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Social Media Intervention Based on the Information-Motivation-Behavioral Skills Model Promotes HIV Testing and Reduces High-Risk Behaviors Among Men Who Have Sex With Men in Resource-Limited Settings in China: Randomized Controlled Trial

Background: Social media intervention may enhance HIV prevention among men who have sex with men, but the effect of this intervention in resource-limited settings remains unclear. Objective: This randomized controlled trial evaluated whether a social media intervention grounded in the information-motivation-behavioral skills (IMB) model could be beneficial for HIV prevention among men who have sex with men in resource-limited settings. Methods: Participants were recruited in Nanning, China, between April 2023 and April 2024. Eligible participants were randomly assigned to either the social media intervention group or the routine HIV prevention services control group. Participants in the intervention group received a 3-month social media intervention, which included completing video-based tasks. Baseline surveys were conducted, followed by follow-up surveys every 3 months, for a total of 2 follow-ups. Outcomes included HIV testing uptake, high-risk behavior, AIDS-related knowledge, safe sex self-efficacy, and attitude. Results: A total of 180 eligible men who have sex with men were enrolled (90 per group). Follow-up rates were 97.8% (88/90) and 95.5% (86/90) for the intervention and control groups, respectively. At the follow-ups, the intervention group demonstrated significantly higher uptake of HIV testing, a lower proportion of participants reporting high-risk sexual behaviors, and higher condom use self-efficacy compared to the control group (all
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VitaTouch: Property-Aware Vision-Tactile-Language Model for Robotic Quality Inspection in Manufacturing

arXiv:2604.03322v1 Announce Type: cross Abstract: Quality inspection in smart manufacturing requires identifying intrinsic material and surface properties beyond visible geometry, yet vision-only methods remain vulnerable to occlusion and reflection. We propose VitaTouch, a property-aware vision-tactile-language model for material-property inference and natural-language attribute description. VitaTouch uses modality-specific encoders and a dual Q-Former to extract language-relevant visual and tactile features, which are compressed into prefix tokens for a large language model. We align each modality with text and explicitly couple vision and touch through contrastive learning. We also construct VitaSet, a multimodal dataset with 186 objects, 52k images, and 5.1k human-verified instruction-answer pairs. VitaTouch achieves the best performance on HCT and the overall TVL benchmark, while remaining competitive on SSVTP. On VitaSet, it reaches 88.89% hardness accuracy, 75.13% roughness accuracy, and 54.81% descriptor recall; the material-description task further achieves a peak semantic similarity of 0.9009. With LoRA-based fine-tuning, VitaTouch attains 100.0%, 96.0%, and 92.0% accuracy for 2-, 3-, and 5-category defect recognition, respectively, and delivers 94.0% closed-loop recognition accuracy and 94.0% end-to-end sorting success in 100 laboratory robotic trials. More details are available at the project page: https://vitatouch.github.io/
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CoopGuard: Stateful Cooperative Agents Safeguarding LLMs Against Evolving Multi-Round Attacks

arXiv:2604.04060v1 Announce Type: cross Abstract: As Large Language Models (LLMs) are increasingly deployed in complex applications, their vulnerability to adversarial attacks raises urgent safety concerns, especially those evolving over multi-round interactions. Existing defenses are largely reactive and struggle to adapt as adversaries refine strategies across rounds. In this work, we propose CoopGuard , a stateful multi-round LLM defense framework based on cooperative agents that maintains and updates an internal defense state to counter evolving attacks. It employs three specialized agents (Deferring Agent, Tempting Agent, and Forensic Agent) for complementary round-level strategies, coordinated by System Agent, which conditions decisions on the evolving defense state (interaction history) and orchestrates agents over time. To evaluate evolving threats, we introduce the EMRA benchmark with 5,200 adversarial samples across 8 attack types, simulating progressively LLM multi-round attacks. Experiments show that CoopGuard reduces attack success rate by 78.9% over state-of-the-art defenses, while improving deceptive rate by 186% and reducing attack efficiency by 167.9%, offering a more comprehensive assessment of multi-round defense. These results demonstrate that CoopGuard provides robust protection for LLMs in multi-round adversarial scenarios.
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Reflection of Episodes: Learning to Play Game from Expert and Self Experiences

arXiv:2502.13388v3 Announce Type: replace Abstract: StarCraft II is a complex and dynamic real-time strategy (RTS) game environment, which is very suitable for artificial intelligence and reinforcement learning research. To address the problem of Large Language Model(LLM) learning in complex environments through self-reflection, we propose a Reflection of Episodes(ROE) framework based on expert experience and self-experience. This framework first obtains key information in the game through a keyframe selection method, then makes decisions based on expert experience and self-experience. After a game is completed, it reflects on the previous experience to obtain new self-experience. Finally, in the experiment, our method beat the robot under the Very Hard difficulty in TextStarCraft II. We analyze the data of the LLM in the process of the game in detail, verified its effectiveness.
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ReFlow: Self-correction Motion Learning for Dynamic Scene Reconstruction

arXiv:2604.01561v1 Announce Type: cross Abstract: We present ReFlow, a unified framework for monocular dynamic scene reconstruction that learns 3D motion in a novel self-correction manner from raw video. Existing methods often suffer from incomplete scene initialization for dynamic regions, leading to unstable reconstruction and motion estimation, which often resorts to external dense motion guidance such as pre-computed optical flow to further stabilize and constrain the reconstruction of dynamic components. However, this introduces additional complexity and potential error propagation. To address these issues, ReFlow integrates a Complete Canonical Space Construction module for enhanced initialization of both static and dynamic regions, and a Separation-Based Dynamic Scene Modeling module that decouples static and dynamic components for targeted motion supervision. The core of ReFlow is a novel self-correction flow matching mechanism, consisting of Full Flow Matching to align 3D scene flow with time-varying 2D observations, and Camera Flow Matching to enforce multi-view consistency for static objects. Together, these modules enable robust and accurate dynamic scene reconstruction. Extensive experiments across diverse scenarios demonstrate that ReFlow achieves superior reconstruction quality and robustness, establishing a novel self-correction paradigm for monocular 4D reconstruction.
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Reflection of Episodes: Learning to Play Game from Expert and Self Experiences

arXiv:2502.13388v2 Announce Type: replace Abstract: StarCraft II is a complex and dynamic real-time strategy (RTS) game environment, which is very suitable for artificial intelligence and reinforcement learning research. To address the problem of Large Language Model(LLM) learning in complex environments through self-reflection, we propose a Reflection of Episodes(ROE) framework based on expert experience and self-experience. This framework first obtains key information in the game through a keyframe selection method, then makes decisions based on expert experience and self-experience. After a game is completed, it reflects on the previous experience to obtain new self-experience. Finally, in the experiment, our method beat the robot under the Very Hard difficulty in TextStarCraft II. We analyze the data of the LLM in the process of the game in detail, verified its effectiveness.
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Generation Is Compression: Zero-Shot Video Coding via Stochastic Rectified Flow

arXiv:2603.26571v2 Announce Type: replace-cross Abstract: Recent advances in generative modeling have enabled perceptual video compression at ultra-low bitrates, yet existing methods predominantly treat the generative model as a refinement or reconstruction module attached to a separately designed codec backbone. We propose \emph{Generative Video Codebook Codec} (GVCC), a zero-shot framework that turns a pretrained video generative model into the codec itself: the transmitted bitstream directly specifies the generative decoding trajectory, with no retraining required. To enable this, we convert the deterministic rectified-flow ODE of modern video foundation models into an equivalent SDE at inference time, unlocking per-step stochastic injection points for codebook-driven compression. Building on this unified backbone, we instantiate three complementary conditioning strategies -- \emph{Image-to-Video} (I2V) with autoregressive GOP chaining, tail latent residual correction, and adaptive atom allocation, \emph{Text-to-Video} (T2V) operating at near-zero side information as a pure generative prior, and \emph{First-Last-Frame-to-Video} (FLF2V) with boundary-sharing GOP chaining for dual-anchor temporal control. Together, these variants span a principled trade-off space between spatial fidelity, temporal coherence, and compression efficiency. Experiments on standard benchmarks show that GVCC achieves high-quality reconstruction below 0.002\,bpp while supporting flexible bitrate control through a single hyperparameter.
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Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain

The development of genetically encoded fluorescent reporters, along with their corresponding knock-in mouse lines for labeling α-Syn inclusions, enables diverse applications in studying the propagation and pathological effects of α-Syn inclusions in the live brain.
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PSPA-Bench: A Personalized Benchmark for Smartphone GUI Agent

arXiv:2603.29318v1 Announce Type: new Abstract: Smartphone GUI agents execute tasks by operating directly on app interfaces, offering a path to broad capability without deep system integration. However, real-world smartphone use is highly personalized: users adopt diverse workflows and preferences, challenging agents to deliver customized assistance rather than generic solutions. Existing GUI agent benchmarks cannot adequately capture this personalization dimension due to sparse user-specific data and the lack of fine-grained evaluation metrics. To address this gap, we present PSPA-Bench, the benchmark dedicated to evaluating personalization in smartphone GUI agents. PSPA-Bench comprises over 12,855 personalized instructions aligned with real-world user behaviors across 10 representative daily-use scenarios and 22 mobile apps, and introduces a structure-aware process evaluation method that measures agents' personalized capabilities at a fine-grained level. Through PSPA-Bench, we benchmark 11 state-of-the-art GUI agents. Results reveal that current methods perform poorly under personalized settings, with even the strongest agent achieving limited success. Our analysis further highlights three directions for advancing personalized GUI agents: (1) reasoning-oriented models consistently outperform general LLMs, (2) perception remains a simple yet critical capability, and (3) reflection and long-term memory mechanisms are key to improving adaptation. Together, these findings establish PSPA-Bench as a foundation for systematic study and future progress in personalized GUI agents.
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FlowPIE: Test-Time Scientific Idea Evolution with Flow-Guided Literature Exploration

arXiv:2603.29557v1 Announce Type: new Abstract: Scientific idea generation (SIG) is critical to AI-driven autonomous research, yet existing approaches are often constrained by a static retrieval-then-generation paradigm, leading to homogeneous and insufficiently divergent ideas. In this work, we propose FlowPIE, a tightly coupled retrieval-generation framework that treats literature exploration and idea generation as a co-evolving process. FlowPIE expands literature trajectories via a flow-guided Monte Carlo Tree Search (MCTS) inspired by GFlowNets, using the quality of current ideas assessed by an LLM-based generative reward model (GRM) as a supervised signal to guide adaptive retrieval and construct a diverse, high-quality initial population. Based on this population, FlowPIE models idea generation as a test-time idea evolution process, applying selection, crossover, and mutation with the isolation island paradigm and GRM-based fitness computation to incorporate cross-domain knowledge. It effectively mitigates the information cocoons arising from over-reliance on parametric knowledge and static literature. Extensive evaluations demonstrate that FlowPIE consistently produces ideas with higher novelty, feasibility and diversity compared to strong LLM-based and agent-based frameworks, while enabling reward scaling during test time.
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iPoster: Content-Aware Layout Generation for Interactive Poster Design via Graph-Enhanced Diffusion Models

arXiv:2603.29469v1 Announce Type: cross Abstract: We present iPoster, an interactive layout generation framework that empowers users to guide content-aware poster layout design by specifying flexible constraints. iPoster enables users to specify partial intentions within the intention module, such as element categories, sizes, positions, or coarse initial drafts. Then, the generation module instantly generates refined, context-sensitive layouts that faithfully respect these constraints. iPoster employs a unified graph-enhanced diffusion architecture that supports various design tasks under user-specified constraints. These constraints are enforced through masking strategies that precisely preserve user input at every denoising step. A cross content-aware attention module aligns generated elements with salient regions of the canvas, ensuring visual coherence. Extensive experiments show that iPoster not only achieves state-of-the-art layout quality, but offers a responsive and controllable framework for poster layout design with constraints.
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Accelerating Diffusion Large Language Models with SlowFast Sampling: The Three Golden Principles

arXiv:2506.10848v3 Announce Type: replace-cross Abstract: Diffusion-based language models (dLLMs) have emerged as a promising alternative to traditional autoregressive LLMs by enabling parallel token generation and significantly reducing inference latency. However, existing sampling strategies for dLLMs, such as confidence-based or semi-autoregressive decoding, often suffer from static behavior, leading to suboptimal efficiency and limited flexibility. In this paper, we propose SlowFast Sampling, a novel dynamic sampling strategy that adaptively alternates between exploratory and accelerated decoding stages. Our method is guided by three golden principles: certainty principle, convergence principle, and positional principle, which govern when and where tokens can be confidently and efficiently decoded. We further integrate our strategy with dLLM-Cache to reduce redundant computation. Extensive experiments across benchmarks and models show that SlowFast Sampling achieves up to 15.63$\times$ speedup on LLaDA with minimal accuracy drop, and up to 34.22$\times$ when combined with caching. Notably, our approach outperforms strong autoregressive baselines like LLaMA3 8B in throughput, demonstrating that well-designed sampling can unlock the full potential of dLLMs for fast and high-quality generation.
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Gene regulatory landscape dissected by single-cell four-omics sequencing

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10322-z

Combining single-cell parallel profiling of genome conformation, histone modifications, chromatin accessibility and gene expression reveals dynamics and intranuclear spatial clustering of epigenome profiles, enabling sophisticated analysis of the regulatory landscape across cell types and tissues.
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Cellular Senescence in Gastric Cancer: Molecular Mechanisms, Microenvironment Remodeling and Therapeutic Implications

Aging Dis. 2026 Mar 19. doi: 10.14336/AD.2025.1571. Online ahead of print.

ABSTRACT

Gastric cancer (GC) remains a leading cause of cancer-related morbidity and mortality worldwide, with poor prognosis for advanced-stage patients. Therefore, in-depth exploration of the mechanisms underlying GC initiation and progression, as well as the development of novel therapeutic strategies, is of crucial importance. Cellular senescence is a stable cell cycle arrest program that plays a dual role in GC. It exerts tumor-suppressive effects via growth arrest but also promotes tumor progression and immune evasion by remodeling the tumor microenvironment (TME) through senescence-associated secretory phenotype (SASP). This review comprehensively elucidates the molecular mechanisms of cellular senescence in GC and the core regulatory networks involving gene regulation, epigenetic modifications, metabolic reprogramming, and cell cycle arrest. Additionally, the review highlights how senescent cells foster an immunosuppressive microenvironment via SASP, forming a self-reinforcing feed-forward loop. Regarding therapeutic strategies, we summarize potential approaches targeting cellular senescence, including senescence induction, senescent cell clearance, SASP modulation, and multi-target synergistic therapy by integrating epigenetic regulation, metabolic intervention, and immune microenvironment modulation. Despite progress, numerous challenges remain. Future studies should leverage multi-omics technologies, novel models' development, and large-scale clinical trials to advance the clinical translation of GC cellular senescence research, providing new insights for improving prognosis.

PMID:41910653 | DOI:10.14336/AD.2025.1571

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WIST: Web-Grounded Iterative Self-Play Tree for Domain-Targeted Reasoning Improvement

arXiv:2603.22352v1 Announce Type: cross Abstract: Recent progress in reinforcement learning with verifiable rewards (RLVR) offers a practical path to self-improvement of language models, but existing methods face a key trade-off: endogenous self-play can drift over iterations, while corpus-grounded approaches rely on curated data environments. We present \textbf{WIST}, a \textbf{W}eb-grounded \textbf{I}terative \textbf{S}elf-play \textbf{T}ree framework for domain-targeted reasoning improvement that learns directly from the open web without requiring any pre-arranged domain corpus. WIST incrementally expands a domain tree for exploration, and retrieves and cleans path-consistent web corpus to construct a controllable training environment. It then performs Challenger--Solver self-play with verifiable rewards, and feeds learnability signals back to update node posteriors and guide subsequent exploration through an adaptive curriculum. Across four backbones, WIST consistently improves over the base models and typically outperforms both purely endogenous self-evolution and corpus-grounded self-play baselines, with the Overall gains reaching \textbf{+9.8} (\textit{Qwen3-4B-Base}) and \textbf{+9.7} (\textit{OctoThinker-8B}). WIST is also domain-steerable, improving \textit{Qwen3-8B-Base} by \textbf{+14.79} in medicine and \textit{Qwen3-4B-Base} by \textbf{+5.28} on PhyBench. Ablations further confirm the importance of WIST's key components for stable open-web learning. Our Code is available at https://github.com/lfy-123/WIST.
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Cheers: Decoupling Patch Details from Semantic Representations Enables Unified Multimodal Comprehension and Generation

arXiv:2603.12793v1 Announce Type: cross Abstract: A recent cutting-edge topic in multimodal modeling is to unify visual comprehension and generation within a single model. However, the two tasks demand mismatched decoding regimes and visual representations, making it non-trivial to jointly optimize within a shared feature space. In this work, we present Cheers, a unified multimodal model that decouples patch-level details from semantic representations, thereby stabilizing semantics for multimodal understanding and improving fidelity for image generation via gated detail residuals. Cheers includes three key components: (i) a unified vision tokenizer that encodes and compresses image latent states into semantic tokens for efficient LLM conditioning, (ii) an LLM-based Transformer that unifies autoregressive decoding for text generation and diffusion decoding for image generation, and (iii) a cascaded flow matching head that decodes visual semantics first and then injects semantically gated detail residuals from the vision tokenizer to refine high-frequency content. Experiments on popular benchmarks demonstrate that Cheers matches or surpasses advanced UMMs in both visual understanding and generation. Cheers also achieves 4x token compression, enabling more efficient high-resolution image encoding and generation. Notably, Cheers outperforms the Tar-1.5B on the popular benchmarks GenEval and MMBench, while requiring only 20% of the training cost, indicating effective and efficient (i.e., 4x token compression) unified multimodal modeling. We will release all code and data for future research.
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LatentChem: From Textual CoT to Latent Thinking in Chemical Reasoning

arXiv:2602.07075v4 Announce Type: replace-cross Abstract: Chemical large language models (LLMs) predominantly rely on explicit Chain-of-Thought (CoT) in natural language to perform complex reasoning. However, chemical reasoning is inherently continuous and structural, and forcing it into discrete linguistic tokens introduces a fundamental representation mismatch that constrains both efficiency and performance. We introduce LatentChem, a latent reasoning interface that decouples chemical computation from textual generation, enabling models to perform multi-step reasoning directly in continuous latent space while emitting language only for final outputs. Remarkably, we observe a consistent emergent behavior: when optimized solely for task success, models spontaneously internalize reasoning, progressively abandoning verbose textual derivations in favor of implicit latent computation. This shift is not merely stylistic but computationally advantageous. Across diverse chemical reasoning benchmarks, LatentChem achieves a 59.88\% non-tie win rate over strong CoT-based baselines on ChemCoTBench, while delivering a 10.84$\times$ average reduction in reasoning overhead. Our results provide empirical evidence that chemical reasoning is more naturally and effectively realized as continuous latent dynamics rather than discretized linguistic trajectories.
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Evo: Autoregressive-Diffusion Large Language Models with Evolving Balance

arXiv:2603.06617v1 Announce Type: cross Abstract: We introduce \textbf{Evo}, a duality latent trajectory model that bridges autoregressive (AR) and diffusion-based language generation within a continuous evolutionary generative framework. Rather than treating AR decoding and diffusion generation as separate paradigms, Evo reconceptualizes text generation as a latent flow: each token is associated with a vector-valued embedding that evolves over a progression variable $t_i \in [0, 1]$, indicating its semantic maturity. Low $t_i$ values correspond to confident AR-like refinement, while high values invoke diffusion-style planning, allowing the model to adaptively balance AR and diffusion based on uncertainty. Theoretically, we show that both AR and diffusion models emerge as discretizations of a shared probability flow, and we derive Evo's training objective from a unified variational ELBO. The model is implemented as a time-conditioned Transformer governed by a shared vector field, trained end-to-end to jointly infer latent codes and their progression times. During decoding, Evo performs efficient, semantics-aware refinement, achieving high-quality outputs without sacrificing speed. Empirically, Evo 8B achieves state-of-the-art or highly competitive results on 15 diverse benchmarks, including reasoning (GSM8K, ARC-C), code generation (HumanEval, MBPP), and general language understanding, while maintaining fast inference speed. Our results demonstrate that Evo delivers a new paradigm for LLM design with strong generation quality, robust symbolic reasoning, and decoding efficiency.
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SketchGraphNet: A Memory-Efficient Hybrid Graph Transformer for Large-Scale Sketch Corpora Recognition

arXiv:2603.07521v1 Announce Type: cross Abstract: This work investigates large-scale sketch recognition from a graph-native perspective, where free-hand sketches are directly modeled as structured graphs rather than raster images or stroke sequences. We propose SketchGraphNet, a hybrid graph neural architecture that integrates local message passing with a memory-efficient global attention mechanism, without relying on auxiliary positional or structural encodings. To support systematic evaluation, we construct SketchGraph, a large-scale benchmark comprising 3.44 million graph-structured sketches across 344 categories, with two variants (A and R) to reflect different noise conditions. Each sketch is represented as a spatiotemporal graph with normalized stroke-order attributes. On SketchGraph-A and SketchGraph-R, SketchGraphNet achieves Top-1 accuracies of 83.62% and 87.61%, respectively, under a unified training configuration. MemEffAttn further reduces peak GPU memory by over 40% and training time by more than 30% compared with Performer-based global attention, while maintaining comparable accuracy.
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