arXiv:2605.24486v1 Announce Type: new Abstract: Recent progress on long-horizon agentic tasks has been driven largely by scaling up individual agents through stronger models, better tools, and more effective scaffolding. In contrast, much less is understood about scaling out: whether multiple peer agents, all targeting the same task, can become an additional source of capability without relying on explicit role specialization or workflow orchestration. We study this question and propose AgentFugue, a collective reasoning framework built around a shared reasoning hub. As peer agents explore the same task in parallel, the hub records concise notes on what each agent has established, attempted, or ruled out, and enables each agent to selectively access what other agents have discovered in a form useful for its current search. This design turns otherwise isolated trajectories into a connected ecology of reusable intermediate reasoning without requiring centralized planning. We instantiate the hub as a plug-in communication layer, trained with supervised fine-tuning and end-to-end reinforcement learning. Across the challenging long-horizon settings we study, AgentFugue improves over strong baselines. Our results suggest that collective reasoning can turn scaling out peer agent systems into a distinct source of capability gains, rather than merely a way of spending more compute.

arXiv:2605.25893v1 Announce Type: new Abstract: Despite the emergence of diffusion large language models (D-LLMs) as an alternative to autoregressive large language models (AR-LLMs), safety monitoring for D-LLMs remains largely unexplored. Unlike AR-LLMs, D-LLMs generate text through a multi-step denoising process, exposing intermediate hidden representations that may contain safety-relevant information unavailable in standard single-step monitoring setups. Motivated by the suitability of lightweight probes for always-on monitoring, we analyze which trajectory-level signals best indicate when such probes are likely to struggle. We find that the most informative signal is safety hesitation: intermediate hidden states repeatedly falling within a small margin of the probe's decision boundary. The number of such hesitation steps in D-LLM's trajectory predicts probe failure effectively, providing a proxy of sample difficulty. Building on this analysis, we propose $D^2$-Monitor, a bi-level safety monitor for D-LLMs. $D^2$-Monitor adopts a lightweight probe as an always-on monitor to jointly estimate hesitation and perform base classification. When the hesitation level exceeds a threshold, a more expressive but computationally heavier probe is activated. This dynamic routing mechanism allocates monitoring resources efficiently at test time. Evaluated on 3 datasets (WildguardMix, ToxicChat, OpenAI-Moderation) across 4 D-LLMs, $D^2$-Monitor achieves state-of-the-art performance with a compact parameter footprint ($\leq$ 0.85M parameters), and exhibits the best trade-off between effectiveness and efficiency relative to 8 baselines.

arXiv:2604.03302v1 Announce Type: cross Abstract: While Multimodal Large Language Models (MLLMs) have demonstrated impressive capabilities in image and video understanding, their ability to comprehend the physical world has become an increasingly important research focus. Despite their improvements, current MLLMs struggle significantly with high-level physics reasoning. In this work, we investigate the first step of physical reasoning, i.e., intuitive physics understanding, revealing substantial limitations in understanding the dynamics of continuum objects. To isolate and evaluate this specific capability, we introduce two fundamental benchmark tasks: Next Frame Selection (NFS) and Temporal Coherence Verification (TCV). Our experiments demonstrate that even state-of-the-art MLLMs perform poorly on these foundational tasks. To address this limitation, we propose Scene Dynamic Field (SDF), a concise approach that leverages physics simulators within a multi-task fine-tuning framework. SDF substantially improves performance, achieving up to 20.7% gains on fluid tasks while showing strong generalization to unseen physical domains. This work not only highlights a critical gap in current MLLMs but also presents a promising cost-efficient approach for developing more physically grounded MLLMs. Our code and data are available at https://github.com/andylinx/Scene-Dynamic-Field.

arXiv:2604.04060v1 Announce Type: cross Abstract: As Large Language Models (LLMs) are increasingly deployed in complex applications, their vulnerability to adversarial attacks raises urgent safety concerns, especially those evolving over multi-round interactions. Existing defenses are largely reactive and struggle to adapt as adversaries refine strategies across rounds. In this work, we propose CoopGuard , a stateful multi-round LLM defense framework based on cooperative agents that maintains and updates an internal defense state to counter evolving attacks. It employs three specialized agents (Deferring Agent, Tempting Agent, and Forensic Agent) for complementary round-level strategies, coordinated by System Agent, which conditions decisions on the evolving defense state (interaction history) and orchestrates agents over time. To evaluate evolving threats, we introduce the EMRA benchmark with 5,200 adversarial samples across 8 attack types, simulating progressively LLM multi-round attacks. Experiments show that CoopGuard reduces attack success rate by 78.9% over state-of-the-art defenses, while improving deceptive rate by 186% and reducing attack efficiency by 167.9%, offering a more comprehensive assessment of multi-round defense. These results demonstrate that CoopGuard provides robust protection for LLMs in multi-round adversarial scenarios.

arXiv:2512.03795v2 Announce Type: replace-cross Abstract: Autonomous Driving (AD) vehicles still struggle to exhibit human-like behavior in highly dynamic and interactive traffic scenarios. The key challenge lies in AD's limited ability to interact with surrounding vehicles, largely due to a lack of understanding the underlying mechanisms of social interaction. To address this issue, we introduce MPCFormer, an explainable socially-aware autonomous driving approach with physics-informed and data-driven coupled social interaction dynamics. In this model, the dynamics are formulated into a discrete space-state representation, which embeds physics priors to enhance modeling explainability. The dynamics coefficients are learned from naturalistic driving data via a Transformer-based encoder-decoder architecture. To the best of our knowledge, MPCFormer is the first approach to explicitly model the dynamics of multi-vehicle social interactions. The learned social interaction dynamics enable the planner to generate manifold, human-like behaviors when interacting with surrounding traffic. By leveraging the MPC framework, the approach mitigates the potential safety risks typically associated with purely learning-based methods. Open-looped evaluation on NGSIM dataset demonstrates that MPCFormer achieves superior social interaction awareness, yielding the lowest trajectory prediction errors compared with other state-of-the-art approaches. The prediction achieves an ADE as low as 0.86 m over a long prediction horizon of 5 seconds. Close-looped experiments in highly intense interaction scenarios, where consecutive lane changes are required to exit an off-ramp, further validate the effectiveness of MPCFormer. Results show that MPCFormer achieves the highest planning success rate of 94.67%, improves driving efficiency by 15.75%, and reduces the collision rate from 21.25% to 0.5%, outperforming a frontier Reinforcement Learning (RL) based planner.

arXiv:2603.13842v2 Announce Type: replace-cross Abstract: End-to-end autonomous driving is typically built upon imitation learning (IL), yet its performance is constrained by the quality of human demonstrations. To overcome this limitation, recent methods incorporate reinforcement learning (RL) through sequential fine-tuning. However, such a paradigm remains suboptimal: sequential RL fine-tuning can introduce policy drift and often leads to a performance ceiling due to its dependence on the pretrained IL policy. To address these issues, we propose PaIR-Drive, a general Parallel framework for collaborative Imitation and Reinforcement learning in end-to-end autonomous driving. During training, PaIR-Drive separates IL and RL into two parallel branches with conflict-free training objectives, enabling fully collaborative optimization. This design eliminates the need to retrain RL when applying a new IL policy. During inference, RL leverages the IL policy to further optimize the final plan, allowing performance beyond prior knowledge of IL. Furthermore, we introduce a tree-structured trajectory neural sampler to group relative policy optimization (GRPO) in the RL branch, which enhances exploration capability. Extensive analysis on NAVSIMv1 and v2 benchmark demonstrates that PaIR-Drive achieves Competitive performance of 91.2 PDMS and 87.9 EPDMS, building upon Transfuser and DiffusionDrive IL baselines. PaIR-Drive consistently outperforms existing RL fine-tuning methods, and could even correct human experts' suboptimal behaviors. Qualitative results further confirm that PaIR-Drive can effectively explore and generate high-quality trajectories.

arXiv:2604.01413v2 Announce Type: replace-cross Abstract: Large Language Models (LLMs) increasingly rely on multi-turn reasoning and interaction, such as adaptive retrieval-augmented generation (RAG) and ReAct-style agents, to answer difficult questions. These methods improve accuracy by iteratively retrieving information, reasoning, or acting, but introduce a key challenge: \textbf{When should the model stop?} Existing approaches rely on heuristic stopping rules or fixed turn budgets and provide no formal guarantees that the final prediction still contains the correct answer. This limitation is particularly problematic in high-stakes domains such as finance and healthcare, where unnecessary turns increase cost and latency, while stopping too early risks incorrect decisions. Conformal prediction (CP) provides formal coverage guarantees, but existing LLM-CP methods only apply to a single model output and cannot handle multi-turn pipelines with adaptive stopping. To address this gap, we propose Multi-Turn Language Models with Conformal Prediction (MiCP), the first CP framework for multi-turn reasoning. MiCP allocates different error budgets across turns, enabling the model to stop early while maintaining an overall coverage guarantee. We demonstrate MiCP on adaptive RAG and ReAct, where it achieves the target coverage on both single-hop and multi-hop question answering benchmarks while reducing the number of turns, inference cost, and prediction set size. We further introduce a new metric that jointly evaluates coverage validity and answering efficiency.

arXiv:2604.02236v1 Announce Type: new Abstract: Emotional tone is pervasive in human communication, yet its influence on large language model (LLM) behaviour remains unclear. Here, we examine how first-person emotional framing in user-side queries affect LLM performance across six benchmark domains, including mathematical reasoning, medical question answering, reading comprehension, commonsense reasoning and social inference. Across models and tasks, static emotional prefixes usually produce only small changes in accuracy, suggesting that affective phrasing is typically a mild perturbation rather than a reliable general-purpose intervention. This stability is not uniform: effects are more variable in socially grounded tasks, where emotional context more plausibly interacts with interpersonal reasoning. Additional analyses show that stronger emotional wording induces only modest extra change, and that human-written prefixes reproduce the same qualitative pattern as LLM-generated ones. We then introduce EmotionRL, an adaptive emotional prompting framework that selects emotional framing adaptively for each query. Although no single emotion is consistently beneficial, adaptive selection yields more reliable gains than fixed emotional prompting. Together, these findings show that emotional tone is neither a dominant driver of LLM performance nor irrelevant noise, but a weak and input-dependent signal that can be exploited through adaptive control.

arXiv:2604.01413v1 Announce Type: cross Abstract: Large Language Models (LLMs) increasingly rely on multi-turn reasoning and interaction, such as adaptive retrieval-augmented generation (RAG) and ReAct-style agents, to answer difficult questions. These methods improve accuracy by iteratively retrieving information, reasoning, or acting, but introduce a key challenge: \textbf{When should the model stop?} Existing approaches rely on heuristic stopping rules or fixed turn budgets and provide no formal guarantees that the final prediction still contains the correct answer. This limitation is particularly problematic in high-stakes domains such as finance and healthcare, where unnecessary turns increase cost and latency, while stopping too early risks incorrect decisions. Conformal prediction (CP) provides formal coverage guarantees, but existing LLM-CP methods only apply to a single model output and cannot handle multi-turn pipelines with adaptive stopping. To address this gap, we propose Multi-Turn Language Models with Conformal Prediction (MiCP), the first CP framework for multi-turn reasoning. MiCP allocates different error budgets across turns, enabling the model to stop early while maintaining an overall coverage guarantee. We demonstrate MiCP on adaptive RAG and ReAct, where it achieves the target coverage on both single-hop and multi-hop question answering benchmarks while reducing the number of turns, inference cost, and prediction set size. We further introduce a new metric that jointly evaluates coverage validity and answering efficiency.

arXiv:2508.18649v2 Announce Type: replace-cross Abstract: Safeguarding vision-language models (VLMs) is a critical challenge, as existing methods often suffer from over-defense, which harms utility, or rely on shallow alignment, failing to detect complex threats that require deep reasoning. To this end, we introduc PRISM (Principled Reasoning for Integrated Safety in Multimodality), a System 2-like framework that aligns VLMs through a structured four-stage reasoning process explicitly designed to handle three distinct categories of multimodal safety violations. Our framework consists of two key components: a structured reasoning pipeline that analyzes each violation category in dedicated stages, and PRISM-DPO, generated via Monte Carlo Tree Search (MCTS) to refine reasoning quality through Direct Preference Optimization. Comprehensive evaluations show that PRISM substantially reduces attack success rates on JailbreakV-28K and VLBreak, improves robustness against adaptive attacks, and generalizes to out-of-distribution multi-image threats, while better preserving model utility on benign multimodal benchmarks. Our code, data, and model weights available at https://github.com/SaFoLab-WISC/PRISM.

arXiv:2603.29139v1 Announce Type: new Abstract: Recent advances in large language models (LLMs) have enabled agentic systems that translate natural language intent into executable scientific visualization (SciVis) tasks. Despite rapid progress, the community lacks a principled and reproducible benchmark for evaluating these emerging SciVis agents in realistic, multi-step analysis settings. We present SciVisAgentBench, a comprehensive and extensible benchmark for evaluating scientific data analysis and visualization agents. Our benchmark is grounded in a structured taxonomy spanning four dimensions: application domain, data type, complexity level, and visualization operation. It currently comprises 108 expert-crafted cases covering diverse SciVis scenarios. To enable reliable assessment, we introduce a multimodal outcome-centric evaluation pipeline that combines LLM-based judging with deterministic evaluators, including image-based metrics, code checkers, rule-based verifiers, and case-specific evaluators. We also conduct a validity study with 12 SciVis experts to examine the agreement between human and LLM judges. Using this framework, we evaluate representative SciVis agents and general-purpose coding agents to establish initial baselines and reveal capability gaps. SciVisAgentBench is designed as a living benchmark to support systematic comparison, diagnose failure modes, and drive progress in agentic SciVis. The benchmark is available at https://scivisagentbench.github.io/.

arXiv:2603.28780v1 Announce Type: cross Abstract: In this paper, we study the problem of distributed training (DT) under Byzantine attacks with communication constraints. While prior work has developed various robust aggregation rules at the server to enhance robustness to Byzantine attacks, the existing methods suffer from a critical limitation in that the solution error does not diminish when the local gradients sent by different devices vary considerably, as a result of data heterogeneity among the subsets held by different devices. To overcome this limitation, we propose a novel DT method, cyclic gradient coding-based DT (LAD). In LAD, the server allocates the entire training dataset to the devices before training begins. In each iteration, it assigns computational tasks redundantly to the devices using cyclic gradient coding. Each honest device then computes local gradients on a fixed number of data subsets and encodes the local gradients before transmitting to the server. The server aggregates the coded vectors from the honest devices and the potentially incorrect messages from Byzantine devices using a robust aggregation rule. Leveraging the redundancy of computation across devices, the convergence performance of LAD is analytically characterized, demonstrating improved robustness against Byzantine attacks and significantly lower solution error. Furthermore, we extend LAD to a communication-efficient variant, compressive and cyclic gradient coding-based DT (Com-LAD), which further reduces communication overhead under constrained settings. Numerical results validate the effectiveness of the proposed methods in enhancing both Byzantine resilience and communication efficiency.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10295-z

AhR functions as a neuronal brake on axon regeneration, integrating environmental sensing, protein homeostasis and metabolic signalling to control the balance between stress adaptation and axonal repair.

arXiv:2603.23184v1 Announce Type: cross Abstract: Reward modeling represents a long-standing challenge in reinforcement learning from human feedback (RLHF) for aligning language models. Current reward modeling is heavily contingent upon experimental feedback data with high collection costs. In this work, we study \textit{implicit reward modeling} -- learning reward models from implicit human feedback (e.g., clicks and copies) -- as a cost-effective alternative. We identify two fundamental challenges in implicit reward modeling: (1) Implicit preference data lacks definitive negative samples, which makes standard positive-negative classification methods inapplicable; (2) Implicit preference data suffers from user preference bias, where different responses have different propensities to elicit user feedback actions, which exacerbates the difficulty of distinguishing definitive negative samples. To address these challenges, we propose ImplicitRM, which aims to learn unbiased reward models from implicit preference data. ImplicitRM stratifies training samples into four latent groups via a stratification model. Building on this, it derives a learning objective through likelihood maximization, which we prove is theoretically unbiased, effectively resolving both challenges. Experiments demonstrate that ImplicitRM learns accurate reward models across implicit preference datasets. Code is available on our project website.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10270-8

Single-nucleus chromatin and RNA sequencing identifies epigenetic chromatin domains that confer vulnerability to paediatric brain tumours such as ependymomas, providing insight into the development of such tumours despite ‘quiet’ genomes.

arXiv:2601.11610v2 Announce Type: replace-cross Abstract: Among the diverse services provided by Location-Based Social Networks (LBSNs), Next Point-of-Interest (POI) recommendation plays a crucial role in inferring user preferences from historical check-in trajectories. However, existing sequential and graph-based methods frequently neglect significant mobility variations across distinct contextual scenarios (e.g., tourists versus locals). This oversight results in suboptimal performance due to two fundamental limitations: the inability to capture scenario-specific features and the failure to resolve inherent inter-scenario conflicts. To overcome these limitations, we propose the Multifaceted Scenario-Aware Hypergraph Learning method (MSAHG), a framework that adopts a scenario-splitting paradigm for next POI recommendation. Our main contributions are: (1) Construction of scenario-specific, multi-view disentangled sub-hypergraphs to capture distinct mobility patterns; (2) A parameter-splitting mechanism to adaptively resolve conflicting optimization directions across scenarios while preserving generalization capability. Extensive experiments on three real-world datasets demonstrate that MSAHG consistently outperforms five state-of-the-art methods across diverse scenarios, confirming its effectiveness in multi-scenario POI recommendation.

Cell Death Discovery, Published online: 07 March 2026; doi:10.1038/s41420-026-02953-y

TRIM27-controlled endothelium-derived exosomes play a central role in podocyte injury in diabetic kidney disease

Oncogene, Published online: 05 March 2026; doi:10.1038/s41388-026-03713-z

KRAS-extrachromosomal DNA drives intratumoral heterogeneity in gastric cancer

arXiv:2603.02640v1 Announce Type: cross Abstract: Online platforms increasingly rely on opinion aggregation to allocate real-world attention and resources, yet common signals such as engagement votes or capital-weighted commitments are easy to amplify and often track visibility rather than reliability. This makes collective judgments brittle under weak truth signals, noisy or delayed feedback, early popularity surges, and strategic manipulation. We propose Credibility Governance (CG), a mechanism that reallocates influence by learning which agents and viewpoints consistently track evolving public evidence. CG maintains dynamic credibility scores for both agents and opinions, updates opinion influence via credibility-weighted endorsements, and updates agent credibility based on the long-run performance of the opinions they support, rewarding early and persistent alignment with emerging evidence while filtering short-lived noise. We evaluate CG in POLIS, a socio-physical simulation environment that models coupled belief dynamics and downstream feedback under uncertainty. Across settings with initial majority misalignment, observation noise and contamination, and misinformation shocks, CG outperforms vote-based, stake-weighted, and no-governance baselines, yielding faster recovery to the true state, reduced lock-in and path dependence, and improved robustness under adversarial pressure. Our implementation and experimental scripts are publicly available at https://github.com/Wanying-He/Credibility_Governance.