arXiv:2605.24171v1 Announce Type: cross Abstract: Large language models are increasingly used for vulnerability detection, yet their reliability under different prompt formulations remains uncharacterized. We present PromptAudit, a controlled evaluation framework that isolates prompt effects by fixing the dataset, decoding, and parsing while varying only the prompting strategy. Using five prompting strategies across five open-weight models on 1,000 CVEs (6,074 code samples spanning 16 programming languages), we evaluate accuracy, recall, abstention, coverage, and effective F1. We find that standard chain-of-thought prompting achieves the strongest overall operational performance, while few-shot prompting provides model-dependent benefits that are most pronounced for prompt-sensitive models. In contrast, adaptive chain-of-thought frequently suppresses recall and self-consistency induces excessive abstention, sharply reducing effective performance. These results show that vulnerability detection behavior is jointly determined by the model and the prompt, and that prompt sensitivity is a first-class system property that must be explicitly characterized in evaluation and deployment.

Opposing oncogenic and tumor-suppressive forces establish a progenitor-like state that builds a self-reinforcing niche to drive benign-to-malignant transition in pancreatic cancer models. Disruption of p53 activity or KRAS inhibits malignancy by collapsing the niche.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10377-y

A human spatial atlas of gene expression in liver based on live donors shows marked porto–central zonation of hepatocytes and non-parenchymal cells, and transcriptomic changes in early steatosis.

Synergizing with senescence-inducing therapies, uPAR CAR T cells eradicate primary and metastatic solid tumors with minimal myelodepletion by targeting both tumor cells and the stroma in preclinical models.

arXiv:2505.17087v2 Announce Type: replace-cross Abstract: This chapter explores the evolution, classification, and health implications of food processing, while emphasizing the transformative role of machine learning, artificial intelligence (AI), and data science in advancing food informatics. It begins with a historical overview and a critical review of traditional classification frameworks such as NOVA, Nutri-Score, and SIGA, highlighting their strengths and limitations, particularly the subjectivity and reproducibility challenges that hinder epidemiological research and public policy. To address these issues, the chapter presents novel computational approaches, including FoodProX, a random forest model trained on nutrient composition data to infer processing levels and generate a continuous FPro score. It also explores how large language models like BERT and BioBERT can semantically embed food descriptions and ingredient lists for predictive tasks, even in the presence of missing data. A key contribution of the chapter is a novel case study using the Open Food Facts database, showcasing how multimodal AI models can integrate structured and unstructured data to classify foods at scale, offering a new paradigm for food processing assessment in public health and research.

arXiv:2603.27817v2 Announce Type: replace-cross Abstract: Street-level imagery contains personally identifiable information (PII), some of which is context-dependent. Existing anonymization methods either over-process images or miss subtle identifiers, while API-based solutions compromise data sovereignty. We present an agentic framework CAIAMAR (\underline{C}ontext-\underline{A}ware \underline{I}mage \underline{A}nonymization with \underline{M}ulti-\underline{A}gent \underline{R}easoning) for context-aware PII segmentation with diffusion-based anonymization, combining pre-defined processing for high-confidence cases with multi-agent reasoning for indirect identifiers. Three specialized agents coordinate via round-robin speaker selection in a Plan-Do-Check-Act (PDCA) cycle, enabling large vision-language models to classify PII based on spatial context (private vs. public property) rather than rigid category rules. The agents implement spatially-filtered coarse-to-fine detection where a scout-and-zoom strategy identifies candidates, open-vocabulary segmentation processes localized crops, and $IoU$-based deduplication ($30\%$ threshold) prevents redundant processing. Modal-specific diffusion guidance with appearance decorrelation substantially reduces re-identification (Re-ID) risks. On CUHK03-NP, our method reduces person Re-ID risk by $73\%$ ($R1$: $16.9\%$ vs. $62.4\%$ baseline). For image quality preservation on CityScapes, we achieve KID: $0.001$, and FID: $9.1$, significantly outperforming existing anonymization. The agentic workflow detects non-direct PII instances across object categories, and downstream semantic segmentation is preserved. Operating entirely on-premise with open-source models, the framework generates human-interpretable audit trails supporting EU's GDPR transparency requirements while flagging failed cases for human review.

MicrobeAtlas (www.microbeatlas.org) is an integrated, reference-based resource for truly planet-wide microbiomics, analyzing hundreds of thousands of microbial lineages across diverse environments, conditions, and technologies.

arXiv:2603.29852v1 Announce Type: cross Abstract: We introduce VectorGym, a comprehensive benchmark suite for Scalable Vector Graphics (SVG) that spans generation from text and sketches, complex editing, and visual understanding. VectorGym addresses the lack of realistic, challenging benchmarks aligned with professional design workflows. Our benchmark comprises four tasks with expert human-authored annotations: the novel Sketch2SVG task (VG-Sketch); a new SVG editing dataset (VG-Edit) featuring complex, multi-step edits with higher-order primitives; Text2SVG generation (VG-Text); and SVG captioning (VG-Cap). Unlike prior benchmarks that rely on synthetic edits, VectorGym provides gold-standard human annotations that require semantic understanding and design intent. We also propose a multi-task reinforcement learning approach that jointly optimizes across all four tasks using rendering-based rewards. Our method, built on GRPO with curriculum learning, trains a Qwen3-VL 8B model that achieves state-of-the-art performance among open-source models, surpassing much larger models including Qwen3-VL 235B and matching GPT-4o. We also introduce a VLM-as-a-Judge metric for SVG generation, validated through human correlation studies. Our evaluation of frontier VLMs reveals significant performance gaps, positioning VectorGym as a rigorous framework for advancing visual code generation. VectorGym is publicly available on huggingface.co/datasets/ServiceNow/VectorGym.

Nature Medicine, Published online: 25 March 2026; doi:10.1038/s41591-026-04299-5

Results of the phase 2 POLAR trial show that biomarker-guided treatment in patients with metastatic pancreatic cancer based on homologous repair deficiency leads to encouraging clinical response rates in immune cell-infiltrated tumors.

Nature, Published online: 06 March 2026; doi:10.1038/d41586-026-00526-8

Disaggregating data by sex is a powerful way to help develop better diagnostics and treatments for women — but researchers say it’s not used enough.

arXiv:2510.05598v2 Announce Type: replace-cross Abstract: Recent agent-based recommendation frameworks aim to simulate user behaviors by incorporating memory mechanisms and prompting strategies, but they struggle with hallucinating non-existent items and full-catalog ranking. Besides, a largely underexplored opportunity lies in leveraging LLMs'commonsense reasoning to capture user intent through substitute and complement relationships between items, which are usually implicit in datasets and difficult for traditional ID-based recommenders to capture. In this work, we propose a novel LLM-agent framework, AgenDR, which bridges LLM reasoning with scalable recommendation tools. Our approach delegates full-ranking tasks to traditional models while utilizing LLMs to (i) integrate multiple recommendation outputs based on personalized tool suitability and (ii) reason over substitute and complement relationships grounded in user history. This design mitigates hallucination, scales to large catalogs, and enhances recommendation relevance through relational reasoning. Through extensive experiments on three public grocery datasets, we show that our framework achieves superior full-ranking performance, yielding on average a twofold improvement over its underlying tools. We also introduce a new LLM-based evaluation metric that jointly measures semantic alignment and ranking correctness.

arXiv:2601.17074v2 Announce Type: replace-cross Abstract: The accurate estimation of Arctic snow depth remains a critical time-varying inverse problem due to the extreme scarcity and noise inherent in associated sea ice parameters. Existing process-based and data-driven models are either highly sensitive to sparse data or lack the physical interpretability required for climate-critical applications. To address this gap, we introduce PhysE-Inv, a novel framework that integrates a sophisticated sequential architecture, an LSTM Encoder-Decoder with Multi-head Attention and physics-guided contrastive learning, with physics-guided inference.Our core innovation lies in a surjective, physics-constrained inversion methodology. This methodology first leverages the hydrostatic balance forward model as a target-formulation proxy, enabling effective learning in the absence of direct $h_s$ ground truth; second, it uses reconstruction physics regularization over a latent space to dynamically discover hidden physical parameters from noisy, incomplete time-series input. Evaluated against state-of-the-art baselines, PhysE-Inv significantly improves prediction performance, reducing error by 20\% while demonstrating superior physical consistency and resilience to data sparsity compared to empirical methods. This approach pioneers a path for noise-tolerant, interpretable inverse modeling, with wide applicability in geospatial and cryospheric domains.

arXiv:2602.14049v1 Announce Type: cross Abstract: Spatio-temporal traffic forecasting is a core component of intelligent transportation systems, supporting various downstream tasks such as signal control and network-level traffic management. In real-world deployments, forecasting models must operate under structural and observational uncertainties, conditions that are rarely considered in model design. Recent approaches achieve strong short-term predictive performance by tightly coupling spatial and temporal modeling, often at the cost of increased complexity and limited modularity. In contrast, efficient time-series models capture long-range temporal dependencies without relying on explicit network structure. We propose UniST-Pred, a unified spatio-temporal forecasting framework that first decouples temporal modeling from spatial representation learning, then integrates both through adaptive representation-level fusion. To assess robustness of the proposed approach, we construct a dataset based on an agent-based, microscopic traffic simulator (MATSim) and evaluate UniST-Pred under severe network disconnection scenarios. Additionally, we benchmark UniST-Pred on standard traffic prediction datasets, demonstrating its competitive performance against existing well-established models despite a lightweight design. The results illustrate that UniST-Pred maintains strong predictive performance across both real-world and simulated datasets, while also yielding interpretable spatio-temporal representations under infrastructure disruptions. The source code and the generated dataset are available at https://anonymous.4open.science/r/UniST-Pred-EF27