arXiv:2604.04387v2 Announce Type: new Abstract: Developers are publishing AI agent skills that replicate a colleague's communication style, encode a supervisor's mentoring heuristics, or preserve a person's behavioral repertoire beyond biological death. To explain why, we propose Gradual Cognitive Externalization (GCE), a framework arguing that ambient AI systems, through sustained causal coupling with users, transition from modeling cognitive functions to constituting part of users' cognitive architectures. GCE adopts an explicit functionalist commitment: cognitive functions are individuated by their causal-functional roles, not by substrate. The framework rests on the behavioral manifold hypothesis and a central falsifiable assumption, the no behaviorally invisible residual (NBIR) hypothesis: for any cognitive function whose behavioral output lies on a learnable manifold, no behaviorally invisible component is necessary for that function's operation. We document evidence from deployed AI systems showing that externalization preconditions are already observable, formalize three criteria separating cognitive integration from tool use (bidirectional adaptation, functional equivalence, causal coupling), and derive five testable predictions with theory-constrained thresholds.

Background: Antimicrobial resistance (AMR) poses a critical global health threat, with inappropriate antibiotic use being a major driver. Timely microbiological specimen submission before initiating antibiotic therapy is a cornerstone of antimicrobial stewardship (AMS), enabling pathogen-directed therapy and reducing unnecessary broad-spectrum exposure. However, suboptimal compliance remains common due to workflow interruptions, technological barriers, and behavioral factors. Failure Mode and Effects Analysis (FMEA), a proactive risk-assessment method widely used in health care quality improvement, provides a systematic framework to identify process vulnerabilities and prioritize corrective actions. Despite its increasing application, few studies have integrated FMEA with hospital informatization to optimize microbiological specimen submission workflows in routine AMS practice. Objective: This study aimed to systematically identify workflow risks affecting preantibiotic microbiological specimen submission and to design, implement, and evaluate informatization-enabled interventions using an FMEA-based framework. Methods: FMEA was conducted at a tertiary hospital in China. A multidisciplinary team identified potential failure modes across 4 domains: health information systems, personnel, administration, and external support. Risk Priority Numbers (RPNs) and Action Priority (AP) indices were calculated for each failure mode. Targeted interventions were implemented, including dual-verification barcode scanning, artificial intelligence-driven clinical decision support alerts, EHR-integrated training modules, and automated compliance dashboards. Pre- and postintervention specimen submission rates (January 2024-December 2024) were analyzed using the Mann-Kendall trend test. Results: The top 5 failure modes included PDA barcode scanning failures (RPN=175), inadequate clinical decision support (RPN=140), insufficient clinician awareness (RPN=56), suboptimal oversight mechanisms, and patient-related barriers. Postintervention, significant upward trends were observed in overall specimen submission rates (

arXiv:2508.01055v4 Announce Type: replace-cross Abstract: Large language models (LLMs) have gained significant attention in chemistry. However, most existing datasets center on molecular-level property prediction and overlook the role of fine-grained functional group (FG) information. Incorporating FG-level data can provide valuable prior knowledge that links molecular structures with textual descriptions, which can be used to build more interpretable, structure-aware LLMs for reasoning on molecule-related tasks. Moreover, LLMs can learn from such fine-grained information to uncover hidden relationships between specific functional groups and molecular properties, thereby advancing molecular design and drug discovery. Here, we introduce FGBench, a dataset comprising 625K molecular property reasoning problems with functional group information. Functional groups are precisely annotated and localized within the molecule, which ensures the dataset's interoperability thereby facilitating further multimodal applications. FGBench includes both regression and classification tasks on 245 different functional groups across three categories for molecular property reasoning: (1) single functional group impacts, (2) multiple functional group interactions, and (3) direct molecular comparisons. In the benchmark of state-of-the-art LLMs on 7K curated data, the results indicate that current LLMs struggle with FG-level property reasoning, highlighting the need to enhance reasoning capabilities in LLMs for chemistry tasks. We anticipate that the methodology employed in FGBench to construct datasets with functional group-level information will serve as a foundational framework for generating new question-answer pairs, enabling LLMs to better understand fine-grained molecular structure-property relationships. The dataset and evaluation code are available at https://github.com/xuanliugit/FGBench.

arXiv:2508.19300v2 Announce Type: replace-cross Abstract: 4D live fluorescence microscopy is often compromised by prolonged high intensity illumination which induces photobleaching and phototoxic effects that generate photo-induced artifacts and severely impair image continuity and detail recovery. To address this challenge, we propose the CellINR framework, a case-specific optimization approach based on implicit neural representation. The method employs blind convolution and structure amplification strategies to map 3D spatial coordinates into the high frequency domain, enabling precise modeling and high-accuracy reconstruction of cellular structures while effectively distinguishing true signals from artifacts. Experimental results demonstrate that CellINR significantly outperforms existing techniques in artifact removal and restoration of structural continuity, and for the first time, a paired 4D live cell imaging dataset is provided for evaluating reconstruction performance, thereby offering a solid foundation for subsequent quantitative analyses and biological research. The code and dataset will be public.