arXiv:2605.24686v1 Announce Type: new Abstract: As large language models (LLMs) are increasingly integrated into emotionally sensitive domains, the structural integrity of their emotional intelligence (EI) becomes a critical frontier for safety and alignment. Current benchmarks often conflate superficial politeness with deep affective reasoning, failing to distinguish between perceptual accuracy and interactive efficacy. Here, we introduce FACET (Functional Affective Competence and Empathy Test), a psychometrically grounded framework comprising 480 expert-crafted items. Unlike previous metrics, FACET is theoretically anchored in the Mayer-Salovey-Caruso four-branch ability model, operationalizing EI through perception, facilitation, understanding, and management of emotions. Through an evaluation of nine frontier models (including GPT-5, Claude-Sonnet-4), we demonstrate that emotional intelligence is not a monolithic capability but is fragmented across cognitive and interactive dimensions. While frontier models demonstrate robust proficiency in objective emotion recognition and social reasoning, this does not consistently translate to interactive success. We categorize these discrepancies into three distinct performance profiles: cognitive-dominant, interactive-dominant, and context-dependent. These typologies indicate that emotional skills do not scale uniformly with general intelligence or model size; rather, they are shaped by specific alignment paradigms. Notably, we identify hidden emotion recognition as a universal performance bottleneck across all architectures. Our results suggest that current RLHF processes may optimize for "stochastic empathy", a statistical mimicry of emotional syntax, at the expense of integrated affective reasoning. These findings challenge the assumption of linear emotional scaling and provide a rigorous roadmap for developing socially aware agents capable of genuine clinical resonance.

Multiomics profiling of healthy individuals reveals differences across molecular layers and key pathways related to immune, metabolic, and microbiome-linked processes across ethnicities, while geographic relocation reshapes these networks and influences aging trajectories.

arXiv:2510.25232v2 Announce Type: replace Abstract: Psychiatric comorbidity is clinically significant yet challenging due to the complexity of multiple co-occurring disorders. To address this, we develop a novel approach integrating synthetic patient electronic medical record (EMR) construction and multi-agent diagnostic dialogue generation. We create 502 synthetic EMRs for common comorbid conditions using a pipeline that ensures clinical relevance and diversity. Our multi-agent framework transfers the clinical interview protocol into a hierarchical state machine and context tree, supporting over 130 diagnostic states while maintaining clinical standards. Through this rigorous process, we construct PsyCoTalk, the first large-scale dialogue dataset supporting comorbidity, containing 3,000 multi-turn diagnostic dialogues validated by psychiatrists. This dataset enhances diagnostic accuracy and treatment planning, offering a valuable resource for psychiatric comorbidity research. Compared to real-world clinical transcripts, PsyCoTalk exhibits high structural and linguistic fidelity in terms of dialogue length, token distribution, and diagnostic reasoning strategies. Licensed psychiatrists confirm the realism and diagnostic validity of the dialogues. This dataset enables the development and evaluation of models capable of multi-disorder psychiatric screening in a single conversational pass.