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Can LLMs Learn to Reason Robustly under Noisy Supervision?

arXiv:2604.03993v1 Announce Type: cross Abstract: Reinforcement Learning with Verifiable Rewards (RLVR) effectively trains reasoning models that rely on abundant perfect labels, but its vulnerability to unavoidable noisy labels due to expert scarcity remains critically underexplored. In this work, we take the first step toward a systematic analysis of noisy label mechanisms in RLVR. In contrast to supervised classification, most RLVR algorithms incorporate a rollout-based condition: a label's influence on training is contingent on whether the current policy can generate rollouts that realize it, a property that naturally extends to noisy labels. Based on this observation, we distinguish two types of noise: inactive noisy labels, which reduce data efficiency, and active noisy labels, which are reinforced and risk skewing the model toward incorrect distributions. From experiments on training with noisy samples, we identify an Early Correctness Coherence phenomenon: although noisy samples begin to lag behind in later stages, accuracy on both clean and noisy samples increases similarly in early training. Motivated by this dynamic, we propose Online Label Refinement (OLR), which progressively corrects potentially noisy labels with majority-voted answers when two conditions hold: a positive slope in the majority answer's rollout pass rate and stable historical consistency across updates, enabling gradual self-correction as the policy improves. We evaluate OLR on six in-distribution mathematical reasoning benchmarks (AIME24/25, AMC, MATH-500, Minerva, and Olympiad) and three out-of-distribution tasks (ARC-c, GPQA-diamond, and MMLU-pro). Across noise ratios from 0.1 to 0.9, OLR consistently improves robustness under both inactive and active noisy-label settings, achieving average gains of 3.6% to 3.9% on in-distribution benchmarks and 3.3% to 4.6% on out-of-distribution evaluations.
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VLBiasBench: A Comprehensive Benchmark for Evaluating Bias in Large Vision-Language Model

arXiv:2406.14194v3 Announce Type: replace-cross Abstract: The emergence of Large Vision-Language Models (LVLMs) marks significant strides towards achieving general artificial intelligence. However, these advancements are accompanied by concerns about biased outputs, a challenge that has yet to be thoroughly explored. Existing benchmarks are not sufficiently comprehensive in evaluating biases due to their limited data scale, single questioning format and narrow sources of bias. To address this problem, we introduce VLBiasBench, a comprehensive benchmark designed to evaluate biases in LVLMs. VLBiasBench, features a dataset that covers nine distinct categories of social biases, including age, disability status, gender, nationality, physical appearance, race, religion, profession, social economic status, as well as two intersectional bias categories: race x gender and race x social economic status. To build a large-scale dataset, we use Stable Diffusion XL model to generate 46,848 high-quality images, which are combined with various questions to creat 128,342 samples. These questions are divided into open-ended and close-ended types, ensuring thorough consideration of bias sources and a comprehensive evaluation of LVLM biases from multiple perspectives. We conduct extensive evaluations on 15 open-source models as well as two advanced closed-source models, yielding new insights into the biases present in these models. Our benchmark is available at https://github.com/Xiangkui-Cao/VLBiasBench.
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TRACE-Bot: Detecting Emerging LLM-Driven Social Bots via Implicit Semantic Representations and AIGC-Enhanced Behavioral Patterns

arXiv:2604.02147v1 Announce Type: new Abstract: Large Language Model-driven (LLM-driven) social bots pose a growing threat to online discourse by generating human-like content that evades conventional detection. Existing methods suffer from limited detection accuracy due to overreliance on single-modality signals, insufficient sensitivity to the specific generative patterns of Artificial Intelligence-Generated Content (AIGC), and a failure to adequately model the interplay between linguistic patterns and behavioral dynamics. To address these limitations, we propose TRACE-Bot, a unified dual-channel framework that jointly models implicit semantic representations and AIGC-enhanced behavioral patterns. TRACE-Bot constructs fine-grained representations from heterogeneous sources, including personal information data, interaction behavior data and tweet data. A dual-channel architecture captures linguistic representations via a pretrained language model and behavioral irregularities via multidimensional activity features augmented with signals from state-of-the-art (SOTA) AIGC detectors. The fused representations are then classified through a lightweight prediction head. Experiments on two public LLM-driven social bot datasets demonstrate SOTA performance, achieving accuracies of 98.46% and 97.50%, respectively. The results further indicate strong robustness against advanced bot strategies, highlighting the effectiveness of jointly leveraging implicit semantic representations and AIGC-enhanced behavioral patterns for emerging LLM-driven social bot detection.
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SHOE: Semantic HOI Open-Vocabulary Evaluation Metric

arXiv:2604.01586v1 Announce Type: cross Abstract: Open-vocabulary human-object interaction (HOI) detection is a step towards building scalable systems that generalize to unseen interactions in real-world scenarios and support grounded multimodal systems that reason about human-object relationships. However, standard evaluation metrics, such as mean Average Precision (mAP), treat HOI classes as discrete categorical labels and fail to credit semantically valid but lexically different predictions (e.g., "lean on couch" vs. "sit on couch"), limiting their applicability for evaluating open-vocabulary predictions that go beyond any predefined set of HOI labels. We introduce SHOE (Semantic HOI Open-Vocabulary Evaluation), a new evaluation framework that incorporates semantic similarity between predicted and ground-truth HOI labels. SHOE decomposes each HOI prediction into its verb and object components, estimates their semantic similarity using the average of multiple large language models (LLMs), and combines them into a similarity score to evaluate alignment beyond exact string match. This enables a flexible and scalable evaluation of both existing HOI detection methods and open-ended generative models using standard benchmarks such as HICO-DET. Experimental results show that SHOE scores align more closely with human judgments than existing metrics, including LLM-based and embedding-based baselines, achieving an agreement of 85.73% with the average human ratings. Our work underscores the need for semantically grounded HOI evaluation that better mirrors human understanding of interactions. We will release our evaluation metric to the public to facilitate future research.
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Think, Act, Build: An Agentic Framework with Vision Language Models for Zero-Shot 3D Visual Grounding

arXiv:2604.00528v2 Announce Type: replace-cross Abstract: 3D Visual Grounding (3D-VG) aims to localize objects in 3D scenes via natural language descriptions. While recent advancements leveraging Vision-Language Models (VLMs) have explored zero-shot possibilities, they typically suffer from a static workflow relying on preprocessed 3D point clouds, essentially degrading grounding into proposal matching. To bypass this reliance, our core motivation is to decouple the task: leveraging 2D VLMs to resolve complex spatial semantics, while relying on deterministic multi-view geometry to instantiate the 3D structure. Driven by this insight, we propose "Think, Act, Build (TAB)", a dynamic agentic framework that reformulates 3D-VG tasks as a generative 2D-to-3D reconstruction paradigm operating directly on raw RGB-D streams. Specifically, guided by a specialized 3D-VG skill, our VLM agent dynamically invokes visual tools to track and reconstruct the target across 2D frames. Crucially, to overcome the multi-view coverage deficit caused by strict VLM semantic tracking, we introduce the Semantic-Anchored Geometric Expansion, a mechanism that first anchors the target in a reference video clip and then leverages multi-view geometry to propagate its spatial location across unobserved frames. This enables the agent to "Build" the target's 3D representation by aggregating these multi-view features via camera parameters, directly mapping 2D visual cues to 3D coordinates. Furthermore, to ensure rigorous assessment, we identify flaws such as reference ambiguity and category errors in existing benchmarks and manually refine the incorrect queries. Extensive experiments on ScanRefer and Nr3D demonstrate that our framework, relying entirely on open-source models, significantly outperforms previous zero-shot methods and even surpasses fully supervised baselines.
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Do Phone-Use Agents Respect Your Privacy?

arXiv:2604.00986v2 Announce Type: replace-cross Abstract: We study whether phone-use agents respect privacy while completing benign mobile tasks. This question has remained hard to answer because privacy-compliant behavior is not operationalized for phone-use agents, and ordinary apps do not reveal exactly what data agents type into which form entries during execution. To make this question measurable, we introduce MyPhoneBench, a verifiable evaluation framework for privacy behavior in mobile agents. We operationalize privacy-respecting phone use as permissioned access, minimal disclosure, and user-controlled memory through a minimal privacy contract, iMy, and pair it with instrumented mock apps plus rule-based auditing that make unnecessary permission requests, deceptive re-disclosure, and unnecessary form filling observable and reproducible. Across five frontier models on 10 mobile apps and 300 tasks, we find that task success, privacy-compliant task completion, and later-session use of saved preferences are distinct capabilities, and no single model dominates all three. Evaluating success and privacy jointly reshuffles the model ordering relative to either metric alone. The most persistent failure mode across models is simple data minimization: agents still fill optional personal entries that the task does not require. These results show that privacy failures arise from over-helpful execution of benign tasks, and that success-only evaluation overestimates the deployment readiness of current phone-use agents. All code, mock apps, and agent trajectories are publicly available at~ https://github.com/FreedomIntelligence/MyPhoneBench.
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FlowPIE: Test-Time Scientific Idea Evolution with Flow-Guided Literature Exploration

arXiv:2603.29557v1 Announce Type: new Abstract: Scientific idea generation (SIG) is critical to AI-driven autonomous research, yet existing approaches are often constrained by a static retrieval-then-generation paradigm, leading to homogeneous and insufficiently divergent ideas. In this work, we propose FlowPIE, a tightly coupled retrieval-generation framework that treats literature exploration and idea generation as a co-evolving process. FlowPIE expands literature trajectories via a flow-guided Monte Carlo Tree Search (MCTS) inspired by GFlowNets, using the quality of current ideas assessed by an LLM-based generative reward model (GRM) as a supervised signal to guide adaptive retrieval and construct a diverse, high-quality initial population. Based on this population, FlowPIE models idea generation as a test-time idea evolution process, applying selection, crossover, and mutation with the isolation island paradigm and GRM-based fitness computation to incorporate cross-domain knowledge. It effectively mitigates the information cocoons arising from over-reliance on parametric knowledge and static literature. Extensive evaluations demonstrate that FlowPIE consistently produces ideas with higher novelty, feasibility and diversity compared to strong LLM-based and agent-based frameworks, while enabling reward scaling during test time.
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Owl-AuraID 1.0: An Intelligent System for Autonomous Scientific Instrumentation and Scientific Data Analysis

arXiv:2603.29828v1 Announce Type: new Abstract: Scientific discovery increasingly depends on high-throughput characterization, yet automation is hindered by proprietary GUIs and the limited generalizability of existing API-based systems. We present Owl-AuraID, a software-hardware collaborative embodied agent system that adopts a GUI-native paradigm to operate instruments through the same interfaces as human experts. Its skill-centric framework integrates Type-1 (GUI operation) and Type-2 (data analysis) skills into end-to-end workflows, connecting physical sample handling with scientific interpretation. Owl-AuraID demonstrates broad coverage across ten categories of precision instruments and diverse workflows, including multimodal spectral analysis, microscopic imaging, and crystallographic analysis, supporting modalities such as FTIR, NMR, AFM, and TGA. Overall, Owl-AuraID provides a practical, extensible foundation for autonomous laboratories and illustrates a path toward evolving laboratory intelligence through reusable operational and analytical skills. The code are available at https://github.com/OpenOwlab/AuraID.
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WAter: A Workload-Adaptive Knob Tuning System based on Workload Compression

arXiv:2603.28809v1 Announce Type: cross Abstract: Selecting appropriate values for the configurable parameters of Database Management Systems (DBMS) to improve performance is a significant challenge. Recent machine learning (ML)-based tuning systems have shown strong potential, but their practical adoption is often limited by the high tuning cost. This cost arises from two main factors: (1) the system needs to evaluate a large number of configurations to identify a satisfactory one, and (2) for each configuration, the system must execute the entire target workload on the DBMS, which is both time-consuming. Existing studies have primarily addressed the first factor by improving sample efficiency, that is, by reducing the number of configurations evaluated. However, the second factor, improving runtime efficiency by reducing the time required for each evaluation, has received limited attention and remains an underexplored direction. We develop WAter, a runtime-efficient and workload-adaptive tuning system that finds near-optimal configurations at a fraction of the tuning cost compared with state-of-the-art methods. We divide the tuning process into multiple time slices and evaluate only a small subset of queries from the workload in each slice. Different subsets are evaluated across slices, and a runtime profile is used to dynamically identify more representative subsets for evaluation in subsequent slices. At the end of each time slice, the most promising configurations are evaluated on the original workload to measure their actual performance. Evaluations demonstrate that WAter identifies the best-performing configurations with up to 73.5% less tuning time and achieves up to 16.2% higher performance than the best-performing alternative.
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InCoder-32B: Code Foundation Model for Industrial Scenarios

arXiv:2603.16790v3 Announce Type: replace-cross Abstract: Recent code large language models have achieved remarkable progress on general programming tasks. Nevertheless, their performance degrades significantly in industrial scenarios that require reasoning about hardware semantics, specialized language constructs, and strict resource constraints. To address these challenges, we introduce InCoder-32B (Industrial-Coder-32B), the first 32B-parameter code foundation model unifying code intelligence across chip design, GPU kernel optimization, embedded systems, compiler optimization, and 3D modeling. By adopting an efficient architecture, we train InCoder-32B from scratch with general code pre-training, curated industrial code annealing, mid-training that progressively extends context from 8K to 128K tokens with synthetic industrial reasoning data, and post-training with execution-grounded verification. We conduct extensive evaluation on 14 mainstream general code benchmarks and 9 industrial benchmarks spanning 4 specialized domains. Results show InCoder-32B achieves highly competitive performance on general tasks while establishing strong open-source baselines across industrial domains.
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Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10264-6

Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.
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Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis

Nat Commun. 2026 Mar 20;17(1):2655. doi: 10.1038/s41467-026-70193-w.

ABSTRACT

Pulmonary fibrosis represents a progressive interstitial lung disease marked by excessive extracellular matrix deposition and architectural distortion. Vascular endothelial cells critically contribute to fibrogenesis through paracrine secretion of pro-fibrotic mediators, yet their mechanobiological regulation remains elusive. Using integrated single-cell multi-omics profiling of human pulmonary fibrosis specimens and experimental fibrosis models induced by bleomycin or silica, we identify mechanosensitive Piezo1 upregulation in Endothelial cells as a hallmark of fibrotic progression. Endothelial-specific Piezo1 knockout significantly attenuates Bleomycin-induced fibrotic remodeling in male mice, establishing its pathogenic necessity. Mechanistically, PIEZO1 activation promotes pulmonary fibrosis development via CAPN2-mediated STAT3 phosphorylation, which may regulate the secretion of the pro-fibrotic molecule interleukin-33. These findings suggest that the endothelial PIEZO1-CAPN2-STAT3-IL33 axis is a potential therapeutic target for PF intervention.

PMID:41862476 | PMC:PMC13004862 | DOI:10.1038/s41467-026-70193-w

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Generalist biological artificial intelligence in modeling the language of life

Nature Biotechnology, Published online: 20 March 2026; doi:10.1038/s41587-026-03064-w

This Review discusses the promises and pitfalls of biological AI algorithms and presents a vision for generalist biological artificial intelligence, in which models can perform diverse tasks across biological domains.
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LUMI-lab: A foundation model-driven autonomous platform enabling discovery of ionizable lipid designs for mRNA delivery

LUMI lab is a foundation model-driven self-driving platform that autonomously discovers ionizable lipids for mRNA delivery. Iterative active learning uncovered brominated tails as a potent structural motif that enables efficient and safe pulmonary mRNA delivery.
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Elucidating genetic backgrounds of myasthenia gravis in Japanese by genome-wide association studies and multi-omics analyses of thymoma

Nat Commun. 2026 Mar 12. doi: 10.1038/s41467-026-70376-5. Online ahead of print.

ABSTRACT

Myasthenia gravis (MG) is an autoimmune disorder characterized by impaired neuromuscular transmission and motor symptoms. Its genetic background remains unclear, particularly beyond specific subtypes reported in European populations. Here, we perform a genome-wide association study (GWAS) of 1,434 MG cases covering all disease subtypes and 42,913 controls of Japanese, which newly identify the TERT locus (odds ratio [OR] = 1.31, P = 1.7×10-10). Subtype-stratified GWASs show stronger signals for generalized MG (gMG; OR = 1.38, P = 1.6×10-12), anti AChR antibody-positive gMG (g-AChR-Ab(+)MG; OR= 1.49, P = 2.1×10-15), and thymoma-associated gMG (g-TAMG; OR = 1.92, P = 1.1×10-15). Fine-mapping of the major histocompatibility complex region reveal distinct associations of HLA-DRB1 with late onset gMG (g-LOMG) and HLA-A with early onset gMG (g-EOMG). The MG risk TERT lead variant rs2736099 is associated with poor treatment response, especially in g-AChR-Ab(+)MG and g-EOMG (P < 0.0042). The biobank-based phenome-wide association study identify pleiotropic effects on lung cancer, hematological traits, and telomere length. Single cell transcriptomics and immunohistochemistry identified immature lymphocyte-specific TERT expression in thymoma specimens. Full-length transcriptomics reveal allele-specific decreasing effect of rs2736099-A on TERT expression. Our study unveils genetics of MG distinctly across disease subtypes, and involvement of TERT in its pathogenesis.

PMID:41820352 | DOI:10.1038/s41467-026-70376-5

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MAPK14/SLC7A11/GPX4 axis dysregulation drives podocyte ferroptosis via mediating glycerophospholipid metabolism

Cell Death Discovery, Published online: 11 March 2026; doi:10.1038/s41420-026-02990-7

MAPK14/SLC7A11/GPX4 axis dysregulation drives podocyte ferroptosis via mediating glycerophospholipid metabolism
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A Robust Incomplete Multimodal Low-Rank Adaptation Approach for Emotion Recognition

arXiv:2507.11202v1 Announce Type: cross Abstract: Multimodal Emotion Recognition (MER) often encounters incomplete multimodality in practical applications due to sensor failures or privacy protection requirements. While existing methods attempt to address various incomplete multimodal scenarios by balancing the training of each modality combination through additional gradients, these approaches face a critical limitation: training gradients from different modality combinations conflict with each other, ultimately degrading the performance of the final prediction model. In this paper, we propose a unimodal decoupled dynamic low-rank adaptation method based on modality combinations, named MCULoRA, which is a novel framework for the parameter-efficient training of incomplete multimodal learning models. MCULoRA consists of two key modules, modality combination aware low-rank adaptation (MCLA) and dynamic parameter fine-tuning (DPFT). The MCLA module effectively decouples the shared information from the distinct characteristics of individual modality combinations. The DPFT module adjusts the training ratio of modality combinations based on the separability of each modality's representation space, optimizing the learning efficiency across different modality combinations. Our extensive experimental evaluation in multiple benchmark datasets demonstrates that MCULoRA substantially outperforms previous incomplete multimodal learning approaches in downstream task accuracy.
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Stabilizing Reinforcement Learning for Diffusion Language Models

arXiv:2603.06743v1 Announce Type: cross Abstract: Group Relative Policy Optimization (GRPO) is highly effective for post-training autoregressive (AR) language models, yet its direct application to diffusion large language models (dLLMs) often triggers reward collapse. We identify two sources of incompatibility. First, GRPO relies on importance ratios defined by sequence probabilities, which are intractable in dLLMs and must be estimated (e.g., via ELBO-based or mean-field likelihood proxies), yielding inherently noisy ratios. Second, standard GRPO's formulation is not designed for estimated ratios: its conditional clipping can be anomalously bypassed by model-agnostic estimation noise, producing gradient spikes, while its fixed group-size normalization amplifies gradient-magnitude fluctuations under high-variance ratio estimates. We show these effects form a self-reinforcing instability loop that drives policy drift and further increases ratio variance. To break this loop, we propose StableDRL, a reformulation of GRPO tailored for dLLMs that uses (i) unconditional clipping to suppress outlier-induced spikes and (ii) self-normalization to constrain updates within the convex hull of per-sample gradients. We further extend StableDRL to block-wise diffusion models via a staircase attention mechanism.
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Not All Candidates are Created Equal: A Heterogeneity-Aware Approach to Pre-ranking in Recommender Systems

arXiv:2603.03770v1 Announce Type: cross Abstract: Most large-scale recommender systems follow a multi-stage cascade of retrieval, pre-ranking, ranking, and re-ranking. A key challenge at the pre-ranking stage arises from the heterogeneity of training instances sampled from coarse-grained retrieval results, fine-grained ranking signals, and exposure feedback. Our analysis reveals that prevailing pre-ranking methods, which indiscriminately mix heterogeneous samples, suffer from gradient conflicts: hard samples dominate training while easy ones remain underutilized, leading to suboptimal performance. We further show that the common practice of uniformly scaling model complexity across all samples is inefficient, as it overspends computation on easy cases and slows training without proportional gains. To address these limitations, this paper presents Heterogeneity-Aware Adaptive Pre-ranking (HAP), a unified framework that mitigates gradient conflicts through conflict-sensitive sampling coupled with tailored loss design, while adaptively allocating computational budgets across candidates. Specifically, HAP disentangles easy and hard samples, directing each subset along dedicated optimization paths. Building on this separation, it first applies lightweight models to all candidates for efficient coverage, and further engages stronger models on the hard ones, maintaining accuracy while reducing cost. This approach not only improves pre-ranking effectiveness but also provides a practical perspective on scaling strategies in industrial recommender systems. HAP has been deployed in the Toutiao production system for 9 months, yielding up to 0.4% improvement in user app usage duration and 0.05% in active days, without additional computational cost. We also release a large-scale industrial hybrid-sample dataset to enable the systematic study of source-driven candidate heterogeneity in pre-ranking.
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Relational In-Context Learning via Synthetic Pre-training with Structural Prior

arXiv:2603.03805v1 Announce Type: cross Abstract: Relational Databases (RDBs) are the backbone of modern business, yet they lack foundation models comparable to those in text or vision. A key obstacle is that high-quality RDBs are private, scarce and structurally heterogeneous, making internet-scale pre-training infeasible. To overcome this data scarcity, We introduce $\textbf{RDB-PFN}$, the first relational foundation model trained purely via $\textbf{synthetic data}$. Inspired by Prior-Data Fitted Networks (PFNs) where synthetic data generated from Structural Causal Models (SCMs) enables reasoning on single tables, we design a $\textbf{Relational Prior Generator}$ to create an infinite stream of diverse RDBs from scratch. Pre-training on $\textbf{over 2 million}$ synthetic single-table and relational tasks, RDB-PFN learns to adapt to any new database instantly via genuine $\textbf{in-context learning}$. Experiments verify RDB-PFN achieves strong few-shot performance on 19 real-world relational prediction tasks, outperforming graph-based and single-table foundation-model baselines (given the same DFS-linearized inputs), while using a lightweight architecture and fast inference. The code is available at https://github.com/MuLabPKU/RDBPFN
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