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From Multi-Agent to Single-Agent: When Is Skill Distillation Beneficial?

arXiv:2604.01608v1 Announce Type: new Abstract: Multi-agent systems (MAS) tackle complex tasks by distributing expertise, though this often comes at the cost of heavy coordination overhead, context fragmentation, and brittle phase ordering. Distilling a MAS into a single-agent skill can bypass these costs, but this conversion lacks a principled answer for when and what to distill. Instead, the empirical outcome is surprisingly inconsistent: skill lift ranges from a 28% improvement to a 2% degradation across metrics of the exact same task. In this work, we reveal that skill utility is governed not by the task, but by the evaluation metric. We introduce Metric Freedom ($F$), the first a priori predictor of skill utility. $F$ measures the topological rigidity of a metric's scoring landscape by quantifying how output diversity couples with score variance via a Mantel test. Guided by $F$, we propose a two-stage adaptive distillation framework. Stage 1 acts as a selective extraction mechanism, extracting tools and knowledge while discarding restrictive structures on "free" metrics to preserve exploration. Stage 2 targets computationally intensive iterative refinement exclusively toward "rigid" metrics ($F \lesssim 0.6$) to eliminate trajectory-local overfitting. Evaluating across 4 tasks, 11 datasets, and 6 metrics, $F$ strongly predicts skill utility ($\rho = -0.62$, $p
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Countering Catastrophic Forgetting of Large Language Models for Better Instruction Following via Weight-Space Model Merging

arXiv:2604.01538v1 Announce Type: cross Abstract: Large language models have been adopted in the medical domain for clinical documentation to reduce clinician burden. However, studies have reported that LLMs often "forget" a significant amount of instruction-following ability when fine-tuned using a task-specific medical dataset, a critical challenge in adopting general-purpose LLMs for clinical applications. This study presents a model merging framework to efficiently adapt general-purpose LLMs to the medical domain by countering this forgetting issue. By merging a clinical foundation model (GatorTronLlama) with a general instruct model (Llama-3.1-8B-Instruct) via interpolation-based merge methods, we seek to derive a domain-adapted model with strong performance on clinical tasks while retaining instruction-following ability. Comprehensive evaluation across medical benchmarks and five clinical generation tasks (e.g., radiology and discharge summarization) shows that merged models can effectively mitigate catastrophic forgetting, preserve clinical domain expertise, and retain instruction-following ability. In addition, our model merging strategies demonstrate training efficiency, achieving performance on par with fully fine-tuned baselines under severely constrained supervision (e.g., 64-shot vs. 256-shot). Consequently, weight-space merging constitutes a highly scalable solution for adapting open-source LLMs to clinical applications, facilitating broader deployment in resource-constrained healthcare environments.
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Unifying Group-Relative and Self-Distillation Policy Optimization via Sample Routing

arXiv:2604.02288v1 Announce Type: cross Abstract: Reinforcement learning with verifiable rewards (RLVR) has become a standard paradigm for post-training large language models. While Group Relative Policy Optimization (GRPO) is widely adopted, its coarse credit assignment uniformly penalizes failed rollouts, lacking the token-level focus needed to efficiently address specific deviations. Self-Distillation Policy Optimization (SDPO) addresses this by providing denser, more targeted logit-level supervision that facilitates rapid early improvement, yet it frequently collapses during prolonged training. We trace this late-stage instability to two intrinsic flaws: self-distillation on already-correct samples introduces optimization ambiguity, and the self-teacher's signal reliability progressively degrades. To resolve these issues, we propose Sample-Routed Policy Optimization (SRPO), a unified on-policy framework that routes correct samples to GRPO's reward-aligned reinforcement and failed samples to SDPO's targeted logit-level correction. SRPO further incorporates an entropy-aware dynamic weighting mechanism to suppress high-entropy, unreliable distillation targets while emphasizing confident ones. Evaluated across five benchmarks and two model scales, SRPO achieves both the rapid early improvement of SDPO and the long-horizon stability of GRPO. It consistently surpasses the peak performance of both baselines, raising the five-benchmark average on Qwen3-8B by 3.4% over GRPO and 6.3% over SDPO, while simultaneously yielding moderate response lengths and lowering per-step compute cost by up to 17.2%.
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MonitorBench: A Comprehensive Benchmark for Chain-of-Thought Monitorability in Large Language Models

arXiv:2603.28590v2 Announce Type: replace Abstract: Large language models (LLMs) can generate chains of thought (CoTs) that are not always causally responsible for their final outputs. When such a mismatch occurs, the CoT no longer faithfully reflects the actual reasons (i.e., decision-critical factors) driving the model's behavior, leading to the reduced CoT monitorability problem. However, a comprehensive and fully open-source benchmark for thoroughly evaluating CoT monitorability remains lacking. To address this gap, we propose MonitorBench, a systematic benchmark for evaluating CoT monitorability in LLMs. MonitorBench provides: (1) a diverse set of 1,514 test instances with carefully designed decision-critical factors across 19 tasks spanning 7 categories to characterize \textit{when} CoTs can be used to monitor the factors driving LLM behavior; and (2) two stress-test settings to quantify \textit{the extent to which} CoT monitorability can be degraded. Extensive experiments across multiple popular LLMs with varying capabilities show that CoT monitorability is higher when the decision-critical factors shape the intermediate reasoning process without merely influencing the final answer. More capable LLMs tend to exhibit lower monitorability. And all evaluated LLMs can intentionally reduce monitorability under stress-tests, with monitorability dropping by up to 30\% in some tasks that do not require structural reasoning over the decision-critical factors. Overall, MonitorBench provides a basis for further research on evaluating future LLMs, studying advanced stress-test monitorability techniques, and developing new monitoring approaches. The code is available at https://github.com/ASTRAL-Group/MonitorBench.
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Group Representational Position Encoding

arXiv:2512.07805v5 Announce Type: replace-cross Abstract: We present GRAPE (Group Representational Position Encoding), a unified framework for positional encoding based on group actions. GRAPE unifies two families of mechanisms: (i) multiplicative rotations (Multiplicative GRAPE) in $\operatorname{SO}(d)$ and (ii) additive logit biases (Additive GRAPE) arising from unipotent actions in the general linear group $\mathrm{GL}$. In Multiplicative GRAPE, a position $n \in \mathbb{Z}$ (or $t \in \mathbb{R}$) acts as $\mathbf{G}(n) = \exp(n \, \omega \, \mathbf{L})$ with a rank-2 skew-symmetric generator $\mathbf{L} \in \mathbb{R}^{d \times d}$, yielding a relative, compositional, norm-preserving map with a closed-form matrix exponential. RoPE is recovered exactly when the $d/2$ planes correspond to canonical coordinate pairs with a log-uniform spectrum. Learned commuting subspaces and compact non-commuting mixtures strictly extend this geometry to capture cross-subspace feature coupling at $O(d)$ and $O(r d)$ cost per head, respectively. In Additive GRAPE, additive logits arise from rank-1 (or low-rank) unipotent actions, recovering ALiBi and the Forgetting Transformer (FoX) as exact special cases while preserving an exact relative law and streaming cacheability. Overall, GRAPE provides a principled design space for positional geometry in long-context models, subsuming RoPE and ALiBi as special cases. Project page: https://github.com/model-architectures/GRAPE.
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Do Phone-Use Agents Respect Your Privacy?

arXiv:2604.00986v2 Announce Type: replace-cross Abstract: We study whether phone-use agents respect privacy while completing benign mobile tasks. This question has remained hard to answer because privacy-compliant behavior is not operationalized for phone-use agents, and ordinary apps do not reveal exactly what data agents type into which form entries during execution. To make this question measurable, we introduce MyPhoneBench, a verifiable evaluation framework for privacy behavior in mobile agents. We operationalize privacy-respecting phone use as permissioned access, minimal disclosure, and user-controlled memory through a minimal privacy contract, iMy, and pair it with instrumented mock apps plus rule-based auditing that make unnecessary permission requests, deceptive re-disclosure, and unnecessary form filling observable and reproducible. Across five frontier models on 10 mobile apps and 300 tasks, we find that task success, privacy-compliant task completion, and later-session use of saved preferences are distinct capabilities, and no single model dominates all three. Evaluating success and privacy jointly reshuffles the model ordering relative to either metric alone. The most persistent failure mode across models is simple data minimization: agents still fill optional personal entries that the task does not require. These results show that privacy failures arise from over-helpful execution of benign tasks, and that success-only evaluation overestimates the deployment readiness of current phone-use agents. All code, mock apps, and agent trajectories are publicly available at~ https://github.com/FreedomIntelligence/MyPhoneBench.
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Psychotherapists’ Trust, Distrust, and Generative AI Practices in Psychotherapy: Qualitative Study

Background: Generative artificial intelligence (GenAI) is increasingly used in mental health care, from client-facing chatbots to clinician-facing documentation aids. Psychotherapists’ willingness to rely on—or withhold reliance from—these tools has significant implications for care quality, yet little is known about how practicing clinicians calibrate trust and distrust in GenAI across tasks and contexts. Given that the therapeutic relationship is central to psychotherapy outcomes, understanding how GenAI intersects with this relational foundation is essential for responsible integration. Objective: This study aims to examine (1) psychotherapists’ experiences with, perceptions of, and trust or distrust in GenAI in therapeutic contexts and (2) how they perceive the role of GenAI within the therapeutic relationship and how their perceptions shape their trust and distrust in GenAI. Methods: We conducted a qualitative interview study using semistructured interviews with 18 actively practicing psychotherapists in the United States between January and May 2025. Participants were recruited through professional mailing lists, social media, and snowball sampling. Interviews (≈60 min each) were conducted via Zoom and explored psychotherapists’ experiences with, perceptions of, and trust or distrust in GenAI in therapeutic contexts. Data were analyzed using the general inductive approach, with iterative coding and team-based interpretation to identify themes. Results: Our findings show that psychotherapists’ GenAI adoption was highly individualized and contingent on maintaining professional role integrity—not merely technical oversight. Trust was sustained when GenAI operated in clinician-supervised, supportive roles for low-stakes tasks (eg, documentation and brainstorming), but diminished when control shifted, tasks involved high-stakes clinical judgment, or GenAI threatened to encroach on the authentic human connection central to therapy. Participants articulated conditions for trust that went beyond “human-in-the-loop” monitoring to include preservation of interpretive authority, ethical responsibility, and relational primacy. Distrust also extended to the broader sociotechnical ecosystem, including concerns about commercial incentives, insurance pressures, and the absence of clear organizational guidelines. Conclusions: Psychotherapists’ perspectives offer critical insights into GenAI’s current usages in their professional practices and the conditions under which they are willing to trust and distrust GenAI tools. Their experiences highlight the importance of maintaining clinician control, ensuring contextual appropriateness, and preserving the human connection central to psychotherapy. Future work should further examine how therapeutic orientation, professional experience, and client characteristics shape trust and distrust in GenAI. As GenAI becomes more embedded in mental health care, research is also needed to explore how specific GenAI system features can be responsibly designed to support clinical workflows and enhance therapeutic relationships. Organizational and policy frameworks will be essential to ensure responsible, ethically aligned, and human-centered GenAI deployment in psychotherapy.
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Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice

Enhancing circadian amplitude in mouse hypothalamic paraventricular nucleus neurons by 3′-deoxyadenosine treatment alleviates age-related pathologies and extends lifespan.
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Unified modeling of 3D molecular generation via atomic interactions with PocketXMol

A versatile, atom-level generative AI model enables unified pocket-interacting tasks, from docking to de novo design, and demonstrates robust experimental validation for both small-molecule and peptide therapeutics.
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Correction: Integrative multi-omics and machine learning reveals the spatial niche distribution and role of CYP27A1+TAMs in immunotherapy response in non-small cell lung cancer

Front Immunol. 2026 Mar 16;17:1822612. doi: 10.3389/fimmu.2026.1822612. eCollection 2026.

ABSTRACT

[This corrects the article DOI: 10.3389/fimmu.2026.1782545.].

PMID:41918731 | PMC:PMC13033988 | DOI:10.3389/fimmu.2026.1822612

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Xuanwu: Evolving General Multimodal Models into an Industrial-Grade Foundation for Content Ecosystems

arXiv:2603.29211v1 Announce Type: new Abstract: In recent years, multimodal large models have continued to improve on general benchmarks. However, in real-world content moderation and adversarial settings, mainstream models still suffer from degraded generalization and catastrophic forgetting because of limited fine-grained visual perception and insufficient modeling of long-tail noise. In this paper, we present Xuanwu VL-2B as a case study of how general multimodal models can be developed into an industrial-grade foundation model for content ecosystems. The model adopts a compact InternViT-300M + MLP + Qwen3 1.7B architecture, balancing fine-grained visual perception, language-semantic alignment, and deployment cost within an approximately 2B-parameter budget. To balance business specialization with the retention of general capabilities, we developed a data iteration and curation mechanism and trained the model through a progressive three-stage pipeline: pre-training, mid-training, and post-training. Ablation studies and offline business evaluations show that Xuanwu VL-2B achieves an average score of 67.90 across seven OpenCompass multimodal metrics (vs. 64.27 for InternVL 3.5 2B), an average recall of 94.38% over seven independent business moderation tasks, and a weighted overall recall of 82.82% on policy-violating text in challenging adversarial OCR scenarios, outperforming Gemini-2.5-Pro (76.72%). These results show that, under a limited parameter budget, Xuanwu VL-2B achieves a practical balance among business alignment, visual perception, general capability retention, and deployment cost.
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Owl-AuraID 1.0: An Intelligent System for Autonomous Scientific Instrumentation and Scientific Data Analysis

arXiv:2603.29828v1 Announce Type: new Abstract: Scientific discovery increasingly depends on high-throughput characterization, yet automation is hindered by proprietary GUIs and the limited generalizability of existing API-based systems. We present Owl-AuraID, a software-hardware collaborative embodied agent system that adopts a GUI-native paradigm to operate instruments through the same interfaces as human experts. Its skill-centric framework integrates Type-1 (GUI operation) and Type-2 (data analysis) skills into end-to-end workflows, connecting physical sample handling with scientific interpretation. Owl-AuraID demonstrates broad coverage across ten categories of precision instruments and diverse workflows, including multimodal spectral analysis, microscopic imaging, and crystallographic analysis, supporting modalities such as FTIR, NMR, AFM, and TGA. Overall, Owl-AuraID provides a practical, extensible foundation for autonomous laboratories and illustrates a path toward evolving laboratory intelligence through reusable operational and analytical skills. The code are available at https://github.com/OpenOwlab/AuraID.
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SemLoc: Structured Grounding of Free-Form LLM Reasoning for Fault Localization

arXiv:2603.29109v1 Announce Type: cross Abstract: Fault localization identifies program locations responsible for observed failures. Existing techniques rank suspicious code using syntactic spectra--signals derived from execution structure such as statement coverage, control-flow divergence, or dependency reachability. These signals collapse for semantic bugs, where failing and passing executions follow identical code paths and differ only in whether semantic intent is satisfied. Recent LLM-based approaches introduce semantic reasoning but produce stochastic, unverifiable outputs that cannot be systematically cross-referenced across tests or distinguish root causes from cascading effects. We present SemLoc, a fault localization framework based on structured semantic grounding. SemLoc converts free-form LLM reasoning into a closed intermediate representation that binds each inferred property to a typed program anchor, enabling runtime checking and attribution to program structure. It executes instrumented programs to construct a semantic violation spectrum--a constraint-by-test matrix--from which suspiciousness scores are derived analogously to coverage-based methods. A counterfactual verification step further prunes over-approximate constraints and isolates primary causal violations. We evaluate SemLoc on SemFault-250, a corpus of 250 Python programs with single semantic faults. SemLoc outperforms five coverage-, reduction-, and LLM-based baselines, achieving Top-1 accuracy of 42.8% and Top-3 of 68%, while reducing inspection to 7.6% of executable lines. Counterfactual verification provides an additional 12% accuracy gain and identifies primary causal semantic constraints.
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Derived Fields Preserve Fine-Scale Detail in Budgeted Neural Simulators

arXiv:2603.29224v1 Announce Type: cross Abstract: Fine-scale-faithful neural simulation under fixed storage budgets remains challenging. Many existing methods reduce high-frequency error by improving architectures, training objectives, or rollout strategies. However, under budgeted coarsen-quantize-decode pipelines, fine detail can already be lost when the carried state is constructed. In the canonical periodic incompressible Navier-Stokes setting, we show that primitive and derived fields undergo systematically different retained-band distortions under the same operator. Motivated by this observation, we formulate Derived-Field Optimization (DerivOpt), a general state-design framework that chooses which physical fields are carried and how storage budget is allocated across them under a calibrated channel model. Across the full time-dependent forward subset of PDEBench, DerivOpt not only improves pooled mean rollout nRMSE, but also delivers a decisive advantage in fine-scale fidelity over a broad set of strong baselines. More importantly, the gains are already visible at input time, before rollout learning begins. This indicates that the carried state is often the dominant bottleneck under tight storage budgets. These results suggest a broader conclusion: in budgeted neural simulation, carried-state design should be treated as a first-class design axis alongside architecture, loss, and rollout strategy.
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Long-Document QA with Chain-of-Structured-Thought and Fine-Tuned SLMs

arXiv:2603.29232v1 Announce Type: cross Abstract: Large language models (LLMs) are widely applied to data analytics over documents, yet direct reasoning over long, noisy documents remains brittle and error-prone. Hence, we study document question answering (QA) that consolidates dispersed evidence into a structured output (e.g., a table, graph, or chunks) to support reliable, verifiable QA. We propose a two-pillar framework, LiteCoST, to achieve both high accuracy and low latency with small language models (SLMs). Pillar 1: Chain-of-Structured-Thought (CoST). We introduce a CoST template, a schema-aware instruction that guides a strong LLM to produce both a step-wise CoST trace and the corresponding structured output. The process induces a minimal structure, normalizes entities/units, aligns records, serializes the output, and verifies/refines it, yielding auditable supervision. Pillar 2: SLM fine-tuning. The compact models are trained on LLM-generated CoST data in two stages: Supervised Fine-Tuning for structural alignment, followed by Group Relative Policy Optimization (GRPO) incorporating triple rewards for answer/format quality and process consistency. By distilling structure-first behavior into SLMs, this approach achieves LLM-comparable quality on multi-domain long-document QA using 3B/7B SLMs, while delivering 2-4x lower latency than GPT-4o and DeepSeek-R1 (671B). The code is available at https://github.com/HKUSTDial/LiteCoST.
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Self-Improving Code Generation via Semantic Entropy and Behavioral Consensus

arXiv:2603.29292v1 Announce Type: cross Abstract: Improving the code generation capabilities of large language models (LLMs) typically relies on supervised fine-tuning or preference optimization, both of which require costly external resources such as powerful teacher models or reliable test units. However, in real-world scenarios, it is much harder to obtain reference solutions and test oracles than problem descriptions and test inputs. In this paper, we tackle a challenging yet realistic question: Can a code language model improve itself without access to a superior teacher and a test oracle? To answer this, we propose ConSelf, a self-improving approach built upon two key ideas. First, we introduce code semantic entropy, a novel metric that measures problem-level uncertainty by assessing the functional diversity of program behaviors, enabling a curriculum construction with the most learnable problems. Second, we present consensus-driven direct preference optimization (Con-DPO), a preference-based fine-tuning method that weights each preference pair by its behavioral consensus, thereby mitigating the impact of noisy self-generated supervision. Experiments on various benchmarks and backbone LLMs demonstrate that ConSelf significantly outperforms baselines, validating the effectiveness of semantic entropy-based curriculum construction and consensus-driven optimization in improving code generation without external supervision.
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IMPASTO: Integrating Model-Based Planning with Learned Dynamics Models for Robotic Oil Painting Reproduction

arXiv:2603.29315v1 Announce Type: cross Abstract: Robotic reproduction of oil paintings using soft brushes and pigments requires force-sensitive control of deformable tools, prediction of brushstroke effects, and multi-step stroke planning, often without human step-by-step demonstrations or faithful simulators. Given only a sequence of target oil painting images, can a robot infer and execute the stroke trajectories, forces, and colors needed to reproduce it? We present IMPASTO, a robotic oil-painting system that integrates learned pixel dynamics models with model-based planning. The dynamics models predict canvas updates from image observations and parameterized stroke actions; a receding-horizon model predictive control optimizer then plans trajectories and forces, while a force-sensitive controller executes strokes on a 7-DoF robot arm. IMPASTO integrates low-level force control, learned dynamics models, and high-level closed-loop planning, learns solely from robot self-play, and approximates human artists' single-stroke datasets and multi-stroke artworks, outperforming baselines in reproduction accuracy. Project website: https://impasto-robopainting.github.io/
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VectorGym: A Multitask Benchmark for SVG Code Generation, Sketching, and Editing

arXiv:2603.29852v1 Announce Type: cross Abstract: We introduce VectorGym, a comprehensive benchmark suite for Scalable Vector Graphics (SVG) that spans generation from text and sketches, complex editing, and visual understanding. VectorGym addresses the lack of realistic, challenging benchmarks aligned with professional design workflows. Our benchmark comprises four tasks with expert human-authored annotations: the novel Sketch2SVG task (VG-Sketch); a new SVG editing dataset (VG-Edit) featuring complex, multi-step edits with higher-order primitives; Text2SVG generation (VG-Text); and SVG captioning (VG-Cap). Unlike prior benchmarks that rely on synthetic edits, VectorGym provides gold-standard human annotations that require semantic understanding and design intent. We also propose a multi-task reinforcement learning approach that jointly optimizes across all four tasks using rendering-based rewards. Our method, built on GRPO with curriculum learning, trains a Qwen3-VL 8B model that achieves state-of-the-art performance among open-source models, surpassing much larger models including Qwen3-VL 235B and matching GPT-4o. We also introduce a VLM-as-a-Judge metric for SVG generation, validated through human correlation studies. Our evaluation of frontier VLMs reveals significant performance gaps, positioning VectorGym as a rigorous framework for advancing visual code generation. VectorGym is publicly available on huggingface.co/datasets/ServiceNow/VectorGym.
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Balancing Efficiency and Empathy: Healthcare Providers' Perspectives on AI-Supported Workflows for Serious Illness Conversations in the Emergency Department

arXiv:2506.00241v2 Announce Type: replace-cross Abstract: Serious Illness Conversations (SICs), discussions about values and care preferences for patients with life-threatening illness, rarely occur in Emergency Departments (EDs), despite evidence that early conversations improve care alignment and reduce unnecessary interventions. We interviewed 11 ED providers to identify challenges in SICs and opportunities for technology support, with a focus on AI. Our analysis revealed a four-stage SIC workflow (identification, preparation, conduction, documentation) and barriers at each stage, including fragmented patient information, limited time and space, lack of conversational guidance, and burdensome documentation. Providers expressed interest in AI systems for synthesizing information, supporting real-time conversations, and automating documentation, but emphasized concerns about preserving human connection and clinical autonomy. This tension highlights the need for technologies that enhance efficiency without undermining the interpersonal nature of SICs. We propose design guidelines for ambient and peripheral AI systems to support providers while preserving the essential humanity of these conversations.
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