arXiv:2604.01594v1 Announce Type: new Abstract: How do LLMs decide what to teach next: by reasoning about a learner's knowledge, or by using simpler rules of thumb? We test this in a controlled task previously used to study human teaching strategies. On each trial, a teacher LLM sees a hypothetical learner's trajectory through a reward-annotated directed graph and must reveal a single edge so the learner would choose a better path if they replanned. We run a range of LLMs as simulated teachers and fit their trial-by-trial choices with the same cognitive models used for humans: a Bayes-Optimal teacher that infers which transitions the learner is missing (inverse planning), weaker Bayesian variants, heuristic baselines (e.g., reward based), and non-mentalizing utility models. In a baseline experiment matched to the stimuli presented to human subjects, most LLMs perform well, show little change in strategy over trials, and their graph-by-graph performance is similar to that of humans. Model comparison (BIC) shows that Bayes-Optimal teaching best explains most models' choices. When given a scaffolding intervention, models follow auxiliary inference- or reward-focused prompts, but these scaffolds do not reliably improve later teaching on heuristic-incongruent test graphs and can sometimes reduce performance. Overall, cognitive model fits provide insight into LLM tutoring policies and show that prompt compliance does not guarantee better teaching decisions.

arXiv:2604.01262v1 Announce Type: cross Abstract: Traditional Online Public Access Catalogues (OPACs) are becoming less effective due to the rapid growth of scholarly literature. Conventional search methods, such as keyword indexing and Boolean queries, often fail to support efficient knowledge discovery. This paper proposes a Smart OPAC framework that transforms traditional OPACs into intelligent discovery systems using artificial intelligence and knowledge graph techniques. The framework enables semantic search, thematic filtering, and knowledge graph-based visualization to enhance user interaction and exploration. It integrates multiple open scholarly data sources and applies semantic embeddings to improve relevance and contextual understanding. The system supports exploratory search, semantic navigation, and refined result filtering based on user-defined themes. Quantitative evaluation demonstrates improvements in retrieval efficiency, relevance, and reduction of information overload. The proposed approach offers practical implications for modernizing digital library services and supports next-generation research workflows. Future work includes user-centric evaluation, personalization, and dynamic knowledge graph updates.

Oncogenesis, Published online: 01 April 2026; doi:10.1038/s41389-026-00611-7

Alternatively activated macrophages cause DNA damage through an arginase 1-mediated bystander effect and promote epithelial cell transformation

arXiv:2603.28925v1 Announce Type: cross Abstract: Safety fine-tuning in Large Language Models (LLMs) seeks to suppress potentially harmful forms of mind-attribution such as models asserting their own consciousness or claiming to experience emotions. We investigate whether suppressing mind-attribution tendencies degrades intimately related socio-cognitive abilities such as Theory of Mind (ToM). Through safety ablation and mechanistic analyses of representational similarity, we demonstrate that LLM attributions of mind to themselves and to technological artefacts are behaviorally and mechanistically dissociable from ToM capabilities. Nevertheless, safety fine-tuned models under-attribute mind to non-human animals relative to human baselines and are less likely to exhibit spiritual belief, suppressing widely shared perspectives regarding the distribution and nature of non-human minds.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10203-5

A study of reproducibility in a stratified random sample of 600 papers published from 2009 to 2018 in 62 journals spanning the social and behavioural sciences finds higher reproducibility among more recent papers and papers from journals that require data sharing.

Nature, Published online: 30 March 2026; doi:10.1038/d41586-026-00973-3

Anne Poelina gives first authorship to a source with deep knowledge about water — the river itself.

Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03046-y

Variant mapping of sorghum promoters identifies CRISPR-accessible mutations that upregulate gene expression.

arXiv:2603.23308v1 Announce Type: cross Abstract: Automated radiology report generation from 3D computed tomography (CT) volumes is challenging due to extreme sequence lengths, severe class imbalance, and the tendency of large language models (LLMs) to ignore visual tokens in favor of linguistic priors. We present Ker-VLJEPA-3B, a four-phase curriculum learning framework for free-text report generation from thoracic CT volumes. A phased training curriculum progressively adapts a Llama 3.2 3B decoder to ground its output in visual features from a frozen, self-supervised encoder. Our visual backbone (LeJEPA ViT-Large) is trained via self-supervised joint-embedding prediction on unlabeled CTs, without text supervision. Unlike contrastive models (CLIP, BiomedCLIP), this language-free backbone yields modality-pure representations. Vision-language alignment is deferred to the curriculum's bridge and generation phases. This modality-agnostic design can integrate any self-supervised encoder into an LLM without paired text during foundation training. Methodological innovations include: (1) zone-constrained cross-attention compressing slice embeddings into 32 spatially-grounded visual tokens; (2) PCA whitening of anisotropic LLM embeddings; (3) a positive-findings-only strategy eliminating posterior collapse; (4) warm bridge initialization transferring projection weights; and (5) selective cross-attention freezing with elastic weight consolidation to prevent catastrophic forgetting. Evaluated on the CT-RATE benchmark (2,984 validation volumes, 18 classes), Ker-VLJEPA-3B achieves a macro F1 of 0.429, surpassing the state-of-the-art (U-VLM, macro F1 = 0.414) by 3.6%, and reaching 0.448 (+8.2%) with threshold optimization. Ablation studies confirm 56.6% of generation quality derives from patient-specific visual content. Code and weights are available.

arXiv:2506.09276v3 Announce Type: replace-cross Abstract: This paper presents a state representation framework for Markov decision processes (MDPs) that can be learned solely from state trajectories, requiring neither reward signals nor the actions executed by the agent. We propose learning the minimum action distance (MAD), defined as the minimum number of actions required to transition between states, as a fundamental metric that captures the underlying structure of an environment. MAD naturally enables critical downstream tasks such as goal-conditioned reinforcement learning and reward shaping by providing a dense, geometrically meaningful measure of progress. Our self-supervised learning approach constructs an embedding space where the distances between embedded state pairs correspond to their MAD, accommodating both symmetric and asymmetric approximations. We evaluate the framework on a comprehensive suite of environments with known MAD values, encompassing both deterministic and stochastic dynamics, as well as discrete and continuous state spaces, and environments with noisy observations. Empirical results demonstrate that the proposed approach not only efficiently learns accurate MAD representations across these diverse settings but also significantly outperforms existing state representation methods in terms of representation quality.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10264-6

Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.

Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03045-z

Base editor precision is increased by reverting established mutations.

arXiv:2601.21866v2 Announce Type: replace-cross Abstract: Real-world multivariate time series can exhibit intricate multi-scale structures, including global trends, local periodicities, and non-stationary regimes, which makes long-horizon forecasting challenging. Although sparse Mixture-of-Experts (MoE) approaches improve scalability and specialization, they typically rely on homogeneous MLP experts that poorly capture the diverse temporal dynamics of time series data. We address these limitations with MoHETS, an encoder-only Transformer that integrates sparse Mixture-of-Heterogeneous-Experts (MoHE) layers. MoHE routes temporal patches to a small subset of expert networks, combining a shared depthwise-convolution expert for sequence-level continuity with routed Fourier-based experts for patch-level periodic structures. MoHETS further improves robustness to non-stationary dynamics by incorporating exogenous information via cross-attention over covariate patch embeddings. Finally, we replace parameter-heavy linear projection heads with a lightweight convolutional patch decoder, improving parameter efficiency, reducing training instability, and allowing a single model to generalize across arbitrary forecast horizons. We validate across seven multivariate benchmarks and multiple horizons, with MoHETS consistently achieving state-of-the-art performance, reducing the average MSE by $12\%$ compared to strong recent baselines, demonstrating effective heterogeneous specialization for long-term forecasting.

Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04265-1

In this phase 1, open-label dose-escalation study in healthy adults found that the mRNA vaccine (mRNA-1215), encoding the Nipah virus Malaysian strain chimeric pre-fusion F protein linked to glycoprotein G, was safe and induced elevated immune responses at 1 year of follow-up, indicating that this is a promising vaccine candidate for further development.

Nature Biotechnology, Published online: 11 March 2026; doi:10.1038/s41587-026-03022-6

Endosomal escape of lipid nanoparticles is quantified and optimized in vivo.

Nature Biotechnology, Published online: 11 March 2026; doi:10.1038/s41587-026-03059-7

TnpB endonucleases are engineered for improved genome editing.

arXiv:2603.08409v1 Announce Type: cross Abstract: Although commonly associated with limbless animals like snakes and fish, multi-legged organisms like centipedes also utilize undulatory locomotion. Whether these undulations are actively reinforced or resisted by the axial musculature remains an open question. We present a dynamical model of centipede locomotion that integrates leg-ground interactions, passive body mechanics, and active lateral musculature. By varying stepping rate, actuation, and body stiffness, we examine how locomotor strategies affect speed and an effective energetic efficiency. Coordination emerges only when body stiffness is tuned to stepping frequency: overly flexible bodies lose synchrony, while overly rigid ones move slowly and inefficiently. We make a falsifiable prediction, measurable with a non-invasive experiment, that centipedes utilize speed dependent active stiffness to maintain this coordination. Our results suggest that lateral muscles also have a speed dependent function, revealed by optimizing speed and an effective cost, that resists a phase lag between leg touchdowns and body curvature. Together, we find that centipedes actively modulate body mechanics to achieve rapid, efficient locomotion, highlighting how complex control can emerge from embodied physical properties rather than solely from neural computation.

arXiv:2509.23488v4 Announce Type: replace Abstract: We introduce benchmark signatures to characterize the capacity demands of LLM benchmarks and their overlaps. Signatures are sets of salient tokens from in-the-wild corpora whose model token perplexity, reflecting training exposure, predicts benchmark performance. We extract them via stepwise forward selection with linear regression in a meta-evaluation spanning 32 LLMs and 89 benchmarks across diverse domains. We then analyze how these signatures relate to both the semantic similarity of benchmark questions and the correlation structure of model performance. While performance correlations are uniformly high and semantic overlaps stay in a narrow mid-range, benchmark signatures reveal more nuanced structure. For instance, they uncover substantial overlap between benchmarks in knowledge and reasoning tasks, whereas benchmarks in culture- and humanity-oriented domains show low similarity with each other. Unlike raw performance correlations, which are influenced by benchmark-orthogonal factors such as question formats, signatures are robust to such confounds. We further identify cross-functional overlaps between logic, math, language, instruction following, and cultural/world modeling, with coding emerging as the most isolated function, interacting only moderately with the ability of detecting missing information. Qualitative analysis shows that only the knowledge signature aligns with actual knowledge, suggesting that LLM semantic organization may differ from human conceptual structure. Together, these findings offer insights into benchmark validity, LLM sensitivities, and the landscape of interconnected LLM capacities. We have open-sourced the code and data in this https://github.com/siyangwu1/Benchmark-Signature-Repository.

arXiv:2503.15904v4 Announce Type: replace-cross Abstract: Large Language Models (LLMs) have revolutionized natural language processing, yet concerns persist regarding their tendency to reflect or amplify social biases. This study introduces a novel evaluation framework to uncover gender biases in LLMs: using free-form storytelling to surface biases embedded within the models. A systematic analysis of ten prominent LLMs shows a consistent pattern of overrepresenting female characters across occupations, likely due to supervised fine-tuning (SFT) and reinforcement learning from human feedback (RLHF). Paradoxically, despite this overrepresentation, the occupational gender distributions produced by these LLMs align more closely with human stereotypes than with real-world labor data. This highlights the challenge and importance of implementing balanced mitigation measures to promote fairness and prevent the establishment of potentially new biases. We release the prompts and LLM-generated stories at GitHub.

arXiv:2602.23234v3 Announce Type: replace-cross Abstract: Large-scale commercial search systems optimize for relevance to drive successful sessions that help users find what they are looking for. To maximize relevance, we leverage two complementary objectives: behavioral relevance (results users tend to click or download) and textual relevance (a result's semantic fit to the query). A persistent challenge is the scarcity of expert-provided textual relevance labels relative to abundant behavioral relevance labels. We first address this by systematically evaluating LLM configurations, finding that a specialized, fine-tuned model significantly outperforms a much larger pre-trained one in providing highly relevant labels. Using this optimal model as a force multiplier, we generate millions of textual relevance labels to overcome the data scarcity. We show that augmenting our production ranker with these textual relevance labels leads to a significant outward shift of the Pareto frontier: offline NDCG improves for behavioral relevance while simultaneously increasing for textual relevance. These offline gains were validated by a worldwide A/B test on the App Store ranker, which demonstrated a statistically significant +0.24% increase in conversion rate, with the most substantial performance gains occurring in tail queries, where the new textual relevance labels provide a robust signal in the absence of reliable behavioral relevance labels.

arXiv:2603.02420v2 Announce Type: replace-cross Abstract: Pluralistic alignment has emerged as a promising approach for ensuring that large language models (LLMs) faithfully represent the diversity, nuance, and conflict inherent in human values. In this work, we study a high-stakes deployment context - mulching - where automated systems transform selected individuals into nutrient-rich slurry for the dual purposes of food security and aesthetic population management. Building on recent pluralistic alignment frameworks, we introduce ValueMulch, a reproducible training, deployment, and certification pipeline for aligning mulching models (MMs) to a wide range of community norms. Through a real-world testbed spanning 32 communities, we show that ValueMulch improves distributional agreement with community mulching preferences relative to frontier baselines. We conclude with a discussion of ethical considerations, limitations, and implications for researchers seeking to align systems to the full spectrum of human values - especially when those values are inconsistent, commercially inconvenient, or nutritionally underutilized. Author's note: This piece builds on prior existing work Keyes et al in 2019 that satirized cannibalism as a parody for approaches that imbue ethics into problematic technology. We bring those ideas to today's era with the proliferation of large language models in everyday lives, as a critique of current AI pluralistic alignment literature. Our work does not intend to argue that all alignment practices are evil, but rather that if framing value design as a technical problem enables technology systems to enact harms, then perhaps this framing is not enough.