-deficient uveal melanoma

Oncogene - Issue - nature.com science feeds

By: Yonghao Li · Churun Zheng · Yanting Liang · Yue Liu · Fanfan Zhou · Xue Zhu · Jing Fang · Renhua Gai · Yanyan Zhuang · Ke Wang · Tao Yuan · Qiaojun He · Bo Yang · Xin Dong · Hong Zhu

4 April 2026 at 08:00

Oncogene, Published online: 04 April 2026; doi:10.1038/s41388-026-03766-0

S100A6 promotes liver metastasis by activating FGFR3 signaling in BAP1-deficient uveal melanoma

Gut-Brain Axis Dysregulation in Inflammatory Bowel Disease: Implications for Coagulation Abnormalities and Extraintestinal Manifestations

(Multiomics OR Omics) AND (Pancreatic)

By: Peng Lu · Maolin Liu · Lei Zhang · Jing-Jing Fan · Guoda Han · Baozhou Hou · Yu Meng · Liang Wang · Yan Sun

31 March 2026 at 18:00

Int J Gen Med. 2026 Mar 24;19:590621. doi: 10.2147/IJGM.S590621. eCollection 2026.

ABSTRACT

Inflammatory bowel disease (IBD) involves chronic intestinal inflammation driven by gut-brain axis imbalance, fostering complications through an "inflammation-neuro-coagulation" triad. Current staging systems inadequately capture the dynamics of this multidimensional network. Therefore, integrated multi-omics analyses-including metagenomics, metabolomics, and single-cell transcriptomics-are essential to construct dynamic models that monitor coagulation, microbiome, and metabolism for precise assessment of disease activity and thrombotic or bleeding risks. Interventions targeting gut-brain axis nodes, such as eliminating tissue factor-positive (TF⁺) T cells or modulating vagal activity, show potential to disrupt the inflammation-coagulation cycle, although rigorous randomized trials are still needed. Artificial intelligence (AI)-assisted systems that integrate real-time biomarker monitoring with multi-omics predictions represent a novel paradigm for managing IBD-related coagulation dysfunction. Key challenges include elucidating gut-brain-liver axis regulation of coagulation and characterizing platelet functional heterogeneity. Future efforts must prioritize ethically compliant multi-omics platforms and racially stratified risk models to advance personalized coagulation management in IBD.

PMID:41913906 | PMC:PMC13033200 | DOI:10.2147/IJGM.S590621

Ref-DGS: Reflective Dual Gaussian Splatting

cs.AI, q-bio.NC updates on arXiv.org

By: Ningjing Fan · Yiqun Wang · Dongming Yan · Peter Wonka

16 March 2026 at 12:00

arXiv:2603.07664v2 Announce Type: replace-cross Abstract: Reflective appearance, especially strong and typically near-field specular reflections, poses a fundamental challenge for accurate surface reconstruction and novel view synthesis. Existing Gaussian splatting methods either fail to model near-field specular reflections or rely on explicit ray tracing at substantial computational cost. We present Ref-DGS, a reflective dual Gaussian splatting framework that addresses this trade-off by decoupling surface reconstruction from specular reflection within an efficient rasterization-based pipeline. Ref-DGS introduces a dual Gaussian scene representation consisting of geometry Gaussians and complementary local reflection Gaussians that capture near-field specular interactions without explicit ray tracing, along with a global environment reflection field for modeling far-field specular reflections. To predict specular radiance, we further propose a lightweight, physically-aware adaptive mixing shader that fuses global and local reflection features. Experiments demonstrate that Ref-DGS achieves state-of-the-art performance on reflective scenes while training substantially faster than ray-based Gaussian methods.

Ref-DGS: Reflective Dual Gaussian Splatting

cs.AI, q-bio.NC updates on arXiv.org

By: Ningjing Fan · Yiqun Wang · Dongming Yan · Peter Wonka

10 March 2026 at 12:00

arXiv:2603.07664v1 Announce Type: cross Abstract: Reflective appearance, especially strong and typically near-field specular reflections, poses a fundamental challenge for accurate surface reconstruction and novel view synthesis. Existing Gaussian splatting methods either fail to model near-field specular reflections or rely on explicit ray tracing at substantial computational cost. We present Ref-DGS, a reflective dual Gaussian splatting framework that addresses this trade-off by decoupling surface reconstruction from specular reflection within an efficient rasterization-based pipeline. Ref-DGS introduces a dual Gaussian scene representation consisting of geometry Gaussians and complementary local reflection Gaussians that capture near-field specular interactions without explicit ray tracing, along with a global environment reflection field for modeling far-field specular reflections. To predict specular radiance, we further propose a lightweight, physically-aware adaptive mixing shader that fuses global and local reflection features. Experiments demonstrate that Ref-DGS achieves state-of-the-art performance on reflective scenes while training substantially faster than ray-based Gaussian methods.

Reading view