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Cryo-SWAN: the Multi-Scale Wavelet-decomposition-inspired Autoencoder Network for molecular density representation of molecular volumes

arXiv:2603.03342v1 Announce Type: cross Abstract: Learning robust representations of 3D shapes from voxelized data is essential for advancing AI methods in biomedical imaging. However, most contemporary 3D computer vision approaches operate on point clouds, meshes, or octrees, while volumetric density maps, the native format of structural biology and cryo-EM, remain comparatively underexplored. We present Cryo-SWAN, a voxel-based variational autoencoder inspired by multi-scale wavelet decomposition. The model performs conditional coarse-to-fine latent encoding and recursive residual quantization across perception scales, enabling accurate capture of both global geometry and high-frequency structural detail in molecular density volumes. Evaluated on ModelNet40, BuildingNet, and a newly curated dataset of cryo-EM volumes, ProteinNet3D, Cryo-SWAN consistently improves reconstruction quality over state-of-the-art 3D autoencoders. We demonstrate that the molecular densities organize in learned latent space according to shared geometric features, while integration with diffusion models enables denoising and conditional shape generation. Together, Cryo-SWAN is a practical framework for data-driven structural biology and volumetric imaging.
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Field imaging framework for morphological characterization of aggregates with computer vision: Algorithms and applications

arXiv:2603.03654v1 Announce Type: cross Abstract: Construction aggregates, including sand and gravel, crushed stone and riprap, are the core building blocks of the construction industry. State-of-the-practice characterization methods mainly relies on visual inspection and manual measurement. State-of-the-art aggregate imaging methods have limitations that are only applicable to regular-sized aggregates under well-controlled conditions. This dissertation addresses these major challenges by developing a field imaging framework for the morphological characterization of aggregates as a multi-scenario solution. For individual and non-overlapping aggregates, a field imaging system was designed and the associated segmentation and volume estimation algorithms were developed. For 2D image analyses of aggregates in stockpiles, an automated 2D instance segmentation and morphological analysis approach was established. For 3D point cloud analyses of aggregate stockpiles, an integrated 3D Reconstruction-Segmentation-Completion (RSC-3D) approach was established: 3D reconstruction procedures from multi-view images, 3D stockpile instance segmentation, and 3D shape completion to predict the unseen sides. First, a 3D reconstruction procedure was developed to obtain high-fidelity 3D models of collected aggregate samples, based on which a 3D aggregate particle library was constructed. Next, two datasets were derived from the 3D particle library for 3D learning: a synthetic dataset of aggregate stockpiles with ground-truth instance labels, and a dataset of partial-complete shape pairs, developed with varying-view raycasting schemes. A state-of-the-art 3D instance segmentation network and a 3D shape completion network were trained on the datasets, respectively. The application of the integrated approach was demonstrated on real stockpiles and validated with ground-truth, showing good performance in capturing and predicting the unseen sides of aggregates.
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Proceedings for the Inaugural Meeting of the International Society for Tractography -- IST 2025 Bordeaux

arXiv:2602.12410v2 Announce Type: replace-cross Abstract: This collection comprises the abstracts presented during poster, power pitch and oral sessions at the Inaugural Conference of the International Society for Tractography (IST Conference 2025), held in Bordeaux, France, from October 13-16, 2025. The conference was designed to foster meaningful exchange and collaboration between disparate fields. The overall focus was on advancing research, innovation, and community in the common fields of interest: neuroanatomy, tractography methods and scientific/clinical applications of tractography. The included abstracts cover the latest advancements in tractography, Diffusion MRI, and related fields including new work on; neurological and psychiatric disorders, deep brain stimulation targeting, and brain development. This landmark event brought together world-leading experts to discuss critical challenges and chart the future direction of the field.
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MedXIAOHE: A Comprehensive Recipe for Building Medical MLLMs

arXiv:2602.12705v3 Announce Type: replace-cross Abstract: We present MedXIAOHE, a medical vision-language foundation model designed to advance general-purpose medical understanding and reasoning in real-world clinical applications. MedXIAOHE achieves state-of-the-art performance across diverse medical benchmarks and surpasses leading closed-source multimodal systems on multiple capabilities. To achieve this, we propose an entity-aware continual pretraining framework that organizes heterogeneous medical corpora to broaden knowledge coverage and reduce long-tail gaps (e.g., rare diseases). For medical expert-level reasoning and interaction, MedXIAOHE incorporates diverse medical reasoning patterns via reinforcement learning and tool-augmented agentic training, enabling multi-step diagnostic reasoning with verifiable decision traces. To improve reliability in real-world use, MedXIAOHE integrates user-preference rubrics, evidence-grounded reasoning, and low-hallucination long-form report generation, with improved adherence to medical instructions. We release this report to document our practical design choices, scaling insights, and evaluation framework, hoping to inspire further research.
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