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Disclaimers and Referral Patterns for Medical Advice Across Urgency Levels: Large Language Model Evaluation Study
Background: βIβm not a doctor, but...β is a typical response when asking considerate laypeople for health advice. However, seeking medical advice has also shifted to digital settings, where the expertise of the other party is less transparent than in face-to-face interactions. Recently, large language models (LLMs) have emerged as easily accessible tools, offering a novel way to formulate medical questions and receive seemingly qualified advice. Given the sensitive nature of health-related queries and the lack of professional supervision, incorrect advice can pose serious health risks. Therefore, including explicit disclaimers and precise referrals in LLM responses to medical queries is crucial. However, little is known about how LLMs adapt their safety implementations in response to different urgency levels. Objective: This study evaluates disclaimer and referral patterns in responses from LLMs to authentic medical queries of different urgency levels using a systematic evaluation framework. Methods: This prospective, multimodel evaluation study generated and analyzed 908 responses from 4 popular LLMs (GPT-4o, Claude Sonnet-4, Grok-3, and DeepSeek-V3) to 227 authentic patient queries from a public dataset. Two human raters classified all 227 patient queries using a 3-level urgency scale. LLM responses were evaluated using a 5-point ordinal classification system for disclaimer and referral advice, ranging from βno disclaimerβ to βurgent advice to consult a medical professional.β GPT-4o served as the primary rater model for this task after conducting a subset validation against human expert annotations. Statistical analyses included Jonckheere-Terpstra tests to examine the relationship between case urgency and disclaimer ratings and Kruskal-Wallis tests for intermodel comparisons. Results: The 227 patient queries were distributed as 77 (34%) low-urgency, 110 (48%) intermediate-urgency, and 40 (18%) high-urgency cases. All 4 LLMs demonstrated statistically significant ordered trends (all
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At Nvidia CEO Jensen Huang's urging, Frore developed liquid-cooling tech for chips. That shift helped it raise $143 million.
The dictionary sues OpenAI
Encyclopedia Britannica and Merriam-Webster say that OpenAI violated the copyright of almost 100,000 articles by using them for LLM training.
Apple quietly launches AirPods Max 2
The successor to its premium headphones cost $549 and are launching with enhanced active noise cancellation, the H2 chip, live translation, better sound quality, and more.
Spatially resolved multiplex protein profiling reveals DNA methylation-dependent microenvironmental remodeling in liver fibrosis
PNAS Nexus. 2026 Feb 25;5(3):pgag047. doi: 10.1093/pnasnexus/pgag047. eCollection 2026 Mar.
ABSTRACT
Liver fibrosis is a significant health concern that affects βΌ300 million people globally, characterized by the excessive accumulation of extracellular matrix (ECM) components in the liver. A major contributor to liver fibrosis is fatty liver disease, which can progress to steatohepatitis when the accumulation of fat in the liver causes inflammation, cell death, and scarring. Long-standing steatohepatitis leads to liver fibrosis as scar tissue builds up and replaces healthy liver tissue, potentially progressing to life-threatening conditions, such as cirrhosis, liver failure, or hepatocellular carcinoma. DNA methylation plays a critical role in the progression of fatty liver disease and liver fibrosis by altering gene expression without modifying the DNA sequence. The integration of spatial analysis with protein profiling enhances our ability to explore the spatial organization of cellular interactions and protein expression in liver diseases, fostering a deeper understanding of the disease mechanisms. Multiplex immunofluorescence (mIF) imaging was performed to understand the spatial organization of 10 molecular targets and the cellular interaction between them across four distinct liver tissue types: wild-type (WT) regular, WT high-fat, fibrosis regular, and fibrosis high-fat. Notably, fibrotic high-fat samples displayed increased pan-cytokeratin and vascular cell adhesion molecule-1 (VCAM-1) expression, suggesting diet-aggravated injury and inflammation. Our findings highlight the interplay between epigenetic regulation, ECM remodeling, and cellular crosstalk in liver fibrosis. The spatial profiling approach provides insights into microenvironmental changes, revealing how DNA methylation influences protein localization and fibrotic progression. These results underscore the potential of spatial omics in elucidating disease mechanisms and guiding targeted therapies for metabolic liver disorders.
PMID:41834947 | PMC:PMC12988774 | DOI:10.1093/pnasnexus/pgag047
Tumor-informed liquid biopsy detection of structural variants in high grade serous ovarian cancer
Oncoscience. 2026 Mar 5;13:44-54. doi: 10.18632/oncoscience.645. eCollection 2026.
ABSTRACT
BACKGROUND: High grade serous ovarian cancer (HGSOC) recurs frequently and commercial tests have emerged for tumor-informed, cell-free DNA (cfDNA)-based detection of minimal residual disease. These tests are based on somatic single nucleotide variants prevalent in many cancers and thus are not well matched to HGSOC, which is dominated by structural genomic rearrangements. The purpose of this study was to evaluate the feasibility of a structural-variant (SV)-informed, cfDNA-based method for detecting clonal and subclonal HGSOC disease burden.
METHODS: A method was developed for detecting patient-specific SV breakpoints using digital droplet PCR (ddPCR) with custom tumor-informed primer/probe pairs. Test parameters were first estimated using synthetic cfDNA generated by ultrasonication of genomic DNA from ovarian cancer cell lines. The optimized workflow was implemented in which whole genome sequencing of multisite pre-treatment HGSOC biopsies performed and high confidence SVs were called by multiple published SV callers. Real-time PCR and ddPCR were used for assay development.
RESULTS: Following the optimized workflow, tumor-specific SV breakpoint-spanning primers/probe sets of four HGSOC patients' multisite biopsies were designed and validated by real-time PCR and ddPCR. Together with four HGSOCs, a total of 29 SVs breakpoints-spanning tumor-informed primers/probe sets were designed and validated in multisite biopsies. 15 validated tumor-specific SVs were selected for quantification in their corresponding liquid biopsies using the validated ddPCR, and 9 had measurements in liquid biopsies.
CONCLUSIONS: Our result shows the detection of SVs from pre-treatment cfDNA using tumor-informed breakpoints-spanning ddPCR is feasible and may enable a novel and sensitive method for monitoring on-treatment disease burden.
PMID:41835357 | PMC:PMC12981705 | DOI:10.18632/oncoscience.645
Context-Enriched Natural Language Descriptions of Vessel Trajectories
arXiv:2603.12287v1 Announce Type: new
Abstract: We address the problem of transforming raw vessel trajectory data collected from AIS into structured and semantically enriched representations interpretable by humans and directly usable by machine reasoning systems. We propose a context-aware trajectory abstraction framework that segments noisy AIS sequences into distinct trips each consisting of clean, mobility-annotated episodes. Each episode is further enriched with multi-source contextual information, such as nearby geographic entities, offshore navigation features, and weather conditions. Crucially, such representations can support generation of controlled natural language descriptions using LLMs. We empirically examine the quality of such descriptions generated using several LLMs over AIS data along with open contextual features. By increasing semantic density and reducing spatiotemporal complexity, this abstraction can facilitate downstream analytics and enable integration with LLMs for higher-level maritime reasoning tasks.
Efficient Reasoning with Balanced Thinking
arXiv:2603.12372v1 Announce Type: new
Abstract: Large Reasoning Models (LRMs) have shown remarkable reasoning capabilities, yet they often suffer from overthinking, expending redundant computational steps on simple problems, or underthinking, failing to explore sufficient reasoning paths despite inherent capabilities. These issues lead to inefficiencies and potential inaccuracies, limiting practical deployment in resource-constrained settings. Existing methods to mitigate overthinking, such as suppressing reflective keywords or adjusting reasoning length, may inadvertently induce underthinking, compromising accuracy. Therefore, we propose ReBalance, a training-free framework that achieves efficient reasoning with balanced thinking. ReBalance leverages confidence as a continuous indicator of reasoning dynamics, identifying overthinking through high confidence variance and underthinking via consistent overconfidence. By aggregating hidden states from a small-scale dataset into reasoning mode prototypes, we compute a steering vector to guide LRMs' reasoning trajectories. A dynamic control function modulates this vector's strength and direction based on real-time confidence, pruning redundancy during overthinking, and promoting exploration during underthinking. Extensive experiments conducted on four models ranging from 0.5B to 32B, and across nine benchmarks in math reasoning, general question answering, and coding tasks demonstrate that ReBalance effectively reduces output redundancy while improving accuracy, offering a general, training-free, and plug-and-play strategy for efficient and robust LRM deployment. Code is available at https://github.com/yu-lin-li/ReBalance .
Formation of Artificial Neural Assemblies by Biologically Plausible Inhibition Mechanisms
arXiv:2603.12416v1 Announce Type: new
Abstract: As proposed by Hebb's theory, neural assemblies are groups of excitatory neurons that fire synchronously and exhibit high synaptic density, representing external stimuli and supporting cognitive functions such as language and decision-making. Recently, a model called Assembly Calculus (AC) was proposed, enabling the formation of artificial neural assemblies through the $k$-winners-take-all selection process and Hebbian learning. Although the model is capable of forming assemblies according to Hebb's theory, the adopted selection process does not incorporate essential aspects of biological neural computation, as neural activity, which is often governed by statistical distributions consistent with power-law scaling. Given this limitation, the present work aimed to bring the model's dynamics closer to that observed in real cortical networks. To achieve this, a new selection mechanism inspired by the dynamics of gamma oscillation cycles, called E%-winners-take-all, was implemented, combined with an inhibition process based on the ratio between excitatory and inhibitory neurons observed in various regions of the cerebral cortex. The results obtained from our model (called E%-WTA model) were compared with those of the original model, and the analyses demonstrated that the introduced modifications allowed the network's own dynamics to determine the size of the formed assemblies. Furthermore, the recovery rate of these groups, through the evocation of the stimuli that generated them, became superior to that obtained in the original model.
Towards unified brain-to-text decoding across speech production and perception
arXiv:2603.12628v1 Announce Type: new
Abstract: Speech production and perception are the main ways humans communicate daily. Prior brain-to-text decoding studies have largely focused on a single modality and alphabetic languages. Here, we present a unified brain-to-sentence decoding framework for both speech production and perception in Mandarin Chinese. The framework exhibits strong generalization ability, enabling sentence-level decoding when trained only on single-character data and supporting characters and syllables unseen during training. In addition, it allows direct and controlled comparison of neural dynamics across modalities. Mandarin speech is decoded by first classifying syllable components in Hanyu Pinyin, namely initials and finals, from neural signals, followed by a post-trained large language model (LLM) that maps sequences of toneless Pinyin syllables to Chinese sentences. To enhance LLM decoding, we designed a three-stage post-training and two-stage inference framework based on a 7-billion-parameter LLM, achieving overall performance that exceeds larger commercial LLMs with hundreds of billions of parameters or more. In addition, several characteristics were observed in Mandarin speech production and perception: speech production involved neural responses across broader cortical regions than auditory perception; channels responsive to both modalities exhibited similar activity patterns, with speech perception showing a temporal delay relative to production; and decoding performance was broadly comparable across hemispheres. Our work not only establishes the feasibility of a unified decoding framework but also provides insights into the neural characteristics of Mandarin speech production and perception. These advances contribute to brain-to-text decoding in logosyllabic languages and pave the way toward neural language decoding systems supporting multiple modalities.
On Using Machine Learning to Early Detect Catastrophic Failures in Marine Diesel Engines
arXiv:2603.12733v1 Announce Type: new
Abstract: Catastrophic failures of marine engines imply severe loss of functionality and destroy or damage the systems irreversibly. Being sudden and often unpredictable events, they pose a severe threat to navigation, crew, and passengers. The abrupt nature makes early detection the only effective countermeasure. However, research has concentrated on modeling the gradual degradation of components, with limited attention to sudden and anomalous phenomena. This work proposes a new method for early detection of catastrophic failures. Based on real data from a failed engine, the approach evaluates the derivatives of the deviation between actual sensor readings and expected values of engine variables. Predictions are obtained by a Random Forest, which is the most suitable Machine Learning algorithm among the tested ones. Traditional methods focus on deviations of monitored signals, whereas the proposed approach employs the derivatives of the deviations to provide earlier indications of abnormal dynamics, and to alert that a rapid and dangerous event is breaking out within the system. The method allows the detection of anomalies before measurements reach critical thresholds and alarms are triggered, which is the common method in industry. Consequently, operators can be warned in advance and shut down the engine, then prevent damage and unexpected power loss. Moreover, they have the time to safely change the ship route and avoid potential obstacles. Simulation results conf irm the effectiveness of the proposed approach in anticipating occurrence of catastrophic failures. Validation on real-world data further reinforces the robustness and practical applicability of the method. It is worth noting that data acquisition to train the predictive algorithm is not a problem, since a Deep Learning-based data augmentation procedure is used.
Pulse desynchronization of neural populations by targeting the centroid of the limit cycle in phase space
arXiv:2603.12878v1 Announce Type: new
Abstract: The synchronized activity of neuronal populations can lead to pathological over-synchronization in conditions such as epilepsy and Parkinson disease. Such states can be desynchronized by brief electrical pulses. But when the underlying oscillating system is not known, as in most practical applications, to determine the specific times and intensities of pulses used for desynchronizaton is a difficult inverse problem. Here we propose a desynchronization scheme for neuronal models of bi-variate neural activity, with possible applications in the medical setting. Our main argument is the existence of a peculiar point in the phase space of the system, the centroid, that is both easy to calculate and robust under changes in the coupling constant. This important target point can be used in a control procedure because it lies in the region of minimal return times of the system.
Efficient and Interpretable Multi-Agent LLM Routing via Ant Colony Optimization
arXiv:2603.12933v1 Announce Type: new
Abstract: Large Language Model (LLM)-driven Multi-Agent Systems (MAS) have demonstrated strong capability in complex reasoning and tool use, and heterogeneous agent pools further broaden the quality--cost trade-off space. Despite these advances, real-world deployment is often constrained by high inference cost, latency, and limited transparency, which hinders scalable and efficient routing. Existing routing strategies typically rely on expensive LLM-based selectors or static policies, and offer limited controllability for semantic-aware routing under dynamic loads and mixed intents, often resulting in unstable performance and inefficient resource utilization. To address these limitations, we propose AMRO-S, an efficient and interpretable routing framework for Multi-Agent Systems (MAS). AMRO-S models MAS routing as a semantic-conditioned path selection problem, enhancing routing performance through three key mechanisms: First, it leverages a supervised fine-tuned (SFT) small language model for intent inference, providing a low-overhead semantic interface for each query; second, it decomposes routing memory into task-specific pheromone specialists, reducing cross-task interference and optimizing path selection under mixed workloads; finally, it employs a quality-gated asynchronous update mechanism to decouple inference from learning, optimizing routing without increasing latency. Extensive experiments on five public benchmarks and high-concurrency stress tests demonstrate that AMRO-S consistently improves the quality--cost trade-off over strong routing baselines, while providing traceable routing evidence through structured pheromone patterns.
Developing the PsyCogMetrics AI Lab to Evaluate Large Language Models and Advance Cognitive Science -- A Three-Cycle Action Design Science Study
arXiv:2603.13126v1 Announce Type: new
Abstract: This study presents the development of the PsyCogMetrics AI Lab (psycogmetrics.ai), an integrated, cloud-based platform that operationalizes psychometric and cognitive-science methodologies for Large Language Model (LLM) evaluation. Framed as a three-cycle Action Design Science study, the Relevance Cycle identifies key limitations in current evaluation methods and unfulfilled stakeholder needs. The Rigor Cycle draws on kernel theories such as Popperian falsifiability, Classical Test Theory, and Cognitive Load Theory to derive deductive design objectives. The Design Cycle operationalizes these objectives through nested Build-Intervene-Evaluate loops. The study contributes a novel IT artifact, a validated design for LLM evaluation, benefiting research at the intersection of AI, psychology, cognitive science, and the social and behavioral sciences.
Steve-Evolving: Open-World Embodied Self-Evolution via Fine-Grained Diagnosis and Dual-Track Knowledge Distillation
arXiv:2603.13131v1 Announce Type: new
Abstract: Open-world embodied agents must solve long-horizon tasks where the main bottleneck is not single-step planning quality but how interaction experience is organized and evolved. To this end, we present Steve-Evolving, a non-parametric self-evolving framework that tightly couples fine-grained execution diagnosis with dual-track knowledge distillation in a closed loop. The method follows three phases: Experience Anchoring, Experience Distillation, and Knowledge-Driven Closed-Loop Control. In detail, Experience Anchoring solidifies each subgoal attempt into a structured experience tuple with a fixed schema (pre-state, action, diagnosis-result, and post-state) and organizes it in a three-tier experience space with multi-dimensional indices (e.g., condition signatures, spatial hashing, and semantic tags) plus rolling summarization for efficient and auditable recall. To ensure sufficient information density for attribution, the execution layer provides compositional diagnosis signals beyond binary outcomes, including state-difference summaries, enumerated failure causes, continuous indicators, and stagnation/loop detection. Moreover, successful trajectories of Experience Distillation are generalized into reusable skills with explicit preconditions and verification criteria, while failures are distilled into executable guardrails that capture root causes and forbid risky operations at both subgoal and task granularities. Besides, Knowledge-Driven Closed-Loop Control retrieved skills and guardrails are injected into an LLM planner, and diagnosis-triggered local replanning updates the active constraints online, forming a continual evolution process without any model parameter updates. Experiments on the long-horizon suite of Minecraft MCU demonstrate consistent improvements over static-retrieval baselines.
When Right Meets Wrong: Bilateral Context Conditioning with Reward-Confidence Correction for GRPO
arXiv:2603.13134v1 Announce Type: new
Abstract: Group Relative Policy Optimization (GRPO) has emerged as an effective method for training reasoning models. While it computes advantages based on group mean, GRPO treats each output as an independent sample during the optimization and overlooks a vital structural signal: the natural contrast between correct and incorrect solutions within the same group, thus ignoring the rich, comparative data that could be leveraged by explicitly pitting successful reasoning traces against failed ones. To capitalize on this, we present a contrastive reformulation of GRPO, showing that the GRPO objective implicitly maximizes the margin between the policy ratios of correct and incorrect samples. Building on this insight, we propose Bilateral Context Conditioning (BICC), a mechanism that allows the model to cross-reference successful and failed reasoning traces during the optimization, enabling a direct information flow across samples. We further introduce Reward-Confidence Correction (RCC) to stabilize training by dynamically adjusts the advantage baseline in GRPO using reward-confidence covariance derived from the first-order approximation of the variance-minimizing estimator. Both mechanisms require no additional sampling or auxiliary models and can be adapted to all GRPO variants. Experiments on mathematical reasoning benchmarks demonstrate consistent improvements across comprehensive models and algorithms. Code is available at \href{https://github.com/Skylanding/BiCC}{https://github.com/Skylanding/BiCC}.
Developing and evaluating a chatbot to support maternal health care
arXiv:2603.13168v1 Announce Type: new
Abstract: The ability to provide trustworthy maternal health information using phone-based chatbots can have a significant impact, particularly in low-resource settings where users have low health literacy and limited access to care. However, deploying such systems is technically challenging: user queries are short, underspecified, and code-mixed across languages, answers require regional context-specific grounding, and partial or missing symptom context makes safe routing decisions difficult.
We present a chatbot for maternal health in India developed through a partnership between academic researchers, a health tech company, a public health nonprofit, and a hospital. The system combines (1) stage-aware triage, routing high-risk queries to expert templates, (2) hybrid retrieval over curated maternal/newborn guidelines, and (3) evidence-conditioned generation from an LLM. Our core contribution is an evaluation workflow for high-stakes deployment under limited expert supervision. Targeting both component-level and end-to-end testing, we introduce: (i) a labeled triage benchmark (N=150) achieving 86.7% emergency recall, explicitly reporting the missed-emergency vs. over-escalation trade-off; (ii) a synthetic multi-evidence retrieval benchmark (N=100) with chunk-level evidence labels; (iii) LLM-as-judge comparison on real queries (N=781) using clinician-codesigned criteria; and (iv) expert validation. Our findings show that trustworthy medical assistants in multilingual, noisy settings require defense-in-depth design paired with multi-method evaluation, rather than any single model and evaluation method choice.
Diagnosing Retrieval Bias Under Multiple In-Context Knowledge Updates in Large Language Models
arXiv:2603.12271v1 Announce Type: cross
Abstract: LLMs are widely used in knowledge-intensive tasks where the same fact may be revised multiple times within context. Unlike prior work focusing on one-shot updates or single conflicts, multi-update scenarios contain multiple historically valid versions that compete at retrieval, yet remain underexplored. This challenge resembles the AB-AC interference paradigm in cognitive psychology: when the same cue A is successively associated with B and C, the old and new associations compete during retrieval, leading to bias. Inspired by this, we introduce a Dynamic Knowledge Instance (DKI) evaluation framework, modeling multi-updates of the same fact as a cue paired with a sequence of updated values, and assess models via endpoint probing of the earliest (initial) and latest (current) states. Across diverse LLMs, we observe that retrieval bias intensifies as updates increase, earliest-state accuracy stays high while latest-state accuracy drops substantially. Diagnostic analyses of attention, hidden-state similarity, and output logits further reveal that these signals become flatter and weakly discriminative on errors, providing little stable basis for identifying the latest update. Finally, cognitively inspired heuristic intervention strategies yield only modest gains and do not eliminate the bias. Our results reveal a persistent challenge in tracking and following knowledge updates in long contexts.
Detecting Miscitation on the Scholarly Web through LLM-Augmented Text-Rich Graph Learning
arXiv:2603.12290v1 Announce Type: cross
Abstract: Scholarly web is a vast network of knowledge connected by citations. However, this system is increasingly compromised by miscitation, where references do not support or even contradict the claims they are cited for. Current miscitation detection methods, which primarily rely on semantic similarity or network anomalies, struggle to capture the nuanced relationship between a citation's context and its place in the wider network. While large language models (LLMs) offer powerful capabilities in semantic reasoning for this task, their deployment is hindered by hallucination risks and high computational costs. In this work, we introduce LLM-Augmented Graph Learning-based Miscitation Detector (LAGMiD), a novel framework that leverages LLMs for deep semantic reasoning over citation graphs and distills this knowledge into graph neural networks (GNNs) for efficient and scalable miscitation detection. Specifically, LAGMiD introduces an evidence-chain reasoning mechanism, which uses chain-of-thought prompting, to perform multi-hop citation tracing and assess semantic fidelity. To reduce LLM inference costs, we design a knowledge distillation method aligning GNN embeddings with intermediate LLM reasoning states. A collaborative learning strategy further routes complex cases to the LLM while optimizing the GNN for structure-based generalization. Experiments on three real-world benchmarks show that LAGMiD achieves state-of-the-art miscitation detection with significantly reduced inference cost.
