FedBPrompt: Federated Domain Generalization Person Re-Identification via Body Distribution Aware Visual Prompts

By: Xin Xu · Weilong Li · Wei Liu · Wenke Huang · Zhixi Yu · Bin Yang · Xiaoying Liao · Kui Jiang

16 March 2026 at 12:00

arXiv:2603.12912v1 Announce Type: cross Abstract: Federated Domain Generalization for Person Re-Identification (FedDG-ReID) learns domain-invariant representations from decentralized data. While Vision Transformer (ViT) is widely adopted, its global attention often fails to distinguish pedestrians from high similarity backgrounds or diverse viewpoints -- a challenge amplified by cross-client distribution shifts in FedDG-ReID. To address this, we propose Federated Body Distribution Aware Visual Prompt (FedBPrompt), introducing learnable visual prompts to guide Transformer attention toward pedestrian-centric regions. FedBPrompt employs a Body Distribution Aware Visual Prompts Mechanism (BAPM) comprising: Holistic Full Body Prompts to suppress cross-client background noise, and Body Part Alignment Prompts to capture fine-grained details robust to pose and viewpoint variations. To mitigate high communication costs, we design a Prompt-based Fine-Tuning Strategy (PFTS) that freezes the ViT backbone and updates only lightweight prompts, significantly reducing communication overhead while maintaining adaptability. Extensive experiments demonstrate that BAPM effectively enhances feature discrimination and cross-domain generalization, while PFTS achieves notable performance gains within only a few aggregation rounds. Moreover, both BAPM and PFTS can be easily integrated into existing ViT-based FedDG-ReID frameworks, making FedBPrompt a flexible and effective solution for federated person re-identification. The code is available at https://github.com/leavlong/FedBPrompt.

CircRNA-encoded RIPK1-98 protein drives lung adenocarcinoma progression

(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)

By: Qi Sun · Runqiu Chi · Xiao Zhang · Tianxiang Chen · Xin Xu · Lifang Ma · Xiaoting Tian · Yayou Miao · Yongchun Yu · Rui Kang · Guido Kroemer · Yi Shi · Daolin Tang · Jiayi Wang

13 March 2026 at 18:00

Dev Cell. 2026 Mar 12:S1534-5807(26)00079-1. doi: 10.1016/j.devcel.2026.02.014. Online ahead of print.

ABSTRACT

Unexplored biological matter-including uncharacterized genetic elements, molecular entities, and microbial components-remains poorly understood. Here, we use integrated multi-omics approaches to identify and characterize previously unrecognized protein products encoded by circular RNAs (circRNAs) in human tissue specimens and to delineate their roles in the progression of lung adenocarcinoma (LUAD). The transcription of precursor mRNA by RNA polymerase Ⅱ subunit A (RPB1) is crucial for the biogenesis of these potential circRNA-encoded proteins. Functional and translational analyses link their expression to distinct pathological stages of LUAD in patients. The protein RIPK1-98, encoded by circRIPK1, was identified as functionally distinct from its parental gene product, receptor-interacting serine/threonine kinase 1 (RIPK1). RIPK1-98 modulates cyclin-dependent kinase 2 (CDK2)-dependent cell-cycle regulation, thereby facilitating tumor proliferation in cellular and animal models. Together, these findings suggest that RIPK1-98 serves as a biomarker for cell-cycle progression in LUAD and highlight its potential as a therapeutic target to counteract resistance to first-line treatments, such as osimertinib.

PMID:41825439 | DOI:10.1016/j.devcel.2026.02.014

CircRNA-encoded RIPK1-98 protein drives lung adenocarcinoma progression

Omics In Lung

By: Qi Sun · Runqiu Chi · Xiao Zhang · Tianxiang Chen · Xin Xu · Lifang Ma · Xiaoting Tian · Yayou Miao · Yongchun Yu · Rui Kang · Guido Kroemer · Yi Shi · Daolin Tang · Jiayi Wang

13 March 2026 at 18:00

Dev Cell. 2026 Mar 12:S1534-5807(26)00079-1. doi: 10.1016/j.devcel.2026.02.014. Online ahead of print.

ABSTRACT

Unexplored biological matter-including uncharacterized genetic elements, molecular entities, and microbial components-remains poorly understood. Here, we use integrated multi-omics approaches to identify and characterize previously unrecognized protein products encoded by circular RNAs (circRNAs) in human tissue specimens and to delineate their roles in the progression of lung adenocarcinoma (LUAD). The transcription of precursor mRNA by RNA polymerase Ⅱ subunit A (RPB1) is crucial for the biogenesis of these potential circRNA-encoded proteins. Functional and translational analyses link their expression to distinct pathological stages of LUAD in patients. The protein RIPK1-98, encoded by circRIPK1, was identified as functionally distinct from its parental gene product, receptor-interacting serine/threonine kinase 1 (RIPK1). RIPK1-98 modulates cyclin-dependent kinase 2 (CDK2)-dependent cell-cycle regulation, thereby facilitating tumor proliferation in cellular and animal models. Together, these findings suggest that RIPK1-98 serves as a biomarker for cell-cycle progression in LUAD and highlight its potential as a therapeutic target to counteract resistance to first-line treatments, such as osimertinib.

PMID:41825439 | DOI:10.1016/j.devcel.2026.02.014

A logic-gated trispecific engager enhances macrophage killing of cancer cells in solid tumors

Nature Biotechnology - Issue - nature.com science feeds

By: Xiaotian Zhao · Weiqiang Jing · Ganyu Wang · Zhanyan Liu · Xinxin Xu · Maosen Han · Zhipeng Fu · Yulin Zhang · Zuolin Zheng · Jing Zhang · Longyu Bo · Xianghui Dong · Caiping Li · Yanhua Sun · Junfeng Zhang · Fabao Zhao · Nianzeng Xing · Kun Zhao · Xinyi Jiang

13 March 2026 at 08:00

Nature Biotechnology, Published online: 13 March 2026; doi:10.1038/s41587-026-03057-9

A trispecific macrophage engager amplifies the antitumor response of macrophages in solid tumors.

Risk-adaptive therapy guided by dynamic ctDNA in nasopharyngeal carcinoma

Nature - Issue - nature.com science feeds

By: Jiawei Lv · Dan-Xue Zheng · Jin-Hui Liang · Ning Zhang · Zu-Lu Ye · Xu-Dong Xu · Melvin. L. K. Chua · Lu-Lu Zhang · Zi-Ming Du · Zi-Chen Zhang · Wen-Fei Li · Ling-Long Tang · Lei Chen · Yan-Ping Mao · Rui Guo · Yu-Pei Chen · Li Lin · Yuan Zhang · Xu Liu · Cheng Xu · Zhi-Xuan Li · Ling-Xin Xu · Pan-Yang Yang · Kun Chen · Deng Bin · Tian-Sheng Gao · Jian-Ye Yan · Lu-Si Chen · Shao Hui Huang · Hong-Yun Zhao · Shu-Bin Hong · Yu-Sheng Jie · Hui-Ling Huang · Xu-Hua Tang · Jing-Ping Yun · Li-Zhi Liu · Li Tian · Hao-Jiang Li · Ji-Bin Li · Guan-Qun Zhou · Jun Ma · Ying Sun

11 March 2026 at 08:00

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10244-w

A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.

PulseLM: A Foundation Dataset and Benchmark for PPG-Text Learning

cs.AI, q-bio.NC updates on arXiv.org

By: Hung Manh Pham · Jinyang Wu · Xiao Ma · Yiming Zhang · Yixin Xu · Aaqib Saeed · Bin Zhu · Zhou Pan · Dong Ma

5 March 2026 at 13:00

arXiv:2603.03331v1 Announce Type: cross Abstract: Photoplethysmography (PPG) is a widely used non-invasive sensing modality for continuous cardiovascular and physiological monitoring across clinical, laboratory, and wearable settings. While existing PPG datasets support a broad range of downstream tasks, they typically provide supervision in the form of numerical measurements or task-specific labels, limiting their suitability for language-based physiological reasoning and multimodal foundation models. In this work, we introduce PulseLM, a large-scale PPG-text dataset designed to bridge raw PPG waveforms and natural language through a unified, closed-ended question answering (QA) formulation. PulseLM aggregates PPG recordings from fifteen publicly available sources and harmonizes heterogeneous annotations into twelve common physiologically QA tasks. The dataset comprises 1.31 million standardized 10-second PPG segments, associated with 3.15 million question-answer pairs. We further define reproducible preprocessing, supervision, and evaluation protocols and establish baseline benchmarks using multimodal PPG-aware large language models. PulseLM provides a standardized foundation for studying multimodal physiological reasoning, cross-dataset generalization, and scalable benchmarking of PPG-based language models. The data and code can be found publicly available at: https://github.com/manhph2211/PulseLM.

Perception-R1: Advancing Multimodal Reasoning Capabilities of MLLMs via Visual Perception Reward

cs.AI, q-bio.NC updates on arXiv.org

By: Tong Xiao · Xin Xu · Zhenya Huang · Hongyu Gao · Quan Liu · Qi Liu · Enhong Chen

4 March 2026 at 13:00

arXiv:2506.07218v3 Announce Type: replace-cross Abstract: Enhancing the multimodal reasoning capabilities of Multimodal Large Language Models (MLLMs) is a challenging task that has attracted increasing attention in the community. Recently, several studies have applied Reinforcement Learning with Verifiable Rewards (RLVR) to the multimodal domain in order to enhance the reasoning abilities of MLLMs. However, these works largely overlook the enhancement of multimodal perception capabilities in MLLMs, which serve as a core prerequisite and foundational component of complex multimodal reasoning. Through McNemar's test, we find that existing RLVR method fails to effectively enhance the multimodal perception capabilities of MLLMs, thereby limiting their further improvement in multimodal reasoning. To address this limitation, we propose Perception-R1, which introduces a novel visual perception reward that explicitly encourages MLLMs to perceive the visual content accurately, thereby can effectively incentivizing both their multimodal perception and reasoning capabilities. Specifically, we first collect textual visual annotations from the CoT trajectories of multimodal problems, which will serve as visual references for reward assignment. During RLVR training, we employ a judging LLM to assess the consistency between the visual annotations and the responses generated by MLLM, and assign the visual perception reward based on these consistency judgments. Extensive experiments on several multimodal reasoning benchmarks demonstrate the effectiveness of our Perception-R1, which achieves state-of-the-art performance on most benchmarks using only 1,442 training data. Our code and dataset will be available at https://github.com/tongxiao2002/Perception-R1.

On Predictability of Reinforcement Learning Dynamics for Large Language Models

cs.AI, q-bio.NC updates on arXiv.org

By: Yuchen Cai · Ding Cao · Xin Xu · Zijun Yao · Yuqing Huang · Zhenyu Tan · Benyi Zhang · Guangzhong Sun · Guiquan Liu · Junfeng Fang

24 February 2026 at 13:00

arXiv:2510.00553v3 Announce Type: replace-cross Abstract: Recent advances in reasoning capabilities of large language models (LLMs) are largely driven by reinforcement learning (RL), yet the underlying parameter dynamics during RL training remain poorly understood. This work identifies two fundamental properties of RL-induced parameter updates in LLMs: (1) Rank-1 Dominance, where the top singular subspace of the parameter update matrix nearly fully determines reasoning improvements, recovering over 99\% of performance gains; and (2) Rank-1 Linear Dynamics, where this dominant subspace evolves linearly throughout training, enabling accurate prediction from early checkpoints. Extensive experiments across 8 LLMs and 7 algorithms validate the generalizability of these properties. More importantly, based on these findings, we propose AlphaRL, a plug-in acceleration framework that extrapolates the final parameter update using a short early training window, achieving up to 2.5 speedup while retaining \textgreater 96\% of reasoning performance without extra modules or hyperparameter tuning. This positions our finding as a versatile and practical tool for large-scale RL, opening a path toward principled, interpretable, and efficient training paradigm for LLMs.

BiasFreeBench: a Benchmark for Mitigating Bias in Large Language Model Responses

cs.AI, q-bio.NC updates on arXiv.org

By: Xin Xu · Xunzhi He · Churan Zhi · Ruizhe Chen · Julian McAuley · Zexue He

17 February 2026 at 13:00

arXiv:2510.00232v2 Announce Type: replace-cross Abstract: Existing studies on bias mitigation methods for large language models (LLMs) use diverse baselines and metrics to evaluate debiasing performance, leading to inconsistent comparisons among them. Moreover, their evaluations are mostly based on the comparison between LLMs' probabilities of biased and unbiased contexts, which ignores the gap between such evaluations and real-world use cases where users interact with LLMs by reading model responses and expect fair and safe outputs rather than LLMs' probabilities. To enable consistent evaluation across debiasing methods and bridge this gap, we introduce BiasFreeBench, an empirical benchmark that comprehensively compares eight mainstream bias mitigation techniques (covering four prompting-based and four training-based methods) on two test scenarios (multi-choice QA and open-ended multi-turn QA) by reorganizing existing datasets into a unified query-response setting. We further introduce a response-level metric, Bias-Free Score, to measure the extent to which LLM responses are fair, safe, and anti-stereotypical. Debiasing performances are systematically compared and analyzed across key dimensions: the prompting vs. training paradigm, model size, and generalization of different training strategies to unseen bias types. We release our benchmark, aiming to establish a unified testbed for bias mitigation research.

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