Gene therapy is transforming hereditary hematological disorders. This review summarizes approved gene addition, editing, and silencing strategies for sickle cell disease, thalassemia, and hemophilia, highlights curative potential, and discusses remaining challenges such as immune responses, cost, and accessibility

Yuan and colleagues demonstrate that inhaled biodegradable nanosilica activates an alveolar macrophage–NK axis, triggering an IL-12/15/18 triad that programs memory-like NK cells. This non-fibrotic, cell-free strategy suppresses melanoma growth, prevents postsurgical recurrence, and synergizes with anti-PD-1, establishing a robust framework for in vivo NK cell immunotherapy.

arXiv:2609.10305v1 Announce Type: cross Abstract: Language models under one million parameters matter for edge deployment, domain adaptation, and reproducible research, yet a two-layer LSTM or Transformer at embedding width d = 128 still spends roughly one third of its capacity on the output matrix W_out in R^(d x |V|). We propose Riemannian Language Models (RiLM), which remove that layer entirely: context unfolds as a trajectory on a Riemannian manifold, and next-token probabilities arise from squared geodesic distance between the current state and vocabulary embeddings. The same embedding map serves input and output -- decoding is geometry. We instantiate the framework on flat R^d (Flat RiLM) and the Poincare ball H^d (HypRiLM) with a shared MLP composition map phi (~290k parameters, d = 128, |V| = 2000). Across five seeds on WikiText-2, HypRiLM reaches 54.2 +/- 0.2 validation perplexity versus 87.6 +/- 0.6 for Flat RiLM; tied and matched LSTM, Transformer, and SSM controls remain at 113-147 PPL on WT-2 -- HypRiLM leads by roughly 2x over the strongest tied recurrent baseline (SSM, 113.0 +/- 3.8). Penn Treebank and a 10k-vocabulary stress test confirm that geodesic decoding transfers across corpora and larger |V|, while hyperbolic curvature helps selectively. We also characterize boundary collapse in naive hyperbolic recurrence and show how Mobius stabilization restores trainability. Claims are scoped to controlled small-model comparisons, not full-vocabulary state of the art.

Cell Death Discovery, Published online: 25 May 2026; doi:10.1038/s41420-026-03142-7

ATP2B4 driven chromatin compaction exacerbates pancreatic cancer radiotherapy resistance

Cell Death Discovery, Published online: 10 April 2026; doi:10.1038/s41420-026-03107-w

NAT10 promotes cisplatin resistance and immune escape by increasing the expression of DUSP1 and PD-L1 in gastric cancer

arXiv:2604.03647v1 Announce Type: cross Abstract: In the unsupervised self-evolution of Multimodal Large Language Models, the quality of feedback signals during post-training is pivotal for stable and effective learning. However, existing self-evolution methods predominantly rely on majority voting to select the most frequent output as the pseudo-golden answer, which may stem from the model's intrinsic biases rather than guaranteeing the objective correctness of the reasoning paths. To counteract the degradation, we propose \textbf{C}ontinuous \textbf{S}oftened \textbf{R}etracing re\textbf{S}ampling (\textbf{CSRS}) in MLLM self-evolution. Specifically, we introduce a Retracing Re-inference Mechanism (\textbf{RRM}) that the model re-inferences from anchor points to expand the exploration of long-tail reasoning paths. Simultaneously, we propose Softened Frequency Reward (\textbf{SFR}), which replaces binary rewards with continuous signals, calibrating reward based on the answers' frequency across sampled reasoning sets. Furthermore, incorporated with Visual Semantic Perturbation (\textbf{VSP}), CSRS ensures the model prioritizes mathematical logic over visual superficiality. Experimental results demonstrate that CSRS significantly enhances the reasoning performance of Qwen2.5-VL-7B on benchmarks such as MathVision. We achieve state-of-the-art (SOTA) results in unsupervised self-evolution on geometric tasks. Our code is avaible at https://github.com/yyy195/CSRS.

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10240-0

Marburgvirus glycoprotein binds to the endosomal receptor NPC1 in a distinct orientation with higher affinity compared with Ebola virus glycoprotein, accompanied by fusion-relevant rearrangements, enabling more efficient viral entry.

arXiv:2603.08453v1 Announce Type: cross Abstract: The quadratic complexity of the attention mechanism and the substantial memory footprint of the Key-Value (KV) cache present severe computational and memory challenges for Large Language Models (LLMs) processing long contexts. Existing retrieval-based methods often compromise semantic integrity through fixed-size chunking and suffer from inefficient linear scanning. In this paper, we propose LycheeCluster, a novel method for efficient KV cache management. LycheeCluster preserves local semantic coherence via boundary-aware chunking and constructs a recursive hierarchical index rooted in the triangle inequality. This design transforms cache retrieval from a linear scan into a theoretically bounded, logarithmic-time pruning process, while a lazy update strategy supports efficient streaming generation. Experiments demonstrate that LycheeCluster achieves up to a 3.6x end-to-end inference speedup with negligible degradation in model performance, outperforming state-of-the-art KV cache management methods (e.g., Quest, ClusterKV). We will release our code and kernels after publication.

arXiv:2603.08526v1 Announce Type: cross Abstract: Unsupervised graph alignment aims to find the node correspondence across different graphs without any anchor node pairs. Despite the recent efforts utilizing deep learning-based techniques, such as the embedding and optimal transport (OT)-based approaches, we observe their limitations in terms of model accuracy-efficiency tradeoff. By focusing on the exploitation of local and global graph information, we formalize them as the ``local representation, global alignment'' paradigm, and present a new ``global representation and alignment'' paradigm to resolve the mismatch between the two phases in the alignment process. We then propose \underline{Gl}obal representation and \underline{o}ptimal transport-\underline{b}ased \underline{Align}ment (\texttt{GlobAlign}), and its variant, \texttt{GlobAlign-E}, for better \underline{E}fficiency. Our methods are equipped with the global attention mechanism and a hierarchical cross-graph transport cost, able to capture long-range and implicit node dependencies beyond the local graph structure. Furthermore, \texttt{GlobAlign-E} successfully closes the time complexity gap between representative embedding and OT-based methods, reducing OT's cubic complexity to quadratic terms. Through extensive experiments, our methods demonstrate superior performance, with up to a 20\% accuracy improvement over the best competitor. Meanwhile, \texttt{GlobAlign-E} achieves the best efficiency, with an order of magnitude speedup against existing OT-based methods.