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Webscraper: Leverage Multimodal Large Language Models for Index-Content Web Scraping
Xuanwu: Evolving General Multimodal Models into an Industrial-Grade Foundation for Content Ecosystems
ATP-Bench: Towards Agentic Tool Planning for MLLM Interleaved Generation
C-TRAIL: A Commonsense World Framework for Trajectory Planning in Autonomous Driving
Human-Like Lifelong Memory: A Neuroscience-Grounded Architecture for Infinite Interaction
Efficient and Scalable Granular-ball Graph Coarsening Method for Large-scale Graph Node Classification
IMPACT: Influence Modeling for Open-Set Time Series Anomaly Detection
AGFT: Alignment-Guided Fine-Tuning for Zero-Shot Adversarial Robustness of Vision-Language Models
MacTok: Robust Continuous Tokenization for Image Generation
Scalable AI-assisted Workflow Management for Detector Design Optimization Using Distributed Computing
Trace2Skill: Distill Trajectory-Local Lessons into Transferable Agent Skills
Balancing Efficiency and Empathy: Healthcare Providers' Perspectives on AI-Supported Workflows for Serious Illness Conversations in the Emergency Department
VLA Models Are More Generalizable Than You Think: Revisiting Physical and Spatial Modeling
Association Between Telemedicine Adoption and Physician Job Satisfaction: Cross-Sectional Study
Pathogenesis and immune regulation of rheumatoid arthritis-associated interstitial lung disease: from basic research to clinical implications
Front Immunol. 2026 Mar 13;17:1770348. doi: 10.3389/fimmu.2026.1770348. eCollection 2026.
ABSTRACT
Interstitial lung disease (ILD) is one of the most common extra-articular manifestations of rheumatoid arthritis (RA). Some patients with RA-ILD may develop progressive pulmonary fibrosis, leading to severe impairment of lung function and respiratory failure, which impacts quality of life and can even be life-threatening. This review identified genetic susceptibility, environmental factors, and immune dysregulation as key contributors to the etiology and pathogenesis of RA-ILD. We highlight that autoantibodies, adaptive immune abnormalities, and tertiary lymphoid organ formation significantly drive pulmonary inflammation and fibrosis, while pro-inflammatory cytokines and epithelial-mesenchymal transition (EMT) further contribute to lung tissue injury. Current treatment options, including glucocorticoids, immunosuppressants, and antifibrotic agents such as nintedanib and pirfenidone, are often limited by substantial side effects. Additionally, emerging therapies like JAK inhibitors, CAR-T cells, and the upcoming phosphodiesterase-4B inhibitor, nerandomilast, show promise, but no curative treatment exists to date. Future research could focus on multi-omics technologies and conducting multicenter clinical trials to establish therapeutic targets and advance precision medicine for RA-ILD.
PMID:41909710 | PMC:PMC13021622 | DOI:10.3389/fimmu.2026.1770348
A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease
npj Digital Medicine, Published online: 30 March 2026; doi:10.1038/s41746-026-02570-0
A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease