Reading view
TRACER: A Semantic-Aware Framework for Fine-Grained Contamination Detection in Code LLMs
Multimodal Functional Maximum Correlation for Emotion Recognition
Sparse Tokens Suffice: Jailbreaking Audio Language Models via Token-Aware Gradient Optimization
Targeting cysteinyl leukotriene receptor 1 reprograms tumor-promoting myelopoiesis and overcomes immune checkpoint therapy resistance
Nature Cancer, Published online: 19 May 2026; doi:10.1038/s43018-026-01174-7
Tang et al. identify cysteinyl leukotriene receptor 1 (CysLTR1) as a critical regulator of tumor-induced myelopoiesis, suggesting CysLTR1 targeting to sensitize tumors to immune checkpoint blockade.Ubiquitin-specific protease 11 suppresses cuproptosis in colorectal cancer by regulating the ubiquitination and stability of ISCU
Oncogenesis, Published online: 08 May 2026; doi:10.1038/s41389-026-00621-5
Ubiquitin-specific protease 11 suppresses cuproptosis in colorectal cancer by regulating the ubiquitination and stability of ISCUEBV strain interacts with host HLA to drive nasopharyngeal carcinoma risk
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10416-8
A genome-to-genome association study identifies host and viral risk factors that interact to drive nasopharyngeal carcinoma endemicity in southern China.GROUNDEDKG-RAG: Grounded Knowledge Graph Index for Long-document Question Answering
Xpertbench: Expert Level Tasks with Rubrics-Based Evaluation
The Latent Space: Foundation, Evolution, Mechanism, Ability, and Outlook
Meta-Learning at Scale for Large Language Models via Low-Rank Amortized Bayesian Meta-Learning
Physiological and Semantic Patterns in Medical Teams Using an Intelligent Tutoring System
IMAGAgent: Orchestrating Multi-Turn Image Editing via Constraint-Aware Planning and Reflection
Boosting foundation models for rare eye disease diagnosis via a multimodal text-to-image generative framework
npj Digital Medicine, Published online: 24 March 2026; doi:10.1038/s41746-026-02560-2
Boosting foundation models for rare eye disease diagnosis via a multimodal text-to-image generative frameworkTaoBench: Do Automated Theorem Prover LLMs Generalize Beyond MathLib?
Profiling of the mycobiome and metabolome: a comparative study of benign pulmonary nodules and lung adenocarcinoma
Front Cell Infect Microbiol. 2026 Feb 23;16:1732958. doi: 10.3389/fcimb.2026.1732958. eCollection 2026.
ABSTRACT
INTRODUCTION: Lung adenocarcinoma (LUAD), the most common subtype of non-small cell lung cancer, is a form of malignant pulmonary nodule that requires clinical differentiation from benign pulmonary nodules (BPN). The mechanisms underlying the development of LUAD are complex, and effective non-invasive methods for differentiating BPN from LUAD are lacking. This study aimed not only to distinguish BPN from LUAD using gut fungi and serum metabolites, but also to establish an integrated network of gut fungi-metabolite-cytokine interactions.
METHODS: Fecal and serum samples from individuals with BPN and patients with LUAD were subjected to internal transcribed spacer sequencing, ultra-performance liquid chromatography-tandem mass spectrometry, and multiplex Luminex assays to quantify gut fungi, metabolites, and cytokines, respectively.
RESULTS: A significant difference in gut fungal communities was observed between the BPN and LUAD groups. Multiple genera and species were more abundant in LUAD than in BPN. Docosapentaenoic acid n-6 (DPAn-6), indole-3-propionic acid (IPA), and interferon-γ-induced protein 10 (IP-10) were significantly elevated in the LUAD group. The integrated model established using a combination of gut fungi and metabolites demonstrated excellent performance in distinguishing BPN from LUAD. A network of interactions was established among differentially abundant gut fungi, serum metabolites, and cytokines.
CONCLUSION: Our study identifies a novel panel of fungal and metabolite biomarkers for differentiating between BPN and LUAD, and constructs a multi-omics network that provides new insights into investigating the mechanistic role of gut mycobiota dysbiosis in LUAD.
PMID:41809995 | PMC:PMC12968269 | DOI:10.3389/fcimb.2026.1732958