Xiao et al. identify α-KG as a rosacea-associated metabolite that activates the OXGR1-Gq-MYL9 axis in the vascular smooth muscle cells to boost contractility and suppress pathological vasodilation underlying erythema. Cryo-EM reveals a bipartite-acid pocket of OXGR1 that enables structure-guided development of A-1, a selective agonist that alleviates erythema in rosacea-like models.

arXiv:2603.28610v2 Announce Type: replace-cross Abstract: Multimodal Large Language Models (MLLMs) achieve stronger visual understanding by scaling input fidelity, yet the resulting visual token growth makes jointly sustaining high spatial resolution and long temporal context prohibitive. We argue that the bottleneck lies not in how post-encoding representations are compressed but in the volume of pixels the encoder receives, and address it with ResAdapt, an Input-side adaptation framework that learns how much visual budget each frame should receive before encoding. ResAdapt couples a lightweight Allocator with an unchanged MLLM backbone, so the backbone retains its native visual-token interface while receiving an operator-transformed input. We formulate allocation as a contextual bandit and train the Allocator with Cost-Aware Policy Optimization (CAPO), which converts sparse rollout feedback into a stable accuracy-cost learning signal. Across budget-controlled video QA, temporal grounding, and image reasoning tasks, ResAdapt improves low-budget operating points and often lies on or near the efficiency-accuracy frontier, with the clearest gains on reasoning-intensive benchmarks under aggressive compression. Notably, ResAdapt supports up to 16x more frames at the same visual budget while delivering over 15% performance gain. Code is available at https://github.com/Xnhyacinth/ResAdapt.