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OASES: Outcome-Aligned Search-Evaluation Co-Training for Agentic Search
UniToolCall: Unifying Tool-Use Representation, Data, and Evaluation for LLM Agents
Dynamic microbiome-host interactions and their associations with systemic metabolism and radiological characteristics during early lung adenocarcinoma
NPJ Precis Oncol. 2026 May 12;10(1):284. doi: 10.1038/s41698-026-01471-5.
ABSTRACT
Lung adenocarcinoma (LUAD) accounts for approximately 40% of non-small cell lung cancer. Although the microbiome may play a role in LUAD, a comprehensive understanding of its ecological landscape and interactions with the tumor host, particularly during early development of LUAD, remains lacking. Here we employed a multi-omic approach to assess the dynamics of the tumor microbiota-host interaction across stages of early LUAD, including benign nodules, adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma (IAC). We found a strong and intricate interaction between the microbiome and host immune and metabolic pathways in AIS, while microbiome-host interactions substantially diminish in MIA and IAC. Serum metabolites and CT-based radiological features, such as atropaldehyde, sterculic acid, nodule morphology and maximum nodule diameter, were closely associated with the microbiome-host interaction network, suggesting they could be non-invasive markers indicating tumor ecological and pathological changes. Multi-omic integration revealed an optimal performance in classifying individual LUAD stages, particularly between AIS and MIA that was otherwise challenging to differentiate using a single data type. Our results highlight the dynamic interaction between microbiome and host during early LUAD, which can be partially reflected in systemic metabolic and radiological manifestations, providing a novel framework for understanding early-stage LUAD.
PMID:42120518 | PMC:PMC13388699 | DOI:10.1038/s41698-026-01471-5
Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson’s disease models
PRAISE: Prefix-Based Rollout Reuse in Agentic Search Training
Robust Embodied Perception in Dynamic Environments via Disentangled Weight Fusion
ActionParty: Multi-Subject Action Binding in Generative Video Games
QuestA: Expanding Reasoning Capacity in LLMs via Question Augmentation
Precipitation observing network gaps limit climate change impact assessment
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10300-5
At present, only 13.4% of the global land surface meets the World Meteorological Organization requirements for annual precipitation monitoring.