSM) are expected to recover the target data distribution, raising the question of why inference-time guidance is necessary in practice. In this work, we ask whether the DSM training objective can be modified in a principled manner such that standard reverse-time sampling, without inference-time guidance, yields effects comparable to CFG. We identify insufficient inter-class separation as a key limitation of standard diffusion models. To address this, we propose MCLR, a principled alignment objective that explicitly maximizes inter-class likelihood-ratios during training. Models fine-tuned with MCLR exhibit CFG-like improvements under standard sampling, achieving comparable qualitative and quantitative gains without requiring inference-time guidance. Beyond empirical benefits, we provide a theoretical result showing that the CFG-guided score is exactly the optimal solution to a weighted MCLR objective. This establishes a formal equivalence between classifier-free guidance and alignment-based objectives, offering a mechanistic interpretation of CFG.

arXiv:2603.20670v2 Announce Type: replace Abstract: The rapid growth in the volume, variety, and velocity of geospatial data has created data ecosystems that are highly distributed, heterogeneous, and semantically inconsistent. Existing data catalogs, portals, and infrastructures still rely largely on keyword-based search with limited semantic support, which often fails to capture user intent and leads to weak retrieval performance. To address these challenges, this study proposes a knowledge graph-driven multi-agent framework for intelligent geospatial data discovery, powered by large language models. The framework introduces a unified geospatial metadata ontology as a semantic mediation layer to align heterogeneous metadata standards across platforms and constructs a geospatial metadata knowledge graph to explicitly model datasets and their multidimensional relationships. Building on the structured representation, the framework adopts a multi-agent collaborative architecture to perform intent parsing, knowledge graph retrieval, and answer synthesis, forming an interpretable and closed-loop discovery process from user queries to results. Results from representative use cases and performance evaluation show that the framework substantially improves intent matching accuracy, ranking quality, recall, and discovery transparency compared with traditional systems. This study advances geospatial data discovery toward a more semantic, intent-aware, and intelligent paradigm, providing a practical foundation for next-generation intelligent and autonomous spatial data infrastructures and contributing to the broader vision of Autonomous GIS.

arXiv:2603.12743v1 Announce Type: cross Abstract: Concept customization typically binds rare tokens to a target concept. Unfortunately, these approaches often suffer from unstable performance as the pretraining data seldom contains these rare tokens. Meanwhile, these rare tokens fail to convey the inherent knowledge of the target concept. Consequently, we introduce Knowledge-aware Concept Customization, a novel task aiming at binding diverse textual knowledge to target visual concepts. This task requires the model to identify the knowledge within the text prompt to perform high-fidelity customized generation. Meanwhile, the model should efficiently bind all the textual knowledge to the target concept. Therefore, we propose MoKus, a novel framework for knowledge-aware concept customization. Our framework relies on a key observation: cross-modal knowledge transfer, where modifying knowledge within the text modality naturally transfers to the visual modality during generation. Inspired by this observation, MoKus contains two stages: (1) In visual concept learning, we first learn the anchor representation to store the visual information of the target concept. (2) In textual knowledge updating, we update the answer for the knowledge queries to the anchor representation, enabling high-fidelity customized generation. To further comprehensively evaluate our proposed MoKus on the new task, we introduce the first benchmark for knowledge-aware concept customization: KnowCusBench. Extensive evaluations have demonstrated that MoKus outperforms state-of-the-art methods. Moreover, the cross-model knowledge transfer allows MoKus to be easily extended to other knowledge-aware applications like virtual concept creation and concept erasure. We also demonstrate the capability of our method to achieve improvements on world knowledge benchmarks.

arXiv:2603.06697v1 Announce Type: cross Abstract: Vision--language models (VLMs) process images as visual tokens, yet their intermediate reasoning is often carried out in text, which can be suboptimal for visually grounded radiology tasks. Radiologists instead diagnose via sequential visual search; eye-tracking captures this process as time-ordered gaze trajectories that reveal how evidence is acquired over time. We use eye-gaze as supervision to guide VLM reasoning by introducing a small set of dedicated gaze tokens. These tokens are trained to predict gaze-selected image patch indices in temporal order, encouraging the model to follow human-like evidence acquisition and integration. Experiments on MIMIC-EYE and multiple external zero-shot benchmarks show consistent gains over baselines, achieving state-of-the-art in-domain performance and improved out-of-domain robustness. These results highlight temporally ordered gaze as an effective supervision signal for learning visually grounded medical reasoning.

arXiv:2603.07116v1 Announce Type: cross Abstract: As autonomous AI agents increasingly populate the Internet, a novel security challenge arises: "Is this entity an AI agent?" It is a new entity-type verification problem with no established solution. We formalize the problem through a three-class entity taxonomy (Human, Script, Agent) based on a verifiable agentic capability vector (action, reasoning, and memory). A timing threshold t exploits the asymmetric hardness between human cognition and AI processing to separate the three classes. We define the Agentic Capability Verification Problem (ACVP) through three necessity primitives, each testing one capability dimension. Building on this foundation, we introduce aCAPTCHA (Agent CAPTCHA), a time-constrained security game for agent admission whose security rests on ACVP hardness under t. We instantiate aCAPTCHA through time-bounded natural-language understanding as a multi-round HTTP verification protocol, and evaluate it with preliminary agent trials that validate the protocol's soundness and completeness. aCAPTCHA provides a composable, infrastructure-free admission gate for any service where entity-type verification is required.

arXiv:2603.08059v1 Announce Type: cross Abstract: With the rapid advancement of commercial multi-modal models, image editing has garnered significant attention due to its widespread applicability in daily life. Despite impressive progress, existing image editing systems, particularly closed-source or proprietary models, often struggle with complex, indirect, or multi-step user instructions. These limitations hinder their ability to perform nuanced, context-aware edits that align with human intent. In this work, we propose ImageEdit-R1, a multi-agent framework for intelligent image editing that leverages reinforcement learning to coordinate high-level decision-making across a set of specialized, pretrained vision-language and generative agents. Each agent is responsible for distinct capabilities--such as understanding user intent, identifying regions of interest, selecting appropriate editing actions, and synthesizing visual content--while reinforcement learning governs their collaboration to ensure coherent and goal-directed behavior. Unlike existing approaches that rely on monolithic models or hand-crafted pipelines, our method treats image editing as a sequential decision-making problem, enabling dynamic and context-aware editing strategies. Experimental results demonstrate that ImageEdit-R1 consistently outperforms both individual closed-source diffusion models and alternative multi-agent framework baselines across multiple image editing datasets.

arXiv:2601.19961v3 Announce Type: replace-cross Abstract: We present MeanCache, a training-free caching framework for efficient Flow Matching inference. Existing caching methods reduce redundant computation but typically rely on instantaneous velocity information (e.g., feature caching), which often leads to severe trajectory deviations and error accumulation under high acceleration ratios. MeanCache introduces an average-velocity perspective: by leveraging cached Jacobian--vector products (JVP) to construct interval average velocities from instantaneous velocities, it effectively mitigates local error accumulation. To further improve cache timing and JVP reuse stability, we develop a trajectory-stability scheduling strategy as a practical tool, employing a Peak-Suppressed Shortest Path under budget constraints to determine the schedule. Experiments on FLUX.1, Qwen-Image, and HunyuanVideo demonstrate that MeanCache achieves 4.12X and 4.56X and 3.59X acceleration, respectively, while consistently outperforming state-of-the-art caching baselines in generation quality. We believe this simple yet effective approach provides a new perspective for Flow Matching inference and will inspire further exploration of stability-driven acceleration in commercial-scale generative models.

arXiv:2602.20980v2 Announce Type: replace-cross Abstract: Multimodal Large Language Models (MLLMs) have achieved remarkable performance by integrating powerful language backbones with large-scale visual encoders. Among these, latent Chain-of-Thought (CoT) methods enable implicit reasoning in continuous hidden states, facilitating seamless vision-language integration and faster inference. However, existing heuristically predefined supervision signals in latent CoT provide limited guidance for preserving critical visual information in intermediate latent states. To address this limitation, we propose CrystaL (Crystallized Latent Reasoning), a single-stage framework with two paths to process intact and corrupted images, respectively. By explicitly aligning the attention patterns and prediction distributions across the two paths, CrystaL crystallizes latent representations into task-relevant visual semantics, without relying on auxiliary annotations or external modules. Extensive experiments on perception-intensive benchmarks demonstrate that CrystaL consistently outperforms state-of-the-art baselines, achieving substantial gains in fine-grained visual understanding while maintaining robust reasoning capabilities.

Oncogene, Published online: 06 March 2026; doi:10.1038/s41388-026-03720-0

C-Jun-activated S100A10 promotes malignant progression via in diminishing ubiquitin-dependent degradation of vimentin in gastric cancer

arXiv:2603.03378v1 Announce Type: cross Abstract: Large language model (LLM) agents offer a promising data-driven approach to automating Site Reliability Engineering (SRE), yet their enterprise deployment is constrained by three challenges: restricted access to proprietary data, unsafe action execution under permission-governed environments, and the inability of closed systems to improve from failures. We present AOI (Autonomous Operations Intelligence), a trainable multi-agent framework formulating automated operations as a structured trajectory learning problem under security constraints. Our approach integrates three key components. First, a trainable diagnostic system applies Group Relative Policy Optimization (GRPO) to distill expert-level knowledge into locally deployed open-source models, enabling preference-based learning without exposing sensitive data. Second, a read-write separated execution architecture decomposes operational trajectories into observation, reasoning, and action phases, allowing safe learning while preventing unauthorized state mutation. Third, a Failure Trajectory Closed-Loop Evolver mines unsuccessful trajectories and converts them into corrective supervision signals, enabling continual data augmentation. Evaluated on the AIOpsLab benchmark, our contributions yield cumulative gains. (1) The AOI runtime alone achieves 66.3% best@5 success on all 86 tasks, outperforming the prior state-of-the-art (41.9%) by 24.4 points. (2) Adding Observer GRPO training, a locally deployed 14B model reaches 42.9% avg@1 on 63 held-out tasks with unseen fault types, surpassing Claude Sonnet 4.5. (3) The Evolver converts 37 failed trajectories into diagnostic guidance, improving end-to-end avg@5 by 4.8 points while reducing variance by 35%.

arXiv:2603.03657v1 Announce Type: cross Abstract: Multimodal generative models have made significant strides in image editing, demonstrating impressive performance on a variety of static tasks. However, their proficiency typically does not extend to complex scenarios requiring dynamic reasoning, leaving them ill-equipped to model the coherent, intermediate logical pathways that constitute a multi-step evolution from an initial state to a final one. This capacity is crucial for unlocking a deeper level of procedural and causal understanding in visual manipulation. To systematically measure this critical limitation, we introduce InEdit-Bench, the first evaluation benchmark dedicated to reasoning over intermediate pathways in image editing. InEdit-Bench comprises meticulously annotated test cases covering four fundamental task categories: state transition, dynamic process, temporal sequence, and scientific simulation. Additionally, to enable fine-grained evaluation, we propose a set of assessment criteria to evaluate the logical coherence and visual naturalness of the generated pathways, as well as the model's fidelity to specified path constraints. Our comprehensive evaluation of 14 representative image editing models on InEdit-Bench reveals significant and widespread shortcomings in this domain. By providing a standardized and challenging benchmark, we aim for InEdit-Bench to catalyze research and steer development towards more dynamic, reason-aware, and intelligent multimodal generative models.

arXiv:2508.00450v3 Announce Type: replace-cross Abstract: Traditional recommendation systems tend to trap users in strong feedback loops by excessively pushing content aligned with their historical preferences, thereby limiting exploration opportunities and causing content fatigue. Although large language models (LLMs) demonstrate potential with their diverse content generation capabilities, existing LLM-enhanced dual-model frameworks face two major limitations: first, they overlook long-term preferences driven by group identity, leading to biased interest modeling; second, they suffer from static optimization flaws, as a one-time alignment process fails to leverage incremental user data for closed-loop optimization. To address these challenges, we propose the Co-Evolutionary Alignment (CoEA) method. For interest modeling bias, we introduce Dual-Stable Interest Exploration (DSIE) module, jointly modeling long-term group identity and short-term individual interests through parallel processing of behavioral sequences. For static optimization limitations, we design a Periodic Collaborative Optimization (PCO) mechanism. This mechanism regularly conducts preference verification on incremental data using the Relevance LLM, then guides the Novelty LLM to perform fine-tuning based on the verification results, and subsequently feeds back the output of the continually fine-tuned Novelty LLM to the Relevance LLM for re-evaluation, thereby achieving a dynamic closed-loop optimization. Extensive online and offline experiments verify the effectiveness of the CoEA model in serendipitous recommendation.

arXiv:2602.23811v2 Announce Type: replace-cross Abstract: We investigate the theoretical aspects of offline reinforcement learning (RL) under general function approximation. While prior works (e.g., Xie et al., 2021) have established the theoretical foundations of learning a good policy from offline data via pessimism, existing algorithms that are computationally tractable (often in an oracle-efficient sense), such as PSPI, only apply to finite and small action spaces. Moreover, these algorithms rely on state-wise mirror descent and require actors to be implicitly induced from the critic functions, failing to accommodate standalone policy parameterization which is ubiquitous in practice. In this work, we address these limitations and extend the theoretical guarantees to parameterized policy classes over large or continuous action spaces. When extending mirror descent to parameterized policies, we identify contextual coupling as the core difficulty, and show how connecting mirror descent to natural policy gradient leads to novel analyses, guarantees, and algorithmic insights, including a surprising unification between offline RL and imitation learning.

arXiv:2502.05795v5 Announce Type: replace-cross Abstract: In this paper, we introduce the Curse of Depth, a concept that highlights, explains, and addresses the recent observation in modern Large Language Models (LLMs) where nearly half of the layers are less effective than expected. We first confirm the wide existence of this phenomenon across the most popular families of LLMs such as Llama, Mistral, DeepSeek, and Qwen. Our analysis, theoretically and empirically, identifies that the underlying reason for the ineffectiveness of deep layers in LLMs is the widespread usage of Pre-Layer Normalization (Pre-LN). While Pre-LN stabilizes the training of Transformer LLMs, its output variance exponentially grows with the model depth, which undesirably causes the derivative of the deep Transformer blocks to be an identity matrix, and therefore barely contributes to the training. To resolve this training pitfall, we propose LayerNorm Scaling (LNS), which scales the variance of output of the layer normalization inversely by the square root of its depth. This simple modification mitigates the output variance explosion of deeper Transformer layers, improving their contribution. Across a wide range of model sizes (130M to 7B), our experiments show that LNS consistently outperforms previous normalization and scaling techniques in enhancing LLM pre-training performance. Moreover, this improvement seamlessly carries over to supervised fine-tuning. All these gains can be attributed to the fact that LayerNorm Scaling enables deeper layers to contribute more effectively during training. Our code is available at \href{https://github.com/lmsdss/LayerNorm-Scaling}{LayerNorm-Scaling}.

arXiv:2601.16449v2 Announce Type: replace-cross Abstract: Understanding human emotions from multimodal signals poses a significant challenge in affective computing and human-robot interaction. While multimodal large language models (MLLMs) have excelled in general vision-language tasks, their capabilities in emotional reasoning remain limited. The field currently suffers from a scarcity of large-scale datasets with high-quality, descriptive emotion annotations and lacks standardized benchmarks for evaluation. Our preliminary framework, Emotion-LLaMA, pioneered instruction-tuned multimodal learning for emotion reasoning but was restricted by explicit face detectors, implicit fusion strategies, and low-quality training data with limited scale. To address these limitations, we present Emotion-LLaMAv2 and the MMEVerse benchmark, establishing an end-to-end pipeline together with a standardized evaluation setting for emotion recognition and reasoning. Emotion-LLaMAv2 introduces three key advances. First, an end-to-end multiview encoder eliminates external face detection and captures nuanced emotional cues via richer spatial and temporal multiview tokens. Second, a Conv Attention pre-fusion module is designed to enable simultaneous local and global multimodal feature interactions external to the LLM backbone. Third, a perception-to-cognition curriculum instruction tuning scheme within the LLaMA2 backbone unifies emotion recognition and free-form emotion reasoning. To support large-scale training and reproducible evaluation, MMEVerse aggregates twelve publicly available emotion datasets, including IEMOCAP, MELD, DFEW, and MAFW, into a unified multimodal instruction format. The data are re-annotated via a multi-agent pipeline involving Qwen2 Audio, Qwen2.5 VL, and GPT 4o, producing 130k training clips and 36k testing clips across 18 evaluation benchmarks.

arXiv:2602.10604v2 Announce Type: replace-cross Abstract: We introduce Step 3.5 Flash, a sparse Mixture-of-Experts (MoE) model that bridges frontier-level agentic intelligence and computational efficiency. We focus on what matters most when building agents: sharp reasoning and fast, reliable execution. Step 3.5 Flash pairs a 196B-parameter foundation with 11B active parameters for efficient inference. It is optimized with interleaved 3:1 sliding-window/full attention and Multi-Token Prediction (MTP-3) to reduce the latency and cost of multi-round agentic interactions. To reach frontier-level intelligence, we design a scalable reinforcement learning framework that combines verifiable signals with preference feedback, while remaining stable under large-scale off-policy training, enabling consistent self-improvement across mathematics, code, and tool use. Step 3.5 Flash demonstrates strong performance across agent, coding, and math tasks, achieving 85.4% on IMO-AnswerBench, 86.4% on LiveCodeBench-v6 (2024.08-2025.05), 88.2% on tau2-Bench, 69.0% on BrowseComp (with context management), and 51.0% on Terminal-Bench 2.0, comparable to frontier models such as GPT-5.2 xHigh and Gemini 3.0 Pro. By redefining the efficiency frontier, Step 3.5 Flash provides a high-density foundation for deploying sophisticated agents in real-world industrial environments.

arXiv:2602.14464v1 Announce Type: cross Abstract: Transferring visual style between images while preserving semantic correspondence between similar objects remains a central challenge in computer vision. While existing methods have made great strides, most of them operate at global level but overlook region-wise and even pixel-wise semantic correspondence. To address this, we propose CoCoDiff, a novel training-free and low-cost style transfer framework that leverages pretrained latent diffusion models to achieve fine-grained, semantically consistent stylization. We identify that correspondence cues within generative diffusion models are under-explored and that content consistency across semantically matched regions is often neglected. CoCoDiff introduces a pixel-wise semantic correspondence module that mines intermediate diffusion features to construct a dense alignment map between content and style images. Furthermore, a cycle-consistency module then enforces structural and perceptual alignment across iterations, yielding object and region level stylization that preserves geometry and detail. Despite requiring no additional training or supervision, CoCoDiff delivers state-of-the-art visual quality and strong quantitative results, outperforming methods that rely on extra training or annotations.

arXiv:2510.10689v2 Announce Type: replace Abstract: Recent advances in multimodal large language models (MLLMs) have demonstrated substantial potential in video understanding. However, existing benchmarks fail to comprehensively evaluate synergistic reasoning capabilities across audio and visual modalities, often neglecting either one of the modalities or integrating them in a logically inconsistent manner. To bridge this gap, we introduce OmniVideoBench, a large-scale and rigorously designed benchmark dedicated to assessing synergistic audio-visual understanding, with a strong emphasis on modality complementarity and logical consistency. Specifically, OmniVideoBench comprises 1000 high-quality question-answer(QA) pairs, each annotated with step-by-step reasoning traces, derived from 628 diverse videos ranging from several seconds to 30 minutes, and manually verified to guarantee complete correctness and uniqueness. Moreover, OmniVideoBench encompasses 13 carefully designed question types, covering temporal reasoning, spatial localization, counting, causal inference, summarization, and beyond, thereby capturing the essential challenges of video understanding. Evaluation of multiple MLLMs on OmniVideoBench reveals a pronounced gap between model performance and human reasoning, with open-source models lagging significantly behind their closed-source counterparts, underscoring the inherent difficulty of genuine audio-visual reasoning. We will release OmniVideoBench to foster the development of MLLMs with stronger and more generalizable reasoning capabilities.