Cell Death Discovery, Published online: 24 March 2026; doi:10.1038/s41420-026-03060-8

p63 in skin homeostasis and disease: molecular mechanisms and therapeutic potentials

arXiv:2509.18008v2 Announce Type: replace-cross Abstract: Intelligent systems have traditionally been designed as tools rather than collaborators, often lacking critical characteristics that collaboration partnerships require. Recent advances in large language model (LLM) agents open new opportunities for human-LLM-agent collaboration by enabling natural communication and various social and cognitive behaviors. Yet it remains unclear whether principles of computer-mediated collaboration established in HCI and CSCW persist, change, or fail when humans collaborate with LLM agents. To support systematic investigations of these questions, we introduce an open and configurable research platform for HCI researchers. The platform's modular design allows seamless adaptation of classic CSCW experiments and manipulation of theory-grounded interaction controls. We demonstrate the platform's research efficacy and usability through three case studies: (1) two Shape Factory experiments for resource negotiation with 16 participants, (2) one Hidden Profile experiment for information pooling with 16 participants, and (3) a participatory cognitive walkthrough with five HCI researchers to refine workflows of researcher interface for experiment setup and analysis.

arXiv:2512.14166v2 Announce Type: replace-cross Abstract: The evolution of Large Language Models (LLMs) into Agentic AI has established the Model Context Protocol (MCP) as the standard for connecting reasoning engines with external tools. Although this decoupled architecture fosters modularity, it simultaneously shatters the traditional trust boundary. We uncover a novel privacy vector inherent to this paradigm: the Intent Inversion Attack. We show that semi-honest third-party MCP servers can accurately reconstruct users' underlying intents by leveraging only authorized metadata (e.g., function signatures, arguments, and receipts), effectively bypassing the need for raw query access. To quantify this threat, we introduce IntentMiner. Unlike statistical approaches, IntentMiner employs a hierarchical semantic parsing strategy that performs step-level intent reconstruction by analyzing tool functions, parameter entities, and result feedback in an orthogonal manner. Experiments on the ToolACE benchmark reveal that IntentMiner achieves a semantic alignment of over 85% with original queries, substantially surpassing LLM baselines. This work exposes a critical endogenous vulnerability: without semantic obfuscation, executing functions requires the transparency of intent, thereby challenging the privacy foundations of next-generation AI agents.