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Energy-Aware Reinforcement Learning for Robotic Manipulation of Articulated Components in Infrastructure Operation and Maintenance

arXiv:2602.12288v3 Announce Type: replace-cross Abstract: With the growth of intelligent civil infrastructure and smart cities, operation and maintenance (O&M) increasingly requires safe, efficient, and energy-conscious robotic manipulation of articulated components, including access doors, service drawers, and pipeline valves. However, existing robotic approaches either focus primarily on grasping or target object-specific articulated manipulation, and they rarely incorporate explicit actuation energy into multi-objective optimisation, which limits their scalability and suitability for long-term deployment in real O&M settings. Therefore, this paper proposes an articulation-agnostic and energy-aware reinforcement learning framework for robotic manipulation in intelligent infrastructure O&M. The method combines part-guided 3D perception, weighted point sampling, and PointNet-based encoding to obtain a compact geometric representation that generalises across heterogeneous articulated objects. Manipulation is formulated as a Constrained Markov Decision Process (CMDP), in which actuation energy is explicitly modelled and regulated via a Lagrangian-based constrained Soft Actor-Critic scheme. The policy is trained end-to-end under this CMDP formulation, enabling effective articulated-object operation while satisfying a long-horizon energy budget. Experiments on representative O&M tasks demonstrate 16%-30% reductions in energy consumption, 16%-32% fewer steps to success, and consistently high success rates, indicating a scalable and sustainable solution for infrastructure O&M manipulation.
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PAK4 functions as an immune suppressor by reprogramming the phosphatidylcholine metabolism of CD8 + T cells within the glioblastoma tumor microenvironment

Oncogene, Published online: 23 March 2026; doi:10.1038/s41388-026-03734-8

PAK4 functions as an immune suppressor by reprogramming the phosphatidylcholine metabolism of CD8 + T cells within the glioblastoma tumor microenvironment
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Mechanisms of Xinwei Tang in stress-induced gastric dysmotility: evidence from rat and In Vitro models

In Vitro Cell Dev Biol Anim. 2026 Mar 18. doi: 10.1007/s11626-026-01151-5. Online ahead of print.

ABSTRACT

Stress is a key trigger of gastric dysmotility, partly via mitochondrial dysfunction and disordered gut-brain hormonal signaling. Xinwei Tang (XWT) is a multi-herb formula used empirically for upper gastrointestinal symptoms, but its mechanisms remain unclear. This study aimed to determine whether XWT alleviates water-immersion restraint stress (WIRS)-induced gastric dysmotility and to delineate underlying mitochondrial and metabolic pathways using integrated in vivo, in vitro and multi-omics approaches. Male rats underwent 7-d WIRS and received vehicle, domperidone (3 mg/kg) or XWT (3, 6, 12 g/kg). Gastric emptying, serum motilin/gastrin, oxidative stress indices and PINK1/Parkin-LC3/p62 proteins were assessed, and Hβ‚‚Oβ‚‚-injured GES-1 cells were treated with XWT-medicated serum. Gastric antra from MOD and XWT-H rats were analyzed by RNA-seq and DIA proteomics (n = 3/group). WIRS reduced gastric emptying by roughly half and lowered motilin/gastrin, increased ROS/MDA and disrupted PINK1/Parkin-LC3/p62 profiles; XWT dose-dependently reversed these changes, with XWT-H approximating domperidone. Omics revealed XWT-associated downregulation of inflammatory/protease and acute-phase genes/proteins and enrichment of oxidative phosphorylation, tricarboxylic-acid cycle and other metabolic pathways, without global activation of canonical autophagy/mitophagy gene sets. These preclinical data indicate that XWT ameliorates stress-induced gastric dysmotility via mitochondria- and metabolism-centred protection with selective tuning of mitophagy-related proteins.

PMID:41851413 | DOI:10.1007/s11626-026-01151-5

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