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Multifaceted Scenario-Aware Hypergraph Learning for Next POI Recommendation

arXiv:2601.11610v2 Announce Type: replace-cross Abstract: Among the diverse services provided by Location-Based Social Networks (LBSNs), Next Point-of-Interest (POI) recommendation plays a crucial role in inferring user preferences from historical check-in trajectories. However, existing sequential and graph-based methods frequently neglect significant mobility variations across distinct contextual scenarios (e.g., tourists versus locals). This oversight results in suboptimal performance due to two fundamental limitations: the inability to capture scenario-specific features and the failure to resolve inherent inter-scenario conflicts. To overcome these limitations, we propose the Multifaceted Scenario-Aware Hypergraph Learning method (MSAHG), a framework that adopts a scenario-splitting paradigm for next POI recommendation. Our main contributions are: (1) Construction of scenario-specific, multi-view disentangled sub-hypergraphs to capture distinct mobility patterns; (2) A parameter-splitting mechanism to adaptively resolve conflicting optimization directions across scenarios while preserving generalization capability. Extensive experiments on three real-world datasets demonstrate that MSAHG consistently outperforms five state-of-the-art methods across diverse scenarios, confirming its effectiveness in multi-scenario POI recommendation.
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TRIM27-controlled endothelium-derived exosomes play a central role in podocyte injury in diabetic kidney disease

Cell Death Discovery, Published online: 07 March 2026; doi:10.1038/s41420-026-02953-y

TRIM27-controlled endothelium-derived exosomes play a central role in podocyte injury in diabetic kidney disease
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<i>KRAS</i>-extrachromosomal DNA drives intratumoral heterogeneity in gastric cancer

Oncogene, Published online: 05 March 2026; doi:10.1038/s41388-026-03713-z

KRAS-extrachromosomal DNA drives intratumoral heterogeneity in gastric cancer
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