Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10315-y

Development of the pangenome-informed genome assembly (PIGA) workflow enabled the generation of 1,116 diploid genome assemblies (55 de novo and 1,061 pangenome-informed), representing an extensive resource of medically relevant genic variations.

arXiv:2603.06648v1 Announce Type: cross Abstract: Recent advances in multimodal large language models (MLLMs) offer a promising approach for natural language-based scene change queries in virtual reality (VR). Prior work on applying MLLMs for object state understanding has focused on egocentric videos that capture the camera wearer's interactions with objects. However, object state changes may occur in the background without direct user interaction, lacking explicit motion cues and making them difficult to detect. Moreover, no benchmark exists for evaluating this challenging scenario. To address these challenges, we introduce ObjChangeVR-Dataset, specifically for benchmarking the question-answering task of object state change. We also propose ObjChangeVR, a framework that combines viewpoint-aware and temporal-based retrieval to identify relevant frames, along with cross-view reasoning that reconciles inconsistent evidence from multiple viewpoints. Extensive experiments demonstrate that ObjChangeVR significantly outperforms baseline approaches across multiple MLLMs.

arXiv:2509.24222v2 Announce Type: replace-cross Abstract: Current foundation models for electroencephalography (EEG) rely on architectures adapted from computer vision or natural language processing, typically treating neural signals as pixel grids or token sequences. This approach overlooks that the neural activity is activated by diverse sparse coding across a complex geometric topological cortex. Inspired by biological neural mechanisms, we propose the Unified Neural Topological Foundation Model (Uni-NTFM), an architecture rooted in three core neuroscience principles. In detail, to align with the brain's decoupled coding mechanism, we design the Heterogeneous Feature Projection Module. This module simultaneously encodes both time-domain non-stationary transients and frequency-domain steady-state rhythms, ensuring high quality in both waveform morphology and spectral rhythms. Moreover, we introduce a Topological Embedding mechanism to inject structured spatial priors and align different sensor configurations onto a unified latent functional topography, effectively reconstructing the geometry of brain regions. Furthermore, we achieve functional modularization and sparse coding efficiency of biological networks by constructing the Mixture-of-Experts Transformer network. This dynamic routing mechanism assigns different signal patterns and tasks to specialized neural subnetworks, and effectively preventing task interference while increasing the model capacity to record-breaking 1.9 billion parameters. Uni-NTFM is pre-trained on a diverse corpus comprising 28,000 hours of EEG data, and outperforms existing models across nine distinct downstream tasks under both linear probing and fine-tuning settings, demonstrating that aligning model architecture with neural mechanisms is significant to learn universal representations and achieve generalizable brain decoding. Our code is available at: https://anonymous.4open.science/r/Uni-NTFM-0924.