arXiv:2604.01621v1 Announce Type: cross Abstract: Large language model (LLM) inference increasingly depends on multi-GPU execution, yet existing inference parallelization strategies require layer-wise inter-rank synchronization, making end-to-end performance sensitive to workload imbalance. We present DWDP (Distributed Weight Data Parallelism), an inference parallelization strategy that preserves data-parallel execution while offloading MoE weights across peer GPUs and fetching missing experts on demand. By removing collective inter-rank synchronization, DWDP allows each GPU to progress independently. We further address the practical overheads of this design with two optimizations for split-weight management and asynchronous remote-weight prefetch. Implemented in TensorRT-LLM and evaluated with DeepSeek-R1 on GB200 NVL72, DWDP improves end-to-end output TPS/GPU by 8.8% at comparable TPS/user in the 20-100 TPS/user serving range under 8K input sequence length and 1K output sequence length.

arXiv:2604.01669v1 Announce Type: cross Abstract: Embodied perception systems face severe challenges of dynamic environment distribution drift when they continuously interact in open physical spaces. However, the existing domain incremental awareness methods often rely on the domain id obtained in advance during the testing phase, which limits their practicability in unknown interaction scenarios. At the same time, the model often overfits to the context-specific perceptual noise, which leads to insufficient generalization ability and catastrophic forgetting. To address these limitations, we propose a domain-id and exemplar-free incremental learning framework for embodied multimedia systems, which aims to achieve robust continuous environment adaptation. This method designs a disentangled representation mechanism to remove non-essential environmental style interference, and guide the model to focus on extracting semantic intrinsic features shared across scenes, thereby eliminating perceptual uncertainty and improving generalization. We further use the weight fusion strategy to dynamically integrate the old and new environment knowledge in the parameter space, so as to ensure that the model adapts to the new distribution without storing historical data and maximally retains the discrimination ability of the old environment. Extensive experiments on multiple standard benchmark datasets show that the proposed method significantly reduces catastrophic forgetting in a completely exemplar-free and domain-id free setting, and its accuracy is better than the existing state-of-the-art methods.

arXiv:2601.10611v4 Announce Type: replace-cross Abstract: Today's strongest video-language models (VLMs) remain proprietary. The strongest open-weight models either rely on synthetic data from proprietary VLMs, effectively distilling from them, or do not disclose their training data or recipe. As a result, the open-source community lacks the foundations needed to improve on the state-of-the-art video (and image) language models. Crucially, many downstream applications require more than just high-level video understanding; they require grounding -- either by pointing or by tracking in pixels. Even proprietary models lack this capability. We present Molmo2, a new family of VLMs that are state-of-the-art among open-source models and demonstrate exceptional new capabilities in point-driven grounding in single image, multi-image, and video tasks. Our key contribution is a collection of 7 new video datasets and 2 multi-image datasets, including a dataset of highly detailed video captions for pre-training, a free-form video Q&A dataset for fine-tuning, a new object tracking dataset with complex queries, and an innovative new video pointing dataset, all collected without the use of closed VLMs. We also present a training recipe for this data utilizing an efficient packing and message-tree encoding scheme, and show bi-directional attention on vision tokens and a novel token-weight strategy improves performance. Our best-in-class 8B model outperforms others in the class of open weight and data models on short videos, counting, and captioning, and is competitive on long-videos. On video-grounding Molmo2 significantly outperforms existing open-weight models like Qwen3-VL (35.5 vs 29.6 accuracy on video counting) and surpasses proprietary models like Gemini 3 Pro on some tasks (38.4 vs 20.0 F1 on video pointing and 56.2 vs 41.1 J&F on video tracking).

arXiv:2603.27346v2 Announce Type: replace-cross Abstract: Robotic manipulation remains challenging for reinforcement learning due to contact-rich dynamics, long horizons, and training instability. Although off-policy actor-critic algorithms such as SAC and TD3 perform well in simulation, they often suffer from policy oscillations and performance collapse in realistic settings, partly due to experience replay strategies that ignore the differing data requirements of the actor and the critic. We propose D-SPEAR: Dual-Stream Prioritized Experience Adaptive Replay, a replay framework that decouples actor and critic sampling while maintaining a shared replay buffer. The critic leverages prioritized replay for efficient value learning, whereas the actor is updated using low-error transitions to stabilize policy optimization. An adaptive anchor mechanism balances uniform and prioritized sampling based on the coefficient of variation of TD errors, and a Huber-based critic objective further improves robustness under heterogeneous reward scales. We evaluate D-SPEAR on challenging robotic manipulation tasks from the robosuite benchmark, including Block-Lifting and Door-Opening. Results demonstrate that D-SPEAR consistently outperforms strong off-policy baselines, including SAC, TD3, and DDPG, in both final performance and training stability, with ablation studies confirming the complementary roles of the actorside and critic-side replay streams.

arXiv:2603.29828v1 Announce Type: new Abstract: Scientific discovery increasingly depends on high-throughput characterization, yet automation is hindered by proprietary GUIs and the limited generalizability of existing API-based systems. We present Owl-AuraID, a software-hardware collaborative embodied agent system that adopts a GUI-native paradigm to operate instruments through the same interfaces as human experts. Its skill-centric framework integrates Type-1 (GUI operation) and Type-2 (data analysis) skills into end-to-end workflows, connecting physical sample handling with scientific interpretation. Owl-AuraID demonstrates broad coverage across ten categories of precision instruments and diverse workflows, including multimodal spectral analysis, microscopic imaging, and crystallographic analysis, supporting modalities such as FTIR, NMR, AFM, and TGA. Overall, Owl-AuraID provides a practical, extensible foundation for autonomous laboratories and illustrates a path toward evolving laboratory intelligence through reusable operational and analytical skills. The code are available at https://github.com/OpenOwlab/AuraID.

arXiv:2506.21458v2 Announce Type: replace Abstract: Can Vision-Language Models (VLMs) imagine the full scene from just a few views, like humans do? Humans form spatial mental models naturally, internal representations of unseen space, to reason about layout, perspective, and motion. Our MindCube benchmark with 21,154 questions across 3,268 images exposes this critical gap, where existing VLMs exhibit near-random performance. Using MindCube, we systematically evaluate how well VLMs build robust spatial mental models through representing positions (cognitive mapping), orientations (perspective-taking), and dynamics (mental simulation for "what-if" movements). We then explore three approaches to help approximate spatial mental models in VLMs, focusing on incorporating unseen intermediate views, natural language reasoning chains, and cognitive maps. The significant improvement comes from a synergistic approach, "map-then-reason", that jointly trains the model to first generate a cognitive map and then reason upon it. By training models to reason over these internal maps, we boosted accuracy from 37.8% to 57.8% (+20.0%). Adding reinforcement learning pushed performance even further to 61.3% (+23.5%). Our key insight is that such scaffolding of spatial mental models, actively constructing and utilizing internal structured spatial representations with flexible reasoning processes, significantly improves understanding of unobservable space.

arXiv:2509.20702v2 Announce Type: replace-cross Abstract: Recent advances in large language model (LLM) embeddings have enabled powerful representations for biological data, but most applications to date focus on gene-level information. We present one of the first systematic frameworks to generate genetic variant-level embeddings across the entire human genome. Using curated annotations from FAVOR, ClinVar, and the GWAS Catalog, we construct functional text descriptions for 8.9 billion possible variants and generated embeddings at three scales: 1.5 million HapMap3/MEGA variants, 90 million imputed UK Biobank (UKB) variants, and 9 billion all possible variants. Embeddings were produced using general purpose models including both OpenAI's text-embedding-3-large and the open-source Qwen3-Embedding-0.6B models. Baseline quality control experiments demonstrate high predictive accuracy for variant-level properties, validating the embeddings as structured representations of genomic variation. We further apply them to real-world embedding-augmented genetic risk predictions that demonstrate the performance of using LLM embeddings in polygenic risk score (PRS) style predictions over the UK Biobank cohort data. These resources, publicly available on Hugging Face, provide a foundation for advancing large-scale genomic discovery and precision medicine.

arXiv:2603.19979v2 Announce Type: replace-cross Abstract: Scalable and reliable evaluation is increasingly critical in the end-to-end era of autonomous driving, where vision--language--action (VLA) policies directly map raw sensor streams to driving actions. Yet, current evaluation pipelines still rely heavily on real-world road testing, which is costly, biased toward limited scenario coverage, and difficult to reproduce. These challenges motivate a real-world simulator that can generate realistic future observations under proposed actions, while remaining controllable and stable over long horizons. We present X-World, an action-conditioned multi-camera generative world model that simulates future observations directly in video space. Given synchronized multi-view camera history and a future action sequence, X-World generates future multi-camera video streams that follow the commanded actions. To ensure reproducible and editable scene rollouts, X-World further supports optional controls over dynamic traffic agents and static road elements, and retains a text-prompt interface for appearance-level control (e.g., weather and time of day). Beyond world simulation, X-World also enables video style transfer by conditioning on appearance prompts while preserving the underlying action and scene dynamics. At the core of X-World is a multi-view latent video generator designed to explicitly encourage cross-view geometric consistency and temporal coherence under diverse control signals. Experiments show that X-World achieves high-quality multi-view video generation with (i) strong view consistency across cameras, (ii) stable temporal dynamics over long rollouts, and (iii) high controllability with strict action following and faithful adherence to optional scene controls. These properties make X-World a practical foundation for scalable and reproducible evaluation.

arXiv:2603.23481v1 Announce Type: cross Abstract: Video-Action Models (VAMs) have emerged as a promising framework for embodied intelligence, learning implicit world dynamics from raw video streams to produce temporally consistent action predictions. Although such models demonstrate strong performance on long-horizon tasks through visual reasoning, they remain limited in contact-rich scenarios where critical interaction states are only partially observable from vision alone. In particular, fine-grained force modulation and contact transitions are not reliably encoded in visual tokens, leading to unstable or imprecise behaviors. To bridge this gap, we introduce the Video-Tactile Action Model (VTAM), a multimodal world modeling framework that incorporates tactile perception as a complementary grounding signal. VTAM augments a pretrained video transformer with tactile streams via a lightweight modality transfer finetuning, enabling efficient cross-modal representation learning without tactile-language paired data or independent tactile pretraining. To stabilize multimodal fusion, we introduce a tactile regularization loss that enforces balanced cross-modal attention, preventing visual latent dominance in the action model. VTAM demonstrates superior performance in contact-rich manipulation, maintaining a robust success rate of 90 percent on average. In challenging scenarios such as potato chip pick-and-place requiring high-fidelity force awareness, VTAM outperforms the pi 0.5 baseline by 80 percent. Our findings demonstrate that integrating tactile feedback is essential for correcting visual estimation errors in world action models, providing a scalable approach to physically grounded embodied foundation models.

arXiv:2512.10766v2 Announce Type: replace-cross Abstract: Text-to-image (T2I) models commonly incorporate defense mechanisms to prevent the generation of sensitive images. Unfortunately, recent jailbreak attacks have shown that adversarial prompts can effectively bypass these mechanisms and induce T2I models to produce sensitive content, revealing critical safety vulnerabilities. However, existing attack methods implicitly assume that the attacker knows the type of deployed defenses, which limits their effectiveness against unknown or diverse defense mechanisms. In this work, we reveal an underexplored vulnerability of T2I models to metaphor-based jailbreak attacks (MJA), which aims to attack diverse defense mechanisms without prior knowledge of their type by generating metaphor-based adversarial prompts. Specifically, MJA consists of two modules: an LLM-based multi-agent generation module (LMAG) and an adversarial prompt optimization module (APO). LMAG decomposes the generation of metaphor-based adversarial prompts into three subtasks: metaphor retrieval, context matching, and adversarial prompt generation. Subsequently, LMAG coordinates three LLM-based agents to generate diverse adversarial prompts by exploring various metaphors and contexts. To enhance attack efficiency, APO first trains a surrogate model to predict the attack results of adversarial prompts and then designs an acquisition strategy to adaptively identify optimal adversarial prompts. Extensive experiments on T2I models with various external and internal defense mechanisms demonstrate that MJA achieves stronger attack performance while using fewer queries, compared with six baseline methods. Additionally, we provide an in-depth vulnerability analysis suggesting that metaphor-based adversarial prompts evade safety mechanisms by inducing semantic ambiguity, while sensitive images arise from the model's probabilistic interpretation of concealed semantics.

arXiv:2509.25084v3 Announce Type: replace-cross Abstract: Data-analytic agents are emerging as a key catalyst for automated scientific discovery and for the vision of Innovating AI. Current approaches, however, rely heavily on prompt engineering over proprietary models, while open-source models struggle to face diverse-format, large-scale data files and long-horizon, multi-step reasoning that real-world analytics demands. This paper introduces DataMind, a scalable data synthesis and agent training recipe designed to build generalist data-analytic agents. DataMind tackles three key challenges in building open-source data-analytic agents, including insufficient data resources, improper training strategy, and unstable code-based multi-turn rollout. Concretely, DataMind applies 1) a fine-grained task taxonomy and a recursive easy-to-hard task composition mechanism to increase the diversity and difficulty of synthesized queries; 2) a knowledge-augmented trajectory sampling strategy followed by model-based and rule-based filtering; 3) a dynamically adjustable training objective combining both SFT and RL losses; 4) a memory-frugal and stable code-based multi-turn rollout framework. Built on DataMind, we curate DataMind-12K, a high-quality trajectory set spanning diverse domains, task categories, and data file formats for data-analytic tasks. Trained on DataMind-12K, our DataMind-14B achieves state-of-the-art with an average score of 71.16% on multiple data analysis benchmarks, outperforming the strongest proprietary baselines DeepSeek-V3.1 and GPT-5. Our DataMind-7B also performs best among all open-source models with a score of 68.10%. We also incorporate some empirical insights gained from our exploratory trials into the analysis experiments, aiming to provide actionable insights about agentic training for the community. We will release DataMind-12K and DataMind-7B,14B for the community's future research.

arXiv:2510.23571v2 Announce Type: replace-cross Abstract: The pursuit of robot generalists, agents capable of performing diverse tasks across diverse environments, demands rigorous and scalable evaluation. Yet real-world testing of robot policies remains fundamentally constrained: it is labor-intensive, slow, unsafe at scale, and difficult to reproduce. As policies expand in scope and complexity, these barriers only intensify, since defining "success" in robotics often hinges on nuanced human judgments of execution quality. We introduce RobotArena Infinity, a new benchmarking framework that overcomes these challenges by shifting vision-language-action (VLA) evaluation into large-scale simulated environments augmented with online human feedback. Leveraging advances in vision-language models, 2D-to-3D generative modeling, and differentiable rendering, our approach automatically converts video demonstrations from widely used robot datasets into simulated counterparts. Within these digital twins, we assess VLA policies using both automated vision-language-model-guided scoring and scalable human preference judgments collected from crowdworkers, transforming human involvement from tedious scene setup, resetting, and safety supervision into lightweight preference comparisons. To measure robustness, we systematically perturb simulated environments along multiple axes, including textures and object placements, stress-testing policy generalization under controlled variation. The result is a continuously evolving, reproducible, and scalable benchmark for real-world-trained robot manipulation policies, addressing a critical missing capability in today's robotics landscape.

arXiv:2511.23342v2 Announce Type: replace-cross Abstract: MeanFlow offers a promising framework for one-step generative modeling by directly learning a mean-velocity field, bypassing expensive numerical integration. However, we find that the highly curved generative trajectories of existing models induce a noisy loss landscape, severely bottlenecking convergence and model quality. We leverage a fundamental geometric principle to overcome this: mean-velocity estimation is drastically simpler along straight paths. Building on this insight, we propose Rectified MeanFlow, a self-distillation approach that learns the mean-velocity field over a straightened velocity field, induced by rectified couplings from a pretrained model. To further promote linearity, we introduce a distance-based truncation heuristic that prunes residual high-curvature pairs. By smoothing the optimization landscape, our method achieves strong one-step generation performance. We improve the FID of baseline MeanFlow models from 30.9 to 8.6 under same training budget, and outperform the recent 2-rectified flow++ by 33.4% in FID while running 26x faster. Our work suggests that the difficulty of one-step flow generation stems partially from the rugged optimization landscapes induced by curved trajectories. Code is available at https://github.com/Xinxi-Zhang/Re-MeanFlow.

Nature, Published online: 16 March 2026; doi:10.1038/d41586-026-00841-0

An exemplary book gets much right, but misses the point that the nation’s tech dominance has more to do with globalization than with policy choices.

Oncogene, Published online: 14 March 2026; doi:10.1038/s41388-026-03714-y

LINC-AC092535.5 regulates MICAL2 mRNA level to inhibit p53-mediated ferroptosis in nasopharyngeal carcinoma

arXiv:2603.08652v1 Announce Type: new Abstract: Recent advancements in Unified Multimodal Models (UMMs) have significantly advanced text-to-image (T2I) generation, particularly through the integration of Chain-of-Thought (CoT) reasoning. However, existing CoT-based T2I methods largely rely on abstract natural-language planning, which lacks the precision required for complex spatial layouts, structured visual elements, and dense textual content. In this work, we propose CoCo (Code-as-CoT), a code-driven reasoning framework that represents the reasoning process as executable code, enabling explicit and verifiable intermediate planning for image generation. Given a text prompt, CoCo first generates executable code that specifies the structural layout of the scene, which is then executed in a sandboxed environment to render a deterministic draft image. The model subsequently refines this draft through fine-grained image editing to produce the final high-fidelity result. To support this training paradigm, we construct CoCo-10K, a curated dataset containing structured draft-final image pairs designed to teach both structured draft construction and corrective visual refinement. Empirical evaluations on StructT2IBench, OneIG-Bench, and LongText-Bench show that CoCo achieves improvements of +68.83%, +54.8%, and +41.23% over direct generation, while also outperforming other generation methods empowered by CoT. These results demonstrate that executable code is an effective and reliable reasoning paradigm for precise, controllable, and structured text-to-image generation. The code is available at: https://github.com/micky-li-hd/CoCo

arXiv:2603.06589v1 Announce Type: cross Abstract: Model calibration and debiasing are fundamental to the reliability and fairness of large scale recommendation systems. We introduce the Isotonic Layer, a novel, differentiable framework that integrates piecewise linear fitting directly into neural architectures. By partitioning the feature space into discrete segments and optimizing non negative slopes via a constrained dot product mechanism, we enforce a global monotonic inductive bias. This ensures model outputs remain logically consistent with critical features such as latent relevance, recency, or quality scores. We further generalize this architecture by parameterizing segment wise slopes as learnable embeddings. This enables the model to adaptively capture context specific distortions, such as position based CTR bias through specialized isotonic profiles. Our approach utilizes a dual task formulation that decouples the recommendation objective into latent relevance estimation and bias aware calibration. A major contribution of this work is the ability to perform highly granular, customized calibration for arbitrary combinations of context features, a level of control difficult to achieve with traditional non parametric methods. We also extend this to Multi Task Learning environments with dedicated embeddings for distinct objectives. Extensive empirical evaluations on real world datasets and production AB tests demonstrate that the Isotonic Layer effectively mitigates systematic bias and enhances calibration fidelity, significantly outperforming production baselines in both predictive accuracy and ranking consistency.

arXiv:2603.06672v1 Announce Type: cross Abstract: Semantic noise initialization has been reported to improve robustness and controllability in image diffusion models. Whether these gains transfer to text-to-video (T2V) generation remains unclear, since temporal coupling can introduce extra degrees of freedom and instability. We benchmark semantic noise initialization against standard Gaussian noise using a frozen VideoCrafter-style T2V diffusion backbone and VBench on 100 prompts. Using prompt-level paired tests with bootstrap confidence intervals and a sign-flip permutation test, we observe a small positive trend on temporal-related dimensions; however, the 95 percent confidence interval includes zero (p ~ 0.17) and the overall score remains on par with the baseline. To understand this outcome, we analyze the induced perturbations in noise space and find patterns consistent with weak or unstable signal. We recommend prompt-level paired evaluation and noise-space diagnostics as standard practice when studying initialization schemes for T2V diffusion.

arXiv:2512.16301v3 Announce Type: replace Abstract: Large language model (LLM) agents are moving beyond prompting alone. ChatGPT marked the rise of general-purpose LLM assistants, DeepSeek showed that on-policy reinforcement learning with verifiable rewards can improve reasoning and tool use, and OpenClaw highlights a newer direction in which agents accumulate persistent memory and reusable skills. Yet the research landscape remains fragmented across post-training, retrieval, memory, and skill systems. This survey studies these developments under a single notion of \emph{adaptation}: improving an agent, its tools, or their interaction after pretraining. We organize the field with a four-paradigm framework spanning agent adaptation and tool adaptation. On the agent side, A1 (tool-execution-signaled) and A2 (agent-output-signaled) improve the agent itself through supervised fine-tuning, preference optimization, and reinforcement learning with verifiable rewards. On the tool side, T1 (agent-agnostic) provides reusable pre-trained modules any agent can call, while T2 (agent-supervised) uses the agent's outputs to train memory systems, skill libraries, or lightweight subagents. Using this framework, we review post-training methods, adaptive memory architectures, and agent skills; compare their trade-offs in cost, flexibility, and generalization; and summarize evaluation practices across deep research, software development, computer use, and drug discovery. We conclude by outlining open problems in agent-tool co-adaptation, continual learning, safety, and efficient deployment.