npj Digital Medicine, Published online: 11 April 2026; doi:10.1038/s41746-026-02602-9

Graphicalized vision-language modeling for comprehensive lung nodule analysis and risk stratification

arXiv:2604.01608v1 Announce Type: new Abstract: Multi-agent systems (MAS) tackle complex tasks by distributing expertise, though this often comes at the cost of heavy coordination overhead, context fragmentation, and brittle phase ordering. Distilling a MAS into a single-agent skill can bypass these costs, but this conversion lacks a principled answer for when and what to distill. Instead, the empirical outcome is surprisingly inconsistent: skill lift ranges from a 28% improvement to a 2% degradation across metrics of the exact same task. In this work, we reveal that skill utility is governed not by the task, but by the evaluation metric. We introduce Metric Freedom ($F$), the first a priori predictor of skill utility. $F$ measures the topological rigidity of a metric's scoring landscape by quantifying how output diversity couples with score variance via a Mantel test. Guided by $F$, we propose a two-stage adaptive distillation framework. Stage 1 acts as a selective extraction mechanism, extracting tools and knowledge while discarding restrictive structures on "free" metrics to preserve exploration. Stage 2 targets computationally intensive iterative refinement exclusively toward "rigid" metrics ($F \lesssim 0.6$) to eliminate trajectory-local overfitting. Evaluating across 4 tasks, 11 datasets, and 6 metrics, $F$ strongly predicts skill utility ($\rho = -0.62$, $p

A versatile, atom-level generative AI model enables unified pocket-interacting tasks, from docking to de novo design, and demonstrates robust experimental validation for both small-molecule and peptide therapeutics.

arXiv:2601.04864v2 Announce Type: replace Abstract: Continual learning aims to enable models to acquire new knowledge while retaining previously learned information. Prompt-based methods have shown remarkable performance in this domain; however, they typically rely on key-value pairing, which can introduce inter-task interference and hinder scalability. To overcome these limitations, we propose a novel approach employing task-specific Prompt-Prototype (ProP), thereby eliminating the need for key-value pairs. In our method, task-specific prompts facilitate more effective feature learning for the current task, while corresponding prototypes capture the representative features of the input. During inference, predictions are generated by binding each task-specific prompt with its associated prototype. Additionally, we introduce regularization constraints during prompt initialization to penalize excessively large values, thereby enhancing stability. Experiments on several widely used datasets demonstrate the effectiveness of the proposed method. In contrast to mainstream prompt-based approaches, our framework removes the dependency on key-value pairs, offering a fresh perspective for future continual learning research.

arXiv:2602.00037v2 Announce Type: replace-cross Abstract: In this work, we propose to apply a new model fusion and learning paradigm, known as Combinatorial Fusion Analysis (CFA), to the field of Bitcoin price prediction. Price prediction of financial product has always been a big topic in finance, as the successful prediction of the price can yield significant profit. Every machine learning model has its own strength and weakness, which hinders progress toward robustness. CFA has been used to enhance models by leveraging rank-score characteristic (RSC) function and cognitive diversity in the combination of a moderate set of diverse and relatively well-performed models. Our method utilizes both score and rank combinations as well as other weighted combination techniques. Key metrics such as RMSE and MAPE are used to evaluate our methodology performance. Our proposal presents a notable MAPE performance of 0.19\%. The proposed method greatly improves upon individual model performance, as well as outperforms other Bitcoin price prediction models.