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Memory Intelligence Agent
Learning Additively Compositional Latent Actions for Embodied AI
DIRECT: Video Mashup Creation via Hierarchical Multi-Agent Planning and Intent-Guided Editing
TSPO: Breaking the Double Homogenization Dilemma in Multi-turn Search Policy Optimization
Xpertbench: Expert Level Tasks with Rubrics-Based Evaluation
Fine-tuning is Not Enough: A Parallel Framework for Collaborative Imitation and Reinforcement Learning in End-to-end Autonomous Driving
ProCeedRL: Process Critic with Exploratory Demonstration Reinforcement Learning for LLM Agentic Reasoning
Bias Is a Subspace, Not a Coordinate: A Geometric Rethinking of Post-hoc Debiasing in Vision-Language Models
Accuracy of Radiomics-Based Machine Learning for Predicting Risk of Recurrence in NonβSmall Cell Lung Cancer: Systematic Review and Meta-Analysis
Trace2Skill: Distill Trajectory-Local Lessons into Transferable Agent Skills
InfiniteVL: Synergizing Linear and Sparse Attention for Highly-Efficient, Unlimited-Input Vision-Language Models
From Static Templates to Dynamic Runtime Graphs: A Survey of Workflow Optimization for LLM Agents
Symbolic Graph Networks for Robust PDE Discovery from Noisy Sparse Data
Not All Tokens Are Created Equal: Query-Efficient Jailbreak Fuzzing for LLMs
Behavioral Consistency Validation for LLM Agents: An Analysis of Trading-Style Switching through Stock-Market Simulation
Boosting foundation models for rare eye disease diagnosis via a multimodal text-to-image generative framework
npj Digital Medicine, Published online: 24 March 2026; doi:10.1038/s41746-026-02560-2
Boosting foundation models for rare eye disease diagnosis via a multimodal text-to-image generative frameworkUnannotated noncoding transcripts as a source of intratumor heterogeneity in malignant cell states
Sci China Life Sci. 2026 Mar 16. doi: 10.1007/s11427-025-3273-6. Online ahead of print.
ABSTRACT
Phenotypic diversity of malignant cells within a tumor underlies intratumor heterogeneity (ITH), a key determinant of cancer metastasis and treatment failure. However, the molecular mechanisms driving this heterogeneity are poorly understood. Here, we curated and analyzed a cohort of 3' tag-based single-cell RNA-seq covering 12 common cancer types. We identified thousands of poly(A) site (PAS) peaks representing the 3' ends of previously unannotated transcripts, whose expression is widely associated with diverse malignant cellular states. By integrating multi-omics data, we characterized the expression patterns and epigenetic landscape of these unannotated PAS peak-associated transcripts (UPTs). The expression heterogeneity of UPTs was supported by multi-region sampling bulk RNA-seq data and recapitulated within cancer cell lines. As proof of principle validation, functional experiments confirmed that two noncoding UPTs promoted the proliferation and migration of lung cancer cells. Our results suggest that epigenetic activation of unannotated noncoding transcripts might represent a previously unrecognized mechanism contributing to transcriptomic ITH.
PMID:41870780 | DOI:10.1007/s11427-025-3273-6
Unannotated noncoding transcripts as a source of intratumor heterogeneity in malignant cell states
Sci China Life Sci. 2026 Mar 16. doi: 10.1007/s11427-025-3273-6. Online ahead of print.
ABSTRACT
Phenotypic diversity of malignant cells within a tumor underlies intratumor heterogeneity (ITH), a key determinant of cancer metastasis and treatment failure. However, the molecular mechanisms driving this heterogeneity are poorly understood. Here, we curated and analyzed a cohort of 3' tag-based single-cell RNA-seq covering 12 common cancer types. We identified thousands of poly(A) site (PAS) peaks representing the 3' ends of previously unannotated transcripts, whose expression is widely associated with diverse malignant cellular states. By integrating multi-omics data, we characterized the expression patterns and epigenetic landscape of these unannotated PAS peak-associated transcripts (UPTs). The expression heterogeneity of UPTs was supported by multi-region sampling bulk RNA-seq data and recapitulated within cancer cell lines. As proof of principle validation, functional experiments confirmed that two noncoding UPTs promoted the proliferation and migration of lung cancer cells. Our results suggest that epigenetic activation of unannotated noncoding transcripts might represent a previously unrecognized mechanism contributing to transcriptomic ITH.
PMID:41870780 | DOI:10.1007/s11427-025-3273-6