arXiv:2604.01687v1 Announce Type: new Abstract: Anthropic proposes the concept of skills for LLM agents to tackle multi-step professional tasks that simple tool invocations cannot address. A tool is a single, self-contained function, whereas a skill is a structured bundle of interdependent multi-file artifacts. Currently, skill generation is not only label-intensive due to manual authoring, but also may suffer from human--machine cognitive misalignment, which can lead to degraded agent performance, as evidenced by evaluations on SkillsBench. Therefore, we aim to enable agents to autonomously generate skills. However, existing self-evolving methods designed for tools cannot be directly applied to skills due to their increased complexity. To address these issues, we propose EvoSkills, a self-evolving skills framework that enables agents to autonomously construct complex, multi-file skill packages. Specifically, EvoSkills couples a Skill Generator that iteratively refines skills with a Surrogate Verifier that co-evolves to provide informative and actionable feedback without access to ground-truth test content. On SkillsBench, EvoSkills achieves the highest pass rate among five baselines on both Claude Code and Codex, and also exhibits strong generalization capabilities to six additional LLMs.

Oncogene, Published online: 01 April 2026; doi:10.1038/s41388-026-03737-5

LDHA-driven lactate metabolism promotes MDSC activation and immunosuppressive microenvironment in prostate cancer

arXiv:2603.22289v1 Announce Type: cross Abstract: Knowledge Tracing (KT) models students' evolving knowledge states to predict future performance, serving as a foundation for personalized education. While traditional deep learning models achieve high accuracy, they often lack interpretability. Large Language Models (LLMs) offer strong reasoning capabilities but struggle with limited context windows and hallucinations. Furthermore, existing LLM-based methods typically require expensive fine-tuning, limiting scalability and adaptability to new data. We propose MERIT (Memory-Enhanced Retrieval for Interpretable Knowledge Tracing), a training-free framework combining frozen LLM reasoning with structured pedagogical memory. Rather than updating parameters, MERIT transforms raw interaction logs into an interpretable memory bank. The framework uses semantic denoising to categorize students into latent cognitive schemas and constructs a paradigm bank where representative error patterns are analyzed offline to generate explicit Chain-of-Thought (CoT) rationales. During inference, a hierarchical routing mechanism retrieves relevant contexts, while a logic-augmented module applies semantic constraints to calibrate predictions. By grounding the LLM in interpretable memory, MERIT achieves state-of-the-art performance on real-world datasets without gradient updates. This approach reduces computational costs and supports dynamic knowledge updates, improving the accessibility and transparency of educational diagnosis.

Histidine scanning represents a broadly applicable technique for the identification of critical interaction sites within TCRs and other mechanosensory receptors to enhance receptor signaling strength and augment therapeutic efficacy via the catch bond mechanism.

arXiv:2603.13224v1 Announce Type: cross Abstract: Vision-to-code tasks require models to reconstruct structured visual inputs, such as charts, tables, and SVGs, into executable or structured representations with high visual fidelity. While recent Large Vision Language Models (LVLMs) achieve strong results via supervised fine-tuning, reinforcement learning remains challenging due to misaligned reward signals. Existing rewards either rely on textual rules or coarse visual embedding similarity, both of which fail to capture fine-grained visual discrepancies and are vulnerable to reward hacking. We propose Visual Equivalence Reward Model (Visual-ERM), a multimodal generative reward model that provides fine-grained, interpretable, and task-agnostic feedback to evaluate vision-to-code quality directly in the rendered visual space. Integrated into RL, Visual-ERM improves Qwen3-VL-8B-Instruct by +8.4 on chart-to-code and yields consistent gains on table and SVG parsing (+2.7, +4.1 on average), and further strengthens test-time scaling via reflection and revision. We also introduce VisualCritic-RewardBench (VC-RewardBench), a benchmark for judging fine-grained image-to-image discrepancies on structured visual data, where Visual-ERM at 8B decisively outperforms Qwen3-VL-235B-Instruct and approaches leading closed-source models. Our results suggest that fine-grained visual reward supervision is both necessary and sufficient for vision-to-code RL, regardless of task specificity.

arXiv:2603.08706v1 Announce Type: new Abstract: Training large language models (LLMs) as autonomous agents often begins with imitation learning, but it only teaches agents what to do without understanding why: agents never contrast successful actions against suboptimal alternatives and thus lack awareness of action quality. Recent approaches attempt to address this by introducing self-reflection supervision derived from contrasts between expert and alternative actions. However, the training paradigm fundamentally remains imitation learning: the model imitates pre-constructed reflection text rather than learning to reason autonomously. We propose Agentic Critical Training (ACT), a reinforcement learning paradigm that trains agents to identify the better action among alternatives. By rewarding whether the model's judgment is correct, ACT drives the model to autonomously develop reasoning about action quality, producing genuine self-reflection rather than imitating it. Across three challenging agent benchmarks, ACT consistently improves agent performance when combined with different post-training methods. It achieves an average improvement of 5.07 points over imitation learning and 4.62 points over reinforcement learning. Compared to approaches that inject reflection capability through knowledge distillation, ACT also demonstrates clear advantages, yielding an average improvement of 2.42 points. Moreover, ACT enables strong out-of-distribution generalization on agentic benchmarks and improves performance on general reasoning benchmarks without any reasoning-specific training data, highlighting the value of our method. These results suggest that ACT is a promising path toward developing more reflective and capable LLM agents.

arXiv:2602.04265v2 Announce Type: replace-cross Abstract: Reinforcement Learning with Verifiable Rewards (RLVR) has emerged as a promising paradigm for enhancing reasoning in Large Language Models (LLMs). However, it frequently encounters challenges such as entropy collapse, excessive verbosity, and insufficient exploration for hard problems. Crucially, existing reward schemes fail to distinguish between the need for extensive search during problem-solving and the efficiency required for mastered knowledge. In this work, we introduce T2T(Thickening-to-Thinning), a dynamic reward framework inspired by human learning processes. Specifically, it implements a dual-phase mechanism: (1) On incorrect attempts, T2T incentivizes "thickening" (longer trajectories) to broaden the search space and explore novel solution paths; (2) Upon achieving correctness, it shifts to "thinning", imposing length penalties to discourage redundancy, thereby fostering model confidence and crystallizing reasoning capabilities. Extensive experiments on mathematical benchmarks (MATH-500, AIME, AMC) across Qwen-series and Deepseek models demonstrate that T2T significantly outperforms standard GRPO and recent baselines, achieving superior performance.

arXiv:2602.14536v2 Announce Type: replace-cross Abstract: Large Language Models (LLMs) have seen remarkable advancements, achieving state-of-the-art results in diverse applications. Fine-tuning, an important step for adapting LLMs to specific downstream tasks, typically involves further training on corresponding datasets. However, a fundamental discrepancy exists between current fine-tuning datasets and the token-level optimization mechanism of LLMs: most datasets are designed at the sentence-level, which introduces token-level noise, causing negative influence to final performance. In this paper, we propose XTF, an explainable token-level noise filtering framework. XTF decomposes the complex and subtle contributions of token-level data to the fine-tuning process into three distinct and explicit attributes (reasoning importance, knowledge novelty, and task relevance), which can be assessed using scoring methods, and then masks the gradients of selected noisy tokens accordingly to optimize the performance of fine-tuned LLMs. We conduct extensive experiments on three representative downstream tasks (math, code and medicine) across 7 mainstream LLMs. The results demonstrate that XTF can significantly improve downstream performance by up to 13.7% compared to regular fine-tuning. Our work highlights the importance of token-level dataset optimization, and demonstrates the potential of strategies based on attribute decomposition for explaining complex training mechanisms.

arXiv:2603.00084v2 Announce Type: replace-cross Abstract: LLM-agents are increasingly used to accelerate the progress of scientific research. Yet a persistent bottleneck is data access: agents not only lack readily available tools for retrieval, but also have to work with unstrcutured, human-centric data on the Internet, such as HTML web-pages and PDF files, leading to excessive token consumption, limit working efficiency, and brittle evidence look-up. This gap motivates the development of \textit{an agentic data interface}, which is designed to enable agents to access and utilize scientific literature in a more effective, efficient, and cost-aware manner. In this paper, we introduce DeepXiv-SDK, which offers a three-layer agentic data interface for scientific literature. 1) Data Layer, which transforms unstructured, human-centric data into normalized and structured representations in JSON format, improving data usability and enabling progressive accessibility of the data. 2) Service Layer, which presents readily available tools for data access and ad-hoc retrieval. It also enables a rich form of agent usage, including CLI, MCP, and Python SDK. 3) Application Layer, which creates a built-in agent, packaging basic tools from the service layer to support complex data access demands. DeepXiv-SDK currently supports the complete ArXiv corpus, and is synchronized daily to incorporate new releases. It is designed to extend to all common open-access corpora, such as PubMed Central, bioRxiv, medRxiv, and chemRxiv. We release RESTful APIs, an open-source Python SDK, and a web demo showcasing deep search and deep research workflows. DeepXiv-SDK is free to use with registration.

arXiv:2602.14536v1 Announce Type: cross Abstract: Large Language Models (LLMs) have seen remarkable advancements, achieving state-of-the-art results in diverse applications. Fine-tuning, an important step for adapting LLMs to specific downstream tasks, typically involves further training on corresponding datasets. However, a fundamental discrepancy exists between current fine-tuning datasets and the token-level optimization mechanism of LLMs: most datasets are designed at the sentence-level, which introduces token-level noise, causing negative influence to final performance. In this paper, we propose XTF, an explainable token-level noise filtering framework. XTF decomposes the complex and subtle contributions of token-level data to the fine-tuning process into three distinct and explicit attributes (reasoning importance, knowledge novelty, and task relevance), which can be assessed using scoring methods, and then masks the gradients of selected noisy tokens accordingly to optimize the performance of fine-tuned LLMs. We conduct extensive experiments on three representative downstream tasks (math, code and medicine) across 7 mainstream LLMs. The results demonstrate that XTF can significantly improve downstream performance by up to 13.7% compared to regular fine-tuning. Our work highlights the importance of token-level dataset optimization, and demonstrates the potential of strategies based on attribute decomposition for explaining complex training mechanisms.