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OneLA: Scaling Linear-Attention Decoding to Large Beams in Generative Recommendation
CircRHBDD1(4,5) drives malignant progression of oral squamous cell carcinoma by enhancing DKK1 mRNA stability through facilitating m<sup>6</sup>A-dependent IGF2BP2 binding
Oncogene, Published online: 11 September 2026; doi:10.1038/s41388-026-03986-4
CircRHBDD1(4,5) drives malignant progression of oral squamous cell carcinoma by enhancing DKK1 mRNA stability through facilitating m6A-dependent IGF2BP2 bindingGrounded Continuation: A Linear-Time Runtime Verifier for LLM Conversations
Targeting KRAS reprograms a Treg-dominant immunosuppressive microenvironment and sensitizes KRAS-mutant gastric adenocarcinoma to CTLA-4 immunotherapy
Sci China Life Sci. 2026 Sep 3. doi: 10.1007/s11427-026-3438-4. Online ahead of print.
ABSTRACT
Oncogenic KRAS mutations define a distinct molecular subset of gastric adenocarcinoma (GA), yet their impact on the tumor immune microenvironment remains incompletely understood. In this study, we established a genetically faithful and immunocompetent KRASG12D-driven mouse model of GA, together with matched organoids and cell lines, to investigate how oncogenic KRAS shapes tumor-immune interactions. KRAS-mutant tumors consistently developed an immunosuppressive microenvironment characterized by enrichment of regulatory T cells (Tregs), accompanied by reduced cytotoxic lymphocyte infiltration and intrinsic resistance to PD-1 blockade. Although pharmacologic targeting of KRAS effectively suppressed tumor growth and increased immune cell infiltration, functional immune analyses revealed persistent Treg-mediated immunosuppression that limited effective antitumor immunity. Mechanistically, TGF-β signaling was required to maintain Treg dominance and suppress effector T cell function in KRAS-driven tumors. Importantly, disruption of this suppressive axis through combined KRAS inhibition and CTLA-4 blockade attenuated TGF-β activity, impaired Treg function, and enhanced antitumor immune responses in vivo. Collectively, these findings identify oncogenic KRAS as a key regulator of TGF-β-dependent immune suppression in GA and provide mechanistic insight into immune evasion within this molecular subtype.
PMID:42714795 | DOI:10.1007/s11427-026-3438-4
CUA-Gym: Scaling Verifiable Training Environments and Tasks for Computer-Use Agents
Nano World Models: A Minimalist Implementation of Future Video Prediction
Adversarial Error Correction for Visual Autoregressive Generation
Hide to Guide: Learning via Semantic Masking
Multi-Objective Learning for Diffusion Models: A Statistical Theory under Semi-Supervised Learning
SAMark: A Self-Anchored Text Watermarking with Paragraph-Level Paraphrase Robustness
Why Your Deep Research Agent Fails? On Hallucination Evaluation in Full Research Trajectory
OASES: Outcome-Aligned Search-Evaluation Co-Training for Agentic Search
EditCaption: Human-Refined SFT and HAE-DPO for Image Editing Instruction Synthesis
From Muscle Bursts to Motor Intent: Self-Supervised Token Modeling for Heterogeneous EMG
Action with Visual Primitives
Fetal monitoring for high-risk pregnancies using a wearable ultrasound patch
Nature Biotechnology, Published online: 26 May 2026; doi:10.1038/s41587-026-03140-1
A wearable ultrasound device is optimized for continuous monitoring of pregnancies.GPX8<sup>+</sup> cancer-associated fibroblast-derived lactate contributes to lenvatinib resistance by facilitating BRPF1 expression through histone H3 lysine 18 lactylation in hepatocellular carcinoma
Oncogene, Published online: 22 May 2026; doi:10.1038/s41388-026-03711-1
GPX8+ cancer-associated fibroblast-derived lactate contributes to lenvatinib resistance by facilitating BRPF1 expression through histone H3 lysine 18 lactylation in hepatocellular carcinomaEBV strain interacts with host HLA to drive nasopharyngeal carcinoma risk
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10416-8
A genome-to-genome association study identifies host and viral risk factors that interact to drive nasopharyngeal carcinoma endemicity in southern China.Composable neural emulators accelerate thermoelectric generator design
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10223-1
A composable neural network emulator is described for speeding up thermoelectric generator design, demonstrating the ability to predict generator performance with >99% accuracy while taking only 0.01% of the time compared with commercial finite-element solvers.