arXiv:2605.23966v1 Announce Type: cross Abstract: Optimization modeling serves as the pivotal bridge between natural-language problem descriptions and optimization solvers, and remains a cornerstone for bringing operations research (OR) into real-world decision making. Recent advances in large language models (LLMs) have driven significant progress in automatic optimization modeling. However, existing methods still lack explicit validation during the modeling process, allowing errors introduced in earlier stages to carry through the pipeline and ultimately reduce final modeling accuracy. To address this challenge, we introduce TriVAL, a tri-validation framework that performs explicit validation at three stages of automatic optimization modeling: semantic specification, mathematical formulation, and code generation. At each stage, TriVAL follows a construct-validate-revise loop that assesses the current result against stage-specific criteria and revises it when needed. This design helps identify and correct errors before they accumulate across stages, helping preserve faithfulness throughout the modeling process. To evaluate automatic optimization modeling on more challenging combinatorial problems, we further introduce NL4COP, a benchmark of 150 instances across 50 diverse problem types with more complex decision logic, more tightly coupled constraints, and more demanding modeling requirements than existing benchmarks. Experiments on NL4COP and established benchmarks show that TriVAL consistently outperforms state-ofthe-art methods, with the largest gains on the most challenging problems.

arXiv:2605.01284v2 Announce Type: replace-cross Abstract: Iterative Retrieval-Augmented Generation (iRAG) has emerged as a powerful paradigm for answering complex multi-hop questions by progressively retrieving and reasoning over external documents. However, current systems predominantly operate on parsed text, which creates two critical bottlenecks: (1) \textit{Coarse-grained attribution}, where users are burdened with manually locating evidence within lengthy documents based on vague text-level citations; and (2) \textit{Visual semantic loss}, where the conversion of visually rich documents (e.g., slides, PDFs with charts) into text discards spatial logic and layout cues essential for reasoning. To bridge this gap, we present \textbf{Chain of Evidence (CoE)}, a retriever-agnostic visual attribution framework that leverages Vision-Language Models to reason directly over screenshots of retrieved document candidates. CoE eliminates format-specific parsing and outputs precise bounding boxes, visualizing the complete reasoning chain within the retrieved candidate set. We evaluate CoE on two distinct benchmarks: \textbf{Wiki-CoE}, a large-scale dataset of structured web pages derived from 2WikiMultiHopQA, and \textbf{SlideVQA}, a challenging dataset of presentation slides featuring complex diagrams and free-form layouts. Experiments demonstrate that fine-tuned Qwen3-VL-8B-Instruct achieves robust performance, significantly outperforming text-based baselines in scenarios requiring visual layout understanding, while establishing a retriever-agnostic solution for pixel-level interpretable iRAG. Our code is available at https://github.com/PeiYangLiu/CoE.git.

Nature Cancer, Published online: 25 May 2026; doi:10.1038/s43018-026-01165-8

In this phase 2 trial, Perez et al. reported the safety of the vitamin D receptor agonist paricalcitol with gemcitabine and nab-paclitaxel in patients with metastatic pancreatic ductal adenocarcinoma and the pharmacodynamic effects of paricalcitol in fibroblasts and immune cells.

arXiv:2504.19959v4 Announce Type: cross Abstract: Verification presents a major bottleneck in Integrated Circuit (IC) development, consuming nearly 70% of the total development effort. While the Universal Verification Methodology (UVM) is widely used in industry to improve verification efficiency through structured and reusable testbenches, constructing these testbenches and generating sufficient stimuli remain challenging. These challenges arise from the considerable manual coding effort required, repetitive manual execution of multiple EDA tools, and the need for in-depth domain expertise to navigate complex designs.Here, we present UVM^2, an automated verification framework that leverages Large Language Models (LLMs) to generate UVM testbenches and iteratively refine them using coverage feedback, significantly reducing manual effort while maintaining rigorous verification standards.To evaluate UVM^2, we introduce a benchmark suite comprising Register Transfer Level (RTL) designs of up to 1.6K lines of code.The results show that UVM^2 reduces testbench setup time by up to UVM^2 compared to experienced engineers, and achieve average code and function coverage of 87.44% and 89.58%, outperforming state-of-the-art solutions by 20.96% and 23.51%, respectively.

arXiv:2604.04804v1 Announce Type: cross Abstract: Learning from experience is critical for building capable large language model (LLM) agents, yet prevailing self-evolving paradigms remain inefficient: agents learn in isolation, repeatedly rediscover similar behaviors from limited experience, resulting in redundant exploration and poor generalization. To address this problem, we propose SkillX, a fully automated framework for constructing a \textbf{plug-and-play skill knowledge base} that can be reused across agents and environments. SkillX operates through a fully automated pipeline built on three synergistic innovations: \textit{(i) Multi-Level Skills Design}, which distills raw trajectories into three-tiered hierarchy of strategic plans, functional skills, and atomic skills; \textit{(ii) Iterative Skills Refinement}, which automatically revises skills based on execution feedback to continuously improve library quality; and \textit{(iii) Exploratory Skills Expansion}, which proactively generates and validates novel skills to expand coverage beyond seed training data. Using a strong backbone agent (GLM-4.6), we automatically build a reusable skill library and evaluate its transferability on challenging long-horizon, user-interactive benchmarks, including AppWorld, BFCL-v3, and $\tau^2$-Bench. Experiments show that SkillKB consistently improves task success and execution efficiency when plugged into weaker base agents, highlighting the importance of structured, hierarchical experience representations for generalizable agent learning. Our code will be publicly available soon at https://github.com/zjunlp/SkillX.

arXiv:2603.22911v1 Announce Type: cross Abstract: Due to the great saving of computation and memory overhead, token compression has become a research hot-spot for MLLMs and achieved remarkable progress in image-language tasks. However, for the video, existing methods still fall short of high-ratio token compression. We attribute this shortcoming to the insufficient modeling of temporal and continual video content, and propose a novel and training-free token pruning method for video MLLMs, termed ForestPrune, which achieves effective and high-ratio pruning via Spatial-temporal Forest Modeling. In practice, ForestPrune construct token forests across video frames based on the semantic, spatial and temporal constraints, making an overall comprehension of videos. Afterwards, ForestPrune evaluates the importance of token trees and nodes based on tree depth and node roles, thereby obtaining a globally optimal pruning decision. To validate ForestPrune, we apply it to two representative video MLLMs, namely LLaVA-Video and LLaVA-OneVision, and conduct extensive experiments on a bunch of video benchmarks. The experimental results not only show the great effectiveness for video MLLMs, e.g., retaining 95.8% average accuracy while reducing 90% tokens for LLaVA-OneVision, but also show its superior performance and efficiency than the compared token compression methods, e.g., +10.1% accuracy on MLVU and -81.4% pruning time than FrameFusion on LLaVA-Video.

Nature Cancer, Published online: 25 March 2026; doi:10.1038/s43018-026-01136-z

Czernilofsky et al. identified factors that reprogram stromal cells into an inflammatory, dysfunctional state, leading to the structural disorganization of lymph nodes in B cell lymphoma at single-cell and spatial resolutions.

Oncogene, Published online: 24 March 2026; doi:10.1038/s41388-026-03728-6

TRIM21-mediated degradation of HILPDA overcomes anti-PD-1 immunotherapy resistance in breast cancer by limiting PD-L1 palmitoylation

Nature, Published online: 16 March 2026; doi:10.1038/s41586-026-10372-3

Direct conversion from alkenes to alkynes

arXiv:2509.08612v3 Announce Type: replace-cross Abstract: Aspect-based sentiment analysis (ABSA) aims to identify aspect terms and determine their sentiment polarity. While dependency trees combined with contextual semantics provide structural cues, existing approaches often rely on dot-product similarity and fixed graphs, which limit their ability to capture nonlinear associations and adapt to noisy contexts. To address these limitations, we propose the Optimal Transport-Enhanced Syntactic-Semantic Graph Network (OTESGN), a model that jointly integrates structural and distributional signals. Specifically, a Syntactic Graph-Aware Attention module models global dependencies with syntax-guided masking, while a Semantic Optimal Transport Attention module formulates aspect-opinion association as a distribution matching problem solved via the Sinkhorn algorithm. An Adaptive Attention Fusion mechanism balances heterogeneous features, and contrastive regularization enhances robustness. Extensive experiments on three benchmark datasets (Rest14, Laptop14, and Twitter) demonstrate that OTESGN delivers state-of-the-art performance. Notably, it surpasses competitive baselines by up to +1.30 Macro-F1 on Laptop14 and +1.01 on Twitter. Ablation studies and visualization analyses further highlight OTESGN's ability to capture fine-grained sentiment associations and suppress noise from irrelevant context.

arXiv:2603.03739v1 Announce Type: cross Abstract: Multimodal large language models (MLLMs) have advanced zero-shot end-to-end Vision-Language Navigation (VLN), yet robust navigation requires not only semantic understanding but also predictive modeling of environment dynamics and spatial structure. We propose PROSPECT, a unified streaming navigation agent that couples a streaming Vision-Language-Action (VLA) policy with latent predictive representation learning. PROSPECT uses CUT3R as a streaming 3D foundation spatial encoder to produce long-context, absolute-scale spatial features, and fuses them with SigLIP semantic features via cross-attention. During training, we introduce learnable stream query tokens that query the streaming context and predict next-step 2D and 3D latent features (rather than pixels or explicit modalities), supervised in the latent spaces of frozen SigLIP and CUT3R teachers. The predictive branch shapes internal representations without inference overhead. Experiments on VLN-CE benchmarks and real-robot deployment demonstrate state-of-the-art performance and improved long-horizon robustness under diverse lighting. We will release code for the community soon.

arXiv:2602.14010v1 Announce Type: cross Abstract: Pathology foundation models (PFMs) have enabled robust generalization in computational pathology through large-scale datasets and expansive architectures, but their substantial computational cost, particularly for gigapixel whole slide images, limits clinical accessibility and scalability. Here, we present LitePath, a deployment-friendly foundational framework designed to mitigate model over-parameterization and patch level redundancy. LitePath integrates LiteFM, a compact model distilled from three large PFMs (Virchow2, H-Optimus-1 and UNI2) using 190 million patches, and the Adaptive Patch Selector (APS), a lightweight component for task-specific patch selection. The framework reduces model parameters by 28x and lowers FLOPs by 403.5x relative to Virchow2, enabling deployment on low-power edge hardware such as the NVIDIA Jetson Orin Nano Super. On this device, LitePath processes 208 slides per hour, 104.5x faster than Virchow2, and consumes 0.36 kWh per 3,000 slides, 171x lower than Virchow2 on an RTX3090 GPU. We validated accuracy using 37 cohorts across four organs and 26 tasks (26 internal, 9 external, and 2 prospective), comprising 15,672 slides from 9,808 patients disjoint from the pretraining data. LitePath ranks second among 19 evaluated models and outperforms larger models including H-Optimus-1, mSTAR, UNI2 and GPFM, while retaining 99.71% of the AUC of Virchow2 on average. To quantify the balance between accuracy and efficiency, we propose the Deployability Score (D-Score), defined as the weighted geometric mean of normalized AUC and normalized FLOP, where LitePath achieves the highest value, surpassing Virchow2 by 10.64%. These results demonstrate that LitePath enables rapid, cost-effective and energy-efficient pathology image analysis on accessible hardware while maintaining accuracy comparable to state-of-the-art PFMs and reducing the carbon footprint of AI deployment.