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AeroTherm-GPT: A Verification-Centered LLM Framework for Thermal Protection System Engineering Workflows

arXiv:2604.01738v1 Announce Type: new Abstract: Integrating Large Language Models (LLMs) into hypersonic thermal protection system (TPS) design is bottlenecked by cascading constraint violations when generating executable simulation artifacts. General-purpose LLMs, treating generation as single-pass text completion, fail to satisfy the sequential, multi-gate constraints inherent in safety-critical engineering workflows. To address this, we propose AeroTherm-GPT, the first TPS-specialized LLM Agent, instantiated through a Constraint-Closed-Loop Generation (CCLG) framework. CCLG organizes TPS artifact generation as an iterative workflow comprising generation, validation, CDG-guided repair, execution, and audit. The Constraint Dependency Graph (CDG) encodes empirical co-resolution structure among constraint categories, directing repair toward upstream fault candidates based on lifecycle ordering priors and empirical co-resolution probabilities. This upstream-priority mechanism resolves multiple downstream violations per action, achieving a Root-Cause Fix Efficiency of 4.16 versus 1.76 for flat-checklist repair. Evaluated on HyTPS-Bench and validated against external benchmarks, AeroTherm-GPT achieves 88.7% End-to-End Success Rate (95% CI: 87.5-89.9), a gain of +12.5 pp over the matched non-CDG ablation baseline, without catastrophic forgetting on scientific reasoning and code generation tasks.
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No Attacker Needed: Unintentional Cross-User Contamination in Shared-State LLM Agents

arXiv:2604.01350v1 Announce Type: cross Abstract: LLM-based agents increasingly operate across repeated sessions, maintaining task states to ensure continuity. In many deployments, a single agent serves multiple users within a team or organization, reusing a shared knowledge layer across user identities. This shared persistence expands the failure surface: information that is locally valid for one user can silently degrade another user's outcome when the agent reapplies it without regard for scope. We refer to this failure mode as unintentional cross-user contamination (UCC). Unlike adversarial memory poisoning, UCC requires no attacker; it arises from benign interactions whose scope-bound artifacts persist and are later misapplied. We formalize UCC through a controlled evaluation protocol, introduce a taxonomy of three contamination types, and evaluate the problem in two shared-state mechanisms. Under raw shared state, benign interactions alone produce contamination rates of 57--71%. A write-time sanitization is effective when shared state is conversational, but leaves substantial residual risk when shared state includes executable artifacts, with contamination often manifesting as silent wrong answers. These results indicate that shared-state agents need artifact-level defenses beyond text-level sanitization to prevent silent cross-user failures.
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PRISM: Robust VLM Alignment with Principled Reasoning for Integrated Safety in Multimodality

arXiv:2508.18649v2 Announce Type: replace-cross Abstract: Safeguarding vision-language models (VLMs) is a critical challenge, as existing methods often suffer from over-defense, which harms utility, or rely on shallow alignment, failing to detect complex threats that require deep reasoning. To this end, we introduc PRISM (Principled Reasoning for Integrated Safety in Multimodality), a System 2-like framework that aligns VLMs through a structured four-stage reasoning process explicitly designed to handle three distinct categories of multimodal safety violations. Our framework consists of two key components: a structured reasoning pipeline that analyzes each violation category in dedicated stages, and PRISM-DPO, generated via Monte Carlo Tree Search (MCTS) to refine reasoning quality through Direct Preference Optimization. Comprehensive evaluations show that PRISM substantially reduces attack success rates on JailbreakV-28K and VLBreak, improves robustness against adaptive attacks, and generalizes to out-of-distribution multi-image threats, while better preserving model utility on benign multimodal benchmarks. Our code, data, and model weights available at https://github.com/SaFoLab-WISC/PRISM.
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When Only the Final Text Survives: Implicit Execution Tracing for Multi-Agent Attribution

arXiv:2603.17445v3 Announce Type: replace Abstract: When a multi-agent system produces an incorrect or harmful answer, who is accountable if execution logs and agent identifiers are unavailable? In practice, generated content is often detached from its execution environment due to privacy or system boundaries, leaving the final text as the only auditable artifact. Existing attribution methods rely on full execution traces and thus become ineffective in such metadata-deprived settings. We propose Implicit Execution Tracing (IET), a provenance-by-design framework that shifts attribution from post-hoc inference to built-in instrumentation. Instead of reconstructing hidden trajectories, IET embeds agent-specific, key-conditioned statistical signals directly into the token generation process, transforming the output text into a self-verifying execution record. At inference time, we recover a linearized execution trace from the final text via transition-aware statistical scoring. Experiments across diverse multi-agent coordination settings demonstrate that IET achieves accurate segment-level attribution and reliable transition recovery under identity removal, boundary corruption, and privacy-preserving redaction, while maintaining generation quality. These results show that embedding provenance into generation provides a practical and robust foundation for accountability in multi-agent language systems when execution metadata is unavailable.
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Curcumol Induces G1 Phase Arrest in SK-Hep-1 Cells by Targeting SKP2-Mediated p27 Degradation

Molecules. 2026 Mar 16;31(6):997. doi: 10.3390/molecules31060997.

ABSTRACT

CONTEXT: S-phase kinase-associated protein 2 (SKP2) is an oncogene and cell cycle regulator that mediates the ubiquitination of cell cycle regulators. Curcumol, a sesquiterpene natural product, has been reported to regulate SKP2-mediated ubiquitination degradation to overcome drug resistance in cancer cells. However, whether the cell cycle arrest effect of curcumol is related to SKP2's function in cancer cells and its mechanisms are still unclear.

OBJECTIVE: To investigate the role of SKP2 in curcumol-induced cell cycle arrest and its underlying mechanisms.

MATERIALS AND METHODS: Transcriptomic and proteomic analyses were used to screen the ubiquitination-related factors in curcumol treated hepatocellular carcinoma cells. Lentiviral overexpression, co-immunoprecipitation assays, ubiquitination analysis, and cell-line-derived xenograft (CDX) models were used to dissect the role and mechanisms of the identified ubiquitination-related factor in the cell cycle arrest effect of curcucmol.

RESULTS: Curcumol modulated the expression of CDK4, CDK6, Cyclin D1, p27 and SKP2. SKP2 was one candidate target of curcumol selected by multi-omics. Overexpressed SKP2 partially reversed curcumol-induced growth inhibition and G1-phase arrest. The increased expression of p27 induced by curcumol was attenuated by overexpressed SKP2. Curcumol impaired the interaction between SKP2 and p27, and led to the ubiquitination and degradation of p27. In vivo, curcumol effectively reduced tumor growth, and its antitumor effect was significantly mitigated by SKP2 overexpression.

DISCUSSION AND CONCLUSIONS: Curcumol reduced SKP2 expression, weakened the interaction between SKP2 and p27, inhibited degradation of p27, and then induced G1 phase cell-cycle arrest in SK-Hep-1 cells.

PMID:41900096 | PMC:PMC13029316 | DOI:10.3390/molecules31060997

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Agent Audit: A Security Analysis System for LLM Agent Applications

arXiv:2603.22853v1 Announce Type: cross Abstract: What should a developer inspect before deploying an LLM agent: the model, the tool code, the deployment configuration, or all three? In practice, many security failures in agent systems arise not from model weights alone, but from the surrounding software stack: tool functions that pass untrusted inputs to dangerous operations, exposed credentials in deployment artifacts, and over-privileged Model Context Protocol (MCP) configurations. We present Agent Audit, a security analysis system for LLM agent applications. Agent Audit analyzes Python agent code and deployment artifacts through an agent-aware pipeline that combines dataflow analysis, credential detection, structured configuration parsing, and privilege-risk checks. The system reports findings in terminal, JSON, and SARIF formats, enabling direct integration with local development workflows and CI/CD pipelines. On a benchmark of 22 samples with 42 annotated vulnerabilities, Agent Audit detects 40 vulnerabilities with 6 false positives, substantially improving recall over common SAST baselines while maintaining sub-second scan times. Agent Audit is open source and installable via pip, making security auditing accessible for agent systems. In the live demonstration, attendees scan vulnerable agent repositories and observe how Agent Audit identifies security risks in tool functions, prompts, and more. Findings are linked to source locations and configuration paths, and can be exported into VS Code and GitHub Code Scanning for interactive inspection.
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GameVerse: Can Vision-Language Models Learn from Video-based Reflection?

arXiv:2603.06656v1 Announce Type: cross Abstract: Human gameplay is a visually grounded interaction loop in which players act, reflect on failures, and watch tutorials to refine strategies. Can Vision-Language Models (VLMs) also learn from video-based reflection? We present GameVerse, a comprehensive video game benchmark that enables a reflective visual interaction loop. Moving beyond traditional fire-and-forget evaluations, it uses a novel reflect-and-retry paradigm to assess how VLMs internalize visual experience and improve policies. To facilitate systematic and scalable evaluation, we also introduce a cognitive hierarchical taxonomy spanning 15 globally popular games, dual action space for both semantic and GUI control, and milestone evaluation using advanced VLMs to quantify progress. Our experiments show that VLMs benefit from video-based reflection in varied settings, and perform best by combining failure trajectories and expert tutorials-a training-free analogue to reinforcement learning (RL) plus supervised fine-tuning (SFT).
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Performance of Conventional EEG Biomarkers Across Different Clinical Phases of Major Depressive Disorder: A Comprehensive Evaluation

arXiv:2603.03864v1 Announce Type: new Abstract: While EEG features differentiate Major Depressive Disorder (MDD) from healthy controls (HC), their clinical utility as biomarkers depends on a monotonic trajectory across the disease spectrum, from the acute (AC) phase to the maintenance (MA) phase and finally to the healthy baseline. However, the progression of the MA phase remains poorly understood in traditional marker analysis. Analyzing EEG data from 74 individuals (24 AC, 23 MA, and 27 HC), this study provides a comprehensive evaluation of classic ERP and resting-state indices across AC, MA, and HC groups. Our results demonstrate that almost no conventional metrics strictly satisfy the criterion of monotonic progression, likely due to profound inter-individual heterogeneity. These findings highlight the inherent limitations of group-level feature extraction and provide critical insights for developing future paradigms and algorithms to identify neurobiological markers with genuine clinical utility.
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Doxing via the Lens: Revealing Location-related Privacy Leakage on Multi-modal Large Reasoning Models

arXiv:2504.19373v5 Announce Type: replace-cross Abstract: Recent advances in multi-modal large reasoning models (MLRMs) have shown significant ability to interpret complex visual content. While these models enable impressive reasoning capabilities, they also introduce novel and underexplored privacy risks. In this paper, we identify a novel category of privacy leakage in MLRMs: Adversaries can infer sensitive geolocation information, such as a user's home address or neighborhood, from user-generated images, including selfies captured in private settings. To formalize and evaluate these risks, we propose a three-level visual privacy risk framework that categorizes image content based on contextual sensitivity and potential for location inference. We further introduce DoxBench, a curated dataset of 500 real-world images reflecting diverse privacy scenarios. Our evaluation across 11 advanced MLRMs and MLLMs demonstrates that these models consistently outperform non-expert humans in geolocation inference and can effectively leak location-related private information. This significantly lowers the barrier for adversaries to obtain users' sensitive geolocation information. We further analyze and identify two primary factors contributing to this vulnerability: (1) MLRMs exhibit strong reasoning capabilities by leveraging visual clues in combination with their internal world knowledge; and (2) MLRMs frequently rely on privacy-related visual clues for inference without any built-in mechanisms to suppress or avoid such usage. To better understand and demonstrate real-world attack feasibility, we propose GeoMiner, a collaborative attack framework that decomposes the prediction process into two stages: clue extraction and reasoning to improve geolocation performance while introducing a novel attack perspective. Our findings highlight the urgent need to reassess inference-time privacy risks in MLRMs to better protect users' sensitive information.
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MapReduce LoRA: Advancing the Pareto Front in Multi-Preference Optimization for Generative Models

arXiv:2511.20629v4 Announce Type: replace-cross Abstract: Reinforcement learning from human feedback (RLHF) with reward models has advanced alignment of generative models to human aesthetic and perceptual preferences. However, jointly optimizing multiple rewards often incurs an alignment tax, improving one dimension while degrading others. To address this, we introduce two complementary methods: MapReduce LoRA and Reward-aware Token Embedding (RaTE). MapReduce LoRA trains preference-specific LoRA experts in parallel and iteratively merges them to refine a shared base model; RaTE learns reward-specific token embeddings that compose at inference for flexible preference control. Experiments on Text-to-Image generation (Stable Diffusion 3.5 Medium and FLUX.1-dev) show improvements of 36.1%, 4.6%, and 55.7%, and 32.7%, 4.3%, and 67.1% on GenEval, PickScore, and OCR, respectively. On Text-to-Video generation (HunyuanVideo), visual and motion quality improve by 48.1% and 90.0%, respectively. On the language task, Helpful Assistant, with Llama-2 7B, helpful and harmless improve by 43.4% and 136.7%, respectively. Our framework sets a new state-of-the-art multi-preference alignment recipe across modalities.
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