❌

Reading view

↗️

BRACE: Anchored Bellman-Residual Correction for Stale Critics in Asynchronous RL

✇cs.AI, q-bio.NC updates on arXiv.org
By: Guanqun Zhao · Zijun Xie · Binbin Zheng · Jiafeng Lu · Enlei Gong · Zeyu Chen
arXiv:2609.09783v1 Announce Type: cross Abstract: Asynchronous reinforcement learning has become the standard way to scale training for language models, but the resulting policy lag biases the critic toward the stale behavior policy. Existing work on asynchronous LLM training corrects the actor and leaves this bias unaddressed, while the off-policy value correction of classical RL does not carry over to long-horizon agentic tasks, since a short correction horizon leaves the regression target free of the reward and a long one lets the product of importance ratios drift exponentially with the trajectory length. We propose BRACE, an anchored Bellman-residual correction for stale value models. BRACE bounds the correction horizon to a prefix of policy tokens and anchors a constant-weight Monte-Carlo tail beyond it, which separates policy correction from reward propagation. BRACE improves mean@1 on BrowseComp-Plus by $2.4\%$ over the strongest baseline, runs $2.46\times$ faster per step than synchronous training, and remains stable $50$ updates off-policy.
  •  
  • ↗️
↗️

How Fragile Is Safety Alignment at Frontier Scale? A Single-Direction Attack on a 320B MoE

✇cs.AI, q-bio.NC updates on arXiv.org
By: Yi Shi · Tanyu Chen · Kai Shen
arXiv:2609.09793v1 Announce Type: cross Abstract: Directional ablation removes an aligned language model's ability to refuse by projecting a single "refusal direction" out of the weights that write the residual stream. It needs no gradient-based training and no optimization, only a few hundred contrastive prompts, which makes it the canonical white-box attack on open-weight alignment. However, it has been established only on dense models up to roughly 70B parameters. We study whether it survives the shift to frontier mixture-of-experts (MoE) models whose residual streams are no longer a single tensor and whose weights ship quantized. We apply it to GLM-5.3-Flash (320B parameters, 288 routed experts, a four-wide hyper-connection residual, block-FP8). The attack survives the architecture, but what it reaches is no longer where a reader of the original recipe would look for it. Editing the attention, dense and routed-expert writers on their own removes 0.039, 0.016 and 0.148 of refusal respectively; editing all three together removes 0.776. As a result, 74% of the effect exists only under the joint intervention. The part the conventional recipe reaches by module-name matching accounts for 0.066 of that 0.776, which is why it fails silently on an MoE. The effect does not follow from removing just any direction: ablating a random direction orthogonal to it leaves refusal unchanged. A category-concentrated residue survives every edit we tried: subspaces fitted on violence, sexual content and hate leave measurable refusal at every rank from 1 to 12. We report the method, the 41-89 percentage-point reductions it achieves across seven harmful benchmarks with no detected change in capability, and the boundary where it stops.
  •  
  • ↗️
↗️

GANDR: Claim Auditing for Verifiable Legal Answer Generation

✇cs.AI, q-bio.NC updates on arXiv.org
By: Chen Qian · Yimeng Wang · Yu Chen · Lingfei Wu · Andreas Stathopoulos
arXiv:2609.10293v1 Announce Type: cross Abstract: In high-stakes domains such as legal practice, a language-model answer is only useful to the extent that a reader can verify each claim against the source the system cites. Current grounded-generation pipelines score the answer as a whole, so a correct conclusion can rest on fabricated or loosely matched citations and still score well. Closing this gap requires both a system built for per-claim verification and an evaluation that measures it. We introduce GANDR (Grounded ANswer DRafter), a two-agent system in which a Drafter writes an answer in a structured legal-reasoning format and a separate Critic, with the same view as a human verifier, audits each claim against its cited source and emits a per-claim audit trace on every round. We pair it with a strict correctness criterion requiring every citation to resolve to a passage the retriever returned. On a 185-item legal benchmark where all six systems share one backbone, one retrieval surface, and one citation instruction, GANDR ranks first on every primary metric, reaching 70.8% strict accuracy and leading the strongest baseline by 11.3 points (p
  •  
  • ↗️
↗️

MOONWALK: Mediating Operations with Intent-Evidence-Action Alignment Across Junior-Supervisor Review Workflows in Animation/VFX Pre-Production

✇cs.AI, q-bio.NC updates on arXiv.org
By: Shih-Yu Lai · Wen-Fan Wang · Sai Ling · Shaune Jan · Bing-Yu Chen · Xiang Anthony Chen
arXiv:2609.10385v1 Announce Type: cross Abstract: Animation and VFX pre-production review requires teams to translate loosely specified creative intent--briefs, evolving specifications, heterogeneous references, and verbal decisions--into revisions that junior artists can execute without repeated clarification. In practice, criteria drift across iterations, review judgments lose their evidential basis, and the reasoning behind a request rarely survives the senior-junior handoff. We contribute a design framework for intent-evidence-action alignment: intent is articulated into a shared project record, judgments are anchored to grounded evidence, and authorized decisions are converted into clear revision tasks tied directly to reference notes. We instantiate this framework in MOONWALK, a professional pre-production review system comprising a shared intent record, reference/specification anchoring, structured work-in-progress comparison, and supervisor-authorized action planning. In this workflow, AI handles administrative coordination--flagging missing context and organizing notes--while artists retain full creative direction. An in-studio study with professional practitioners compares MOONWALK with a chat-only (chatbot) interface using matched production materials, while participants' existing workflows provide a retrospective ecological baseline. Results indicate stronger intent alignment, decision traceability, and checklist executability, while also showing that aesthetic authority and final prioritization must remain with practitioners. The evaluation establishes the value of the integrated structured workflow over unstructured conversational AI chatbot. Code: https://github.com/Akinesia112/Moonwalk/tree/english-version
  •  
  • ↗️
↗️

S1P-TREM2 axis protects immunosuppressive neutrophils from ferroptosis to promote tumour progression in hepatocellular carcinoma

✇Omics in Hepatocellular
By: Jun Ma · Tong Wu · Diyu Chen · Can Zhu · Shanhe Huang · Keyi Du · Chuanhui Peng · Junru Chen · Yunhao Chen · Haiyang Xie · Feng Zhang · Jianzhong Chen · Shusen Zheng · Jian Wu

Gut. 2026 Sep 7:gutjnl-2025-337414. doi: 10.1136/gutjnl-2025-337414. Online ahead of print.

ABSTRACT

BACKGROUND: Neutrophils are increasingly recognised as immunosuppressive drivers of hepatocellular carcinoma (HCC), yet their persistence in the oxidative, lipid-rich tumour microenvironment remains poorly understood.

OBJECTIVE: To elucidate the metabolic and molecular programmes that enable tumour-associated neutrophils (TANs) to resist ferroptosis and sustain immunosuppression in HCC.

DESIGN: We employed human HCC samples, multiple murine HCC models, transcriptomic and lipidomic profiling, genetic loss-of-function systems and therapeutic interventions. Ferroptosis sensitivity, lipid metabolic rewiring and immunological consequences of TANs were systematically evaluated across models and validated in patient datasets and biospecimens.

RESULTS: TANs in human HCC and mouse models exhibit pronounced lipid accumulation and oxidative stress compared with peripheral neutrophils. Multi-omic profiling revealed that TANs are enriched for lipid-binding gene programmes and undergo rewiring towards sphingolipid and unsaturated fatty acid metabolism. We identified triggering receptor expressed on myeloid cells 2 (TREM2) as a key lipid-sensing receptor selectively expressed in TANs. Functional deletion of TREM2 reprogrammed the tumour immune microenvironment, restoring CD8+ T cell activity and suppressing HCC progression. Mechanistically, tumour-derived sphingosine-1-phosphate (S1P) activates TREM2, triggering nuclear factor erythroid 2-related factor 2 (NRF2)-mediated transcription of glutathione peroxidase 4 (GPX4) and solute carrier family 7 member 11 (SLC7A11), thereby promoting ferroptosis resistance. TREM2 expression is transcriptionally induced by granulocyte-macrophage colony-stimulating factor-signal transducer and activator of transcription 3 (GM-CSF-STAT3) signalling. Genetic deletion of TREM2, clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9)-mediated knockout of sphingosine kinase 1/2 (SPHK1/2) in tumour cells, or pharmacological inhibition of S1P synthesis disrupts this protective lipid-immune circuit, sensitises TANs to ferroptosis and restricts tumour growth. Therapeutically, a peptide-based TREM2 inhibitor reprogrammes TANs, restores CD8+ T cell function and enhances anti-programmed cell death protein 1 (PD-1) immunotherapy efficacy. Clinically, TREM2+ polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are enriched in HCC tumours, correlate with SPHK1/2 expression and T cell dysfunction and associate with poor patient prognosis.

CONCLUSION: Our study uncovers the S1P-TREM2-NRF2 axis as a critical metabolic-immune circuit that preserves neutrophil survival and immunosuppressive function in HCC. Targeting this lipid-dependent ferroptosis resistance pathway offers a promising therapeutic strategy to overcome immunotherapy resistance in liver cancer.

PMID:42705697 | DOI:10.1136/gutjnl-2025-337414

  •  
  • ↗️
↗️

S1P-TREM2 axis protects immunosuppressive neutrophils from ferroptosis to promote tumour progression in hepatocellular carcinoma

✇(Multiomics OR Omics) AND (Pancreatic)
By: Jun Ma · Tong Wu · Diyu Chen · Can Zhu · Shanhe Huang · Keyi Du · Chuanhui Peng · Junru Chen · Yunhao Chen · Haiyang Xie · Feng Zhang · Jianzhong Chen · Shusen Zheng · Jian Wu

Gut. 2026 Sep 7:gutjnl-2025-337414. doi: 10.1136/gutjnl-2025-337414. Online ahead of print.

ABSTRACT

BACKGROUND: Neutrophils are increasingly recognised as immunosuppressive drivers of hepatocellular carcinoma (HCC), yet their persistence in the oxidative, lipid-rich tumour microenvironment remains poorly understood.

OBJECTIVE: To elucidate the metabolic and molecular programmes that enable tumour-associated neutrophils (TANs) to resist ferroptosis and sustain immunosuppression in HCC.

DESIGN: We employed human HCC samples, multiple murine HCC models, transcriptomic and lipidomic profiling, genetic loss-of-function systems and therapeutic interventions. Ferroptosis sensitivity, lipid metabolic rewiring and immunological consequences of TANs were systematically evaluated across models and validated in patient datasets and biospecimens.

RESULTS: TANs in human HCC and mouse models exhibit pronounced lipid accumulation and oxidative stress compared with peripheral neutrophils. Multi-omic profiling revealed that TANs are enriched for lipid-binding gene programmes and undergo rewiring towards sphingolipid and unsaturated fatty acid metabolism. We identified triggering receptor expressed on myeloid cells 2 (TREM2) as a key lipid-sensing receptor selectively expressed in TANs. Functional deletion of TREM2 reprogrammed the tumour immune microenvironment, restoring CD8+ T cell activity and suppressing HCC progression. Mechanistically, tumour-derived sphingosine-1-phosphate (S1P) activates TREM2, triggering nuclear factor erythroid 2-related factor 2 (NRF2)-mediated transcription of glutathione peroxidase 4 (GPX4) and solute carrier family 7 member 11 (SLC7A11), thereby promoting ferroptosis resistance. TREM2 expression is transcriptionally induced by granulocyte-macrophage colony-stimulating factor-signal transducer and activator of transcription 3 (GM-CSF-STAT3) signalling. Genetic deletion of TREM2, clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9)-mediated knockout of sphingosine kinase 1/2 (SPHK1/2) in tumour cells, or pharmacological inhibition of S1P synthesis disrupts this protective lipid-immune circuit, sensitises TANs to ferroptosis and restricts tumour growth. Therapeutically, a peptide-based TREM2 inhibitor reprogrammes TANs, restores CD8+ T cell function and enhances anti-programmed cell death protein 1 (PD-1) immunotherapy efficacy. Clinically, TREM2+ polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are enriched in HCC tumours, correlate with SPHK1/2 expression and T cell dysfunction and associate with poor patient prognosis.

CONCLUSION: Our study uncovers the S1P-TREM2-NRF2 axis as a critical metabolic-immune circuit that preserves neutrophil survival and immunosuppressive function in HCC. Targeting this lipid-dependent ferroptosis resistance pathway offers a promising therapeutic strategy to overcome immunotherapy resistance in liver cancer.

PMID:42705697 | DOI:10.1136/gutjnl-2025-337414

  •  
  • ↗️
↗️

LC-ERD: Mining Latent Logic for Self-Evolving Reasoning via Consistency-Regulated Reward Decomposition

✇cs.AI, q-bio.NC updates on arXiv.org
By: Yanyu Chen · Jiyue Jiang · Dianzhi Yu · Zheng Wu · Jiahong Liu · Jiaming Han · Xiao Guo · Jinhu Qi · Yu Li · Yifei Zhang · Irwin King
arXiv:2605.24005v1 Announce Type: new Abstract: The evolution of Large Language Model (LLM) reasoning is bottlenecked by the scarcity of high-quality process data. While self-alignment via endogenous rewards offers a solution, mining valid supervision faces three challenges: (1) Label Noise via Mimetic Bias, where rewards prioritize statistical likelihood over logical truth, creating a "correctness illusion" that masks compounding errors; (2) Coarse-Grained Supervision, where sparse global outcomes (e.g., in GRPO) fail to provide granular guidance, treating reasoning chains as monolithic; and (3) Distributional Collapse, where signals fail to generalize without amplifying pre-training biases. To address these, we introduce LC-ERD (Logic-Consistent Endogenous Reward Decomposition), a framework framing self-alignment as latent structure mining. We derive a Variational Logic Potential by aggregating consensus from the model's Latent Logic Expertise (LLE) to denoise the reasoning manifold, and introduce a Multi-Agent Value Decomposition protocol based on the IGM principle to quantify individual step utility. Experiments show LC-ERD delivers a robust self-evolution path, uncovering trade-offs between logic consistency and accuracy while identifying high-value reasoning patterns missed by standard rewards. Our code is available at https://github.com/Reinhardmannn/LC-ERD.
  •  
  • ↗️
↗️

STREAM: A Data-Centric Framework for Mining High-Value Task-Oriented Dialogues from Streaming Media

✇cs.AI, q-bio.NC updates on arXiv.org
By: Liang Xue · Haoyu Liu · Cheng Wang · Pengyu Chen · Haozhuo Zheng · Yang Liu
arXiv:2605.25162v1 Announce Type: cross Abstract: Large language models for vertical domains are bottlenecked by the scarcity of complex, domain-specific task-oriented dialogues. Existing data acquisition pipelines face a persistent trilemma: expert annotation is expensive, real-world service conversations are constrained by privacy and commercial restrictions, and static corpora quickly become temporally stale. We propose Stream, a data-centric framework that leverages publicly available streaming media (live streams and short videos) to synthesize high-value service dialogues at scale. Stream mines authentic interaction signals from noisy streams and synthesizes conversations by integrating role-grounded persona construction with Conversational Blueprint construction; it further adopts retrieval-augmented generation (RAG) to support knowledge-aware responses. Based on Stream, we release StreamDial, a large-scale multi-domain dataset covering Automotive, Restaurant, and Hotel. StreamDial contains 87,498 dialogue sessions and 1,497,320 turns in total, with an average of 17.11 turns per session and a comparable scale across domains. Each session is organized as a structured quadruplet $\langle P_u, P_a, B, H \rangle$ that pairs dialogue history with explicit user/agent personas and a Conversational Blueprint, capturing realistic service behaviors such as requirement mining, constraint conflicts, negotiation, and recovery. Evaluations with automatic judges and downstream tasks show that StreamDial improves intrinsic dialogue quality over strong baselines, and models trained with StreamDial improve Dialogue State Tracking across backbones; we further report a completed human-evaluation set and encouraging multilingual transfer on Qwen3-8B under a controlled training budget. The data is released in https://github.com/hitxueliang/DialogDataSetBySTREAM.
  •  
  • ↗️
↗️

Extreme Region Policy Distillation

✇cs.AI, q-bio.NC updates on arXiv.org
By: Changyu Chen · Xiting Wang · Rui Yan
arXiv:2605.25582v1 Announce Type: cross Abstract: Reinforcement learning for large language models faces a fundamental trade-off between sample efficiency and asymptotic performance: strictly on-policy methods discard trajectories after a single update, while off-policy reuse introduces distribution mismatch that existing trust-region techniques mitigate primarily by enforcing conservative optimization, often leaving rich training signals underutilized. To investigate this, we perform extensive off-policy updates on fixed data. Our experiments reveal that aggressive multi-step optimization brings rapid initial gains, but excessive updates cause trajectory probabilities to deviate and entropy to collapse, with performance plateauing early. Tightening KL constraints merely lowers the ceiling without resolving the degradation. This motivates Extreme Region Policy Distillation (ERPD), a two-stage framework that decouples sample efficiency from KL efficiency. The first stage performs weakly constrained off-policy optimization on fixed data to maximally extract training signals. The resulting policy provides token-level supervision. In the second stage, we distill these signals into the base policy under trust-region constraints, filtering harmful drift while preserving useful signals. The distilled policy achieves comparable or better performance with substantially smaller KL divergence, indicating that much of the first-stage divergence was spent on unnecessary drift rather than genuine improvement. Crucially, ERPD accommodates both strong and weak teachers: when aggressive optimization yields no stronger policy, even degenerate teachers provide effective supervision via alternative signal construction strategies. We validate ERPD on mathematical reasoning, showing gains for strong base models where on-policy training plateaus, and reliable improvements with weak teachers.
  •  
  • ↗️
↗️

OASIS: Observation-Action Space Alignment via SE(3) Trajectory Prediction for Robotic Manipulation

✇cs.AI, q-bio.NC updates on arXiv.org
By: Xinzhe Chen · Sihua Ren · Liqi Huang · Haowen Sun · Mingyang Li · Xingyu Chen · Zeyang Liu · Xuguang Lan
arXiv:2605.25829v1 Announce Type: cross Abstract: Recent vision-language-action (VLA) models and world action models (WAMs) advance robotic manipulation by enriching intermediate representations with auxiliary spatial features or future visual-state prediction. However, these representations largely remain within the observation space and do not share the rigid-body geometry of the action space, forcing the action decoder to implicitly recover this geometry. We propose OASIS, a visuomotor policy that aligns the intermediate representation with the action space via $SE(3)$ end-effector trajectory prediction. OASIS couples a 3D-aware feature encoder that fuses vision-language and metric-depth features with an $SE(3)$ trajectory predictor that produces a camera-frame end-effector trajectory. Conditioned on the predictor's pose-supervised hidden states, the action decoder generates action chunks consistent with rigid-body motion. Across simulation and real-world experiments, OASIS outperforms VLA and WAM baselines in success rate and out-of-distribution generalization. Our project page is available at https://npuhandsome.github.io/OASIS_web.
  •  
  • ↗️
↗️

PowerFlow: Unlocking the Dual Nature of LLMs via Principled Distribution Matching

✇cs.AI, q-bio.NC updates on arXiv.org
By: Ruishuo Chen · Yu Chen · Zhuoran Li · Longbo Huang
arXiv:2603.18363v2 Announce Type: replace-cross Abstract: Unsupervised Reinforcement Learning from Internal Feedback (RLIF) has emerged as a promising paradigm for eliciting the latent capabilities of Large Language Models (LLMs) without external supervision. However, current methods rely on heuristic intrinsic rewards, which often lack a well-defined theoretical optimization target and are prone to degenerative biases. In this work, we introduce PowerFlow, a principled framework that reformulates unsupervised fine-tuning as a distribution matching problem. By casting GFlowNet as an amortized variational sampler for unnormalized densities, we propose a length-aware Trajectory-Balance objective that explicitly neutralizes the structural length biases inherent in autoregressive generation. By targeting $\alpha$-power distributions, PowerFlow enables the directional elicitation of the dual nature of LLMs: sharpening the distribution ($\alpha > 1$) to intensify logical reasoning, or flattening it ($\alpha
  •  
  • ↗️
↗️

SURGE: Surrogate Gradient Adaptation in Binary Neural Networks

✇cs.AI, q-bio.NC updates on arXiv.org
By: Haoyu Huang · Boyu Liu · Linlin Yang · Yanjing Li · Yuguang Yang · Xuhui Liu · Canyu Chen · Zhongqian Fu · Baochang Zhang
arXiv:2605.10989v3 Announce Type: replace-cross Abstract: The training of Binary Neural Networks (BNNs) is fundamentally based on gradient approximation for non-differentiable binarization operations (e.g., sign function). However, prevailing methods including the Straight-Through Estimator (STE) and its improved variants, rely on hand-crafted designs that suffer from gradient mismatch problem and information loss induced by fixed-range gradient clipping. To address this, we propose SURrogate GradiEnt Adaptation (SURGE), a novel learnable gradient compensation framework with theoretical grounding. SURGE mitigates gradient mismatch through auxiliary backpropagation. Specifically, we design a Dual-Path Gradient Compensator (DPGC) that constructs a parallel full-precision auxiliary branch for each binarized layer, decoupling gradient flow via output decomposition during backpropagation. DPGC enables bias-reduced gradient estimation by leveraging the full-precision branch to estimate components beyond STE's first-order approximation. To further enhance training stability, we introduce an Adaptive Gradient Scaler (AGS) based on an optimal scale factor to dynamically balance inter-branch gradient contributions via norm-based scaling. Experiments on image classification, object detection, and language understanding tasks demonstrate that SURGE performs best over state-of-the-art methods.
  •  
  • ↗️
↗️

ClaimDiff-RL: Fine-Grained Caption Reinforcement Learning through Visual Claim Comparison

✇cs.AI, q-bio.NC updates on arXiv.org
By: Tianle Li · Xuyang Shen · Yan Ma · Rongxin Guo · Shaoxiang Chen · Jiacheng Chen · Haochen Wang · Hongyang Tang · Yucong Zhou · Yu Cheng
arXiv:2605.20278v2 Announce Type: replace-cross Abstract: Long-form image captioning exposes a reward granularity problem in RL: captions are judged as whole sequences, while the important errors occur at the level of individual visual claims. A good dense caption should be both faithful and informative, avoiding hallucination without omitting salient details. Yet pairwise preferences, reference-based metrics, and holistic scalar rewards compress these local errors into a single sequence-level signal, obscuring the tradeoff between factuality and coverage. We introduce ClaimDiff-RL, a framework that uses reference-conditioned atomic claim differences as the reward unit for caption RL. Given an image, an actor caption, and a reference caption, a multimodal judge enumerates visually grounded differences, verifies each difference against the image, assigns open-vocabulary error types and severity levels, and produces per-difference statistics for reward composition. This makes hallucinated claims and omitted salient facts separately measurable and tunable. Experiments show that holistic scalar rewards can reduce hallucination by increasing missing facts, while ClaimDiff-RL exposes this faithfulness and coverage tradeoff and enables more balanced operating points. On a 160-image human-labeled diagnostic benchmark, public captioning benchmarks, and VQA benchmarks, ClaimDiff-RL improves the hallucination--missing-fact balance, preserves general capability, and even surpasses Gemini-3-Pro-Preview on several fine-grained Capability dimensions such as object counting, spatial relations, and scene recognition. These results suggest that typed, verifiable claim differences are an effective reward unit for fine-grained and diagnosable caption RL.
  •  
  • ↗️
↗️

AnyMo: Geometry-Aware Setup-Agnostic Modeling of Human Motion in the Wild

✇cs.AI, q-bio.NC updates on arXiv.org
By: Baiyu Chen · Zechen Li · Wilson Wongso · Lihuan Li · Xiachong Lin · Hao Xue · Benjamin Tag · Flora Salim
arXiv:2605.22715v2 Announce Type: replace-cross Abstract: As wearable and mobile devices become increasingly embedded in daily life, they offer a practical way to continuously sense human motion in the wild. But inertial signals are highly dependent on the sensing setup, including body location, mounting position, sensor orientation, device hardware, and sampling protocol. This setup dependence makes it difficult to learn motion representations that transfer across devices and datasets, and limits the broader use of wearable IMUs beyond closed-set recognition. We introduce AnyMo, a geometry-aware framework for setup-agnostic human motion modeling. AnyMo uses physics-grounded IMU simulation over dense body-surface placements to generate diverse and plausible synthetic signals, pre-trains a graph encoder from paired synthetic placement views and masked partial observations, tokenizes multi-position IMU into full-body motion tokens, and aligns these tokens with an LLM for motion-language understanding. We evaluate AnyMo on three complementary tasks: zero-shot activity recognition across 14 unseen downstream datasets, cross-modal retrieval, and wearable IMU motion captioning, where it improves average Accuracy/F1/R@2 by 11.7\%/11.6\%/22.6\% on HAR, increases zero-shot IMU-to-text and text-to-IMU retrieval MRR by 15.9\% and 28.6\%, respectively, and improves zero-shot captioning BERT-F1 by 18.8\%. These results support AnyMo as a generalist model for wearable motion understanding in the wild. Project page: https://baiyuchen.com/project/AnyMo.
  •  
  • ↗️
↗️

SSDAU: Structured Semantic Data Augmentation for Joint Entity and Relation Extraction

✇cs.AI, q-bio.NC updates on arXiv.org
By: Jiawei He · Mengyu Shi · Jiawei Liu · Zhijie Wang · Chunrong Fang · Xikai Yang · Zhenyu Chen
arXiv:2605.23440v2 Announce Type: replace-cross Abstract: Joint Entity and Relation Extraction (JERE) is highly susceptible to weak generalization due to low-quality training data. Data augmentation is a common strategy to enhance model generalization across different domains. However, existing data augmentation methods often overlook text relevance and may disrupt semantic structures and dependencies, making it difficult to generate effective augmented data for improving model generalization. In this paper, we propose Structured Semantic Data Augmentation (SSDAU), a novel method designed to preserve the semantic structure of text during augmentation. SSDAU segments text based on entity labels and employs an encoder to capture semantic features of entities through context awareness. It then performs entity semantic restructuring to generate augmented data. To distinguish semantically similar entities, SSDAU fuses contextualized embeddings with traditional similarity scores. To mitigate potential topic ambiguity and information loss, we apply the BERTTopic model to filter out irrelevant topics, ensuring topic consistency. We evaluate SSDAU on datasets with different annotation types and compare its performance on five representative JERE models against seven popular data augmentation baselines. Experiments demonstrate that SSDAU generates semantically consistent data with superior robustness against ambiguity (8.26% F1 decrease vs. 31.91% for baselines), significantly outperforming all existing methods across all metrics.
  •  
  • ↗️
↗️

Multi-omics Analysis Reveals the Protection of a Quadruple Probiotic Mixture in Experimental Autoimmune Hepatitis

✇(Multiomics OR Omics) AND (Pancreatic)
By: Yu Chen · Shuhui Wang · Anzhuo Chen · Zhuoying Lin · Han Wang · Wanneng Li · Jun Liu · Jia Yao · Dean Tian · Yu Lei · Mei Liu

Probiotics Antimicrob Proteins. 2026 May 23. doi: 10.1007/s12602-026-11062-2. Online ahead of print.

ABSTRACT

Autoimmune hepatitis (AIH) is a chronic progressive inflammatory liver disease with a rising global incidence. The treatment of AIH remains challenging because first-line drugs show limited efficacy and systemic side effects. Gut microbiota plays a crucial role in the pathogenesis of AIH, leading to growing interest in developing probiotic-based therapies. In this study, we used multi-omics analysis to investigate the therapeutic effects of a quadruple probiotic mixture (Probiotic-quad) consisting of Bifidobacterium infantis, Lactobacillus acidophilus, Enterococcus faecalis, and Bacillus cereus in a well-established chronic AIH murine model. Our results showed that Probiotic-quad treatment significantly alleviated AIH progression, as evidenced by lower serum liver enzyme levels, ameliorated hepatic inflammatory infiltration and histopathological damage. Metagenomic sequencing results showed that gut dysbiosis in AIH mice was partially reversed after Probiotic-quad administration. Additionally, the integrity of the intestinal epithelial barrier was restored, accompanied by a reduction in serum lipopolysaccharide levels. Untargeted metabolomic and transcriptomic analysis revealed that Probiotic-quad treatment was linked to alterations in hepatic metabolism, including the citrate cycle and tryptophan metabolism, and was associated with reduced activation of the NF-κB and NOD-like receptor signaling pathways. These findings suggest that Probiotic-quad treatment ameliorates AIH severity and is potentially associated with changes in hepatic immune responses, metabolism, gut microbiota, and intestinal barrier function, highlighting its potential as an adjuvant therapy for AIH.

PMID:42176246 | DOI:10.1007/s12602-026-11062-2

  •  
  • ↗️
↗️

Child Vaccination Status and Behavioral and Social Drivers of Vaccination Among Their Caregivers in the Philippines: Cross-Sectional Survey Study Comparison of Household, Mobile, and Online Modes

✇Journal of Medical Internet Research
By: Kimberly E Bonner · Mikka Hipol · Dominique Sy · Rivandra Royono · Douglas Johnson · Isabel del Rosario · Alice Redfern · Darahlyn Biel-Romualdo · Man Kai Wong · Eugene Lam · Shibani Kulkarni · Kirsten Ward · Romel Lacson · Meng-Yu Chen · James Matthew Miraflor · Devon Ray Pacial · Rowena Bunoan · Hugo Catan · Talya Shragai
Background: The World Health Organization recommends that countries routinely collect data on the behavioral and social drivers (BeSD) of vaccination to inform public health interventions that increase vaccine uptake. There is a need to identify data collection methods that can rapidly and inexpensively collect representative data, particularly in low- and middle-income countries. Objective: This study aimed to understand BeSD drivers of vaccination in the Philippines and assess the trade-offs between survey methods. We compared responses to household, mobile, and online surveys in terms of demographics, vaccination status, responses to BeSD questions, and cost. Methods: We conducted concurrent household, mobile (SMS text messaging and interactive voice response), and online surveys among caregivers of children 2 years of age and below in Regions V and XII of the Philippines, with sampling differing by survey method. We assessed, for each survey method, (1) respondent demographics (sex, age, region, and socioeconomic status) and (2) the weighted proportion of responses from caregivers of children who received at least one dose of diphtheria-pertussis-tetanus (DPT)–containing vaccine. We estimated the weighted proportion of each BeSD survey response option and calculated the financial cost (monetary outlays) per survey response from an implementer’s perspective by summing the costs incurred in each survey method and dividing by the number of responses received. Results: We surveyed a total of 1201 household respondents, 2153 mobile respondents, and 398 online respondents from January to March 2025. We found that online and mobile survey respondents were more likely to be male and have completed high school than household survey respondents. The weighted proportion of respondents indicating that their child had received at least one dose of DPT vaccine was 91.8% (n=1090; 95% CI 90%‐93.3%) for the household survey, 90.3% (n=1853) for the mobile survey, and 85% (n=346) for the online survey. With regard to vaccine demand, more than 85% of respondents in each survey method indicated that vaccines are very important, very safe, supported by family, and that they knew where to bring a child for vaccination. More than 30% of mobile and online survey respondents indicated that it was not easy to pay for vaccination. The financial cost to conduct the survey per survey response was US $2.61 for the online survey, US $6.93 for the mobile survey, and US $29.38 for the household survey. Conclusions: In the Philippines, household, mobile, and online survey methods reached caregivers of children who were unvaccinated against DPT, and these proportions were similar across survey methods. BeSD responses indicated high vaccine demand and challenges in caregivers’ cost to access vaccination. Determining the most appropriate survey method depends on trade-offs between representativeness and costs. However, areas with strong connectivity and high mobile device ownership can consider mobile and online methods as a lower-cost alternative to rapidly collect BeSD data.
  •  
  • ↗️
↗️

Superconductivity and electronic structures of nickelate thin film superstructures

✇Nature - Issue - nature.com science feeds
By: Zihao Nie · Yueying Li · Wei Lv · Lizhi Xu · Zhicheng Jiang · Peng Fu · Guangdi Zhou · Wenhua Song · Yaqi Chen · Heng Wang · Haoliang Huang · Junhao Lin · Jin-Feng Jia · Dawei Shen · Peng Li · Qi-Kun Xue · Zhuoyu Chen

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10352-7

Engineered Ruddlesden–Popper nickelate superstructures show that specific Fermi surface features enable ambient-pressure superconductivity, linking structural configuration, electronic structure and superconducting behaviour. .
  •  
  • ↗️
❌