Nature Biotechnology, Published online: 13 March 2026; doi:10.1038/s41587-026-03057-9

A trispecific macrophage engager amplifies the antitumor response of macrophages in solid tumors.

arXiv:2603.07438v1 Announce Type: new Abstract: Regulatory stress testing requires projecting credit losses under hypothetical macroeconomic scenarios -- a fundamentally causal question typically treated as a prediction problem. We propose a framework for policy-path counterfactual inference in panels that transparently separates what can be learned from data from what requires assumptions about confounding. Our approach has four components: (i) observational identification of path-conditional means via iterated regression, enabling continuous macro-path contrasts without requiring a control group; (ii) causal set identification under bounded confounding, yielding sharp identified sets with interpretable breakdown values that communicate robustness in a single number; (iii) an oracle inequality showing that recursive rollout error is governed by a horizon-dependent amplification factor, providing a concrete answer to how far ahead one can reliably predict under stress; and (iv) importance-weighted conformal calibration bands with diagnostics that quantify extrapolation cost and trigger abstention when coverage guarantees degrade. The final output is a three-layer uncertainty decomposition that cleanly separates estimation uncertainty from confounding uncertainty. We validate all results through simulation and semi-synthetic experiments with real unemployment data, including a Covid retrospective demonstrating the framework's diagnostic value under extreme scenarios.