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MAVEN: A Mesh-Aware Volumetric Encoding Network for Simulating 3D Flexible Deformation

arXiv:2604.04474v1 Announce Type: cross Abstract: Deep learning-based approaches, particularly graph neural networks (GNNs), have gained prominence in simulating flexible deformations and contacts of solids, due to their ability to handle unstructured physical fields and nonlinear regression on graph structures. However, existing GNNs commonly represent meshes with graphs built solely from vertices and edges. These approaches tend to overlook higher-dimensional spatial features, e.g., 2D facets and 3D cells, from the original geometry. As a result, it is challenging to accurately capture boundary representations and volumetric characteristics, though this information is critically important for modeling contact interactions and internal physical quantity propagation, particularly under sparse mesh discretization. In this paper, we introduce MAVEN, a mesh-aware volumetric encoding network for simulating 3D flexible deformation, which explicitly models geometric mesh elements of higher dimension to achieve a more accurate and natural physical simulation. MAVEN establishes learnable mappings among 3D cells, 2D facets, and vertices, enabling flexible mutual transformations. Explicit geometric features are incorporated into the model to alleviate the burden of implicitly learning geometric patterns. Experimental results show that MAVEN consistently achieves state-of-the-art performance across established datasets and a novel metal stretch-bending task featuring large deformations and prolonged contacts.
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Cardinality Estimation for High Dimensional Similarity Queries with Adaptive Bucket Probing

arXiv:2604.04603v1 Announce Type: cross Abstract: In this work, we address the problem of cardinality estimation for similarity search in high-dimensional spaces. Our goal is to design a framework that is lightweight, easy to construct, and capable of providing accurate estimates with satisfying online efficiency. We leverage locality-sensitive hashing (LSH) to partition the vector space while preserving distance proximity. Building on this, we adopt the principles of classical multi-probe LSH to adaptively explore neighboring buckets, accounting for distance thresholds of varying magnitudes. To improve online efficiency, we employ progressive sampling to reduce the number of distance computations and utilize asymmetric distance computation in product quantization to accelerate distance calculations in high-dimensional spaces. In addition to handling static datasets, our framework includes updating algorithm designed to efficiently support large-scale dynamic scenarios of data updates.Experiments demonstrate that our methods can accurately estimate the cardinality of similarity queries, yielding satisfying efficiency.
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FAST-CAD: A Fairness-Aware Framework for Non-Contact Stroke Diagnosis

arXiv:2511.08887v4 Announce Type: replace-cross Abstract: Stroke is an acute cerebrovascular disease, and timely diagnosis significantly improves patient survival. However, existing automated diagnosis methods suffer from fairness issues across demographic groups, potentially exacerbating healthcare disparities. In this work we propose FAST-CAD, a theoretically grounded framework that combines domain-adversarial training (DAT) with group distributionally robust optimization (Group-DRO) for fair and accurate non-contact stroke diagnosis. Our approach is built on domain adaptation and minimax fairness theory and provides convergence guarantees and fairness bounds. We curate a multimodal dataset covering 12 demographic subgroups defined by age, gender, and posture. FAST-CAD employs self-supervised encoders with adversarial domain discrimination to learn demographic-invariant representations, while Group-DRO optimizes worst-group risk to ensure robust performance across all subgroups. Extensive experiments show that our method achieves superior diagnostic performance while maintaining fairness across demographic groups, and our theoretical analysis supports the effectiveness of the unified DAT + Group-DRO framework. This work provides both practical advances and theoretical insights for fair medical AI systems.
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Not All Tokens See Equally: Perception-Grounded Policy Optimization for Large Vision-Language Models

arXiv:2604.01840v1 Announce Type: new Abstract: While Reinforcement Learning from Verifiable Rewards (RLVR) has advanced reasoning in Large Vision-Language Models (LVLMs), prevailing frameworks suffer from a foundational methodological flaw: by distributing identical advantages across all generated tokens, these methods inherently dilute the learning signals essential for optimizing the critical, visually-grounded steps of multimodal reasoning. To bridge this gap, we formulate \textit{Token Visual Dependency}, quantifying the causal information gain of visual inputs via the Kullback-Leibler (KL) divergence between visual-conditioned and text-only predictive distributions. Revealing that this dependency is highly sparse and semantically pivotal, we introduce Perception-Grounded Policy Optimization (PGPO), which is a novel fine-grained credit assignment framework that dynamically reshapes advantages at the token level. Through a threshold-gated, mass-conserving mechanism, PGPO actively amplifies learning signals for visually-dependent tokens while suppressing gradient noise from linguistic priors. Extensive experiments based on the Qwen2.5-VL series across seven challenging multimodal reasoning benchmarks demonstrate that PGPO boosts models by 18.7% on average. Both theoretical and empirical analyses confirm that PGPO effectively reduces gradient variance, prevents training collapse, and acts as a potent regularizer for robust, perception-grounded multimodal reasoning. Code will be published on https://github.com/Yzk1114/PGPO.
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Robust transcriptomic hallmarks targeting intratumor heterogeneity in intrahepatic cholangiocarcinoma

Cell Rep Med. 2026 Mar 30:102708. doi: 10.1016/j.xcrm.2026.102708. Online ahead of print.

ABSTRACT

Intratumor heterogeneity (ITH) undermines transcriptome-based stratification in intrahepatic cholangiocarcinoma (iCCA). Here, we integrate multi-omics data from multi-region, single-region, and single-cell RNA sequencing cohorts to systematically characterize gene expression ITH. We uncover that immune and stromal heterogeneity are primary drivers of ITH, leading to misclassification of a median 27.8% of tumors by existing subtyping systems. To overcome this, we identify a low-intratumor-heterogeneity/high-intertumor-variability (LIHV) gene set and develop an ITH-insensitive classification system defining five subgroups: inflammatory (SI), metabolic (SII), atypical (SIII-1), immune-silent (SIII-2), and neurodegenerative (SIII-3). These subgroups exhibit distinct clinical outcomes, molecular features, immune landscapes, and therapeutic vulnerabilities. GPRC5A and VTCN1 serve as robust immunohistochemical biomarkers for SI and SIII tumors, while serum CEA and CA19-9 identify inflammatory iCCA. Therapeutically, HSP90 inhibition synergizes with anti-PD1 in inflammatory iCCA, whereas combined anti-PD1 and anti-TIM3 suppresses neurodegenerative iCCA. Collectively, our study provides a robust molecular framework and actionable therapeutic strategies for iCCA.

PMID:41916296 | DOI:10.1016/j.xcrm.2026.102708

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1S-DAug: One-Shot Data Augmentation for Robust Few-Shot Generalization

arXiv:2602.00114v3 Announce Type: replace-cross Abstract: Few-shot learning (FSL) challenges model generalization to novel classes based on just a few shots of labeled examples, a testbed where traditional test-time augmentations fail to be effective. We introduce 1S-DAug, a one-shot generative augmentation operator that synthesizes diverse yet faithful variants from just one example image at test time. 1S-DAug couples traditional geometric perturbations with controlled noise injection and a denoising diffusion process conditioned on the original image. The generated images are then encoded and aggregated, alongside the original image, into a combined representation for more robust FSL predictions. Integrated as a training-free model-agnostic plugin, 1S-DAug consistently improves FSL across standard benchmarks of 4 different datasets without any model parameter update, including achieving up to 20% relative accuracy improvement on the miniImagenet 5-way-1-shot benchmark. Code will be released.
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MovieTeller: Tool-augmented Movie Synopsis with ID Consistent Progressive Abstraction

arXiv:2602.23228v2 Announce Type: replace-cross Abstract: With the explosive growth of digital entertainment, automated video summarization has become indispensable for applications such as content indexing, personalized recommendation, and efficient media archiving. Automatic synopsis generation for long-form videos, such as movies and TV series, presents a significant challenge for existing Vision-Language Models (VLMs). While proficient at single-image captioning, these general-purpose models often exhibit critical failures in long-duration contexts, primarily a lack of ID-consistent character identification and a fractured narrative coherence. To overcome these limitations, we propose MovieTeller, a novel framework for generating movie synopses via tool-augmented progressive abstraction. Our core contribution is a training-free, tool-augmented, fact-grounded generation process. Instead of requiring costly model fine-tuning, our framework directly leverages off-the-shelf models in a plug-and-play manner. We first invoke a specialized face recognition model as an external "tool" to establish Factual Groundings--precise character identities and their corresponding bounding boxes. These groundings are then injected into the prompt to steer the VLM's reasoning, ensuring the generated scene descriptions are anchored to verifiable facts. Furthermore, our progressive abstraction pipeline decomposes the summarization of a full-length movie into a multi-stage process, effectively mitigating the context length limitations of current VLMs. Experiments demonstrate that our approach yields significant improvements in factual accuracy, character consistency, and overall narrative coherence compared to end-to-end baselines.
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Think with Grounding: Curriculum Reinforced Reasoning with Video Grounding for Long Video Understanding

arXiv:2602.18702v1 Announce Type: cross Abstract: Long video understanding is challenging due to rich and complicated multimodal clues in long temporal range.Current methods adopt reasoning to improve the model's ability to analyze complex video clues in long videos via text-form reasoning.However,the existing literature suffers from the fact that the text-only reasoning under fixed video context may exacerbate hallucinations since detailed crucial clues are often ignored under limited video context length due to the temporal redundancy of long videos.To address this gap,we propose Video-TwG,a curriculum reinforced framework that employs a novel Think-with-Grounding paradigm,enabling video LLMs to actively decide when to perform on-demand grounding during interleaved text-video reasoning, selectively zooming into question-relevant clips only when necessary.Video-TwG can be trained end-to-end in a straightforward manner, without relying on complex auxiliary modules or heavily annotated reasoning tracesIn detail,we design a Two-stage Reinforced Curriculum Strategy, where the model first learns think-with-grounding behavior on a small short-video GQA dataset with grounding labels,and then scales to diverse general QA data with videos of diverse domains to encourage generalization. Further, to handle complex think-with-grounding reasoning for various kinds of data,we propose TwG-GRPO algorithm which features the fine-grained grounding reward, self-confirmed pseudo reward and accuracy-gated mechanism.Finally,we propose to construct a new TwG-51K dataset that facilitates training. Experiments on Video-MME, LongVideoBench, and MLVU show that Video-TwG consistently outperforms strong LVU baselines.Further ablation validates the necessity of our Two-stage Reinforced Curriculum Strategy and shows our TwG-GRPO better leverages diverse unlabeled data to improve grounding quality and reduce redundant groundings without sacrificing QA performance.
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Step 3.5 Flash: Open Frontier-Level Intelligence with 11B Active Parameters

arXiv:2602.10604v2 Announce Type: replace-cross Abstract: We introduce Step 3.5 Flash, a sparse Mixture-of-Experts (MoE) model that bridges frontier-level agentic intelligence and computational efficiency. We focus on what matters most when building agents: sharp reasoning and fast, reliable execution. Step 3.5 Flash pairs a 196B-parameter foundation with 11B active parameters for efficient inference. It is optimized with interleaved 3:1 sliding-window/full attention and Multi-Token Prediction (MTP-3) to reduce the latency and cost of multi-round agentic interactions. To reach frontier-level intelligence, we design a scalable reinforcement learning framework that combines verifiable signals with preference feedback, while remaining stable under large-scale off-policy training, enabling consistent self-improvement across mathematics, code, and tool use. Step 3.5 Flash demonstrates strong performance across agent, coding, and math tasks, achieving 85.4% on IMO-AnswerBench, 86.4% on LiveCodeBench-v6 (2024.08-2025.05), 88.2% on tau2-Bench, 69.0% on BrowseComp (with context management), and 51.0% on Terminal-Bench 2.0, comparable to frontier models such as GPT-5.2 xHigh and Gemini 3.0 Pro. By redefining the efficiency frontier, Step 3.5 Flash provides a high-density foundation for deploying sophisticated agents in real-world industrial environments.
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