arXiv:2603.06636v1 Announce Type: cross Abstract: Due to the strong context-awareness capabilities demonstrated by large language models (LLMs), recent research has begun exploring their integration into smart home assistants to help users manage and adjust their living environments. While LLMs have been shown to effectively understand user needs and provide appropriate responses, most existing studies primarily focus on interpreting and executing user behaviors or instructions. However, a critical function of smart home assistants is the ability to detect when the home environment is in an anomalous state. This involves two key requirements: the LLM must accurately determine whether an anomalous condition is present, and provide either a clear explanation or actionable suggestions. To enhance the anomaly detection capabilities of next-generation LLM-based smart home assistants, we introduce SmartBench, which is the first smart home dataset designed for LLMs, containing both normal and anomalous device states as well as normal and anomalous device state transition contexts. We evaluate 13 mainstream LLMs on this benchmark. The experimental results show that most state-of-the-art models cannot achieve good anomaly detection performance. For example, Claude-Sonnet-4.5 achieves only 66.1% detection accuracy on context-independent anomaly categories, and performs even worse on context-dependent anomalies, with an accuracy of only 57.8%. More experimental results suggest that next-generation LLM-based smart home assistants are still far from being able to effectively detect and handle anomalous conditions in the smart home environment. Our dataset is publicly available at https://github.com/horizonsinzqs/SmartBench.

arXiv:2603.06748v1 Announce Type: cross Abstract: Protein sequence design must balance designability, defined as the ability to recover a target backbone, with multiple, often competing, developability properties such as solubility, thermostability, and expression. Existing approaches address these properties through post hoc mutation, inference-time biasing, or retraining on property-specific subsets, yet they are target dependent and demand substantial domain expertise or careful hyperparameter tuning. In this paper, we introduce ProtAlign, a multi-objective preference alignment framework that fine-tunes pretrained inverse folding models to satisfy diverse developability objectives while preserving structural fidelity. ProtAlign employs a semi-online Direct Preference Optimization strategy with a flexible preference margin to mitigate conflicts among competing objectives and constructs preference pairs using in silico property predictors. Applied to the widely used ProteinMPNN backbone, the resulting model MoMPNN enhances developability without compromising designability across tasks including sequence design for CATH 4.3 crystal structures, de novo generated backbones, and real-world binder design scenarios, making it an appealing framework for practical protein sequence design.